HUMAN:DVL1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DVL1
Protein Name(s)	Segment polarity protein dishevelled homolog DVL-1 Dishevelled-1 DSH homolog 1
External Links
UniProt	O14640
EMBL	AF006011 AL139287 AL139287
CCDS	CCDS22.1
RefSeq	NP_004412.2 XP_005244788.1
UniGene	Hs.731450
ProteinModelPortal	O14640
SMR	O14640
BioGrid	108188
DIP	DIP-40773N
IntAct	O14640
MINT	MINT-100885
STRING	9606.ENSP00000368169
BindingDB	O14640
ChEMBL	CHEMBL6027
PhosphoSite	O14640
MaxQB	O14640
PRIDE	O14640
Ensembl	ENST00000378888 ENST00000378891
GeneID	1855
KEGG	hsa:1855
UCSC	uc001aer.4 uc002quu.3
CTD	1855
GeneCards	GC01M001262
HGNC	HGNC:3084
HPA	CAB011538
MIM	601365
neXtProt	NX_O14640
PharmGKB	PA27540
GeneTree	ENSGT00390000013552
HOGENOM	HOG000017084
HOVERGEN	HBG005542
InParanoid	O14640
KO	K02353
OMA	YPRYGMS
OrthoDB	EOG7BP82N
PhylomeDB	O14640
TreeFam	TF318198
Reactome	REACT_172581 REACT_200610 REACT_200668 REACT_200777 REACT_200841 REACT_228242
SignaLink	O14640
GeneWiki	DVL1
GenomeRNAi	1855
NextBio	7599
PRO	PR:O14640
Proteomes	UP000005640
Bgee	O14640
CleanEx	HS_DVL1
ExpressionAtlas	O14640
Genevestigator	O14640
GO	GO:0030424 GO:0005938 GO:0030136 GO:0016023 GO:0031410 GO:0005829 GO:0030425 GO:0030426 GO:0005874 GO:0043025 GO:0005886 GO:0045202 GO:0019899 GO:0005109 GO:0042802 GO:0019901 GO:0048365 GO:0048675 GO:0007411 GO:0060070 GO:0090103 GO:0048668 GO:0060026 GO:0022007 GO:0031122 GO:0048813 GO:0035556 GO:0032091 GO:0006469 GO:0021915 GO:0007528 GO:0007269 GO:0090179 GO:0090263 GO:0010976 GO:0032436 GO:0045893 GO:0030177 GO:0060134 GO:0035372 GO:0034504 GO:0043113 GO:0001505 GO:0071340 GO:0035176 GO:0050808 GO:0006366 GO:0060071
Gene3D	1.10.10.10 2.30.42.10
InterPro	IPR000591 IPR024580 IPR008339 IPR003351 IPR001158 IPR015506 IPR008340 IPR001478 IPR029071 IPR011991
PANTHER	PTHR10878 PTHR10878:SF5
Pfam	PF00610 PF02377 PF00778 PF12316 PF00595
PRINTS	PR01760
SMART	SM00021 SM00049 SM00228
SUPFAM	SSF50156 SSF54236
PROSITE	PS50186 PS50841 PS50106

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0019900	kinase binding	19643732	ECO:0000021		UniProtKB:Q6P3W7	F		Fig 1C. Immunoprecipitation analysis: positive signal of Dvl in anti-CVAK104 precipitates, but not with control rabbit IgG.	Missing: reference
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:12556519^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49674,UniProtKB:Q92837	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:12556519^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0150012	positive regulation of neuron projection arborization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WVB9	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:19625296^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0030426	growth cone	PMID:19625296^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	PMID:24431302^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:18093802^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P51141	P		Seeded From UniProt	complete
involved_in	GO:1903827	regulation of cellular protein localization	PMID:19625296^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q5S007)	Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:19625296^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	stabilizes:(UniProtKB:Q5S007)	Seeded From UniProt	complete
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	PMID:12805222^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:17593335^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:14747478^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:11113207^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51141	P		Seeded From UniProt	complete
involved_in	GO:0048813	dendrite morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51141	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17593335^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12805222^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51141	C		Seeded From UniProt	complete
involved_in	GO:0043113	receptor clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51141	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:10330181^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14640	F		Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	PMID:10330181^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:20177058^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q969F2)	Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	PMID:19643732^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:11113207^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0021915	neural tube development	PMID:8817329^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:19643732^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q6P3W7	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:19643732^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8CFE4	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:19643732^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P97346	F		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	PMID:20177058^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51141	C		Seeded From UniProt	complete
involved_in	GO:0007528	neuromuscular junction development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51141	P		Seeded From UniProt	complete
involved_in	GO:0007269	neurotransmitter secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51141	P		Seeded From UniProt	complete
involved_in	GO:0006469	negative regulation of protein kinase activity	PMID:10330181^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001505	regulation of neurotransmitter levels	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51141	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:15454084^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P34925	F		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:11742073^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:19388021^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75084	F		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:19388021^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9ULV1	F		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:19388021^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NPG1	F		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:19388021^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14332	F		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:19388021^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UP38	F		Seeded From UniProt	complete
involved_in	GO:0090179	planar cell polarity pathway involved in neural tube closure	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106613 MGI:MGI:108100 MGI:MGI:94941 PANTHER:PTN000853715	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000499 MGI:MGI:106613 MGI:MGI:108100 MGI:MGI:2679721 MGI:MGI:94941 PANTHER:PTN000093945 UniProtKB:O14640 UniProtKB:O14641 UniProtKB:Q92997 ZFIN:ZDB-GENE-030721-2	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106613 PANTHER:PTN000093945 UniProtKB:Q155Q3 UniProtKB:Q92997	C		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106613 PANTHER:PTN000093831 UniProtKB:O14640 UniProtKB:O14641 UniProtKB:Q92997	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:10330181^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14640	F		Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
part_of	GO:1990909	Wnt signalosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	C		Seeded From UniProt	complete
involved_in	GO:0099173	postsynapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0099054	presynapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	C		Seeded From UniProt	complete
involved_in	GO:0090179	planar cell polarity pathway involved in neural tube closure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0090103	cochlea morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0071340	skeletal muscle acetylcholine-gated channel clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0060134	prepulse inhibition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0060029	convergent extension involved in organogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0048813	dendrite morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0048675	axon extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0048668	collateral sprouting	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	C		Seeded From UniProt	complete
involved_in	GO:0043113	receptor clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0035372	protein localization to microtubule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	C		Seeded From UniProt	complete
involved_in	GO:0031122	cytoplasmic microtubule organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	C		Seeded From UniProt	complete
part_of	GO:0030136	clathrin-coated vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	C		Seeded From UniProt	complete
involved_in	GO:0022007	convergent extension involved in neural plate elongation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	F		Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	C		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	F		Seeded From UniProt	complete
involved_in	GO:0007528	neuromuscular junction development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0007269	neurotransmitter secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	C		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:0001505	regulation of neurotransmitter levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51141 ensembl:ENSMUSP00000030948	P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVB9 ensembl:ENSRNOP00000026439	P		Seeded From UniProt	complete
involved_in	GO:0150012	positive regulation of neuron projection arborization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVB9 ensembl:ENSRNOP00000026439	P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVB9 ensembl:ENSRNOP00000026439	P		Seeded From UniProt	complete
enables	GO:0048365	Rac GTPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVB9 ensembl:ENSRNOP00000026439	F		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVB9 ensembl:ENSRNOP00000026439	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVB9 ensembl:ENSRNOP00000026439	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVB9 ensembl:ENSRNOP00000026439	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVB9 ensembl:ENSRNOP00000026439	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVB9 ensembl:ENSRNOP00000026439	C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVB9 ensembl:ENSRNOP00000026439	F		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVB9 ensembl:ENSRNOP00000026439	P		Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVB9 ensembl:ENSRNOP00000026439	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVB9 ensembl:ENSRNOP00000026439	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVB9 ensembl:ENSRNOP00000026439	C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008339 InterPro:IPR008340 InterPro:IPR015506	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000591	P		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:25424568^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:25424568^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035567	non-canonical Wnt signaling pathway	PMID:25424568^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905386	positive regulation of protein localization to presynapse	PMID:24449494^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	part_of:(GO:0007416)	Seeded From UniProt	complete
involved_in	GO:0099054	presynapse assembly	PMID:24449494^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904886	beta-catenin destruction complex disassembly	Reactome:R-HSA-4641262	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	Reactome:R-HSA-4641258	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-1458902 Reactome:R-HSA-4641260 Reactome:R-HSA-4641159 Reactome:R-HSA-4641155 Reactome:R-HSA-3772436 Reactome:R-HSA-3772435 Reactome:R-HSA-3772434 Reactome:R-HSA-201717 Reactome:R-HSA-201677 Reactome:R-HSA-1504186	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Hino, S et al. (2003) Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. J. Biol. Chem. 278 14066-73 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Sancho, RM et al. (2009) Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways. Hum. Mol. Genet. 18 3955-68 PubMed GONUTS page
↑ Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page
↑ Lee, YN et al. (2008) Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. Cell. Signal. 20 443-52 PubMed GONUTS page
↑ ^5.0 ^5.1 Hocevar, BA et al. (2003) Regulation of the Wnt signaling pathway by disabled-2 (Dab2). EMBO J. 22 3084-94 PubMed GONUTS page
↑ ^6.0 ^6.1 Ding, VW et al. (2007) Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways. J. Mol. Med. 85 1281-9 PubMed GONUTS page
↑ Golan, T et al. (2004) The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade. J. Biol. Chem. 279 14879-88 PubMed GONUTS page
↑ ^8.0 ^8.1 Hino, S et al. (2001) Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Mol. Cell. Biol. 21 330-42 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Kishida, S et al. (1999) DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. Mol. Cell. Biol. 19 4414-22 PubMed GONUTS page
↑ ^10.0 ^10.1 Hu, T et al. (2010) Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane. J. Biol. Chem. 285 13561-8 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Terabayashi, T et al. (2009) A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5). J. Biol. Chem. 284 26716-24 PubMed GONUTS page
↑ Pizzuti, A et al. (1996) cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. Hum. Mol. Genet. 5 953-8 PubMed GONUTS page
↑ Lu, W et al. (2004) Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119 97-108 PubMed GONUTS page
↑ Chen, W et al. (2001) beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. Proc. Natl. Acad. Sci. U.S.A. 98 14889-94 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Punchihewa, C et al. (2009) Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins. Protein Sci. 18 994-1002 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Bian, WJ et al. (2015) A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4. Dev Neurobiol 75 805-22 PubMed GONUTS page
↑ ^18.0 ^18.1 Purro, SA et al. (2014) Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases. J Mol Cell Biol 6 75-80 PubMed GONUTS page

[PMID:12556519-1] 1.0 ^1.1 Hino, S et al. (2003) Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. J. Biol. Chem. 278 14066-73 PubMed GONUTS page

[PMID:19625296-2] 2.0 ^2.1 ^2.2 ^2.3 Sancho, RM et al. (2009) Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways. Hum. Mol. Genet. 18 3955-68 PubMed GONUTS page

[PMID:24431302-3] Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page

[PMID:18093802-4] Lee, YN et al. (2008) Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. Cell. Signal. 20 443-52 PubMed GONUTS page

[PMID:12805222-5] 5.0 ^5.1 Hocevar, BA et al. (2003) Regulation of the Wnt signaling pathway by disabled-2 (Dab2). EMBO J. 22 3084-94 PubMed GONUTS page

[PMID:17593335-6] 6.0 ^6.1 Ding, VW et al. (2007) Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways. J. Mol. Med. 85 1281-9 PubMed GONUTS page

[PMID:14747478-7] Golan, T et al. (2004) The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade. J. Biol. Chem. 279 14879-88 PubMed GONUTS page

[PMID:11113207-8] 8.0 ^8.1 Hino, S et al. (2001) Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Mol. Cell. Biol. 21 330-42 PubMed GONUTS page

[PMID:10330181-9] 9.0 ^9.1 ^9.2 ^9.3 Kishida, S et al. (1999) DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. Mol. Cell. Biol. 19 4414-22 PubMed GONUTS page

[PMID:20177058-10] 10.0 ^10.1 Hu, T et al. (2010) Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane. J. Biol. Chem. 285 13561-8 PubMed GONUTS page

[PMID:19643732-11] 11.0 ^11.1 ^11.2 ^11.3 Terabayashi, T et al. (2009) A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5). J. Biol. Chem. 284 26716-24 PubMed GONUTS page

[PMID:8817329-12] Pizzuti, A et al. (1996) cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. Hum. Mol. Genet. 5 953-8 PubMed GONUTS page

[PMID:15454084-13] Lu, W et al. (2004) Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119 97-108 PubMed GONUTS page

[PMID:11742073-14] Chen, W et al. (2001) beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. Proc. Natl. Acad. Sci. U.S.A. 98 14889-94 PubMed GONUTS page

[PMID:19388021-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Punchihewa, C et al. (2009) Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins. Protein Sci. 18 994-1002 PubMed GONUTS page

[PMID:21873635-16] 16.0 ^16.1 ^16.2 ^16.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25424568-17] 17.0 ^17.1 ^17.2 Bian, WJ et al. (2015) A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4. Dev Neurobiol 75 805-22 PubMed GONUTS page

[PMID:24449494-18] 18.0 ^18.1 Purro, SA et al. (2014) Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases. J Mol Cell Biol 6 75-80 PubMed GONUTS page

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