HUMAN:CTNB1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CTNNB1 (synonyms: CTNNB)
Protein Name(s)	Catenin beta-1 Beta-catenin
External Links
UniProt	P35222
EMBL	X87838 Z19054 AF130085 AY463360 AK289932 AC104307 CH471055 BC058926 AY081165 AB062292
CCDS	CCDS2694.1
PIR	A38973
RefSeq	NP_001091679.1 NP_001091680.1 NP_001895.1 XP_005264943.1
UniGene	Hs.476018
PDB	1G3J 1JDH 1JPW 1LUJ 1P22 1QZ7 1T08 1TH1 2G57 2GL7 2Z6H 3DIW 3FQN 3FQR 3SL9 3SLA 3TX7 4DJS
PDBsum	1G3J 1JDH 1JPW 1LUJ 1P22 1QZ7 1T08 1TH1 2G57 2GL7 2Z6H 3DIW 3FQN 3FQR 3SL9 3SLA 3TX7 4DJS
ProteinModelPortal	P35222
SMR	P35222
BioGrid	107880
DIP	DIP-122N
IntAct	P35222
MINT	MINT-105089
STRING	9606.ENSP00000344456
BindingDB	P35222
ChEMBL	CHEMBL3038464
PhosphoSite	P35222
DMDM	461854
MaxQB	P35222
PaxDb	P35222
PRIDE	P35222
DNASU	1499
Ensembl	ENST00000349496 ENST00000396183 ENST00000396185 ENST00000405570
GeneID	1499
KEGG	hsa:1499
UCSC	uc003ckp.2 uc003ckt.1
CTD	1499
GeneCards	GC03P041236
H-InvDB	HIX0163439 HIX0163473
HGNC	HGNC:2514
HPA	CAB000108 CAB001950 HPA029159 HPA029160
MIM	114500 116806 132600 155255 156240 167000 181030 615075
neXtProt	NX_P35222
Orphanet	85142 54595 873 88673 91414 404473
PharmGKB	PA27013
eggNOG	NOG297695
GeneTree	ENSGT00730000110821
HOGENOM	HOG000230958
HOVERGEN	HBG000919
InParanoid	P35222
KO	K02105
OMA	MRAFQDT
OrthoDB	EOG7X9G6B
PhylomeDB	P35222
TreeFam	TF317997
Reactome	REACT_11063 REACT_11065 REACT_13579 REACT_163743 REACT_172761 REACT_19195 REACT_200610 REACT_200731 REACT_200753 REACT_200777 REACT_200799 REACT_21402 REACT_228016 REACT_228106 REACT_228137 REACT_228159 REACT_228251 REACT_228261 REACT_228314 REACT_24019
SignaLink	P35222
ChiTaRS	CTNNB1
EvolutionaryTrace	P35222
GeneWiki	Beta-catenin
GenomeRNAi	1499
NextBio	6161
PMAP-CutDB	P35222
PRO	PR:P35222
Proteomes	UP000005640
Bgee	P35222
CleanEx	HS_CTNNB1
ExpressionAtlas	P35222
Genevestigator	P35222
GO	GO:0005912 GO:0045177 GO:0016323 GO:0030877 GO:0070369 GO:0016342 GO:0005938 GO:0030054 GO:0071944 GO:0005913 GO:0005911 GO:0005813 GO:0005737 GO:0009898 GO:0005829 GO:0043198 GO:0030057 GO:0070062 GO:0005916 GO:0005925 GO:0030027 GO:0016328 GO:0016020 GO:0031528 GO:0005654 GO:0005634 GO:0048471 GO:0005886 GO:0032993 GO:0034750 GO:0000922 GO:0045202 GO:0005923 GO:0005667 GO:0030018 GO:0005915 GO:0045294 GO:0050681 GO:0045296 GO:0003682 GO:0003690 GO:0019899 GO:0030331 GO:0070411 GO:0044325 GO:0019900 GO:0035257 GO:0008022 GO:0019901 GO:0019903 GO:0070412 GO:0001102 GO:0003700 GO:0004871 GO:0046332 GO:0005198 GO:0003713 GO:0008134 GO:0044212 GO:0034333 GO:0030521 GO:0009948 GO:0006915 GO:0045453 GO:0001658 GO:0060070 GO:0044336 GO:0061324 GO:0044334 GO:0007155 GO:0001708 GO:0048469 GO:0007160 GO:0006921 GO:0071363 GO:0071681 GO:1990314 GO:0071260 GO:0022009 GO:0007016 GO:0048262 GO:0009950 GO:0007398 GO:0000578 GO:0042733 GO:0048617 GO:0035115 GO:0035050 GO:0035116 GO:0030326 GO:0036023 GO:0001711 GO:0061154 GO:0060742 GO:0001837 GO:0060441 GO:0061198 GO:0001702 GO:0035112 GO:0007403 GO:0035315 GO:0031069 GO:0060789 GO:0030902 GO:0001701 GO:0045087 GO:0021819 GO:0002089 GO:0001889 GO:0060479 GO:0060492 GO:0060484 GO:0030539 GO:0060916 GO:0003337 GO:0007494 GO:0042692 GO:0045445 GO:2001234 GO:0008285 GO:0032331 GO:0003136 GO:0045976 GO:1901215 GO:0048715 GO:0045671 GO:0033234 GO:0000122 GO:0045892 GO:0072079 GO:0001840 GO:0001764 GO:0042475 GO:0048599 GO:0030316 GO:0060066 GO:0031016 GO:0001569 GO:0043065 GO:0061047 GO:2000017 GO:0045603 GO:0060769 GO:0010718 GO:0045743 GO:0010909 GO:0043123 GO:0043410 GO:0002053 GO:0051149 GO:0002052 GO:0045669 GO:0045944 GO:0045893 GO:0032481 GO:0051291 GO:0034394 GO:0009954 GO:0045765 GO:0090279 GO:0030997 GO:0070602 GO:0048145 GO:0031641 GO:0072182 GO:2000008 GO:0003266 GO:0048660 GO:0042129 GO:0072053 GO:0072054 GO:0072033 GO:0046686 GO:0034097 GO:0042493 GO:0032355 GO:0014010 GO:0016337 GO:0051145 GO:0061549 GO:0050808 GO:0048489 GO:0033077 GO:0048538 GO:0043587 GO:0060440 GO:0006351 GO:0016055
Gene3D	1.25.10.10
InterPro	IPR011989 IPR016024 IPR000225 IPR013284
Pfam	PF00514
PRINTS	PR01869
SMART	SM00185
SUPFAM	SSF48371
PROSITE	PS50176

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0016328	lateral plasma membrane		ECO:0000314			C		Source: MGI	Missing: reference
	GO:0004871	signal transducer activity		ECO:0000303			F		Source: ProtInc	Missing: reference
	GO:0001837	epithelial to mesenchymal transition		ECO:0000304			P		Source: HGNC	Missing: reference
involved_in	GO:0000209	protein polyubiquitination	PMID:29374064^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:29374064^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	PMID:28051089^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:12154096^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:18193033^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18193033^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:18193033^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02248	C		Seeded From UniProt	complete
involved_in	GO:1904798	positive regulation of core promoter binding	PMID:22723415^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(GO:0005634) occurs_at:(SO:0000170) has_regulation_target:(UniProtKB:P24928)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12138115^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12138115^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1904948	midbrain dopaminergic neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02248	P	occurs_in:(UBERON:0003307)	Seeded From UniProt	complete
involved_in	GO:1904954	canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	GO_REF:0000111	ECO:0000305	curator inference used in manual assertion	GO:0060070,GO:1904948	P		Seeded From UniProt	complete
part_of	GO:0070369	beta-catenin-TCF7L2 complex	PMID:12651860^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:12651860^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:12651860^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:12651860^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12651860^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990138	neuron projection extension	PMID:19830702^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02248	P	part_of:(GO:1904639)	Seeded From UniProt	complete
	GO:0019900	kinase binding	PMID:20307497^[9]	ECO:0000021		UniProtKB:Q9H2X6	F		figure S1	complete
enables	GO:0045296	cadherin binding	PMID:25468996^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
	GO:0005634	nucleus	PMID:20307497^[9]	ECO:0000314			C		figure 1E	complete
enables	GO:0003682	chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02248	F	has_direct_input:(ENSEMBL:ENSG00000006283)	Seeded From UniProt	complete
	GO:0005737	cytoplasm	PMID:20307497^[9]	ECO:0000314			C		figure 1E	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02248	P	regulates_transcription_of:(ENSEMBL:ENSG00000006283)	Seeded From UniProt	complete
	GO:0016310	phosphorylation	PMID:20307497^[9]	ECO:0000315			P		figure 3C	complete
part_of	GO:0005737	cytoplasm	PMID:22467863^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:15905404^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O43524	F	part_of:(GO:0034599)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19591802^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:11533658^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13526	F		Seeded From UniProt	complete
part_of	GO:1990909	Wnt signalosome	PMID:24115276^[15]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:24862762^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002563) exists_during:(GO:0045198) exists_during:(GO:0022612) part_of:(UBERON:0000333)	Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	PMID:19591802^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:2000097)	Seeded From UniProt	complete
part_of	GO:1990907	beta-catenin-TCF complex	PMID:18936100^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UJU2	C		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:18936100^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UJU2	F	occurs_in:(GO:0005634)	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:15905404^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P98177)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:7806582^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	PMID:22723415^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22723415^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(ENSEMBL:ENSG00000164362)	Seeded From UniProt	complete
involved_in	GO:0051571	positive regulation of histone H3-K4 methylation	PMID:22723415^[5]	ECO:0000305	curator inference used in manual assertion	GO:0045944	P		Seeded From UniProt	complete
involved_in	GO:2000144	positive regulation of DNA-templated transcription, initiation	PMID:22723415^[5]	ECO:0000305	curator inference used in manual assertion	GO:0045944	P	has_regulation_target:(UniProtKB:O14746)	Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	PMID:23136403^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UI47	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:21724833^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9H3S7	F		Seeded From UniProt	complete
involved_in	GO:0061549	sympathetic ganglion development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02248	P		Seeded From UniProt	complete
involved_in	GO:0045976	negative regulation of mitotic cell cycle, embryonic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02248	P		Seeded From UniProt	complete
involved_in	GO:0002052	positive regulation of neuroblast proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02248	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[21]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:29367600^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
	GO:0005737	cytoplasm	PMID:7806582^[18]	ECO:0000314			C		Fig 2B shows cytoplasmic localisation of B catenin through immunofluorescence	complete CACAO 2915
part_of	GO:0070062	extracellular exosome	PMID:19199708^[23]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:28829046^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000008	regulation of protein localization to cell surface	PMID:19996314^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090279	regulation of calcium ion import	PMID:19996314^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	PMID:19038973^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	PMID:16858403^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070602	regulation of centromeric sister chromatid cohesion	PMID:20300119^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	PMID:18593713^[29]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15105	F		Seeded From UniProt	complete
part_of	GO:0070369	beta-catenin-TCF7L2 complex	PMID:9065402^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070369	beta-catenin-TCF7L2 complex	PMID:9065401^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0061324	canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02248	P		Seeded From UniProt	complete
involved_in	GO:0061154	endothelial tube morphogenesis	PMID:20123964^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048660	regulation of smooth muscle cell proliferation	PMID:17122440^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:19038973^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:18593713^[29]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15105	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19328798^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15592430^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:14660579^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9065402^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:11751639^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18787224^[38]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:18287330^[39]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P33151	F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	PMID:7890674^[40]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35221	F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	PMID:7650039^[41]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35221	F		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:12154096^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0043066)	Seeded From UniProt	complete
involved_in	GO:0044334	canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition	PMID:17072303^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:19996314^[25]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UBN4	F		Seeded From UniProt	complete
involved_in	GO:0036023	embryonic skeletal limb joint morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02248	P		Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	PMID:12799378^[43]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
involved_in	GO:0034394	protein localization to cell surface	PMID:20086044^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034333	adherens junction assembly	PMID:20123964^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034333	adherens junction assembly	PMID:20086044^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:10825188^[45]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	PMID:15304487^[46]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:16188939^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:8638126^[48]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	PMID:15304487^[46]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P03372	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	PMID:19038973^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	PMID:20412773^[49]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	PMID:8638126^[48]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:18356165^[50]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UBN7	F		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	PMID:7650039^[41]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	PMID:20302655^[51]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	PMID:18593713^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	PMID:18593713^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:10644691^[52]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process	PMID:15853773^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:20123964^[32]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UJU2	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:19101069^[54]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:19038973^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:19101069^[54]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:20086044^[44]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:19996314^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:20300119^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18787224^[38]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9707618^[55]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:11751639^[37]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18756595^[56]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18787224^[38]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9707618^[55]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:9065402^[30]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:11751639^[37]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	PMID:20123964^[32]	ECO:0000305	curator inference used in manual assertion	GO:0061154	P		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	PMID:19443654^[57]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NQB0	F		Seeded From UniProt	complete
involved_in	GO:0072182	regulation of nephron tubule epithelial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02248	P		Seeded From UniProt	complete
involved_in	GO:0071681	cellular response to indole-3-methanol	PMID:10868478^[58]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:12937339^[59]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:19187541^[60]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	PMID:15572661^[61]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:19038973^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12949260^[62]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12970740^[63]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:19653274^[64]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:19038973^[26]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P12830	F		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:12734196^[65]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q86UP0-2	F		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:12734196^[65]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q86UP0-1	F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:18579517^[66]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:18193033^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:12970740^[63]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:18291362^[67]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033234	negative regulation of protein sumoylation	PMID:22155184^[68]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030997	regulation of centriole-centriole cohesion	PMID:18086858^[69]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030521	androgen receptor signaling pathway	PMID:15572661^[61]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:16574648^[70]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q92729	F		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:8663237^[71]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15262	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WU82	C		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:12970740^[63]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:10773885^[72]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P25054	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:15843474^[73]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:10403777^[74]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:18086858^[69]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	PMID:16858403^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12970740^[63]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:10980594^[75]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:19187541^[60]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:18086858^[69]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19095296^[76]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11793365^[77]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12937339^[59]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12970740^[63]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10980594^[75]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19095296^[76]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19187541^[60]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18193033^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16858403^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:12949260^[62]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[78]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000117 MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P35222 WB:WBGene00000238 WB:WBGene00001979	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:21873635^[78]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 RGD:70487 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00001979	F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	PMID:21873635^[78]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 MGI:MGI:96650 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00001979	F		Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	PMID:21873635^[78]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P35222	F		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:21873635^[78]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222	F		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	PMID:21873635^[78]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000117 MGI:MGI:88276 MGI:MGI:96650 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00001979 ZFIN:ZDB-GENE-980526-362	C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:21873635^[78]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 MGI:MGI:96650 PANTHER:PTN001153077 RGD:620412 RGD:70487 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00000238 WB:WBGene00001979	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:21873635^[78]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00000238 WB:WBGene00001979	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:22083958^[79]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	PMID:12072559^[80]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:23983127^[81]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9NX18	P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:19151727^[82]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:1990907	beta-catenin-TCF complex	PMID:11955446^[83]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O00512,UniProtKB:P15884	C		Seeded From UniProt	complete
part_of	GO:1990907	beta-catenin-TCF complex	PMID:28296634^[84]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001234	negative regulation of apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:2000179	positive regulation of neural precursor cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:2000144	positive regulation of DNA-templated transcription, initiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:2000017	positive regulation of determination of dorsal identity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
part_of	GO:1990909	Wnt signalosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:1990907	beta-catenin-TCF complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
involved_in	GO:1990791	dorsal root ganglion development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:1990403	embryonic brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:1904948	midbrain dopaminergic neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:1904888	cranial skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:1904798	positive regulation of core promoter binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:1904796	regulation of core promoter binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:1904793	regulation of euchromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:1904501	positive regulation of chromatin-mediated maintenance of transcription	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:1903204	negative regulation of oxidative stress-induced neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0098831	presynaptic active zone cytoplasmic component	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	F		Seeded From UniProt	complete
involved_in	GO:0097091	synaptic vesicle clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0072182	regulation of nephron tubule epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0072079	nephron tubule formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0072054	renal outer medulla development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0072053	renal inner medulla development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0072033	renal vesicle formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0070602	regulation of centromeric sister chromatid cohesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	F		Seeded From UniProt	complete
involved_in	GO:0061550	cranial ganglion development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0061549	sympathetic ganglion development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0061324	canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0061198	fungiform papilla formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0061047	positive regulation of branching involved in lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0060916	mesenchymal cell proliferation involved in lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0060789	hair follicle placode formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0060769	positive regulation of epithelial cell proliferation involved in prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0060742	epithelial cell differentiation involved in prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0060492	lung induction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0060484	lung-associated mesenchyme development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0060479	lung cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0060441	epithelial tube branching involved in lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0060440	trachea formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0060439	trachea morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0060173	limb development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0060066	oviduct development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0051884	regulation of timing of anagen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0051145	smooth muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0050768	negative regulation of neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0048715	negative regulation of oligodendrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0048643	positive regulation of skeletal muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0048617	embryonic foregut morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0048599	oocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0048513	animal organ development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0048489	synaptic vesicle transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0048469	cell maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0048096	chromatin-mediated maintenance of transcription	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	F		Seeded From UniProt	complete
involved_in	GO:0045976	negative regulation of mitotic cell cycle, embryonic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0045671	negative regulation of osteoclast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0045670	regulation of osteoclast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0045667	regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0045603	positive regulation of endothelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0045596	negative regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0045595	regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0045453	bone resorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	F		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0044798	nuclear transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
involved_in	GO:0044093	positive regulation of molecular function	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0043588	skin development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
part_of	GO:0043296	apical junction complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0042475	odontogenesis of dentin-containing tooth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0042129	regulation of T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0036023	embryonic skeletal limb joint morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	F		Seeded From UniProt	complete
involved_in	GO:0035116	embryonic hindlimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0035115	embryonic forelimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0035112	genitalia morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0035050	embryonic heart tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
part_of	GO:0034750	Scrib-APC-beta-catenin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
involved_in	GO:0034613	cellular protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0034332	adherens junction organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0033077	T cell differentiation in thymus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0032331	negative regulation of chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0032212	positive regulation of telomere maintenance via telomerase	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0031641	regulation of myelination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
part_of	GO:0031528	microvillus membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0031253	cell projection membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
involved_in	GO:0031069	hair follicle morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0031016	pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0030902	hindbrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0030901	midbrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
involved_in	GO:0030858	positive regulation of epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0030856	regulation of epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0030539	male genitalia development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0030316	osteoclast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0030097	hemopoiesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
involved_in	GO:0022405	hair cycle process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0022009	central nervous system vasculogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0021819	layer formation in cerebral cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	F		Seeded From UniProt	complete
part_of	GO:0016600	flotillin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
involved_in	GO:0016331	morphogenesis of embryonic epithelium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0009987	cellular process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0009954	proximal/distal pattern formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0009950	dorsal/ventral axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0009948	anterior/posterior axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0007403	glial cell fate determination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0007398	ectoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0007160	cell-matrix adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0005916	fascia adherens	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	F		Seeded From UniProt	complete
involved_in	GO:0003340	negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0003338	metanephros morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0003266	regulation of secondary heart field cardioblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0002089	lens morphogenesis in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0002052	positive regulation of neuroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0001944	vasculature development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0001894	tissue homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0001840	neural plate development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0001711	endodermal cell fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0001709	cell fate determination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0001708	cell fate specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0001706	endoderm formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0001702	gastrulation with mouth forming second	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	F		Seeded From UniProt	complete
involved_in	GO:0000904	cell morphogenesis involved in differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0000578	embryonic axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02248 ensembl:ENSMUSP00000007130	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013284	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013284	F		Seeded From UniProt	complete
involved_in	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process	PMID:23164821^[85]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24115276^[15] PMID:24431302^[86]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000185774)	Seeded From UniProt	complete
involved_in	GO:0050767	regulation of neurogenesis	PMID:24431302^[86]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	regulates_o_results_in_acquisition_of_features_of:(CL:0000700)	Seeded From UniProt	complete
involved_in	GO:0019827	stem cell population maintenance	PMID:22723415^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	PMID:16344550^[87]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:16344550^[87]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048145	regulation of fibroblast proliferation	PMID:16858403^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045765	regulation of angiogenesis	PMID:18756595^[56]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035315	hair cell differentiation	PMID:19251162^[88]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:14679171^[89]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	PMID:17047063^[90]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1904886	beta-catenin destruction complex disassembly	Reactome:R-HSA-4641262	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904837	beta-catenin-TCF complex assembly	Reactome:R-HSA-201722	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060828	regulation of canonical Wnt signaling pathway	Reactome:R-HSA-201669	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051149	positive regulation of muscle cell differentiation	Reactome:R-HSA-375170	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035635	entry of bacterium into host cell	Reactome:R-HSA-8876493	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	Reactome:R-HSA-1834949	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	Reactome:R-HSA-195721	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007223	Wnt signaling pathway, calcium modulating pathway	Reactome:R-HSA-4086398	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8877003 Reactome:R-HSA-8876993 Reactome:R-HSA-8876948 Reactome:R-HSA-8876497 Reactome:R-HSA-5672304 Reactome:R-HSA-5339713 Reactome:R-HSA-448958 Reactome:R-HSA-3769392 Reactome:R-HSA-375140 Reactome:R-HSA-3134914 Reactome:R-HSA-3134904 Reactome:R-HSA-3134901 Reactome:R-HSA-2130286 Reactome:R-HSA-2130282 Reactome:R-HSA-2130279 Reactome:R-HSA-202969 Reactome:R-HSA-201685 Reactome:R-HSA-201669 Reactome:R-HSA-195318 Reactome:R-HSA-195304 Reactome:R-HSA-195300 Reactome:R-HSA-195287 Reactome:R-HSA-195283 Reactome:R-HSA-195280 Reactome:R-HSA-195275	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-3451144 Reactome:R-HSA-8951442 Reactome:R-HSA-8951428 Reactome:R-HSA-8944362 Reactome:R-HSA-5665608 Reactome:R-HSA-5626938 Reactome:R-HSA-5368580 Reactome:R-HSA-4411383 Reactome:R-HSA-4411367 Reactome:R-HSA-4411351 Reactome:R-HSA-3772430 Reactome:R-HSA-3769394 Reactome:R-HSA-3769393 Reactome:R-HSA-3769392 Reactome:R-HSA-3769391 Reactome:R-HSA-3769383 Reactome:R-HSA-3451153 Reactome:R-HSA-3364042 Reactome:R-HSA-3364026 Reactome:R-HSA-3364014 Reactome:R-HSA-3361751 Reactome:R-HSA-3322427 Reactome:R-HSA-3322424 Reactome:R-HSA-3322422 Reactome:R-HSA-3299569 Reactome:R-HSA-3134914 Reactome:R-HSA-3134883 Reactome:R-HSA-201712 Reactome:R-HSA-201669	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965 UniProtKB-SubCell:SL-0038	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0009	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0448	C		Seeded From UniProt	complete
	GO:0005886	plasma membrane	PMID:10330189^[91]	ECO:0000314			C		Fig. 3A and B	complete CACAO 9019
	GO:0005737	cytoplasm	PMID:10330189^[91]	ECO:0000314			C		Fig. 3A and B	complete CACAO 9020
	GO:0005634	nucleus	PMID:12893825^[92]	ECO:0000314			C		Figure 7B	complete CACAO 11844
	GO:0005737	cytoplasm	PMID:12893825^[92]	ECO:0000314			C		Figure 7B	complete CACAO 11845
	GO:0005634	nucleus	PMID:15040835^[93]	ECO:0000314			C		Figure 2A	complete CACAO 11846
	GO:0005634	nucleus	PMID:20097766^[94]	ECO:0000314			C		Figure 4C shows localization of beta catenin in the nucleus	complete CACAO 11861
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Higashimori, A et al. (2018) Forkhead Box F2 Suppresses Gastric Cancer through a Novel FOXF2-IRF2BPL-β-Catenin Signaling Axis. Cancer Res. 78 1643-1656 PubMed GONUTS page
↑ Caldwell, JM et al. (2017) Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation. Mucosal Immunol 10 1190-1201 PubMed GONUTS page
↑ ^3.0 ^3.1 Longo, KA et al. (2002) Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. J. Biol. Chem. 277 38239-44 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Li, J & Wang, CY (2008) TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis. Nat. Cell Biol. 10 160-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Hoffmeyer, K et al. (2012) Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science 336 1549-54 PubMed GONUTS page
↑ ^6.0 ^6.1 Karasawa, T et al. (2002) Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling. J. Biol. Chem. 277 37479-86 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Ghiselli, G et al. (2003) The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway. J. Biol. Chem. 278 20259-67 PubMed GONUTS page
↑ Lin, CC et al. (2009) GSKIP, an inhibitor of GSK3beta, mediates the N-cadherin/beta-catenin pool in the differentiation of SH-SY5Y cells. J. Cell. Biochem. 108 1325-36 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Kim, EA et al. (2010) Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation. Biochem. Biophys. Res. Commun. 394 966-71 PubMed GONUTS page
↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ Valderrama, F et al. (2012) Radixin regulates cell migration and cell-cell adhesion through Rac1. J. Cell. Sci. 125 3310-9 PubMed GONUTS page
↑ ^12.0 ^12.1 Essers, MA et al. (2005) Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308 1181-4 PubMed GONUTS page
↑ ^13.0 ^13.1 Rawal, N et al. (2009) Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling. Biochem. Biophys. Res. Commun. 388 473-8 PubMed GONUTS page
↑ Ryo, A et al. (2001) Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat. Cell Biol. 3 793-801 PubMed GONUTS page
↑ ^15.0 ^15.1 Berwick, DC & Harvey, K (2014) The regulation and deregulation of Wnt signaling by PARK genes in health and disease. J Mol Cell Biol 6 3-12 PubMed GONUTS page
↑ Georgescu, MM et al. (2014) NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane. Neoplasia 16 365-74.e1-2 PubMed GONUTS page
↑ ^17.0 ^17.1 Gao, X et al. (2008) Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. J. Biol. Chem. 283 35679-88 PubMed GONUTS page
↑ ^18.0 ^18.1 Hülsken, J et al. (1994) E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J. Cell Biol. 127 2061-9 PubMed GONUTS page
↑ van Hengel, J et al. (2013) Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. Eur. Heart J. 34 201-10 PubMed GONUTS page
↑ Lin, G et al. (2011) Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'. Genes Dev. 25 1412-25 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ Li, M et al. (2018) Transmembrane protein 170B is a novel breast tumorigenesis suppressor gene that inhibits the Wnt/β-catenin pathway. Cell Death Dis 9 91 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ Lu, Y et al. (2017) Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis. Cell Res. 27 1422-1440 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 Graziani, A et al. (2010) Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction. J. Biol. Chem. 285 4213-23 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 ^26.4 ^26.5 Wang, HX et al. (2009) Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. Mol. Hum. Reprod. 15 11-7 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 Markiewicz, E et al. (2006) The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus. EMBO J. 25 3275-85 PubMed GONUTS page
↑ ^28.0 ^28.1 Hadjihannas, MV et al. (2010) Conductin/axin2 and Wnt signalling regulates centrosome cohesion. EMBO Rep. 11 317-24 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 ^29.3 Tang, Y et al. (2008) Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion. J. Biol. Chem. 283 23956-63 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Morin, PJ et al. (1997) Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275 1787-90 PubMed GONUTS page
↑ Korinek, V et al. (1997) Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science 275 1784-7 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 ^32.3 Humtsoe, JO et al. (2010) Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures. Mol. Cell. Biol. 30 1593-606 PubMed GONUTS page
↑ Quasnichka, H et al. (2006) Regulation of smooth muscle cell proliferation by beta-catenin/T-cell factor signaling involves modulation of cyclin D1 and p21 expression. Circ. Res. 99 1329-37 PubMed GONUTS page
↑ Fritzmann, J et al. (2009) A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential. Gastroenterology 137 165-75 PubMed GONUTS page
↑ Chamorro, MN et al. (2005) FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. EMBO J. 24 73-84 PubMed GONUTS page
↑ Sekiya, T et al. (2004) Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells. J. Biol. Chem. 279 6840-6 PubMed GONUTS page
↑ ^37.0 ^37.1 ^37.2 Tutter, AV et al. (2001) Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro. Genes Dev. 15 3342-54 PubMed GONUTS page
↑ ^38.0 ^38.1 ^38.2 Gelebart, P et al. (2008) Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. Blood 112 5171-9 PubMed GONUTS page
↑ Guo, M et al. (2008) VE-cadherin and beta-catenin binding dynamics during histamine-induced endothelial hyperpermeability. Am. J. Physiol., Cell Physiol. 294 C977-84 PubMed GONUTS page
↑ Rubinfeld, B et al. (1995) The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin. J. Biol. Chem. 270 5549-55 PubMed GONUTS page
↑ ^41.0 ^41.1 Sacco, PA et al. (1995) Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. J. Biol. Chem. 270 20201-6 PubMed GONUTS page
↑ Yook, JI et al. (2006) A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat. Cell Biol. 8 1398-406 PubMed GONUTS page
↑ Amir, AL et al. (2003) A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4. J. Biol. Chem. 278 30828-34 PubMed GONUTS page
↑ ^44.0 ^44.1 ^44.2 Peng, X et al. (2010) Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin. J. Cell. Sci. 123 567-77 PubMed GONUTS page
↑ Zhurinsky, J et al. (2000) Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin. Mol. Cell. Biol. 20 4238-52 PubMed GONUTS page
↑ ^46.0 ^46.1 Kouzmenko, AP et al. (2004) Wnt/beta-catenin and estrogen signaling converge in vivo. J. Biol. Chem. 279 40255-8 PubMed GONUTS page
↑ Penman, GA et al. (2005) The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions. J. Cell. Sci. 118 4741-50 PubMed GONUTS page
↑ ^48.0 ^48.1 Rubinfeld, B et al. (1996) Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272 1023-6 PubMed GONUTS page
↑ Varelas, X et al. (2010) The Hippo pathway regulates Wnt/beta-catenin signaling. Dev. Cell 18 579-91 PubMed GONUTS page
↑ Li, Y et al. (2008) HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. J. Biol. Chem. 283 12686-90 PubMed GONUTS page
↑ Lee, CH et al. (2010) Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer. Mol. Cancer 9 64 PubMed GONUTS page
↑ Strovel, ET et al. (2000) Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription. J. Biol. Chem. 275 2399-403 PubMed GONUTS page
↑ Ghiselli, G & Agrawal, A (2005) The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway. Biochem. J. 390 493-9 PubMed GONUTS page
↑ ^54.0 ^54.1 Nygren, MK et al. (2009) beta-catenin is involved in N-cadherin-dependent adhesion, but not in canonical Wnt signaling in E2A-PBX1-positive B acute lymphoblastic leukemia cells. Exp. Hematol. 37 225-33 PubMed GONUTS page
↑ ^55.0 ^55.1 Tanaka, S et al. (1998) A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. Proc. Natl. Acad. Sci. U.S.A. 95 10164-9 PubMed GONUTS page
↑ ^56.0 ^56.1 Togo, N et al. (2008) Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. World J. Gastroenterol. 14 4880-8 PubMed GONUTS page
↑ Hong, CF et al. (2009) MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation. J. Biol. Chem. 284 19613-22 PubMed GONUTS page
↑ Meng, Q et al. (2000) Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes. J. Mol. Med. 78 155-65 PubMed GONUTS page
↑ ^59.0 ^59.1 Ohira, T et al. (2003) WNT7a induces E-cadherin in lung cancer cells. Proc. Natl. Acad. Sci. U.S.A. 100 10429-34 PubMed GONUTS page
↑ ^60.0 ^60.1 ^60.2 Maher, MT et al. (2009) Issues associated with assessing nuclear localization of N-terminally unphosphorylated beta-catenin with monoclonal antibody 8E7. Biol. Direct 4 5 PubMed GONUTS page
↑ ^61.0 ^61.1 Lin, DY et al. (2004) Negative modulation of androgen receptor transcriptional activity by Daxx. Mol. Cell. Biol. 24 10529-41 PubMed GONUTS page
↑ ^62.0 ^62.1 Jordan, BK et al. (2003) Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy. Proc. Natl. Acad. Sci. U.S.A. 100 10866-71 PubMed GONUTS page
↑ ^63.0 ^63.1 ^63.2 ^63.3 ^63.4 Usami, N et al. (2003) Beta-catenin inhibits cell growth of a malignant mesothelioma cell line, NCI-H28, with a 3p21.3 homozygous deletion. Oncogene 22 7923-30 PubMed GONUTS page
↑ Jesse, S et al. (2010) Lef-1 isoforms regulate different target genes and reduce cellular adhesion. Int. J. Cancer 126 1109-20 PubMed GONUTS page
↑ ^65.0 ^65.1 Katafiasz, BJ et al. (2003) Characterization of cadherin-24, a novel alternatively spliced type II cadherin. J. Biol. Chem. 278 27513-9 PubMed GONUTS page
↑ Hebenstreit, D et al. (2008) LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element. J. Biol. Chem. 283 22490-7 PubMed GONUTS page
↑ Han, A et al. (2008) Sulindac suppresses beta-catenin expression in human cancer cells. Eur. J. Pharmacol. 583 26-31 PubMed GONUTS page
↑ Satow, R et al. (2012) β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells. Gastroenterology 142 572-81 PubMed GONUTS page
↑ ^69.0 ^69.1 ^69.2 Bahmanyar, S et al. (2008) beta-Catenin is a Nek2 substrate involved in centrosome separation. Genes Dev. 22 91-105 PubMed GONUTS page
↑ Yan, HX et al. (2006) Protein-tyrosine phosphatase PCP-2 inhibits beta-catenin signaling and increases E-cadherin-dependent cell adhesion. J. Biol. Chem. 281 15423-33 PubMed GONUTS page
↑ Fuchs, M et al. (1996) Association of human protein-tyrosine phosphatase kappa with members of the armadillo family. J. Biol. Chem. 271 16712-9 PubMed GONUTS page
↑ Askham, JM et al. (2000) Regulation and function of the interaction between the APC tumour suppressor protein and EB1. Oncogene 19 1950-8 PubMed GONUTS page
↑ Plisov, S et al. (2005) Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning. J. Am. Soc. Nephrol. 16 1632-44 PubMed GONUTS page
↑ Hegland, DD et al. (1999) Regulation of endothelial cell adherens junctions by a Ras-dependent signal transduction pathway. Biochem. Biophys. Res. Commun. 260 371-6 PubMed GONUTS page
↑ ^75.0 ^75.1 Roth, W et al. (2000) Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells. Oncogene 19 4210-20 PubMed GONUTS page
↑ ^76.0 ^76.1 Chung, MT et al. (2009) SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway. Gynecol. Oncol. 112 646-53 PubMed GONUTS page
↑ Wong, SC et al. (2002) Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours. J. Pathol. 196 145-53 PubMed GONUTS page
↑ ^78.0 ^78.1 ^78.2 ^78.3 ^78.4 ^78.5 ^78.6 ^78.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Nishiyama, M et al. (2012) Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-β-catenin signaling pathway. Mol. Cell. Biol. 32 501-12 PubMed GONUTS page
↑ Anderson, CB et al. (2002) Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon. Proc. Natl. Acad. Sci. U.S.A. 99 8683-8 PubMed GONUTS page
↑ Liu, J et al. (2013) Succinate dehydrogenase 5 (SDH5) regulates glycogen synthase kinase 3β-β-catenin-mediated lung cancer metastasis. J. Biol. Chem. 288 29965-73 PubMed GONUTS page
↑ Kleaveland, B et al. (2009) Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat. Med. 15 169-76 PubMed GONUTS page
↑ Kramps, T et al. (2002) Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell 109 47-60 PubMed GONUTS page
↑ van Tienen, LM et al. (2017) Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9. Elife 6 PubMed GONUTS page
↑ Killick, R et al. (2014) Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol. Psychiatry 19 88-98 PubMed GONUTS page
↑ ^86.0 ^86.1 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page
↑ ^87.0 ^87.1 Yang, CK et al. (2006) Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1. J. Biol. Chem. 281 3389-97 PubMed GONUTS page
↑ Sohn, KC et al. (2009) Pitx2, a beta-catenin-regulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro. J. Dermatol. Sci. 54 6-11 PubMed GONUTS page
↑ Kalluri, R & Neilson, EG (2003) Epithelial-mesenchymal transition and its implications for fibrosis. J. Clin. Invest. 112 1776-84 PubMed GONUTS page
↑ Strumane, K et al. (2006) E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion. Cancer Res. 66 10007-15 PubMed GONUTS page
↑ ^91.0 ^91.1 Prieve, MG & Waterman, ML (1999) Nuclear localization and formation of beta-catenin-lymphoid enhancer factor 1 complexes are not sufficient for activation of gene expression. Mol. Cell. Biol. 19 4503-15 PubMed GONUTS page
↑ ^92.0 ^92.1 Tuli, R et al. (2003) Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk. J. Biol. Chem. 278 41227-36 PubMed GONUTS page
↑ Zhou, S et al. (2004) Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J. Bone Miner. Res. 19 463-70 PubMed GONUTS page
↑ Zhang, M et al. (2010) Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes. J. Biol. Chem. 285 8703-10 PubMed GONUTS page

[PMID:29374064-1] 1.0 ^1.1 Higashimori, A et al. (2018) Forkhead Box F2 Suppresses Gastric Cancer through a Novel FOXF2-IRF2BPL-β-Catenin Signaling Axis. Cancer Res. 78 1643-1656 PubMed GONUTS page

[PMID:28051089-2] Caldwell, JM et al. (2017) Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation. Mucosal Immunol 10 1190-1201 PubMed GONUTS page

[PMID:12154096-3] 3.0 ^3.1 Longo, KA et al. (2002) Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. J. Biol. Chem. 277 38239-44 PubMed GONUTS page

[PMID:18193033-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Li, J & Wang, CY (2008) TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis. Nat. Cell Biol. 10 160-9 PubMed GONUTS page

[PMID:22723415-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Hoffmeyer, K et al. (2012) Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science 336 1549-54 PubMed GONUTS page

[PMID:12138115-6] 6.0 ^6.1 Karasawa, T et al. (2002) Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling. J. Biol. Chem. 277 37479-86 PubMed GONUTS page

[PMID:12651860-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Ghiselli, G et al. (2003) The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway. J. Biol. Chem. 278 20259-67 PubMed GONUTS page

[PMID:19830702-8] Lin, CC et al. (2009) GSKIP, an inhibitor of GSK3beta, mediates the N-cadherin/beta-catenin pool in the differentiation of SH-SY5Y cells. J. Cell. Biochem. 108 1325-36 PubMed GONUTS page

[PMID:20307497-9] 9.0 ^9.1 ^9.2 ^9.3 Kim, EA et al. (2010) Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation. Biochem. Biophys. Res. Commun. 394 966-71 PubMed GONUTS page

[PMID:25468996-10] Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:22467863-11] Valderrama, F et al. (2012) Radixin regulates cell migration and cell-cell adhesion through Rac1. J. Cell. Sci. 125 3310-9 PubMed GONUTS page

[PMID:15905404-12] 12.0 ^12.1 Essers, MA et al. (2005) Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308 1181-4 PubMed GONUTS page

[PMID:19591802-13] 13.0 ^13.1 Rawal, N et al. (2009) Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling. Biochem. Biophys. Res. Commun. 388 473-8 PubMed GONUTS page

[PMID:11533658-14] Ryo, A et al. (2001) Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat. Cell Biol. 3 793-801 PubMed GONUTS page

[PMID:24115276-15] 15.0 ^15.1 Berwick, DC & Harvey, K (2014) The regulation and deregulation of Wnt signaling by PARK genes in health and disease. J Mol Cell Biol 6 3-12 PubMed GONUTS page

[PMID:24862762-16] Georgescu, MM et al. (2014) NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane. Neoplasia 16 365-74.e1-2 PubMed GONUTS page

[PMID:18936100-17] 17.0 ^17.1 Gao, X et al. (2008) Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. J. Biol. Chem. 283 35679-88 PubMed GONUTS page

[PMID:7806582-18] 18.0 ^18.1 Hülsken, J et al. (1994) E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J. Cell Biol. 127 2061-9 PubMed GONUTS page

[PMID:23136403-19] van Hengel, J et al. (2013) Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. Eur. Heart J. 34 201-10 PubMed GONUTS page

[PMID:21724833-20] Lin, G et al. (2011) Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'. Genes Dev. 25 1412-25 PubMed GONUTS page

[PMID:21423176-21] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:29367600-22] Li, M et al. (2018) Transmembrane protein 170B is a novel breast tumorigenesis suppressor gene that inhibits the Wnt/β-catenin pathway. Cell Death Dis 9 91 PubMed GONUTS page

[PMID:19199708-23] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:28829046-24] Lu, Y et al. (2017) Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis. Cell Res. 27 1422-1440 PubMed GONUTS page

[PMID:19996314-25] 25.0 ^25.1 ^25.2 ^25.3 Graziani, A et al. (2010) Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction. J. Biol. Chem. 285 4213-23 PubMed GONUTS page

[PMID:19038973-26] 26.0 ^26.1 ^26.2 ^26.3 ^26.4 ^26.5 Wang, HX et al. (2009) Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. Mol. Hum. Reprod. 15 11-7 PubMed GONUTS page

[PMID:16858403-27] 27.0 ^27.1 ^27.2 ^27.3 Markiewicz, E et al. (2006) The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus. EMBO J. 25 3275-85 PubMed GONUTS page

[PMID:20300119-28] 28.0 ^28.1 Hadjihannas, MV et al. (2010) Conductin/axin2 and Wnt signalling regulates centrosome cohesion. EMBO Rep. 11 317-24 PubMed GONUTS page

[PMID:18593713-29] 29.0 ^29.1 ^29.2 ^29.3 Tang, Y et al. (2008) Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion. J. Biol. Chem. 283 23956-63 PubMed GONUTS page

[PMID:9065402-30] 30.0 ^30.1 ^30.2 Morin, PJ et al. (1997) Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275 1787-90 PubMed GONUTS page

[PMID:9065401-31] Korinek, V et al. (1997) Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science 275 1784-7 PubMed GONUTS page

[PMID:20123964-32] 32.0 ^32.1 ^32.2 ^32.3 Humtsoe, JO et al. (2010) Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures. Mol. Cell. Biol. 30 1593-606 PubMed GONUTS page

[PMID:17122440-33] Quasnichka, H et al. (2006) Regulation of smooth muscle cell proliferation by beta-catenin/T-cell factor signaling involves modulation of cyclin D1 and p21 expression. Circ. Res. 99 1329-37 PubMed GONUTS page

[PMID:19328798-34] Fritzmann, J et al. (2009) A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential. Gastroenterology 137 165-75 PubMed GONUTS page

[PMID:15592430-35] Chamorro, MN et al. (2005) FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. EMBO J. 24 73-84 PubMed GONUTS page

[PMID:14660579-36] Sekiya, T et al. (2004) Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells. J. Biol. Chem. 279 6840-6 PubMed GONUTS page

[PMID:11751639-37] 37.0 ^37.1 ^37.2 Tutter, AV et al. (2001) Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro. Genes Dev. 15 3342-54 PubMed GONUTS page

[PMID:18787224-38] 38.0 ^38.1 ^38.2 Gelebart, P et al. (2008) Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. Blood 112 5171-9 PubMed GONUTS page

[PMID:18287330-39] Guo, M et al. (2008) VE-cadherin and beta-catenin binding dynamics during histamine-induced endothelial hyperpermeability. Am. J. Physiol., Cell Physiol. 294 C977-84 PubMed GONUTS page

[PMID:7890674-40] Rubinfeld, B et al. (1995) The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin. J. Biol. Chem. 270 5549-55 PubMed GONUTS page

[PMID:7650039-41] 41.0 ^41.1 Sacco, PA et al. (1995) Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. J. Biol. Chem. 270 20201-6 PubMed GONUTS page

[PMID:17072303-42] Yook, JI et al. (2006) A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat. Cell Biol. 8 1398-406 PubMed GONUTS page

[PMID:12799378-43] Amir, AL et al. (2003) A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4. J. Biol. Chem. 278 30828-34 PubMed GONUTS page

[PMID:20086044-44] 44.0 ^44.1 ^44.2 Peng, X et al. (2010) Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin. J. Cell. Sci. 123 567-77 PubMed GONUTS page

[PMID:10825188-45] Zhurinsky, J et al. (2000) Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin. Mol. Cell. Biol. 20 4238-52 PubMed GONUTS page

[PMID:15304487-46] 46.0 ^46.1 Kouzmenko, AP et al. (2004) Wnt/beta-catenin and estrogen signaling converge in vivo. J. Biol. Chem. 279 40255-8 PubMed GONUTS page

[PMID:16188939-47] Penman, GA et al. (2005) The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions. J. Cell. Sci. 118 4741-50 PubMed GONUTS page

[PMID:8638126-48] 48.0 ^48.1 Rubinfeld, B et al. (1996) Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272 1023-6 PubMed GONUTS page

[PMID:20412773-49] Varelas, X et al. (2010) The Hippo pathway regulates Wnt/beta-catenin signaling. Dev. Cell 18 579-91 PubMed GONUTS page

[PMID:18356165-50] Li, Y et al. (2008) HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. J. Biol. Chem. 283 12686-90 PubMed GONUTS page

[PMID:20302655-51] Lee, CH et al. (2010) Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer. Mol. Cancer 9 64 PubMed GONUTS page

[PMID:10644691-52] Strovel, ET et al. (2000) Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription. J. Biol. Chem. 275 2399-403 PubMed GONUTS page

[PMID:15853773-53] Ghiselli, G & Agrawal, A (2005) The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway. Biochem. J. 390 493-9 PubMed GONUTS page

[PMID:19101069-54] 54.0 ^54.1 Nygren, MK et al. (2009) beta-catenin is involved in N-cadherin-dependent adhesion, but not in canonical Wnt signaling in E2A-PBX1-positive B acute lymphoblastic leukemia cells. Exp. Hematol. 37 225-33 PubMed GONUTS page

[PMID:9707618-55] 55.0 ^55.1 Tanaka, S et al. (1998) A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. Proc. Natl. Acad. Sci. U.S.A. 95 10164-9 PubMed GONUTS page

[PMID:18756595-56] 56.0 ^56.1 Togo, N et al. (2008) Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. World J. Gastroenterol. 14 4880-8 PubMed GONUTS page

[PMID:19443654-57] Hong, CF et al. (2009) MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation. J. Biol. Chem. 284 19613-22 PubMed GONUTS page

[PMID:10868478-58] Meng, Q et al. (2000) Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes. J. Mol. Med. 78 155-65 PubMed GONUTS page

[PMID:12937339-59] 59.0 ^59.1 Ohira, T et al. (2003) WNT7a induces E-cadherin in lung cancer cells. Proc. Natl. Acad. Sci. U.S.A. 100 10429-34 PubMed GONUTS page

[PMID:19187541-60] 60.0 ^60.1 ^60.2 Maher, MT et al. (2009) Issues associated with assessing nuclear localization of N-terminally unphosphorylated beta-catenin with monoclonal antibody 8E7. Biol. Direct 4 5 PubMed GONUTS page

[PMID:15572661-61] 61.0 ^61.1 Lin, DY et al. (2004) Negative modulation of androgen receptor transcriptional activity by Daxx. Mol. Cell. Biol. 24 10529-41 PubMed GONUTS page

[PMID:12949260-62] 62.0 ^62.1 Jordan, BK et al. (2003) Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy. Proc. Natl. Acad. Sci. U.S.A. 100 10866-71 PubMed GONUTS page

[PMID:12970740-63] 63.0 ^63.1 ^63.2 ^63.3 ^63.4 Usami, N et al. (2003) Beta-catenin inhibits cell growth of a malignant mesothelioma cell line, NCI-H28, with a 3p21.3 homozygous deletion. Oncogene 22 7923-30 PubMed GONUTS page

[PMID:19653274-64] Jesse, S et al. (2010) Lef-1 isoforms regulate different target genes and reduce cellular adhesion. Int. J. Cancer 126 1109-20 PubMed GONUTS page

[PMID:12734196-65] 65.0 ^65.1 Katafiasz, BJ et al. (2003) Characterization of cadherin-24, a novel alternatively spliced type II cadherin. J. Biol. Chem. 278 27513-9 PubMed GONUTS page

[PMID:18579517-66] Hebenstreit, D et al. (2008) LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element. J. Biol. Chem. 283 22490-7 PubMed GONUTS page

[PMID:18291362-67] Han, A et al. (2008) Sulindac suppresses beta-catenin expression in human cancer cells. Eur. J. Pharmacol. 583 26-31 PubMed GONUTS page

[PMID:22155184-68] Satow, R et al. (2012) β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells. Gastroenterology 142 572-81 PubMed GONUTS page

[PMID:18086858-69] 69.0 ^69.1 ^69.2 Bahmanyar, S et al. (2008) beta-Catenin is a Nek2 substrate involved in centrosome separation. Genes Dev. 22 91-105 PubMed GONUTS page

[PMID:16574648-70] Yan, HX et al. (2006) Protein-tyrosine phosphatase PCP-2 inhibits beta-catenin signaling and increases E-cadherin-dependent cell adhesion. J. Biol. Chem. 281 15423-33 PubMed GONUTS page

[PMID:8663237-71] Fuchs, M et al. (1996) Association of human protein-tyrosine phosphatase kappa with members of the armadillo family. J. Biol. Chem. 271 16712-9 PubMed GONUTS page

[PMID:10773885-72] Askham, JM et al. (2000) Regulation and function of the interaction between the APC tumour suppressor protein and EB1. Oncogene 19 1950-8 PubMed GONUTS page

[PMID:15843474-73] Plisov, S et al. (2005) Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning. J. Am. Soc. Nephrol. 16 1632-44 PubMed GONUTS page

[PMID:10403777-74] Hegland, DD et al. (1999) Regulation of endothelial cell adherens junctions by a Ras-dependent signal transduction pathway. Biochem. Biophys. Res. Commun. 260 371-6 PubMed GONUTS page

[PMID:10980594-75] 75.0 ^75.1 Roth, W et al. (2000) Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells. Oncogene 19 4210-20 PubMed GONUTS page

[PMID:19095296-76] 76.0 ^76.1 Chung, MT et al. (2009) SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway. Gynecol. Oncol. 112 646-53 PubMed GONUTS page

[PMID:11793365-77] Wong, SC et al. (2002) Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours. J. Pathol. 196 145-53 PubMed GONUTS page

[PMID:21873635-78] 78.0 ^78.1 ^78.2 ^78.3 ^78.4 ^78.5 ^78.6 ^78.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22083958-79] Nishiyama, M et al. (2012) Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-β-catenin signaling pathway. Mol. Cell. Biol. 32 501-12 PubMed GONUTS page

[PMID:12072559-80] Anderson, CB et al. (2002) Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon. Proc. Natl. Acad. Sci. U.S.A. 99 8683-8 PubMed GONUTS page

[PMID:23983127-81] Liu, J et al. (2013) Succinate dehydrogenase 5 (SDH5) regulates glycogen synthase kinase 3β-β-catenin-mediated lung cancer metastasis. J. Biol. Chem. 288 29965-73 PubMed GONUTS page

[PMID:19151727-82] Kleaveland, B et al. (2009) Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat. Med. 15 169-76 PubMed GONUTS page

[PMID:11955446-83] Kramps, T et al. (2002) Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell 109 47-60 PubMed GONUTS page

[PMID:28296634-84] van Tienen, LM et al. (2017) Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9. Elife 6 PubMed GONUTS page

[PMID:23164821-85] Killick, R et al. (2014) Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol. Psychiatry 19 88-98 PubMed GONUTS page

[PMID:24431302-86] 86.0 ^86.1 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page

[PMID:16344550-87] 87.0 ^87.1 Yang, CK et al. (2006) Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1. J. Biol. Chem. 281 3389-97 PubMed GONUTS page

[PMID:19251162-88] Sohn, KC et al. (2009) Pitx2, a beta-catenin-regulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro. J. Dermatol. Sci. 54 6-11 PubMed GONUTS page

[PMID:14679171-89] Kalluri, R & Neilson, EG (2003) Epithelial-mesenchymal transition and its implications for fibrosis. J. Clin. Invest. 112 1776-84 PubMed GONUTS page

[PMID:17047063-90] Strumane, K et al. (2006) E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion. Cancer Res. 66 10007-15 PubMed GONUTS page

[PMID:10330189-91] 91.0 ^91.1 Prieve, MG & Waterman, ML (1999) Nuclear localization and formation of beta-catenin-lymphoid enhancer factor 1 complexes are not sufficient for activation of gene expression. Mol. Cell. Biol. 19 4503-15 PubMed GONUTS page

[PMID:12893825-92] 92.0 ^92.1 Tuli, R et al. (2003) Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk. J. Biol. Chem. 278 41227-36 PubMed GONUTS page

[PMID:15040835-93] Zhou, S et al. (2004) Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J. Bone Miner. Res. 19 463-70 PubMed GONUTS page

[PMID:20097766-94] Zhang, M et al. (2010) Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes. J. Biol. Chem. 285 8703-10 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

[35]

[36]

[37]

[38]

[39]

[40]

[41]

[42]

[43]

[44]

[45]

[46]

[47]

[48]

[49]

[50]

[51]

[52]

[53]

[54]

[55]

[56]

[57]

[58]

[59]

[60]

[61]

[62]

[63]

[64]

[65]

[66]

[67]

[68]

[69]

[70]

[71]

[72]

[73]

[74]

[75]

[76]

[77]

[78]

[79]

[80]

[81]

[82]

[83]

[84]

[85]

[86]

[87]

[88]

[89]

[90]

[91]

[92]

[93]

[94]

HUMAN:CTNB1

Contents

Annotations

Notes

References

a

b

c

d

e

f

g

h

i

k

l

m

n

o

p

r

s

t

v

w

z

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools