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HUMAN:WNT2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) WNT2 (synonyms: INT1L1, IRP)
Protein Name(s) Protein Wnt-2

Int-1-like protein 1 Int-1-related protein IRP

External Links
UniProt P09544
EMBL X07876
AK056742
BT019608
AC002465
AC006326
CH236947
CH471070
BC029854
BC078170
CCDS CCDS5771.1
PIR S00834
RefSeq NP_003382.1
UniGene Hs.567356
ProteinModelPortal P09544
SMR P09544
BioGrid 113309
IntAct P09544
STRING 9606.ENSP00000265441
BindingDB P09544
ChEMBL CHEMBL1255132
PhosphoSite P09544
DMDM 139750
PaxDb P09544
PRIDE P09544
DNASU 7472
Ensembl ENST00000265441
GeneID 7472
KEGG hsa:7472
UCSC uc003viz.3
CTD 7472
GeneCards GC07M116916
HGNC HGNC:12780
HPA CAB017098
HPA020920
MIM 147870
neXtProt NX_P09544
PharmGKB PA37381
eggNOG NOG284879
GeneTree ENSGT00760000118943
HOGENOM HOG000039529
HOVERGEN HBG001595
InParanoid P09544
KO K00182
OMA GYDTSRI
OrthoDB EOG7C8GJ8
PhylomeDB P09544
TreeFam TF105310
Reactome REACT_163710
REACT_18372
SignaLink P09544
GeneWiki WNT2
GenomeRNAi 7472
NextBio 29268
PRO PR:P09544
Proteomes UP000005640
Bgee P09544
CleanEx HS_WNT2
ExpressionAtlas P09544
Genevestigator P09544
GO GO:0005737
GO:0031012
GO:0005576
GO:0005615
GO:0005578
GO:0005125
GO:0005109
GO:0048018
GO:0055009
GO:0060070
GO:0060317
GO:0045165
GO:0007267
GO:0071300
GO:0071560
GO:0061072
GO:0060716
GO:0002088
GO:0030324
GO:0060492
GO:0061180
GO:0030182
GO:0090263
GO:0060045
GO:0008284
GO:0001938
GO:0060501
GO:0048146
GO:0002053
GO:0051091
GO:0045944
GO:0016055
InterPro IPR005817
IPR009140
IPR018161
PANTHER PTHR12027
Pfam PF00110
PRINTS PR01842
PR01349
SMART SM00097
PROSITE PS00246

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1904954

canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation

PMID:20018874[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1904948

midbrain dopaminergic neuron differentiation

PMID:20018874[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033278

cell proliferation in midbrain

PMID:20018874[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:20018874[1]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0000700)

Seeded From UniProt

complete

part_of

GO:1990909

Wnt signalosome

PMID:10557084[2]

ECO:0000305

curator inference used in manual assertion

GO:0048018
GO:0060070

C

Seeded From UniProt

complete

enables

GO:0048018

receptor ligand activity

PMID:10557084[2]

ECO:0000314

direct assay evidence used in manual assertion

F

part_of:(GO:0016055)

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

PMID:20018874[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061072

iris morphogenesis

PMID:16258938[3]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3L257

P

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

PMID:10347172[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051091

positive regulation of DNA-binding transcription factor activity

PMID:10557084[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048146

positive regulation of fibroblast proliferation

PMID:19734317[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0048018

receptor ligand activity

PMID:17948129[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:10347172[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007267

cell-cell signaling

PMID:10557084[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031232

extrinsic component of external side of plasma membrane

PMID:19038973[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

PMID:10557084[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0002088

lens development in camera-type eye

PMID:16258938[3]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3L257

P

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

PMID:17948129[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071560

cellular response to transforming growth factor beta stimulus

PMID:15040835[8]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071300

cellular response to retinoic acid

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56706

P

Seeded From UniProt

complete

involved_in

GO:0061180

mammary gland epithelium development

PMID:8168088[9]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:15507471[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56706

P

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

PMID:10557084[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:19239325[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:19038973[7]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000711)

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:2971536[12]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

PMID:19038973[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O00144

F

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

PMID:10557084[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9UP38

F

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

PMID:19038973[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9NPG1

F

Seeded From UniProt

complete

involved_in

GO:0045165

cell fate commitment

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98957
PANTHER:PTN000246517
UniProtKB:P49339
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000246517
RGD:69250
UniProtKB:P56706
UniProtKB:Q98SN7

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010194
MGI:MGI:108061
MGI:MGI:1197020
MGI:MGI:98953
MGI:MGI:98954
MGI:MGI:98956
MGI:MGI:98958
MGI:MGI:98960
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
UniProtKB:P41221
UniProtKB:Q98SN7
WB:WBGene00000858
WB:WBGene00003029
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
MGI:MGI:98956
MGI:MGI:98957
PANTHER:PTN000246517
RGD:1311441
RGD:69250
UniProtKB:P41221
UniProtKB:P56704
UniProtKB:P56705
UniProtKB:Q2LMP1
UniProtKB:Q9UBV4
UniProtKB:Q9YGX6

C

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
FB:FBgn0004360
FB:FBgn0010453
FB:FBgn0038134
MGI:MGI:98956
MGI:MGI:98957
MGI:MGI:98958
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
RGD:69079
UniProtKB:P09544
UniProtKB:P41221
UniProtKB:P56703
UniProtKB:Q98SN7

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:23610556[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048018

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048018

P

Seeded From UniProt

complete

involved_in

GO:0060716

labyrinthine layer blood vessel development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21552
ensembl:ENSMUSP00000010941

P

Seeded From UniProt

complete

involved_in

GO:0060501

positive regulation of epithelial cell proliferation involved in lung morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21552
ensembl:ENSMUSP00000010941

P

Seeded From UniProt

complete

involved_in

GO:0060492

lung induction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21552
ensembl:ENSMUSP00000010941

P

Seeded From UniProt

complete

involved_in

GO:0060317

cardiac epithelial to mesenchymal transition

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21552
ensembl:ENSMUSP00000010941

P

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21552
ensembl:ENSMUSP00000010941

P

Seeded From UniProt

complete

involved_in

GO:0060045

positive regulation of cardiac muscle cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21552
ensembl:ENSMUSP00000010941

P

Seeded From UniProt

complete

involved_in

GO:0055009

atrial cardiac muscle tissue morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21552
ensembl:ENSMUSP00000010941

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21552
ensembl:ENSMUSP00000010941

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21552
ensembl:ENSMUSP00000010941

P

Seeded From UniProt

complete

involved_in

GO:0002053

positive regulation of mesenchymal cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21552
ensembl:ENSMUSP00000010941

P

Seeded From UniProt

complete

involved_in

GO:0030324

lung development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q2IBD1
ensembl:ENSRNOP00000071025

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q2IBD1
ensembl:ENSRNOP00000071025

C

Seeded From UniProt

complete

involved_in

GO:0001938

positive regulation of endothelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q2IBD1
ensembl:ENSRNOP00000071025

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009140

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009140

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009140

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009140

P

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

PMID:24431302[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0022008

neurogenesis

PMID:24431302[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

results_in_acquisition_of_features_of:(CL:0000700)

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

Reactome:R-HSA-195721

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-3247843

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Sousa, KM et al. (2010) Wnt2 regulates progenitor proliferation in the developing ventral midbrain. J. Biol. Chem. 285 7246-53 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Gazit, A et al. (1999) Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene 18 5959-66 PubMed GONUTS page
  3. 3.0 3.1 Fokina, VM & Frolova, EI (2006) Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Dev. Dyn. 235 496-505 PubMed GONUTS page
  4. 4.0 4.1 Bafico, A et al. (1999) Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling. J. Biol. Chem. 274 16180-7 PubMed GONUTS page
  5. Salazar, KD et al. (2009) Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. Am. J. Physiol. Lung Cell Mol. Physiol. 297 L1002-11 PubMed GONUTS page
  6. 6.0 6.1 Matushansky, I et al. (2007) Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway. J. Clin. Invest. 117 3248-57 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Wang, HX et al. (2009) Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. Mol. Hum. Reprod. 15 11-7 PubMed GONUTS page
  8. Zhou, S et al. (2004) Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J. Bone Miner. Res. 19 463-70 PubMed GONUTS page
  9. Huguet, EL et al. (1994) Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res. 54 2615-21 PubMed GONUTS page
  10. Le Floch, N et al. (2005) The proinvasive activity of Wnt-2 is mediated through a noncanonical Wnt pathway coupled to GSK-3beta and c-Jun/AP-1 signaling. FASEB J. 19 144-6 PubMed GONUTS page
  11. Park, JK et al. (2009) Overexpression of Wnt-2 in colorectal cancers. Neoplasma 56 119-23 PubMed GONUTS page
  12. Wainwright, BJ et al. (1988) Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. EMBO J. 7 1743-8 PubMed GONUTS page
  13. 13.0 13.1 13.2 13.3 13.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  14. Lu, J et al. (2013) A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 11 e1001536 PubMed GONUTS page
  15. 15.0 15.1 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page