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PMID:9488439
| Citation |
Korinek, V, Barker, N, Willert, K, Molenaar, M, Roose, J, Wagenaar, G, Markman, M, Lamers, W, Destree, O and Clevers, H (1998) Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol. Cell. Biol. 18:1248-56 |
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| Abstract |
Tcf transcription factors interact with beta-catenin and Armadillo to mediate Wnt/Wingless signaling. We now report the characterization of genes encoding two murine members of the Tcf family, mTcf-3 and mTcf-4. mTcf-3 mRNA is ubiquitously present in embryonic day 6.5 (E6.5) mouse embryos but gradually disappears over the next 3 to 4 days. mTcf-4 expression occurs first at E10.5 and is restricted to di- and mesencephalon and the intestinal epithelium during embryogenesis. The mTcf-3 and mTcf-4 proteins bind a canonical Tcf DNA motif and can complex with the transcriptional coactivator beta-catenin. Overexpression of Wnt-1 in a mammary epithelial cell line leads to the formation of a nuclear complex between beta-catenin and Tcf proteins and to Tcf reporter gene transcription. These data demonstrate a direct link between Wnt stimulation and beta-catenin/Tcf transcriptional activation and imply a role for mTcf-3 and -4 in early Wnt-driven developmental decisions in the mouse embryo. |
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| Keywords |
3T3 Cells; Amino Acid Sequence; Animals; Cell Line; Cell Nucleus/metabolism; Chickens; Cloning, Molecular; Cytoskeletal Proteins/metabolism; Embryonic and Fetal Development; Gene Expression; Genes, Reporter; HMGB Proteins; Humans; Luciferases/genetics; Mice; Molecular Sequence Data; PC12 Cells; Proto-Oncogene Proteins/biosynthesis; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Rats; Signal Transduction; TCF Transcription Factors; Trans-Activators; Transcription Factor 7-Like 1 Protein; Transcription Factor 7-Like 2 Protein; Transcription Factors/biosynthesis; Transcription Factors/metabolism; Transcriptional Activation; Wnt Proteins; Wnt1 Protein; Zebrafish Proteins; beta Catenin |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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