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HUMAN:WNT2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | WNT2 (synonyms: INT1L1, IRP) | |
| Protein Name(s) | Protein Wnt-2
Int-1-like protein 1 Int-1-related protein IRP | |
| External Links | ||
| UniProt | P09544 | |
| EMBL | X07876 AK056742 BT019608 AC002465 AC006326 CH236947 CH471070 BC029854 BC078170 | |
| CCDS | CCDS5771.1 | |
| PIR | S00834 | |
| RefSeq | NP_003382.1 | |
| UniGene | Hs.567356 | |
| ProteinModelPortal | P09544 | |
| SMR | P09544 | |
| BioGrid | 113309 | |
| IntAct | P09544 | |
| STRING | 9606.ENSP00000265441 | |
| BindingDB | P09544 | |
| ChEMBL | CHEMBL1255132 | |
| PhosphoSite | P09544 | |
| DMDM | 139750 | |
| PaxDb | P09544 | |
| PRIDE | P09544 | |
| DNASU | 7472 | |
| Ensembl | ENST00000265441 | |
| GeneID | 7472 | |
| KEGG | hsa:7472 | |
| UCSC | uc003viz.3 | |
| CTD | 7472 | |
| GeneCards | GC07M116916 | |
| HGNC | HGNC:12780 | |
| HPA | CAB017098 HPA020920 | |
| MIM | 147870 | |
| neXtProt | NX_P09544 | |
| PharmGKB | PA37381 | |
| eggNOG | NOG284879 | |
| GeneTree | ENSGT00760000118943 | |
| HOGENOM | HOG000039529 | |
| HOVERGEN | HBG001595 | |
| InParanoid | P09544 | |
| KO | K00182 | |
| OMA | GYDTSRI | |
| OrthoDB | EOG7C8GJ8 | |
| PhylomeDB | P09544 | |
| TreeFam | TF105310 | |
| Reactome | REACT_163710 REACT_18372 | |
| SignaLink | P09544 | |
| GeneWiki | WNT2 | |
| GenomeRNAi | 7472 | |
| NextBio | 29268 | |
| PRO | PR:P09544 | |
| Proteomes | UP000005640 | |
| Bgee | P09544 | |
| CleanEx | HS_WNT2 | |
| ExpressionAtlas | P09544 | |
| Genevestigator | P09544 | |
| GO | GO:0005737 GO:0031012 GO:0005576 GO:0005615 GO:0005578 GO:0005125 GO:0005109 GO:0048018 GO:0055009 GO:0060070 GO:0060317 GO:0045165 GO:0007267 GO:0071300 GO:0071560 GO:0061072 GO:0060716 GO:0002088 GO:0030324 GO:0060492 GO:0061180 GO:0030182 GO:0090263 GO:0060045 GO:0008284 GO:0001938 GO:0060501 GO:0048146 GO:0002053 GO:0051091 GO:0045944 GO:0016055 | |
| InterPro | IPR005817 IPR009140 IPR018161 | |
| PANTHER | PTHR12027 | |
| Pfam | PF00110 | |
| PRINTS | PR01842 PR01349 | |
| SMART | SM00097 | |
| PROSITE | PS00246 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:1904954 |
canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904948 |
midbrain dopaminergic neuron differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033278 |
cell proliferation in midbrain |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0000700) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:1990909 |
Wnt signalosome |
ECO:0000305 |
curator inference used in manual assertion |
GO:0048018 GO:0060070 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0048018 |
receptor ligand activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
part_of:(GO:0016055) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061072 |
iris morphogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048146 |
positive regulation of fibroblast proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0048018 |
receptor ligand activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007267 |
cell-cell signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031232 |
extrinsic component of external side of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002088 |
lens development in camera-type eye |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071560 |
cellular response to transforming growth factor beta stimulus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071300 |
cellular response to retinoic acid |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061180 |
mammary gland epithelium development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030182 |
neuron differentiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000711) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005109 |
frizzled binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005109 |
frizzled binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005109 |
frizzled binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045165 |
cell fate commitment |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98957 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030182 |
neuron differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000246517 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0010194 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004009 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005109 |
frizzled binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004009 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0048018 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0048018 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060716 |
labyrinthine layer blood vessel development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21552 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060501 |
positive regulation of epithelial cell proliferation involved in lung morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21552 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060492 |
lung induction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21552 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060317 |
cardiac epithelial to mesenchymal transition |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21552 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21552 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060045 |
positive regulation of cardiac muscle cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21552 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0055009 |
atrial cardiac muscle tissue morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21552 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21552 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21552 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002053 |
positive regulation of mesenchymal cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21552 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030324 |
lung development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q2IBD1 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q2IBD1 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001938 |
positive regulation of endothelial cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q2IBD1 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0022008 |
neurogenesis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
results_in_acquisition_of_features_of:(CL:0000700) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
Reactome:R-HSA-195721 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-3247843 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Sousa, KM et al. (2010) Wnt2 regulates progenitor proliferation in the developing ventral midbrain. J. Biol. Chem. 285 7246-53 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Gazit, A et al. (1999) Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene 18 5959-66 PubMed GONUTS page
- ↑ 3.0 3.1 Fokina, VM & Frolova, EI (2006) Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Dev. Dyn. 235 496-505 PubMed GONUTS page
- ↑ 4.0 4.1 Bafico, A et al. (1999) Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling. J. Biol. Chem. 274 16180-7 PubMed GONUTS page
- ↑ Salazar, KD et al. (2009) Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. Am. J. Physiol. Lung Cell Mol. Physiol. 297 L1002-11 PubMed GONUTS page
- ↑ 6.0 6.1 Matushansky, I et al. (2007) Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway. J. Clin. Invest. 117 3248-57 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Wang, HX et al. (2009) Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. Mol. Hum. Reprod. 15 11-7 PubMed GONUTS page
- ↑ Zhou, S et al. (2004) Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J. Bone Miner. Res. 19 463-70 PubMed GONUTS page
- ↑ Huguet, EL et al. (1994) Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res. 54 2615-21 PubMed GONUTS page
- ↑ Le Floch, N et al. (2005) The proinvasive activity of Wnt-2 is mediated through a noncanonical Wnt pathway coupled to GSK-3beta and c-Jun/AP-1 signaling. FASEB J. 19 144-6 PubMed GONUTS page
- ↑ Park, JK et al. (2009) Overexpression of Wnt-2 in colorectal cancers. Neoplasma 56 119-23 PubMed GONUTS page
- ↑ Wainwright, BJ et al. (1988) Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. EMBO J. 7 1743-8 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 13.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Lu, J et al. (2013) A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 11 e1001536 PubMed GONUTS page
- ↑ 15.0 15.1 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page
c
- GO:0060070 ! canonical Wnt signaling pathway
- GO:0060317 ! cardiac epithelial to mesenchymal transition
- Catarrhini
- GO:0007267 ! cell-cell signaling
- GO:0071560 ! cellular response to transforming growth factor beta stimulus
- GO:0071300 ! cellular response to retinoic acid
- GO:0045165 ! cell fate commitment
- GO:0033278 ! cell proliferation in midbrain
- Chordata
- Craniata
- GO:0005125 ! cytokine activity
- GO:0005737 ! cytoplasm
e
l
m
o
p
- GO:0060501 ! positive regulation of epithelial cell proliferation involved in lung morphogenesis
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0002053 ! positive regulation of mesenchymal cell proliferation
- GO:0060045 ! positive regulation of cardiac muscle cell proliferation
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0048146 ! positive regulation of fibroblast proliferation
- GO:0001938 ! positive regulation of endothelial cell proliferation
- Primates