MOUSE:GP124

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Gpr124 (synonyms: Tem5)
Protein Name(s)	G-protein coupled receptor 124 Tumor endothelial marker 5
External Links
UniProt	Q91ZV8
EMBL	AF378759 BC138451 BC138452
CCDS	CCDS22210.2
RefSeq	NP_473385.2
UniGene	Mm.87046
ProteinModelPortal	Q91ZV8
SMR	Q91ZV8
PhosphoSite	Q91ZV8
PaxDb	Q91ZV8
PRIDE	Q91ZV8
Ensembl	ENSMUST00000033876
GeneID	78560
KEGG	mmu:78560
UCSC	uc009lhx.2
CTD	25960
MGI	MGI:1925810
eggNOG	NOG307919
GeneTree	ENSGT00390000016104
HOGENOM	HOG000112767
HOVERGEN	HBG051777
InParanoid	Q91ZV8
KO	K08461
OMA	RTLCAYP
PhylomeDB	Q91ZV8
TreeFam	TF331206
NextBio	349093
PRO	PR:Q91ZV8
Proteomes	UP000000589
Bgee	Q91ZV8
CleanEx	MM_GPR124
ExpressionAtlas	Q91ZV8
Genevestigator	Q91ZV8
GO	GO:0009986 GO:0016021 GO:0005886 GO:0004930 GO:0001525 GO:0007417 GO:0043542 GO:1900747 GO:0007218 GO:0010595 GO:0045765 GO:0050920 GO:0090210 GO:0002040
Gene3D	2.60.40.10
InterPro	IPR000483 IPR017981 IPR001879 IPR000832 IPR017983 IPR000203 IPR007110 IPR013783 IPR003599 IPR001611 IPR003591
Pfam	PF00002 PF01825 PF02793 PF13855
SMART	SM00409 SM00369 SM00082
PROSITE	PS00650 PS50227 PS50261 PS50221 PS50835 PS51450

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0002040	sprouting angiogenesis	PMID:21282641^[1]	ECO:0000315			P		Fig. 3. Gpr124 is required for normal angiogenic sprouting and development of vasculature within the forebrain and spinal cord.	complete
	GO:0060462	lung lobe development	PMID:21282641^[1]	ECO:0000315			P		Fig. 2. D. Hypoplasia of lungs in Gpr124-deficient embryos.	complete
	GO:0060022	hard palate development	PMID:21282641^[1]	ECO:0000315			P		Fig. 2. B. Failure in secondary palate formation in Gpr124-deficient embryos.	complete
part_of	GO:1990909	Wnt signalosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96PE1	C		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:28803732^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:28803732^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090210	regulation of establishment of blood-brain barrier	PMID:28288111^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050920	regulation of chemotaxis	PMID:21071672^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045765	regulation of angiogenesis	PMID:21071672^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043542	endothelial cell migration	PMID:21071672^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:21071672^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	PMID:21071672^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1925810 PANTHER:PTN000245141	P		Seeded From UniProt	complete
part_of	GO:1990909	Wnt signalosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PE1	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	PMID:21421844^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4949903	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PE1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090210	regulation of establishment of blood-brain barrier	PMID:21421844^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4949903	P	regulates_o_occurs_in:(EMAPA:18631)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010595	positive regulation of endothelial cell migration	PMID:21421844^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:21421844^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000071)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11559528^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	EMBL:AF378755	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002040	sprouting angiogenesis	PMID:23918385^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5544776	P	occurs_in:(EMAPA:16895)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:21421844^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4949903	P	has_participant:(EMAPA:16894)	Seeded From UniProt	complete
part_of	GO:1990909	Wnt signalosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96PE1 ensembl:ENSP00000406367	C		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96PE1 ensembl:ENSP00000406367	P		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000832 InterPro:IPR001879 InterPro:IPR017983 InterPro:IPR036445	F		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000832 InterPro:IPR017983	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001879 InterPro:IPR036445	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000832 InterPro:IPR017981	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
part_of	GO:0030175	filopodium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0286	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Anderson, KD et al. (2011) Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor. Proc. Natl. Acad. Sci. U.S.A. 108 2807-12 PubMed GONUTS page
↑ ^2.0 ^2.1 Cho, C et al. (2017) Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation. Neuron 95 1056-1073.e5 PubMed GONUTS page
↑ Chang, J et al. (2017) Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. Nat. Med. 23 450-460 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Kuhnert, F et al. (2010) Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science 330 985-9 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Cullen, M et al. (2011) GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc. Natl. Acad. Sci. U.S.A. 108 5759-64 PubMed GONUTS page
↑ Carson-Walter, EB et al. (2001) Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Res. 61 6649-55 PubMed GONUTS page
↑ Economides, AN et al. (2013) Conditionals by inversion provide a universal method for the generation of conditional alleles. Proc. Natl. Acad. Sci. U.S.A. 110 E3179-88 PubMed GONUTS page

[PMID:21282641-1] 1.0 ^1.1 ^1.2 Anderson, KD et al. (2011) Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor. Proc. Natl. Acad. Sci. U.S.A. 108 2807-12 PubMed GONUTS page

[PMID:28803732-2] 2.0 ^2.1 Cho, C et al. (2017) Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation. Neuron 95 1056-1073.e5 PubMed GONUTS page

[PMID:28288111-3] Chang, J et al. (2017) Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. Nat. Med. 23 450-460 PubMed GONUTS page

[PMID:21071672-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Kuhnert, F et al. (2010) Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science 330 985-9 PubMed GONUTS page

[PMID:21873635-5] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21421844-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Cullen, M et al. (2011) GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc. Natl. Acad. Sci. U.S.A. 108 5759-64 PubMed GONUTS page

[PMID:11559528-7] Carson-Walter, EB et al. (2001) Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Res. 61 6649-55 PubMed GONUTS page

[PMID:23918385-8] Economides, AN et al. (2013) Conditionals by inversion provide a universal method for the generation of conditional alleles. Proc. Natl. Acad. Sci. U.S.A. 110 E3179-88 PubMed GONUTS page

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MOUSE:GP124

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