MOUSE:AXIN1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Axin1 (synonyms: Axin, Fu)
Protein Name(s)	Axin-1 Axis inhibition protein 1 Protein Fused
External Links
UniProt	O35625
EMBL	AF009011 AC126438 AC140047
RefSeq	NP_033863.2
UniGene	Mm.23684
PDB	3UTM
PDBsum	3UTM
ProteinModelPortal	O35625
SMR	O35625
BioGrid	198287
DIP	DIP-42637N
IntAct	O35625
MINT	MINT-1543084
PhosphoSite	O35625
PaxDb	O35625
PRIDE	O35625
GeneID	12005
KEGG	mmu:12005
CTD	8312
MGI	MGI:1096327
eggNOG	NOG238205
HOVERGEN	HBG004324
InParanoid	O35625
KO	K02157
Reactome	REACT_203336 REACT_207044 REACT_216784 REACT_218396 REACT_219129 REACT_230286 REACT_234076 REACT_248000 REACT_250714 REACT_252458 REACT_258576 REACT_260752 REACT_261276
ChiTaRS	Axin1
NextBio	280195
PRO	PR:O35625
Proteomes	UP000000589
CleanEx	MM_AXIN1
ExpressionAtlas	O35625
Genevestigator	O35625
GO	GO:0030877 GO:0005938 GO:0005737 GO:0016023 GO:0005794 GO:0016328 GO:0005634 GO:0048471 GO:0005886 GO:0014069 GO:0043234 GO:0070016 GO:0008013 GO:0005096 GO:0070411 GO:0042802 GO:0002039 GO:0008022 GO:0032947 GO:0019904 GO:0042803 GO:0019901 GO:0043621 GO:0070412 GO:0004871 GO:0031625 GO:0007257 GO:0006915 GO:0048318 GO:0048320 GO:0060070 GO:0060823 GO:0008219 GO:0043623 GO:0071407 GO:0031122 GO:0007368 GO:0009950 GO:0009953 GO:0048048 GO:0021797 GO:0071514 GO:0001701 GO:0055001 GO:0090090 GO:0045599 GO:0051248 GO:0034244 GO:0030178 GO:0006913 GO:0030910 GO:0001743 GO:0043547 GO:0046330 GO:0043507 GO:0032436 GO:0001934 GO:0031398 GO:2000060 GO:0045893 GO:0030511 GO:0051443 GO:0036342 GO:0030163 GO:0051260 GO:0000209 GO:0035412 GO:0001932 GO:0007605 GO:0038032 GO:0016055 GO:0090244 GO:0021881
Gene3D	1.10.196.10
InterPro	IPR029797 IPR014936 IPR001158 IPR016137 IPR024066 IPR029071
PANTHER	PTHR10845:SF11
Pfam	PF08833 PF00778 PF00615
PRINTS	PR01301
SMART	SM00021 SM00315
SUPFAM	SSF48097 SSF54236
PROSITE	PS50841 PS50132

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045860	positive regulation of protein kinase activity	PMID:15526030^[1]	ECO:0000314			P		Figures 4,6,8: Axin activates HIPK2 (homeodomain-interacting protein kinase-2)-mediated p53 phosphorylation and p53-dependent transcription and apoptosis.	complete CACAO 3582
part_of	GO:0005886	plasma membrane	PMID:12138115^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:1990909	Wnt signalosome	PMID:22899650^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:11955436^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q02248)	Seeded From UniProt	complete
involved_in	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	PMID:11955436^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q02248)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11336703^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:22899650^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q5S006	F	occurs_in:(GO:0005737) occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	PMID:15526030^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	PMID:16601693^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051443	positive regulation of ubiquitin-protein transferase activity	PMID:16601693^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16601693^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0060090	molecular adaptor activity	PMID:16601693^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:16601693^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99ML9	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16601693^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:17681137^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:17681137^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O35625	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16815997^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	PMID:16601693^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620859	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:19204372^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:15579909^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620859	P		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071514	genetic imprinting	PMID:12601169^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856035	P		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	PMID:16601693^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8BUN5	F		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	PMID:16601693^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O35182 UniProtKB:O35253	F		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	F		Seeded From UniProt	complete
enables	GO:0070016	armadillo repeat domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620859	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060828	regulation of canonical Wnt signaling pathway	PMID:14981260^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060322	head development	PMID:21344612^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4941943	P		Seeded From UniProt	complete
enables	GO:0060090	molecular adaptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:19075000^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:10937998^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051443	positive regulation of ubiquitin-protein transferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	PMID:10318824^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620859	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051248	negative regulation of protein metabolic process	PMID:10330403^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048320	axial mesoderm formation	PMID:9230313^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857546	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048318	axial mesoderm development	PMID:9230313^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857546	P		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046330	positive regulation of JNK cascade	PMID:18316368^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856035	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045860	positive regulation of protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620859	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045599	negative regulation of fat cell differentiation	PMID:10937998^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	PMID:15579909^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O35625	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043507	positive regulation of JUN kinase activity	PMID:15579909^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043507	positive regulation of JUN kinase activity	PMID:12878610^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043507	positive regulation of JUN kinase activity	PMID:12878610^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043507	positive regulation of JUN kinase activity	PMID:17681137^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P57094	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:18632848^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O35625	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:15579909^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O35625	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:9920888^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O35625	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620859	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036342	post-anal tail morphogenesis	PMID:12601169^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856035	P		Seeded From UniProt	complete
enables	GO:0035591	signaling adaptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034622	cellular protein-containing complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter	PMID:19204372^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter	PMID:10318824^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:16601693^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:16601693^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032147	activation of protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:16601693^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99ML9	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:11113207^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620859	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031398	positive regulation of protein ubiquitination	PMID:16601693^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1934919	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031398	positive regulation of protein ubiquitination	PMID:16601693^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031398	positive regulation of protein ubiquitination	PMID:16601693^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031122	cytoplasmic microtubule organization	PMID:14734535^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:94941	P		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:10318824^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	C		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620859	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	PMID:16601693^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1934919	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	PMID:16601693^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	PMID:16601693^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030178	negative regulation of Wnt signaling pathway	PMID:9230313^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030178	negative regulation of Wnt signaling pathway	PMID:17681137^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030178	negative regulation of Wnt signaling pathway	PMID:12717450^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030163	protein catabolic process	PMID:12717450^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:17681137^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8C4Q6	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:15579909^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q60838	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620859	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:15526030^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9QZR5	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:10318824^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620859	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	F		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016055	Wnt signaling pathway	PMID:11113207^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P51141	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016055	Wnt signaling pathway	PMID:11113207^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620859	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	PMID:18076571^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:18316368^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856035	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:17681137^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P57094	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009950	dorsal/ventral axis specification	PMID:10330403^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009950	dorsal/ventral axis specification	PMID:17681137^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P57094	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:9920888^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63330	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:10318824^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:18632848^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q02248	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:10330403^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:10318824^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q02248	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620859	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:21003499^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856035	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006913	nucleocytoplasmic transport	PMID:14981260^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:10330403^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10330403^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620859	C		Seeded From UniProt	complete
colocalizes_with	GO:0005881	cytoplasmic microtubule	PMID:14734535^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620859	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18606656^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11113207^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10330403^[17]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9YGY0	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620859	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:15526030^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02340	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	PMID:10330403^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15169	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001932	regulation of protein phosphorylation	PMID:14734535^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:94941	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:19204372^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:19204372^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3840236 MGI:MGI:3840238	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000209	protein polyubiquitination	PMID:16601693^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029797	P		Seeded From UniProt	complete
enables	GO:0030159	receptor signaling complex adaptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029797	F		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029797	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030178	negative regulation of Wnt signaling pathway	PMID:10581160^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:10581160^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:11955436^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-209146 Reactome:R-MMU-209148 Reactome:R-MMU-209096 Reactome:R-MMU-209059	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Rui, Y et al. (2004) Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J. 23 4583-94 PubMed GONUTS page
↑ Karasawa, T et al. (2002) Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling. J. Biol. Chem. 277 37479-86 PubMed GONUTS page
↑ ^3.0 ^3.1 Berwick, DC & Harvey, K (2012) LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6. Hum. Mol. Genet. 21 4966-79 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Liu, C et al. (2002) Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108 837-47 PubMed GONUTS page
↑ Mao, J et al. (2001) Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol. Cell 7 801-9 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 ^6.16 ^6.17 ^6.18 Liu, W et al. (2006) Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J. 25 1646-58 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Rui, Y et al. (2007) A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev. Cell 13 268-82 PubMed GONUTS page
↑ Chen, HJ et al. (2006) The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev. 20 1933-45 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Chia, IV et al. (2009) Both the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesis. Genetics 181 1359-68 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Luo, W et al. (2005) Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. J. Biol. Chem. 280 5054-60 PubMed GONUTS page
↑ ^11.0 ^11.1 Rakyan, VK et al. (2003) Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc. Natl. Acad. Sci. U.S.A. 100 2538-43 PubMed GONUTS page
↑ ^12.0 ^12.1 Cong, F & Varmus, H (2004) Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin. Proc. Natl. Acad. Sci. U.S.A. 101 2882-7 PubMed GONUTS page
↑ Xie, R et al. (2011) Generation of Axin1 conditional mutant mice. Genesis 49 98-102 PubMed GONUTS page
↑ Haÿ, E et al. (2009) N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation. Mol. Cell. Biol. 29 953-64 PubMed GONUTS page
↑ ^15.0 ^15.1 Ross, SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289 950-3 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Sakanaka, C & Williams, LT (1999) Functional domains of axin. Importance of the C terminus as an oligomerization domain. J. Biol. Chem. 274 14090-3 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 Fagotto, F et al. (1999) Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization. J. Cell Biol. 145 741-56 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Zeng, L et al. (1997) The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell 90 181-92 PubMed GONUTS page
↑ ^19.0 ^19.1 Lu, Z et al. (2008) Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling. J. Biol. Chem. 283 13132-9 PubMed GONUTS page
↑ ^20.0 ^20.1 Luo, W et al. (2003) Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation. J. Biol. Chem. 278 37451-8 PubMed GONUTS page
↑ ^21.0 ^21.1 Kim, MJ et al. (2008) SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability. FASEB J. 22 3785-94 PubMed GONUTS page
↑ ^22.0 ^22.1 Hsu, W et al. (1999) Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain. J. Biol. Chem. 274 3439-45 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 Hino, S et al. (2001) Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Mol. Cell. Biol. 21 330-42 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Ciani, L et al. (2004) A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules. J. Cell Biol. 164 243-53 PubMed GONUTS page
↑ ^25.0 ^25.1 Reya, T et al. (2003) A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423 409-14 PubMed GONUTS page
↑ Ohshima, R et al. (2007) Putative tumor suppressor EDD interacts with and up-regulates APC. Genes Cells 12 1339-45 PubMed GONUTS page
↑ DUNN, LC & CASPARI, E (1945) A case of neighboring loci with similar effects. Genetics 30 543-68 PubMed GONUTS page
↑ Grujic, M et al. (2008) Delayed contraction of the CD8+ T cell response toward lymphocytic choriomeningitis virus infection in mice lacking serglycin. J. Immunol. 181 1043-51 PubMed GONUTS page
↑ ^29.0 ^29.1 Jho, Eh et al. (1999) A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression. Biochem. Biophys. Res. Commun. 266 28-35 PubMed GONUTS page

[PMID:15526030-1] 1.0 ^1.1 ^1.2 ^1.3 Rui, Y et al. (2004) Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J. 23 4583-94 PubMed GONUTS page

[PMID:12138115-2] Karasawa, T et al. (2002) Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling. J. Biol. Chem. 277 37479-86 PubMed GONUTS page

[PMID:22899650-3] 3.0 ^3.1 Berwick, DC & Harvey, K (2012) LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6. Hum. Mol. Genet. 21 4966-79 PubMed GONUTS page

[PMID:11955436-4] 4.0 ^4.1 ^4.2 Liu, C et al. (2002) Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108 837-47 PubMed GONUTS page

[PMID:11336703-5] Mao, J et al. (2001) Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol. Cell 7 801-9 PubMed GONUTS page

[PMID:16601693-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 ^6.16 ^6.17 ^6.18 Liu, W et al. (2006) Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J. 25 1646-58 PubMed GONUTS page

[PMID:17681137-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Rui, Y et al. (2007) A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev. Cell 13 268-82 PubMed GONUTS page

[PMID:16815997-8] Chen, HJ et al. (2006) The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev. 20 1933-45 PubMed GONUTS page

[PMID:19204372-9] 9.0 ^9.1 ^9.2 ^9.3 Chia, IV et al. (2009) Both the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesis. Genetics 181 1359-68 PubMed GONUTS page

[PMID:15579909-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Luo, W et al. (2005) Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. J. Biol. Chem. 280 5054-60 PubMed GONUTS page

[PMID:12601169-11] 11.0 ^11.1 Rakyan, VK et al. (2003) Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc. Natl. Acad. Sci. U.S.A. 100 2538-43 PubMed GONUTS page

[PMID:14981260-12] 12.0 ^12.1 Cong, F & Varmus, H (2004) Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin. Proc. Natl. Acad. Sci. U.S.A. 101 2882-7 PubMed GONUTS page

[PMID:21344612-13] Xie, R et al. (2011) Generation of Axin1 conditional mutant mice. Genesis 49 98-102 PubMed GONUTS page

[PMID:19075000-14] Haÿ, E et al. (2009) N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation. Mol. Cell. Biol. 29 953-64 PubMed GONUTS page

[PMID:10937998-15] 15.0 ^15.1 Ross, SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289 950-3 PubMed GONUTS page

[PMID:10318824-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Sakanaka, C & Williams, LT (1999) Functional domains of axin. Importance of the C terminus as an oligomerization domain. J. Biol. Chem. 274 14090-3 PubMed GONUTS page

[PMID:10330403-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 Fagotto, F et al. (1999) Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization. J. Cell Biol. 145 741-56 PubMed GONUTS page

[PMID:9230313-18] 18.0 ^18.1 ^18.2 Zeng, L et al. (1997) The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell 90 181-92 PubMed GONUTS page

[PMID:18316368-19] 19.0 ^19.1 Lu, Z et al. (2008) Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling. J. Biol. Chem. 283 13132-9 PubMed GONUTS page

[PMID:12878610-20] 20.0 ^20.1 Luo, W et al. (2003) Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation. J. Biol. Chem. 278 37451-8 PubMed GONUTS page

[PMID:18632848-21] 21.0 ^21.1 Kim, MJ et al. (2008) SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability. FASEB J. 22 3785-94 PubMed GONUTS page

[PMID:9920888-22] 22.0 ^22.1 Hsu, W et al. (1999) Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain. J. Biol. Chem. 274 3439-45 PubMed GONUTS page

[PMID:11113207-23] 23.0 ^23.1 ^23.2 ^23.3 Hino, S et al. (2001) Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Mol. Cell. Biol. 21 330-42 PubMed GONUTS page

[PMID:14734535-24] 24.0 ^24.1 ^24.2 Ciani, L et al. (2004) A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules. J. Cell Biol. 164 243-53 PubMed GONUTS page

[PMID:12717450-25] 25.0 ^25.1 Reya, T et al. (2003) A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423 409-14 PubMed GONUTS page

[PMID:18076571-26] Ohshima, R et al. (2007) Putative tumor suppressor EDD interacts with and up-regulates APC. Genes Cells 12 1339-45 PubMed GONUTS page

[PMID:21003499-27] DUNN, LC & CASPARI, E (1945) A case of neighboring loci with similar effects. Genetics 30 543-68 PubMed GONUTS page

[PMID:18606656-28] Grujic, M et al. (2008) Delayed contraction of the CD8+ T cell response toward lymphocytic choriomeningitis virus infection in mice lacking serglycin. J. Immunol. 181 1043-51 PubMed GONUTS page

[PMID:10581160-29] 29.0 ^29.1 Jho, Eh et al. (1999) A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression. Biochem. Biophys. Res. Commun. 266 28-35 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

MOUSE:AXIN1

Contents

Annotations

Notes

References

a

b

c

d

e

g

h

i

l

m

n

o

p

r

s

u

v

w

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools