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MOUSE:LRRK2
Contents
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0010628 |
positive regulation of gene expression |
PubMed ID: 20728949 |
ECO:0000314 |
P |
Figure 3A shows that using qRT-PCR the levels of LRRK2 are detected to be substantially higher in B2 cells than B1 cells for samples obtained from spleen, peripheral blood, peritoneal cavity, and bone marrow. |
complete | ||||
| GO:0045577 |
regulation of B cell differentiation |
PubMed ID: 20728949 |
ECO:0000314 |
P |
Figure 3A shows that pre-B cells separated from bone marrow tissue had a low amount of LRRK2 mRNA. Suggests differentiation-related expression profile. |
complete | ||||
| GO:0030217 |
T cell differentiation |
PubMed ID: 20728949 |
ECO:0000314 |
P |
Figure 3A shows the T cells isolated from bone marrow have zero or very little LRRK2 expression. |
complete | ||||
|
NOT |
GO:0051059 |
NF-kappaB binding |
PubMed ID: 20728949 |
ECO:0000315 |
F |
mutations are present in the NF-kB inducing kinase gene in alymphoplasia mice, yet figure 3A still shows the B-2 cells expressed a higher level of LRRK2 mRNA than B-1 cells in both the peritoneal cavity and spleen therefore the exxpression of LRRK2 by B cells can not be regulated by the NF-κB pathway. |
complete | |||
| GO:0023019 |
regulation of gene expression as a consequence of signal transmission |
PubMed ID: 20728949 |
ECO:0000315 |
P |
Figure 4B: qRT-PCR shows that in mutant mice: LRRK2 expression by B-2 cells was downregulated upon activation. |
complete | ||||
| GO:0023019 |
regulation of gene expression as a consequence of signal transmission |
PubMed ID: 20728949 |
ECO:0000314 |
P |
Figure 4A: LRRK2 expression by B-2 cells was downregulated by activation. |
complete | ||||
|
involved_in |
GO:0007029 |
endoplasmic reticulum organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060628 |
regulation of ER to Golgi vesicle-mediated transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070973 |
protein localization to endoplasmic reticulum exit site |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070971 |
endoplasmic reticulum exit site |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044877 |
protein-containing complex binding |
ECO:0000305 |
curator inference used in manual assertion |
GO:0005515 |
F |
has_direct_input:(GO:0030904) |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0090263 |
positive regulation of canonical Wnt signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
occurs_at:(GO:0016020) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030159 |
receptor signaling complex adaptor activity |
ECO:0000305 |
curator inference used in manual assertion |
GO:0005515 GO:1904713 |
F |
|
Seeded From UniProt |
complete | |
|
part_of |
GO:1990909 |
Wnt signalosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904887 |
Wnt signalosome assembly |
ECO:0000305 |
curator inference used in manual assertion |
GO:0005515,GO:1904713 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:1904713 |
beta-catenin destruction complex binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060828 |
regulation of canonical Wnt signaling pathway |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:O35625 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043204 |
perikaryon |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030424 |
axon |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005768 |
endosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902803 |
regulation of synaptic vesicle transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061001 |
regulation of dendritic spine morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
occurs_in:(CL:0002613) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060159 |
regulation of dopamine receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0001890) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060079 |
excitatory postsynaptic potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0002613) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090394 |
negative regulation of excitatory postsynaptic potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051966 |
regulation of synaptic transmission, glutamatergic |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0002613) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0051018 |
protein kinase A binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043195 |
terminal bouton |
ECO:0000305 |
curator inference used in manual assertion |
GO:1902803 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035641 |
locomotory exploration behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0002609) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034613 |
cellular protein localization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:1001571) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010738 |
regulation of protein kinase A signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0002609) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001933 |
negative regulation of protein phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0001890) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035564 |
regulation of kidney size |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017048 |
Rho GTPase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010508 |
positive regulation of autophagy |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048812 |
neuron projection morphogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043204 |
perikaryon |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030424 |
axon |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900242 |
regulation of synaptic vesicle endocytosis |
ECO:0006013 |
patch-clamp recording evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1900242 |
regulation of synaptic vesicle endocytosis |
ECO:0006013 |
patch-clamp recording evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1900242 |
regulation of synaptic vesicle endocytosis |
ECO:0005589 |
confocal microscopy evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1900242 |
regulation of synaptic vesicle endocytosis |
ECO:0005589 |
confocal microscopy evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1900242 |
regulation of synaptic vesicle endocytosis |
ECO:0001225 |
knockout evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1900242 |
regulation of synaptic vesicle endocytosis |
ECO:0001225 |
knockout evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0099523 |
presynaptic cytosol |
ECO:0005589 |
confocal microscopy evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0099523 |
presynaptic cytosol |
ECO:0005589 |
confocal microscopy evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0006013 |
patch-clamp recording evidence used in manual assertion |
C |
part_of:(UBERON:0002421) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0005589 |
confocal microscopy evidence used in manual assertion |
C |
part_of:(UBERON:0002421) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0001225 |
knockout evidence used in manual assertion |
C |
part_of:(UBERON:0002421) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1905279 |
regulation of retrograde transport, endosome to Golgi |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000585172 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902902 |
negative regulation of autophagosome assembly |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000585172 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902803 |
regulation of synaptic vesicle transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1913975 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061001 |
regulation of dendritic spine morphogenesis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1913975 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045121 |
membrane raft |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1913975 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000585172 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031966 |
mitochondrial membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000585172 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019722 |
calcium-mediated signaling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000585172 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017048 |
Rho GTPase binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1913975 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007005 |
mitochondrion organization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000585172 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1913975 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000585172 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1913975 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1913975 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005768 |
endosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1913975 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1913975 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003924 |
GTPase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003779 |
actin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0000187 |
activation of MAPK activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0000186 |
activation of MAPKK activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0000165 |
MAPK cascade |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000149 |
SNARE binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:2000300 |
regulation of synaptic vesicle exocytosis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:2000172 |
regulation of branching morphogenesis of a nerve |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:1990909 |
Wnt signalosome |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:1990904 |
ribonucleoprotein complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:16894) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1905289 |
regulation of CAMKK-AMPK signaling cascade |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1905279 |
regulation of retrograde transport, endosome to Golgi |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1904887 |
Wnt signalosome assembly |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1904469 |
positive regulation of tumor necrosis factor secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1561168 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1903980 |
positive regulation of microglial cell activation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1561168 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1903351 |
cellular response to dopamine |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1903215 |
negative regulation of protein targeting to mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1903206 |
negative regulation of hydrogen peroxide-induced cell death |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1903125 |
negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1902902 |
negative regulation of autophagosome assembly |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1902692 |
regulation of neuroblast proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1902499 |
positive regulation of protein autoubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1902236 |
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1901727 |
positive regulation of histone deacetylase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1901215 |
negative regulation of neuron death |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1901214 |
regulation of neuron death |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1900244 |
positive regulation of synaptic vesicle endocytosis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1561168 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0140058 |
neuron projection arborization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1561168 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0099400 |
caveola neck |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097487 |
multivesicular body, internal vesicle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0090263 |
positive regulation of canonical Wnt signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0072593 |
reactive oxygen species metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071287 |
cellular response to manganese ion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0070997 |
neuron death |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0070973 |
protein localization to endoplasmic reticulum exit site |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070971 |
endoplasmic reticulum exit site |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0061001 |
regulation of dendritic spine morphogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060161 |
positive regulation of dopamine receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051900 |
regulation of mitochondrial depolarization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051770 |
positive regulation of nitric-oxide synthase biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1561168 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0051646 |
mitochondrion localization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051018 |
protein kinase A binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0048812 |
neuron projection morphogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0048312 |
intracellular distribution of mitochondria |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0046777 |
protein autophosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0046777 |
protein autophosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0046039 |
GTP metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045202 |
synapse |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:16894) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045202 |
synapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1561168 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045121 |
membrane raft |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044754 |
autolysosome |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044753 |
amphisome |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044325 |
ion channel binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1561168 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043204 |
perikaryon |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043204 |
perikaryon |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1561168 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043068 |
positive regulation of programmed cell death |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1561168 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1561168 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042391 |
regulation of membrane potential |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0040012 |
regulation of locomotion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036479 |
peroxidase inhibitor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0035751 |
regulation of lysosomal lumen pH |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0035640 |
exploration behavior |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0034599 |
cellular response to oxidative stress |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0034260 |
negative regulation of GTPase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034211 |
GTP-dependent protein kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034211 |
GTP-dependent protein kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032839 |
dendrite cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032473 |
cytoplasmic side of mitochondrial outer membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032092 |
positive regulation of protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032091 |
negative regulation of protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031966 |
mitochondrial membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031647 |
regulation of protein stability |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031398 |
positive regulation of protein ubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030426 |
growth cone |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1561168 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030424 |
axon |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030424 |
axon |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1561168 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030276 |
clathrin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0022028 |
tangential migration from the subventricular zone to the olfactory bulb |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0021772 |
olfactory bulb development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0019722 |
calcium-mediated signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0018107 |
peptidyl-threonine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0018105 |
peptidyl-serine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017075 |
syntaxin-1 binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017048 |
Rho GTPase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0016310 |
phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0016242 |
negative regulation of macroautophagy |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016234 |
inclusion body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1561168 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0015631 |
tubulin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0014041 |
regulation of neuron maturation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010977 |
negative regulation of neuron projection development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1561168 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010955 |
negative regulation of protein processing |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010508 |
positive regulation of autophagy |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010506 |
regulation of autophagy |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010468 |
regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5644525 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0009267 |
cellular response to starvation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008340 |
determination of adult lifespan |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0008021 |
synaptic vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007528 |
neuromuscular junction development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007040 |
lysosome organization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007030 |
Golgi organization |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2385107 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007030 |
Golgi organization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007029 |
endoplasmic reticulum organization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007005 |
mitochondrion organization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006979 |
response to oxidative stress |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006897 |
endocytosis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006606 |
protein import into nucleus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006606 |
protein import into nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005902 |
microvillus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005802 |
trans-Golgi network |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005802 |
trans-Golgi network |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005798 |
Golgi-associated vesicle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1561168 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005525 |
GTP binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005525 |
GTP binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004708 |
MAP kinase kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005096 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005096 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005096 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098794 |
postsynapse |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0060079 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904469 |
positive regulation of tumor necrosis factor secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LNJ1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1903980 |
positive regulation of microglial cell activation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LNJ1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1900244 |
positive regulation of synaptic vesicle endocytosis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LNJ1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0140058 |
neuron projection arborization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LNJ1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071407 |
cellular response to organic cyclic compound |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LNJ1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051770 |
positive regulation of nitric-oxide synthase biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LNJ1 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045202 |
synapse |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LNJ1 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LNJ1 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043204 |
perikaryon |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LNJ1 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LNJ1 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LNJ1 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LNJ1 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030424 |
axon |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LNJ1 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0021756 |
striatum development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LNJ1 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LNJ1 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010977 |
negative regulation of neuron projection development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LNJ1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007283 |
spermatogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LNJ1 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1LNJ1 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000300 |
regulation of synaptic vesicle exocytosis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000172 |
regulation of branching morphogenesis of a nerve |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:1990909 |
Wnt signalosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1905289 |
regulation of CAMKK-AMPK signaling cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1905279 |
regulation of retrograde transport, endosome to Golgi |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904887 |
Wnt signalosome assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1903351 |
cellular response to dopamine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1903215 |
negative regulation of protein targeting to mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1903206 |
negative regulation of hydrogen peroxide-induced cell death |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1903125 |
negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902902 |
negative regulation of autophagosome assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902692 |
regulation of neuroblast proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902499 |
positive regulation of protein autoubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902236 |
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1901215 |
negative regulation of neuron death |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1901214 |
regulation of neuron death |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0099400 |
caveola neck |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0097487 |
multivesicular body, internal vesicle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090263 |
positive regulation of canonical Wnt signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0072593 |
reactive oxygen species metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071287 |
cellular response to manganese ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070997 |
neuron death |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070973 |
protein localization to endoplasmic reticulum exit site |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070971 |
endoplasmic reticulum exit site |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061001 |
regulation of dendritic spine morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060161 |
positive regulation of dopamine receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051900 |
regulation of mitochondrial depolarization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051646 |
mitochondrion localization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0051018 |
protein kinase A binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048812 |
neuron projection morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048312 |
intracellular distribution of mitochondria |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046777 |
protein autophosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046039 |
GTP metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0044754 |
autolysosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0044753 |
amphisome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0044325 |
ion channel binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043204 |
perikaryon |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043068 |
positive regulation of programmed cell death |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042391 |
regulation of membrane potential |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0040012 |
regulation of locomotion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0036479 |
peroxidase inhibitor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035751 |
regulation of lysosomal lumen pH |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035640 |
exploration behavior |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034599 |
cellular response to oxidative stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034260 |
negative regulation of GTPase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0034211 |
GTP-dependent protein kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032839 |
dendrite cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032473 |
cytoplasmic side of mitochondrial outer membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032092 |
positive regulation of protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032091 |
negative regulation of protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031966 |
mitochondrial membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031647 |
regulation of protein stability |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031398 |
positive regulation of protein ubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030426 |
growth cone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030424 |
axon |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030276 |
clathrin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0022028 |
tangential migration from the subventricular zone to the olfactory bulb |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0021772 |
olfactory bulb development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019722 |
calcium-mediated signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018107 |
peptidyl-threonine phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018105 |
peptidyl-serine phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017075 |
syntaxin-1 binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017048 |
Rho GTPase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016242 |
negative regulation of macroautophagy |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016234 |
inclusion body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0015631 |
tubulin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014041 |
regulation of neuron maturation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010955 |
negative regulation of protein processing |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010508 |
positive regulation of autophagy |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010506 |
regulation of autophagy |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009267 |
cellular response to starvation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008340 |
determination of adult lifespan |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007528 |
neuromuscular junction development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007040 |
lysosome organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007030 |
Golgi organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007029 |
endoplasmic reticulum organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007005 |
mitochondrion organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006979 |
response to oxidative stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006897 |
endocytosis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005902 |
microvillus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005798 |
Golgi-associated vesicle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005525 |
GTP binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004708 |
MAP kinase kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003924 |
GTPase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003779 |
actin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000187 |
activation of MAPK activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000186 |
activation of MAPKK activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000165 |
MAPK cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000149 |
SNARE binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5S007 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005525 |
GTP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036465 |
synaptic vesicle recycling |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045202 |
synapse |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005525 |
GTP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005768 |
endosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006914 |
autophagy |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030424 |
axon |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030672 |
synaptic vesicle membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043204 |
perikaryon |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Cho, HJ et al. (2014) Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export. EMBO J. 33 2314-31 PubMed GONUTS page
- ↑ 2.0 2.1 Chen, ZC et al. (2017) Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease. Sci Signal 10 PubMed GONUTS page
- ↑ MacLeod, DA et al. (2013) RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk. Neuron 77 425-39 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Berwick, DC & Harvey, K (2012) LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6. Hum. Mol. Genet. 21 4966-79 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Biskup, S et al. (2006) Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Ann. Neurol. 60 557-69 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Piccoli, G et al. (2011) LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool. J. Neurosci. 31 2225-37 PubMed GONUTS page
- ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 Parisiadou, L et al. (2014) LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity. Nat. Neurosci. 17 367-76 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Tong, Y et al. (2010) Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc. Natl. Acad. Sci. U.S.A. 107 9879-84 PubMed GONUTS page
- ↑ Haebig, K et al. (2010) ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. PLoS ONE 5 e13762 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 10.4 10.5 10.6 10.7 10.8 Arranz, AM et al. (2015) LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism. J. Cell. Sci. 128 541–52 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 11.5 Hatano, T et al. (2007) Leucine-rich repeat kinase 2 associates with lipid rafts. Hum. Mol. Genet. 16 678-90 PubMed GONUTS page
- ↑ 12.00 12.01 12.02 12.03 12.04 12.05 12.06 12.07 12.08 12.09 12.10 12.11 12.12 12.13 12.14 12.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 13.4 13.5 13.6 13.7 Han, KA et al. (2017) Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation. Hum. Mol. Genet. 26 1-18 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Beilina, A et al. (2014) Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. Proc. Natl. Acad. Sci. U.S.A. 111 2626-31 PubMed GONUTS page
- ↑ 15.0 15.1 Dorval, V et al. (2014) Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models. PLoS ONE 9 e85510 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 16.3 Smith, WW et al. (2006) Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nat. Neurosci. 9 1231-3 PubMed GONUTS page
- ↑ 17.0 17.1 Xiong, Y et al. (2012) ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2. J. Neurosci. 32 3877-86 PubMed GONUTS page
- ↑ Guaitoli, G et al. (2016) Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts. Proc. Natl. Acad. Sci. U.S.A. 113 E4357-66 PubMed GONUTS page
- ↑ Civiero, L et al. (2012) Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers. PLoS ONE 7 e43472 PubMed GONUTS page
- ↑ Li, X et al. (2011) Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease. PLoS ONE 6 e17153 PubMed GONUTS page
a
c
- GO:0019722 ! calcium-mediated signaling
- GO:0099400 ! caveola neck
- GO:0034613 ! cellular protein localization
- GO:0034599 ! cellular response to oxidative stress
- GO:1903351 ! cellular response to dopamine
- GO:0071287 ! cellular response to manganese ion
- GO:0071407 ! cellular response to organic cyclic compound
- GO:0009267 ! cellular response to starvation
- GO:0030154 ! cell differentiation
- GO:0030054 ! cell junction
- GO:0042995 ! cell projection
- Chordata
- GO:0030276 ! clathrin binding
- Craniata
- GO:0005737 ! cytoplasm
- GO:0031410 ! cytoplasmic vesicle
- GO:0032473 ! cytoplasmic side of mitochondrial outer membrane
- GO:0005829 ! cytosol
d
e
- GO:0006897 ! endocytosis
- GO:0007029 ! endoplasmic reticulum organization
- GO:0070971 ! endoplasmic reticulum exit site
- GO:0005783 ! endoplasmic reticulum
- GO:0005768 ! endosome
- Euarchontoglires
- Eukaryota
- Euteleostomi
- Eutheria
- GO:0060079 ! excitatory postsynaptic potential
- GO:0035640 ! exploration behavior
g
- Glires
- GO:0098978 ! glutamatergic synapse
- GO:0005798 ! Golgi-associated vesicle
- GO:0005794 ! Golgi apparatus
- GO:0007030 ! Golgi organization
- GO:0030426 ! growth cone
- GO:0034211 ! GTP-dependent protein kinase activity
- GO:0005096 ! GTPase activator activity
- GO:0003924 ! GTPase activity
- GO:0005525 ! GTP binding
- GO:0046039 ! GTP metabolic process
i
l
m
- GO:0000287 ! magnesium ion binding
- Mammalia
- GO:0000165 ! MAPK cascade
- GO:0004708 ! MAP kinase kinase activity
- GO:0016020 ! membrane
- GO:0045121 ! membrane raft
- Metazoa
- GO:0005902 ! microvillus
- GO:0005741 ! mitochondrial outer membrane
- GO:0005743 ! mitochondrial inner membrane
- GO:0005759 ! mitochondrial matrix
- GO:0031966 ! mitochondrial membrane
- GO:0005739 ! mitochondrion
- GO:0051646 ! mitochondrion localization
- GO:0007005 ! mitochondrion organization
- GO:0097487 ! multivesicular body, internal vesicle
- Muridae
- Murinae
- Muroidea
- Mus
- Mus musculus
n
- GO:1903215 ! negative regulation of protein targeting to mitochondrion
- GO:0016242 ! negative regulation of macroautophagy
- GO:0001933 ! negative regulation of protein phosphorylation
- GO:0010955 ! negative regulation of protein processing
- GO:0034260 ! negative regulation of GTPase activity
- GO:0010977 ! negative regulation of neuron projection development
- GO:0090394 ! negative regulation of excitatory postsynaptic potential
- GO:0032091 ! negative regulation of protein binding
- GO:1903125 ! negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
- GO:1902902 ! negative regulation of autophagosome assembly
- GO:1902236 ! negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
- GO:0007528 ! neuromuscular junction development
- GO:0043025 ! neuronal cell body
- GO:0140058 ! neuron projection arborization
- GO:0048812 ! neuron projection morphogenesis
- GO:0043005 ! neuron projection
- GO:0051059 ! NF-kappaB binding
- GO:0000166 ! nucleotide binding
- GO:0005634 ! nucleus
o
- GO:0000186 ! obsolete activation of MAPKK activity
- GO:0000187 ! obsolete activation of MAPK activity
- GO:1903206 ! obsolete negative regulation of hydrogen peroxide-induced cell death
- GO:1901215 ! obsolete negative regulation of neuron death
- GO:0070997 ! obsolete neuron death
- GO:0051770 ! obsolete positive regulation of nitric-oxide synthase biosynthetic process
- GO:1901727 ! obsolete positive regulation of histone deacetylase activity
- GO:1901214 ! obsolete regulation of neuron death
- GO:0021772 ! olfactory bulb development
p
- GO:0018105 ! peptidyl-serine phosphorylation
- GO:0018107 ! peptidyl-threonine phosphorylation
- GO:0043204 ! perikaryon
- GO:0036479 ! peroxidase inhibitor activity
- GO:0016310 ! phosphorylation
- GO:0005886 ! plasma membrane
- GO:1903980 ! positive regulation of microglial cell activation
- GO:0010628 ! positive regulation of gene expression
- GO:0090263 ! positive regulation of canonical Wnt signaling pathway
- GO:0043547 ! positive regulation of GTPase activity
- GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- GO:0001934 ! positive regulation of protein phosphorylation
- GO:0010508 ! positive regulation of autophagy
- GO:0031398 ! positive regulation of protein ubiquitination
- GO:1904469 ! positive regulation of tumor necrosis factor secretion
- GO:0032092 ! positive regulation of protein binding
- GO:1902499 ! positive regulation of protein autoubiquitination
- GO:1900244 ! positive regulation of synaptic vesicle endocytosis
- GO:0043068 ! positive regulation of programmed cell death
- GO:0060161 ! positive regulation of dopamine receptor signaling pathway
- GO:0098794 ! postsynapse
- GO:0099523 ! presynaptic cytosol
- GO:0044877 ! protein-containing complex binding
- GO:0046777 ! protein autophosphorylation
- GO:0005515 ! protein binding
- GO:0042803 ! protein homodimerization activity
- GO:0006606 ! protein import into nucleus
- GO:0004672 ! protein kinase activity
- GO:0051018 ! protein kinase A binding
- GO:0070973 ! protein localization to endoplasmic reticulum exit site
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
r
- GO:0072593 ! reactive oxygen species metabolic process
- GO:1900242 ! regulation of synaptic vesicle endocytosis
- GO:0060628 ! regulation of ER to Golgi vesicle-mediated transport
- GO:0010738 ! regulation of protein kinase A signaling
- GO:0035564 ! regulation of kidney size
- GO:0060828 ! regulation of canonical Wnt signaling pathway
- GO:0060159 ! regulation of dopamine receptor signaling pathway
- GO:0061001 ! regulation of dendritic spine morphogenesis
- GO:1902803 ! regulation of synaptic vesicle transport
- GO:0051966 ! regulation of synaptic transmission, glutamatergic
- GO:1905279 ! regulation of retrograde transport, endosome to Golgi
- GO:1902692 ! regulation of neuroblast proliferation
- GO:1905289 ! regulation of CAMKK-AMPK signaling cascade
- GO:0045577 ! regulation of B cell differentiation
- GO:0031647 ! regulation of protein stability
- GO:0035751 ! regulation of lysosomal lumen pH
- GO:0010468 ! regulation of gene expression
- GO:0010506 ! regulation of autophagy
- GO:2000300 ! regulation of synaptic vesicle exocytosis
- GO:2000172 ! regulation of branching morphogenesis of a nerve
- GO:0014041 ! regulation of neuron maturation
- GO:0051900 ! regulation of mitochondrial depolarization
- GO:0040012 ! regulation of locomotion
- GO:0042391 ! regulation of membrane potential
- GO:0006979 ! response to oxidative stress
- GO:0030904 ! retromer complex
- GO:0017048 ! Rho GTPase binding
- GO:1990904 ! ribonucleoprotein complex
- Rodentia
s
- Sciurognathi
- GO:0030159 ! signaling receptor complex adaptor activity
- GO:0023019 ! signal transduction involved in regulation of gene expression
- GO:0000149 ! SNARE binding
- GO:0007283 ! spermatogenesis
- GO:0021756 ! striatum development
- GO:0045202 ! synapse
- GO:0036465 ! synaptic vesicle recycling
- GO:0030672 ! synaptic vesicle membrane
- GO:0008021 ! synaptic vesicle
- GO:0017075 ! syntaxin-1 binding
t
