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PMID:11371349

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Citation

Huelsken, J, Vogel, R, Erdmann, B, Cotsarelis, G and Birchmeier, W (2001) beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 105:533-45

Abstract

beta-Catenin is an essential molecule in Wnt/wingless signaling, which controls decisive steps in embryogenesis. To study the role of beta-catenin in skin development, we introduced a conditional mutation of the gene in the epidermis and hair follicles using Cre/loxP technology. When beta-catenin is mutated during embryogenesis, formation of placodes that generate hair follicles is blocked. We show that beta-catenin is required genetically downstream of tabby/downless and upstream of bmp and shh in placode formation. If beta-catenin is deleted after hair follicles have formed, hair is completely lost after the first hair cycle. Further analysis demonstrates that beta-catenin is essential for fate decisions of skin stem cells: in the absence of beta-catenin, stem cells fail to differentiate into follicular keratinocytes, but instead adopt an epidermal fate.

Links

PubMed

Keywords

Animals; Cell Differentiation/physiology; Cell Lineage/physiology; Cytoskeletal Proteins/genetics; Cytoskeletal Proteins/metabolism; Gene Deletion; Gene Expression Regulation, Enzymologic; Hair Follicle/cytology; Hair Follicle/embryology; Integrases/genetics; Keratin-14; Keratinocytes/cytology; Keratinocytes/metabolism; Keratins/genetics; Mice; Mice, Knockout; Mutagenesis, Insertional/physiology; Phenotype; Stem Cells/cytology; Stem Cells/metabolism; Trans-Activators; Viral Proteins; beta Catenin

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:CTNB1

acts_upstream_of_or_within

GO:0022405: hair cycle process

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2148594,MGI:MGI:2148596

P

Seeded From UniProt

complete

MOUSE:CTNB1

acts_upstream_of_or_within

GO:0031069: hair follicle morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2148594,MGI:MGI:2148596

P

Seeded From UniProt

complete

MOUSE:CTNB1

acts_upstream_of_or_within

GO:0022405: hair cycle process

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2148594,MGI:MGI:2148596

P

has_participant:(EMAPA:17525)

Seeded From UniProt

complete

MOUSE:CTNB1

acts_upstream_of_or_within

GO:0031069: hair follicle morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2148594,MGI:MGI:2148596

P

has_participant:(EMAPA:17525)

Seeded From UniProt

complete

MOUSE:CTNB1

acts_upstream_of_or_within

GO:0060789: hair follicle placode formation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2148594,MGI:MGI:2148596

P

Seeded From UniProt

complete


See also

References

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