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PMID:9230313

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Citation

Zeng, L, Fagotto, F, Zhang, T, Hsu, W, Vasicek, TJ, Perry, WL 3rd, Lee, JJ, Tilghman, SM, Gumbiner, BM and Costantini, F (1997) The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell 90:181-92

Abstract

Mutations at the mouse Fused locus have pleiotropic developmental effects, including the formation of axial duplications in homozygous embryos. The product of the Fused locus, Axin, displays similarities to RGS (Regulators of G-Protein Signaling) and Dishevelled proteins. Mutant Fused alleles that cause axial duplications disrupt the major mRNA, suggesting that Axin negatively regulates the response to an axis-inducing signal. Injection of Axin mRNA into Xenopus embryos inhibits dorsal axis formation by interfering with signaling through the Wnt pathway. Furthermore, ventral injection of an Axin mRNA lacking the RGS domain induces an ectopic axis, apparently through a dominant-negative mechanism. Thus, Axin is a novel inhibitor of Wnt signaling and regulates an early step in embryonic axis formation in mammals and amphibians.

Links

PubMed

Keywords

Amino Acid Sequence; Amphibians; Animals; Axin Protein; Chickens; Cloning, Molecular; Embryo, Nonmammalian/physiology; Embryonic Induction; Humans; Mammals; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Biosynthesis; Proteins/chemistry; Proteins/genetics; RNA, Messenger/biosynthesis; Rats; Recombinant Proteins/biosynthesis; Recombinant Proteins/chemistry; Repressor Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Stem Cells/physiology; Xenopus; Xenopus Proteins

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:AXIN1

involved_in

GO:0030178: negative regulation of Wnt signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:AXIN1

involved_in

GO:0048318: axial mesoderm development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857546

P

Seeded From UniProt

complete

MOUSE:AXIN1

involved_in

GO:0048320: axial mesoderm formation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857546

P

Seeded From UniProt

complete

MOUSE:CTNB1

involved_in

GO:0000578: embryonic axis specification

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:AXIN1

acts_upstream_of_or_within

GO:0048318: axial mesoderm development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857546

P

Seeded From UniProt

complete

MOUSE:AXIN1

acts_upstream_of_or_within

GO:0048320: axial mesoderm formation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857546

P

Seeded From UniProt

complete

MOUSE:AXIN1

acts_upstream_of_or_within

GO:0030178: negative regulation of Wnt signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:CTNB1

acts_upstream_of_or_within

GO:0000578: embryonic axis specification

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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