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PMID:14622577
| Citation |
Bamji, SX, Shimazu, K, Kimes, N, Huelsken, J, Birchmeier, W, Lu, B and Reichardt, LF (2003) Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. Neuron 40:719-31 |
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| Abstract |
Cadherins and catenins are thought to promote adhesion between pre and postsynaptic elements in the brain. Here we show a role for beta-catenin in localizing the reserved pool of vesicles at presynaptic sites. Deletion of beta-catenin in hippocampal pyramidal neurons in vivo resulted in a reduction in the number of reserved pool vesicles per synapse and an impaired response to prolonged repetitive stimulation. This corresponded to a dispersion of vesicles along the axon in cultured neurons. Interestingly, these effects are not due to beta-catenin's involvement in cadherin-mediated adhesion or wnt signaling. Instead, beta-catenin modulates vesicle localization via its PDZ binding domain to recruit PDZ proteins such as Veli to cadherin at synapses. This study defines a specific role for cadherins and catenins in synapse organization beyond their roles in mediating cell adhesion. |
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| Keywords |
Animals; Cadherins/metabolism; Carrier Proteins/metabolism; Cells, Cultured; Cytoskeletal Proteins/deficiency; Cytoskeletal Proteins/genetics; Cytoskeletal Proteins/metabolism; Electric Stimulation; Fetus; Hippocampus/metabolism; Hippocampus/ultrastructure; Male; Mice; Mice, Transgenic; Microscopy, Electron; Presynaptic Terminals/metabolism; Presynaptic Terminals/ultrastructure; Protein Structure, Tertiary/physiology; Pyramidal Cells/metabolism; Pyramidal Cells/ultrastructure; Rats; Synaptic Membranes/metabolism; Synaptic Membranes/ultrastructure; Synaptic Transmission/physiology; Synaptic Vesicles/metabolism; Synaptic Vesicles/ultrastructure; Trans-Activators/deficiency; Trans-Activators/genetics; Trans-Activators/metabolism; Vesicular Transport Proteins; beta Catenin |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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References
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