MOUSE:RECK

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Reck
Protein Name(s)	Reversion-inducing cysteine-rich protein with Kazal motifs mRECK
External Links
UniProt	Q9Z0J1
EMBL	AB006960 AL772204 AL773539 AL773539 AL772204
CCDS	CCDS18116.1
PIR	PC7035
RefSeq	NP_057887.2
UniGene	Mm.331573
ProteinModelPortal	Q9Z0J1
SMR	Q9Z0J1
STRING	10090.ENSMUSP00000030198
PhosphoSite	Q9Z0J1
MaxQB	Q9Z0J1
PaxDb	Q9Z0J1
PRIDE	Q9Z0J1
Ensembl	ENSMUST00000030198
GeneID	53614
KEGG	mmu:53614
UCSC	uc012ddg.1
CTD	8434
MGI	MGI:1855698
eggNOG	NOG315643
GeneTree	ENSGT00390000018540
HOGENOM	HOG000007167
HOVERGEN	HBG036100
InParanoid	Q9Z0J1
KO	K17461
OMA	VNRKGCP
OrthoDB	EOG7X0VGC
TreeFam	TF324424
NextBio	310331
PRO	PR:Q9Z0J1
Proteomes	UP000000589
Bgee	Q9Z0J1
Genevestigator	Q9Z0J1
GO	GO:0031225 GO:0005886 GO:0004866 GO:0004867 GO:0001955 GO:0007566 GO:0030198 GO:0010951
InterPro	IPR002350
Pfam	PF07648
SMART	SM00280
PROSITE	PS00282 PS51465

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0008191	metalloendopeptidase inhibitor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95980	F		Seeded From UniProt	complete
involved_in	GO:1904684	negative regulation of metalloendopeptidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95980	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:30026314^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O00755	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:30026314^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:1990909	Wnt signalosome	PMID:30026314^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:30026314^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:1904928	coreceptor activity involved in canonical Wnt signaling pathway	PMID:30026314^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:28803732^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:28803732^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045765	regulation of angiogenesis	PMID:28803732^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090210	regulation of establishment of blood-brain barrier	PMID:28803732^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904684	negative regulation of metalloendopeptidase activity	PMID:24812324^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002544)	Seeded From UniProt	complete
involved_in	GO:1904684	negative regulation of metalloendopeptidase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1855698 PANTHER:PTN001004003	P		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1855698 PANTHER:PTN001004003	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001004003 UniProtKB:O95980	C		Seeded From UniProt	complete
enables	GO:0004866	endopeptidase inhibitor activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1855698 PANTHER:PTN001004003 UniProtKB:O95980	F		Seeded From UniProt	complete
involved_in	GO:0001955	blood vessel maturation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1855698 PANTHER:PTN002668932	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904684	negative regulation of metalloendopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95980	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035115	embryonic forelimb morphogenesis	PMID:23213437^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4830337	P	occurs_in:(EMAPA:17412)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030336	negative regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95980	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030198	extracellular matrix organization	PMID:11747814^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3623517	P	occurs_in:(EMAPA:16530)\|occurs_in:(EMAPA:16201)\|occurs_in:(EMAPA:16240)	Seeded From UniProt	complete
enables	GO:0008191	metalloendopeptidase inhibitor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95980	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007566	embryo implantation	PMID:18556655^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95980	C		Seeded From UniProt	complete
enables	GO:0004866	endopeptidase inhibitor activity	PMID:11747814^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:101900)\|has_regulation_target:(MGI:MGI:97009)\|has_regulation_target:(MGI:MGI:97011)	Seeded From UniProt	complete
enables	GO:0004866	endopeptidase inhibitor activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95980	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001955	blood vessel maturation	PMID:11747814^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97009	P	results_in_maturation_of:(EMAPA:16201)\|results_in_maturation_of:(EMAPA:16240)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001955	blood vessel maturation	PMID:11747814^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3623517	P	results_in_maturation_of:(EMAPA:16201)\|results_in_maturation_of:(EMAPA:16240)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1904928	P		Seeded From UniProt	complete
involved_in	GO:1904684	negative regulation of metalloendopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95980 ensembl:ENSP00000367202	P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95980 ensembl:ENSP00000367202	P		Seeded From UniProt	complete
enables	GO:0008191	metalloendopeptidase inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95980 ensembl:ENSP00000367202	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95980 ensembl:ENSP00000367202	C		Seeded From UniProt	complete
enables	GO:0004866	endopeptidase inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95980 ensembl:ENSP00000367202	F		Seeded From UniProt	complete
involved_in	GO:0001944	vasculature development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039016	P		Seeded From UniProt	complete
enables	GO:0008191	metalloendopeptidase inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039016	F		Seeded From UniProt	complete
involved_in	GO:0060828	regulation of canonical Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039016	P		Seeded From UniProt	complete
involved_in	GO:1904684	negative regulation of metalloendopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039016	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0031225	anchored component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0336	C		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0722	F		Seeded From UniProt	complete
enables	GO:0030414	peptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0010466	negative regulation of peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Eubelen, M et al. (2018) A molecular mechanism for Wnt ligand-specific signaling. Science 361 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Cho, C et al. (2017) Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation. Neuron 95 1056-1073.e5 PubMed GONUTS page
↑ Kim, CW et al. (2014) Prevention of abdominal aortic aneurysm by anti-microRNA-712 or anti-microRNA-205 in angiotensin II-infused mice. Arterioscler. Thromb. Vasc. Biol. 34 1412-21 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Yamamoto, M et al. (2012) The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs. Biol Open 1 458-66 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Oh, J et al. (2001) The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell 107 789-800 PubMed GONUTS page
↑ Hu, SJ et al. (2008) MicroRNA expression and regulation in mouse uterus during embryo implantation. J. Biol. Chem. 283 23473-84 PubMed GONUTS page

[PMID:30026314-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Eubelen, M et al. (2018) A molecular mechanism for Wnt ligand-specific signaling. Science 361 PubMed GONUTS page

[PMID:28803732-2] 2.0 ^2.1 ^2.2 ^2.3 Cho, C et al. (2017) Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation. Neuron 95 1056-1073.e5 PubMed GONUTS page

[PMID:24812324-3] Kim, CW et al. (2014) Prevention of abdominal aortic aneurysm by anti-microRNA-712 or anti-microRNA-205 in angiotensin II-infused mice. Arterioscler. Thromb. Vasc. Biol. 34 1412-21 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23213437-5] Yamamoto, M et al. (2012) The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs. Biol Open 1 458-66 PubMed GONUTS page

[PMID:11747814-6] 6.0 ^6.1 ^6.2 ^6.3 Oh, J et al. (2001) The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell 107 789-800 PubMed GONUTS page

[PMID:18556655-7] Hu, SJ et al. (2008) MicroRNA expression and regulation in mouse uterus during embryo implantation. J. Biol. Chem. 283 23473-84 PubMed GONUTS page

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MOUSE:RECK

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