HUMAN:LRP5

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	LRP5 (synonyms: LR3, LRP7)
Protein Name(s)	Low-density lipoprotein receptor-related protein 5 LRP-5
External Links
UniProt	O75197
EMBL	AF077820 AF064548 AF283321 AF283320 AB017498 AP000807 CH471076 BC150595
CCDS	CCDS8181.1
PIR	JE0372
RefSeq	NP_001278831.1 NP_002326.2
UniGene	Hs.6347
ProteinModelPortal	O75197
SMR	O75197
BioGrid	110220
DIP	DIP-47265N
IntAct	O75197
MINT	MINT-1189744
STRING	9606.ENSP00000294304
PhosphoSite	O75197
MaxQB	O75197
PaxDb	O75197
PRIDE	O75197
Ensembl	ENST00000294304
GeneID	4041
KEGG	hsa:4041
UCSC	uc001ont.3
CTD	4041
GeneCards	GC11P068080
GeneReviews	LRP5
HGNC	HGNC:6697
HPA	CAB013001
MIM	144750 166710 259770 601813 601884 603506 607634 607636
neXtProt	NX_O75197
Orphanet	2783 2790 891 3416 85193 2924 2788 178377 90050
PharmGKB	PA30455
eggNOG	NOG121718
GeneTree	ENSGT00760000118968
HOGENOM	HOG000230697
HOVERGEN	HBG049167
InParanoid	O75197
KO	K03068
OMA	LFWTCEA
OrthoDB	EOG75XGK3
PhylomeDB	O75197
TreeFam	TF315253
Reactome	REACT_200610 REACT_200643 REACT_200716 REACT_200777 REACT_228096 REACT_228188
SignaLink	O75197
ChiTaRS	LRP5
GeneWiki	LRP5
GenomeRNAi	4041
NextBio	15826
PRO	PR:O75197
Proteomes	UP000005640
Bgee	O75197
CleanEx	HS_LRP5
ExpressionAtlas	O75197
Genevestigator	O75197
GO	GO:0005783 GO:0016021 GO:0005739 GO:0005886 GO:0043235 GO:0015026 GO:0042813 GO:0017147 GO:0060612 GO:0060033 GO:0009952 GO:1902262 GO:0048539 GO:0060349 GO:0046849 GO:0060444 GO:0060070 GO:0042074 GO:0060764 GO:0042632 GO:0008203 GO:0048596 GO:0042733 GO:0030326 GO:0060059 GO:0006897 GO:0035426 GO:0001702 GO:0006007 GO:0045668 GO:0071901 GO:0002076 GO:0008284 GO:0045600 GO:0002053 GO:0045840 GO:0033690 GO:0051091 GO:0045944 GO:0045893 GO:0042981 GO:0008217 GO:0046850 GO:0060828 GO:0061178 GO:0043434 GO:0060042 GO:0061304 GO:0035019 GO:0016055 GO:0044332
Gene3D	2.120.10.30 4.10.400.10
InterPro	IPR011042 IPR000742 IPR023415 IPR000033 IPR002172 IPR017049
Pfam	PF00057 PF00058
PIRSF	PIRSF036314
PRINTS	PR00261
SMART	SM00181 SM00192 SM00135
SUPFAM	SSF57424
PROSITE	PS01209 PS50068 PS51120

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
Contributes to	GO:0060042	retina morphogenesis in camera-type eye	PMID:20096619^[1]	ECO:0000315			P		Fig. 2- The frame shift mutations in the LRP5 gene can cause proteins involved in bone and retinal development to be ineffective. The problems associated with this mutation are called osteoporosis-pseudoglioma syndrome.	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91VN0	P		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	PMID:25920554^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	PMID:24706814^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:25920554^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:24706814^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:15908424^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:16805831^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O00755,UniProtKB:P02649	P		Seeded From UniProt	complete
part_of	GO:1990909	Wnt signalosome	PMID:24115276^[6]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:1904928	coreceptor activity involved in canonical Wnt signaling pathway	PMID:24431302^[7]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0071936	coreceptor activity involved in Wnt signaling pathway	PMID:11336703^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04426	F	has_direct_input:(UniProtKB:P04628)	Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:11336703^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04426	F	part_of:(GO:0016055)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:11336703^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04426	P		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91VN0	F		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91VN0	F		Seeded From UniProt	complete
involved_in	GO:0071901	negative regulation of protein serine/threonine kinase activity	PMID:19107203^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061304	retinal blood vessel morphogenesis	PMID:15024691^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061304	retinal blood vessel morphogenesis	PMID:15346351^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:18044981^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060612	adipose tissue development	PMID:17680723^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060349	bone morphogenesis	PMID:20146170^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060349	bone morphogenesis	PMID:20630166^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060349	bone morphogenesis	PMID:19673927^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:19673927^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0110135	Norrin signaling pathway	PMID:15035989^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:12121999^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:12857724^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060042	retina morphogenesis in camera-type eye	PMID:15346351^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048539	bone marrow development	PMID:17680723^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12857724^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17955262^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15035989^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045840	positive regulation of mitotic nuclear division	PMID:9790987^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045668	negative regulation of osteoblast differentiation	PMID:17680723^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045600	positive regulation of fat cell differentiation	PMID:17680723^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:11029007^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:18762581^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:18721193^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:20146170^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|enables	GO:0019534	toxin transmembrane transporter activity	PMID:18350154^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0110135	Norrin signaling pathway	PMID:17955262^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:9790987^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	PMID:18721193^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006007	glucose catabolic process	PMID:19673927^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17680723^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002053	positive regulation of mesenchymal cell proliferation	PMID:17680723^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061304	retinal blood vessel morphogenesis	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000056265 UniProtKB:O75197	P		Seeded From UniProt	complete
involved_in	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1278315 PANTHER:PTN000056265	P		Seeded From UniProt	complete
involved_in	GO:0060612	adipose tissue development	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000056265 UniProtKB:O75197	P		Seeded From UniProt	complete
involved_in	GO:0060444	branching involved in mammary gland duct morphogenesis	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1278315 PANTHER:PTN000056265	P		Seeded From UniProt	complete
involved_in	GO:0060349	bone morphogenesis	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000056265 UniProtKB:O75197	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000119 MGI:MGI:1278315 PANTHER:PTN000056248 UniProtKB:O75197 ZFIN:ZDB-GENE-050518-2	P		Seeded From UniProt	complete
involved_in	GO:0048539	bone marrow development	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000056265 UniProtKB:O75197	P		Seeded From UniProt	complete
involved_in	GO:0046849	bone remodeling	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1278315 PANTHER:PTN000056265	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000056265 UniProtKB:O75197	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000056261 UniProtKB:O75197	C		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000119 MGI:MGI:1278315 PANTHER:PTN000056248	F		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000056265 UniProtKB:O75197	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000119 MGI:MGI:1278315 PANTHER:PTN000056248 UniProtKB:O75197	F		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1278315 PANTHER:PTN000056265	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95290 PANTHER:PTN000056261 UniProtKB:O75197	C		Seeded From UniProt	complete
involved_in	GO:0002076	osteoblast development	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1278315 PANTHER:PTN000056265	P		Seeded From UniProt	complete
involved_in	GO:0001702	gastrulation with mouth forming second	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1278315 PANTHER:PTN000056265	P		Seeded From UniProt	complete
involved_in	GO:1901998	toxin transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019534	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017049	F		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017049	F		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017049	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:22988876^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:1990851	Wnt-Frizzled-LRP5/6 complex	PMID:22988876^[27] PMID:20093360^[28]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-NUL-1458902 Reactome:R-HSA-5339711 Reactome:R-HSA-201677	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Marques-Pinheiro, A et al. (2010) Novel LRP5 gene mutation in a patient with osteoporosis-pseudoglioma syndrome. Joint Bone Spine 77 151-3 PubMed GONUTS page
↑ ^2.0 ^2.1 Cnossen, WR et al. (2016) LRP5 variants may contribute to ADPKD. Eur. J. Hum. Genet. 24 237-42 PubMed GONUTS page
↑ ^3.0 ^3.1 Cnossen, WR et al. (2014) Whole-exome sequencing reveals LRP5 mutations and canonical Wnt signaling associated with hepatic cystogenesis. Proc. Natl. Acad. Sci. U.S.A. 111 5343-8 PubMed GONUTS page
↑ Semënov, M et al. (2005) SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J. Biol. Chem. 280 26770-5 PubMed GONUTS page
↑ Caruso, A et al. (2006) Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells. J. Neurochem. 98 364-71 PubMed GONUTS page
↑ Berwick, DC & Harvey, K (2014) The regulation and deregulation of Wnt signaling by PARK genes in health and disease. J Mol Cell Biol 6 3-12 PubMed GONUTS page
↑ Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Mao, J et al. (2001) Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol. Cell 7 801-9 PubMed GONUTS page
↑ Piao, S et al. (2008) Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling. PLoS ONE 3 e4046 PubMed GONUTS page
↑ Toomes, C et al. (2004) Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q. Am. J. Hum. Genet. 74 721-30 PubMed GONUTS page
↑ ^11.0 ^11.1 Jiao, X et al. (2004) Autosomal recessive familial exudative vitreoretinopathy is associated with mutations in LRP5. Am. J. Hum. Genet. 75 878-84 PubMed GONUTS page
↑ Björklund, P et al. (2007) An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling. PLoS Med. 4 e328 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Qiu, W et al. (2007) Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells. J. Bone Miner. Res. 22 1720-31 PubMed GONUTS page
↑ ^14.0 ^14.1 Jiang, XY et al. (2010) Association of LPR5 polymorphism with bone mass density and cholesterol level in population of Chinese Han. Exp. Clin. Endocrinol. Diabetes 118 388-91 PubMed GONUTS page
↑ Stathopoulou, MG et al. (2010) Low-density lipoprotein receptor-related protein 5 polymorphisms are associated with bone mineral density in Greek postmenopausal women: an interaction with calcium intake. J Am Diet Assoc 110 1078-83 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Saarinen, A et al. (2010) Low density lipoprotein receptor-related protein 5 (LRP5) mutations and osteoporosis, impaired glucose metabolism and hypercholesterolaemia. Clin. Endocrinol. (Oxf) 72 481-8 PubMed GONUTS page
↑ ^17.0 ^17.1 Xu, Q et al. (2004) Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell 116 883-95 PubMed GONUTS page
↑ Holmen, SL et al. (2002) A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. J. Biol. Chem. 277 34727-35 PubMed GONUTS page
↑ ^19.0 ^19.1 Caricasole, A et al. (2003) Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. J. Biol. Chem. 278 37024-31 PubMed GONUTS page
↑ ^20.0 ^20.1 Qin, M et al. (2008) Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy. Hum. Genet. 122 615-23 PubMed GONUTS page
↑ ^21.0 ^21.1 Dong, Y et al. (1998) Molecular cloning and characterization of LR3, a novel LDL receptor family protein with mitogenic activity. Biochem. Biophys. Res. Commun. 251 784-90 PubMed GONUTS page
↑ Tamai, K et al. (2000) LDL-receptor-related proteins in Wnt signal transduction. Nature 407 530-5 PubMed GONUTS page
↑ Ding, Y et al. (2008) Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. J. Cell Biol. 182 865-72 PubMed GONUTS page
↑ ^24.0 ^24.1 Lappalainen, S et al. (2009) LRP5 in premature adrenarche and in metabolic characteristics of prepubertal children. Clin. Endocrinol. (Oxf) 70 725-31 PubMed GONUTS page
↑ Ryan, PL & Young, JA (2008) Evidence against a human cell-specific role for LRP6 in anthrax toxin entry. PLoS ONE 3 e1817 PubMed GONUTS page
↑ ^26.00 ^26.01 ^26.02 ^26.03 ^26.04 ^26.05 ^26.06 ^26.07 ^26.08 ^26.09 ^26.10 ^26.11 ^26.12 ^26.13 ^26.14 ^26.15 ^26.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^27.0 ^27.1 Berwick, DC & Harvey, K (2012) The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem. Soc. Trans. 40 1123-8 PubMed GONUTS page
↑ Bourhis, E et al. (2010) Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. J. Biol. Chem. 285 9172-9 PubMed GONUTS page

[PMID:20096619-1] Marques-Pinheiro, A et al. (2010) Novel LRP5 gene mutation in a patient with osteoporosis-pseudoglioma syndrome. Joint Bone Spine 77 151-3 PubMed GONUTS page

[PMID:25920554-2] 2.0 ^2.1 Cnossen, WR et al. (2016) LRP5 variants may contribute to ADPKD. Eur. J. Hum. Genet. 24 237-42 PubMed GONUTS page

[PMID:24706814-3] 3.0 ^3.1 Cnossen, WR et al. (2014) Whole-exome sequencing reveals LRP5 mutations and canonical Wnt signaling associated with hepatic cystogenesis. Proc. Natl. Acad. Sci. U.S.A. 111 5343-8 PubMed GONUTS page

[PMID:15908424-4] Semënov, M et al. (2005) SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J. Biol. Chem. 280 26770-5 PubMed GONUTS page

[PMID:16805831-5] Caruso, A et al. (2006) Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells. J. Neurochem. 98 364-71 PubMed GONUTS page

[PMID:24115276-6] Berwick, DC & Harvey, K (2014) The regulation and deregulation of Wnt signaling by PARK genes in health and disease. J Mol Cell Biol 6 3-12 PubMed GONUTS page

[PMID:24431302-7] Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page

[PMID:11336703-8] 8.0 ^8.1 ^8.2 Mao, J et al. (2001) Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol. Cell 7 801-9 PubMed GONUTS page

[PMID:19107203-9] Piao, S et al. (2008) Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling. PLoS ONE 3 e4046 PubMed GONUTS page

[PMID:15024691-10] Toomes, C et al. (2004) Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q. Am. J. Hum. Genet. 74 721-30 PubMed GONUTS page

[PMID:15346351-11] 11.0 ^11.1 Jiao, X et al. (2004) Autosomal recessive familial exudative vitreoretinopathy is associated with mutations in LRP5. Am. J. Hum. Genet. 75 878-84 PubMed GONUTS page

[PMID:18044981-12] Björklund, P et al. (2007) An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling. PLoS Med. 4 e328 PubMed GONUTS page

[PMID:17680723-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Qiu, W et al. (2007) Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells. J. Bone Miner. Res. 22 1720-31 PubMed GONUTS page

[PMID:20146170-14] 14.0 ^14.1 Jiang, XY et al. (2010) Association of LPR5 polymorphism with bone mass density and cholesterol level in population of Chinese Han. Exp. Clin. Endocrinol. Diabetes 118 388-91 PubMed GONUTS page

[PMID:20630166-15] Stathopoulou, MG et al. (2010) Low-density lipoprotein receptor-related protein 5 polymorphisms are associated with bone mineral density in Greek postmenopausal women: an interaction with calcium intake. J Am Diet Assoc 110 1078-83 PubMed GONUTS page

[PMID:19673927-16] 16.0 ^16.1 ^16.2 Saarinen, A et al. (2010) Low density lipoprotein receptor-related protein 5 (LRP5) mutations and osteoporosis, impaired glucose metabolism and hypercholesterolaemia. Clin. Endocrinol. (Oxf) 72 481-8 PubMed GONUTS page

[PMID:15035989-17] 17.0 ^17.1 Xu, Q et al. (2004) Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell 116 883-95 PubMed GONUTS page

[PMID:12121999-18] Holmen, SL et al. (2002) A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. J. Biol. Chem. 277 34727-35 PubMed GONUTS page

[PMID:12857724-19] 19.0 ^19.1 Caricasole, A et al. (2003) Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. J. Biol. Chem. 278 37024-31 PubMed GONUTS page

[PMID:17955262-20] 20.0 ^20.1 Qin, M et al. (2008) Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy. Hum. Genet. 122 615-23 PubMed GONUTS page

[PMID:9790987-21] 21.0 ^21.1 Dong, Y et al. (1998) Molecular cloning and characterization of LR3, a novel LDL receptor family protein with mitogenic activity. Biochem. Biophys. Res. Commun. 251 784-90 PubMed GONUTS page

[PMID:11029007-22] Tamai, K et al. (2000) LDL-receptor-related proteins in Wnt signal transduction. Nature 407 530-5 PubMed GONUTS page

[PMID:18762581-23] Ding, Y et al. (2008) Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. J. Cell Biol. 182 865-72 PubMed GONUTS page

[PMID:18721193-24] 24.0 ^24.1 Lappalainen, S et al. (2009) LRP5 in premature adrenarche and in metabolic characteristics of prepubertal children. Clin. Endocrinol. (Oxf) 70 725-31 PubMed GONUTS page

[PMID:18350154-25] Ryan, PL & Young, JA (2008) Evidence against a human cell-specific role for LRP6 in anthrax toxin entry. PLoS ONE 3 e1817 PubMed GONUTS page

[PMID:21873635-26] 26.00 ^26.01 ^26.02 ^26.03 ^26.04 ^26.05 ^26.06 ^26.07 ^26.08 ^26.09 ^26.10 ^26.11 ^26.12 ^26.13 ^26.14 ^26.15 ^26.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22988876-27] 27.0 ^27.1 Berwick, DC & Harvey, K (2012) The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem. Soc. Trans. 40 1123-8 PubMed GONUTS page

[PMID:20093360-28] Bourhis, E et al. (2010) Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. J. Biol. Chem. 285 9172-9 PubMed GONUTS page

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