MOUSE:WNT1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Wnt1 (synonyms: Int-1, Wnt-1)
Protein Name(s)	Proto-oncogene Wnt-1 Proto-oncogene Int-1
External Links
UniProt	P04426
EMBL	K02593 M11943 BC005449
CCDS	CCDS27807.1
PIR	A23447
RefSeq	NP_067254.1 XP_006520953.1
UniGene	Mm.1123
ProteinModelPortal	P04426
SMR	P04426
BioGrid	204567
DIP	DIP-39896N
IntAct	P04426
STRING	10090.ENSMUSP00000023734
PhosphoSite	P04426
PRIDE	P04426
Ensembl	ENSMUST00000023734
GeneID	22408
KEGG	mmu:22408
UCSC	uc007xnx.1
CTD	7471
MGI	MGI:98953
eggNOG	NOG284879
HOGENOM	HOG000039528
HOVERGEN	HBG001595
InParanoid	P04426
KO	K03209
OMA	AIKECKW
OrthoDB	EOG7C8GJ8
PhylomeDB	P04426
TreeFam	TF105310
Reactome	REACT_207044 REACT_213918 REACT_214043 REACT_216784 REACT_250061 REACT_252217 REACT_27166
NextBio	302801
PRO	PR:P04426
Proteomes	UP000000589
Bgee	P04426
CleanEx	MM_WNT1
ExpressionAtlas	P04426
Genevestigator	P04426
GO	GO:0009986 GO:0005788 GO:0005615 GO:0005578 GO:0005125 GO:0005109 GO:0019904 GO:0005102 GO:0044212 GO:0030509 GO:0060348 GO:0001658 GO:0060070 GO:0044336 GO:0007267 GO:0071375 GO:0021551 GO:0021588 GO:0021536 GO:0000578 GO:0021797 GO:0071425 GO:0070365 GO:0042472 GO:0022037 GO:0030901 GO:0030917 GO:0022004 GO:0007520 GO:0014902 GO:0030514 GO:0090344 GO:0045596 GO:0022408 GO:0010812 GO:0045599 GO:2000059 GO:0030512 GO:0048663 GO:0048664 GO:0009887 GO:0031100 GO:0008284 GO:0061184 GO:0048146 GO:0043568 GO:0010592 GO:0045747 GO:0001934 GO:0051091 GO:0045944 GO:0045893 GO:0009611 GO:0007165 GO:0042770 GO:0060061 GO:0021527 GO:0033077 GO:0030579 GO:0016055
InterPro	IPR005817 IPR009139 IPR018161
PANTHER	PTHR12027
Pfam	PF00110
PRINTS	PR01841 PR01349
SMART	SM00097
PROSITE	PS00246

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0071542	dopaminergic neuron differentiation	PMID:23324743^[1]	ECO:0000315			P		Figure 1 shows reduced Dopaminergic neurogenesis in Wnt1-/- mutant mice when compared with wild type.	complete CACAO 6371
involved_in	GO:1904948	midbrain dopaminergic neuron differentiation	PMID:23324743^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:11357136^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:17239604^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8848044^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSMUSG00000058665) part_of:(GO:0030901) part_of:(GO:0021549)	Seeded From UniProt	complete
involved_in	GO:0021549	cerebellum development	PMID:8848044^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030901	midbrain development	PMID:8848044^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033278	cell proliferation in midbrain	PMID:14557550^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0022008)	Seeded From UniProt	complete
involved_in	GO:0033278	cell proliferation in midbrain	PMID:15121182^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0007420)	Seeded From UniProt	complete
involved_in	GO:1990403	embryonic brain development	PMID:15121182^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:15121182^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P	part_of:(GO:0033278) part_of:(GO:1990403)	Seeded From UniProt	complete
involved_in	GO:0036520	astrocyte-dopaminergic neuron signaling	PMID:21752258^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001891)	Seeded From UniProt	complete
part_of	GO:1990909	Wnt signalosome	PMID:10557084^[8]	ECO:0000305	curator inference used in manual assertion	GO:0048018	C		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:10557084^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0016055)	Seeded From UniProt	complete
involved_in	GO:0030901	midbrain development	PMID:14557550^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0022008	neurogenesis	PMID:14557550^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0001891)	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:11336703^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:21752258^[7]	ECO:0000305	curator inference used in manual assertion	GO:1903204	F	has_direct_input:(UniProtKB:O70421) part_of:(GO:0060070)	Seeded From UniProt	complete
involved_in	GO:1903204	negative regulation of oxidative stress-induced neuron death	PMID:21752258^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_agent:(CL:0000127) regulates_o_occurs_in:(CL:2000097)	Seeded From UniProt	complete
involved_in	GO:1904954	canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	PMID:19951692^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19951692^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSMUSG00000021848) part_of:(GO:0060070) part_of:(GO:0071542)\|regulates_transcription_of(ENSEMBL:ENSMUSG00000025229)\|regulates_transcription_of(ENSEMBL:ENSMUSG00000026686)	Seeded From UniProt	complete
involved_in	GO:0071542	dopaminergic neuron differentiation	PMID:23324743^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045596	negative regulation of cell differentiation	PMID:9473323^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0003089)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:15265686^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:12121999^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060061	Spemann organizer formation	PMID:9192640^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:15035989^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	PMID:10937998^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030901	midbrain development	PMID:2202907^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021588	cerebellum formation	PMID:2202907^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021551	central nervous system morphogenesis	PMID:2202907^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:10557084^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:10557084^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000578	embryonic axis specification	PMID:2534596^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060348	bone development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04628	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12937339^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:15454084^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q01887	F		Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98957 PANTHER:PTN000246517 UniProtKB:P49339 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246517 RGD:69250 UniProtKB:P56706 UniProtKB:Q98SN7	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010194 MGI:MGI:108061 MGI:MGI:1197020 MGI:MGI:98953 MGI:MGI:98954 MGI:MGI:98956 MGI:MGI:98958 MGI:MGI:98960 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 UniProtKB:P41221 UniProtKB:Q98SN7 WB:WBGene00000858 WB:WBGene00003029 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 MGI:MGI:98956 MGI:MGI:98957 PANTHER:PTN000246517 RGD:1311441 RGD:69250 UniProtKB:P41221 UniProtKB:P56704 UniProtKB:P56705 UniProtKB:Q2LMP1 UniProtKB:Q9UBV4 UniProtKB:Q9YGX6	C		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 FB:FBgn0004360 FB:FBgn0010453 FB:FBgn0038134 MGI:MGI:98956 MGI:MGI:98957 MGI:MGI:98958 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 RGD:69079 UniProtKB:P09544 UniProtKB:P41221 UniProtKB:P56703 UniProtKB:Q98SN7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	PMID:16601693^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090344	negative regulation of cell aging	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04628	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071425	hematopoietic stem cell proliferation	PMID:9160667^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16846) acts_on_population_of:(CL:0001008)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070365	hepatocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1597195	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061184	positive regulation of dermatome development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04628	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060348	bone development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04628	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:15143170^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1329040	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:9652750^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:20383322^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:16543246^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:16207730^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:15282335^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:15064719^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:11265645^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:10937998^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04628	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048664	neuron fate determination	PMID:16339193^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3046939	P	results_in_determination_of:(CL:0000700)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048663	neuron fate commitment	PMID:16339193^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153126	P	has_participant:(EMAPA:16974) results_in_commitment_to:(CL:0000700)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04628	P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04628	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15574752^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1919385 MGI:MGI:1924828 MGI:MGI:1933114	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9769173^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15574752^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9356179^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04628	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045747	positive regulation of Notch signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04628	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045599	negative regulation of fat cell differentiation	PMID:15728361^[36]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_results_in_acquisition_of_features_of:(CL:0000136)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045599	negative regulation of fat cell differentiation	PMID:10937998^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04628	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04628	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04628	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042770	signal transduction in response to DNA damage	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04628	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:15961523^[37]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98956	P	has_participant:(EMAPA:16194)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033077	T cell differentiation in thymus	PMID:11265645^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031100	animal organ regeneration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1597195	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030917	midbrain-hindbrain boundary development	PMID:2205396^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857490	P	results_in_development_of:(EMAPA:16478)\|results_in_development_of:(EMAPA:16472)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030901	midbrain development	PMID:2205396^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857490	P	results_in_development_of:(EMAPA:16472)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030579	ubiquitin-dependent SMAD protein catabolic process	PMID:16601693^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04628	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	PMID:16601693^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:19850029^[39]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q91029	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022408	negative regulation of cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04628	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022037	metencephalon development	PMID:2205396^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857490	P	results_in_development_of:(EMAPA:16478)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022004	midbrain-hindbrain boundary maturation during brain development	PMID:8555108^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856382	P	occurs_in:(EMAPA:16472)\|occurs_in:(EMAPA:16478)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021797	forebrain anterior/posterior pattern specification	PMID:18094027^[41]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102764	P	has_participant:(EMAPA:16641)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021536	diencephalon development	PMID:18094027^[41]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102764	P	results_in_development_of:(EMAPA:16641)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021527	spinal cord association neuron differentiation	PMID:11877374^[42]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98956	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014902	myotube differentiation	PMID:15282335^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96573	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010812	negative regulation of cell-substrate adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04628	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010592	positive regulation of lamellipodium assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04628	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:8710372^[43]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:9160667^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04628	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007520	myoblast fusion	PMID:15282335^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96573	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007520	myoblast fusion	PMID:15282335^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04628	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	PMID:15143170^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001658	branching involved in ureteric bud morphogenesis	PMID:16054034^[44]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1197020	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0071375	cellular response to peptide hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A9J2 ensembl:ENSRNOP00000071688	P		Seeded From UniProt	complete
involved_in	GO:0070365	hepatocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A9J2 ensembl:ENSRNOP00000071688	P		Seeded From UniProt	complete
involved_in	GO:0031100	animal organ regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A9J2 ensembl:ENSRNOP00000071688	P		Seeded From UniProt	complete
involved_in	GO:0090344	negative regulation of cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04628 ensembl:ENSP00000293549	P		Seeded From UniProt	complete
involved_in	GO:0061184	positive regulation of dermatome development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04628 ensembl:ENSP00000293549	P		Seeded From UniProt	complete
involved_in	GO:0060348	bone development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04628 ensembl:ENSP00000293549	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04628 ensembl:ENSP00000293549	P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04628 ensembl:ENSP00000293549	P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04628 ensembl:ENSP00000293549	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04628 ensembl:ENSP00000293549	P		Seeded From UniProt	complete
involved_in	GO:0045747	positive regulation of Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04628 ensembl:ENSP00000293549	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04628 ensembl:ENSP00000293549	F		Seeded From UniProt	complete
involved_in	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04628 ensembl:ENSP00000293549	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04628 ensembl:ENSP00000293549	P		Seeded From UniProt	complete
involved_in	GO:0042770	signal transduction in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04628 ensembl:ENSP00000293549	P		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04628 ensembl:ENSP00000293549	P		Seeded From UniProt	complete
involved_in	GO:0022408	negative regulation of cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04628 ensembl:ENSP00000293549	P		Seeded From UniProt	complete
involved_in	GO:0010812	negative regulation of cell-substrate adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04628 ensembl:ENSP00000293549	P		Seeded From UniProt	complete
involved_in	GO:0010592	positive regulation of lamellipodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04628 ensembl:ENSP00000293549	P		Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04628 ensembl:ENSP00000293549	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04628 ensembl:ENSP00000293549	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04628 ensembl:ENSP00000293549	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009139	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009139	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009139	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009139	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:26049140^[45]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_regulation_target:(ENSEMBL:ENSMUSG00000026686)\|has_regulation_target:(ENSEMBL:ENSMUSG00000031603)\|has_regulation_target:(ENSEMBL:ENSMUSG00000027985)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:26049140^[45]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:26049140^[45] PMID:26049140^[45]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	acts_on_population_of:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0071542	dopaminergic neuron differentiation	PMID:16243425^[46]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-MMU-3238692	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:9889131^[47]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007267	cell-cell signaling	PMID:9889131^[47]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007165	signal transduction	PMID:9889131^[47]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:9889131^[47]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Andersson, ER et al. (2013) Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells. Proc. Natl. Acad. Sci. U.S.A. 110 E602-10 PubMed GONUTS page
↑ Mao, B et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411 321-5 PubMed GONUTS page
↑ George, A et al. (2007) The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling. Neurobiol. Dis. 26 125-33 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Danielian, PS & McMahon, AP (1996) Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature 383 332-4 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Castelo-Branco, G et al. (2003) Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc. Natl. Acad. Sci. U.S.A. 100 12747-52 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Panhuysen, M et al. (2004) Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region. Mol. Cell. Neurosci. 26 101-11 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 L'episcopo, F et al. (2011) A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection. Mol Neurodegener 6 49 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Gazit, A et al. (1999) Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene 18 5959-66 PubMed GONUTS page
↑ Mao, J et al. (2001) Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol. Cell 7 801-9 PubMed GONUTS page
↑ ^10.0 ^10.1 Chung, S et al. (2009) Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway. Cell Stem Cell 5 646-58 PubMed GONUTS page
↑ Capdevila, J et al. (1998) Control of dorsoventral somite patterning by Wnt-1 and beta-catenin. Dev. Biol. 193 182-94 PubMed GONUTS page
↑ Lyons, JP et al. (2004) Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells. Exp. Cell Res. 298 369-87 PubMed GONUTS page
↑ Holmen, SL et al. (2002) A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. J. Biol. Chem. 277 34727-35 PubMed GONUTS page
↑ Finch, PW et al. (1997) Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. Proc. Natl. Acad. Sci. U.S.A. 94 6770-5 PubMed GONUTS page
↑ Xu, Q et al. (2004) Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell 116 883-95 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Ross, SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289 950-3 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Thomas, KR & Capecchi, MR (1990) Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 346 847-50 PubMed GONUTS page
↑ McMahon, AP & Moon, RT (1989) int-1--a proto-oncogene involved in cell signalling. Development 107 Suppl 161-7 PubMed GONUTS page
↑ Ohira, T et al. (2003) WNT7a induces E-cadherin in lung cancer cells. Proc. Natl. Acad. Sci. U.S.A. 100 10429-34 PubMed GONUTS page
↑ Lu, W et al. (2004) Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119 97-108 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Liu, W et al. (2006) Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J. 25 1646-58 PubMed GONUTS page
↑ ^23.0 ^23.1 Austin, TW et al. (1997) A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells. Blood 89 3624-35 PubMed GONUTS page
↑ ^24.0 ^24.1 González-Sancho, JM et al. (2004) Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol. Cell. Biol. 24 4757-68 PubMed GONUTS page
↑ Bafico, A et al. (1998) Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts. Oncogene 16 2819-25 PubMed GONUTS page
↑ Dietrich, MF et al. (2010) Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo. PLoS ONE 5 e9960 PubMed GONUTS page
↑ Nam, JS et al. (2006) Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. J. Biol. Chem. 281 13247-57 PubMed GONUTS page
↑ Johnson, EB et al. (2005) Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice. Hum. Mol. Genet. 14 3523-38 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 ^29.3 Rochat, A et al. (2004) Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy. Mol. Biol. Cell 15 4544-55 PubMed GONUTS page
↑ Brennan, K et al. (2004) Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins. Oncogene 23 4873-84 PubMed GONUTS page
↑ ^31.0 ^31.1 Staal, FJ et al. (2001) Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription. Eur. J. Immunol. 31 285-93 PubMed GONUTS page
↑ ^32.0 ^32.1 Prakash, N et al. (2006) A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development 133 89-98 PubMed GONUTS page
↑ ^33.0 ^33.1 Adachi, S et al. (2004) Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. Cancer Res. 64 8496-501 PubMed GONUTS page
↑ Dassule, HR & McMahon, AP (1998) Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev. Biol. 202 215-27 PubMed GONUTS page
↑ Fan, CM et al. (1997) A role for WNT proteins in induction of dermomyotome. Dev. Biol. 191 160-5 PubMed GONUTS page
↑ Bennett, CN et al. (2005) Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc. Natl. Acad. Sci. U.S.A. 102 3324-9 PubMed GONUTS page
↑ Riccomagno, MM et al. (2005) Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh. Genes Dev. 19 1612-23 PubMed GONUTS page
↑ ^38.0 ^38.1 ^38.2 McMahon, AP & Bradley, A (1990) The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62 1073-85 PubMed GONUTS page
↑ Misra, K & Matise, MP (2010) A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev. Biol. 337 74-83 PubMed GONUTS page
↑ Bally-Cuif, L et al. (1995) Involvement of Wnt-1 in the formation of the mes/metencephalic boundary. Mech. Dev. 53 23-34 PubMed GONUTS page
↑ ^41.0 ^41.1 Lavado, A et al. (2008) Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon. Development 135 441-50 PubMed GONUTS page
↑ Muroyama, Y et al. (2002) Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. Genes Dev. 16 548-53 PubMed GONUTS page
↑ Schryver, B et al. (1996) Properties of Wnt-1 protein that enable cell surface association. Oncogene 13 333-42 PubMed GONUTS page
↑ Carroll, TJ et al. (2005) Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev. Cell 9 283-92 PubMed GONUTS page
↑ ^45.0 ^45.1 ^45.2 ^45.3 Zhang, J et al. (2015) A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice. Neurobiol. Dis. 82 32-45 PubMed GONUTS page
↑ Jankovic, J et al. () The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Prog. Neurobiol. 77 128-38 PubMed GONUTS page
↑ ^47.0 ^47.1 ^47.2 ^47.3 Loureiro, JJ (1999) The Wnts. Curr. Biol. 9 R4 PubMed GONUTS page

[PMID:23324743-1] 1.0 ^1.1 ^1.2 Andersson, ER et al. (2013) Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells. Proc. Natl. Acad. Sci. U.S.A. 110 E602-10 PubMed GONUTS page

[PMID:11357136-2] Mao, B et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411 321-5 PubMed GONUTS page

[PMID:17239604-3] George, A et al. (2007) The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling. Neurobiol. Dis. 26 125-33 PubMed GONUTS page

[PMID:8848044-4] 4.0 ^4.1 ^4.2 Danielian, PS & McMahon, AP (1996) Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature 383 332-4 PubMed GONUTS page

[PMID:14557550-5] 5.0 ^5.1 ^5.2 Castelo-Branco, G et al. (2003) Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc. Natl. Acad. Sci. U.S.A. 100 12747-52 PubMed GONUTS page

[PMID:15121182-6] 6.0 ^6.1 ^6.2 Panhuysen, M et al. (2004) Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region. Mol. Cell. Neurosci. 26 101-11 PubMed GONUTS page

[PMID:21752258-7] 7.0 ^7.1 ^7.2 L'episcopo, F et al. (2011) A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection. Mol Neurodegener 6 49 PubMed GONUTS page

[PMID:10557084-8] 8.0 ^8.1 ^8.2 ^8.3 Gazit, A et al. (1999) Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene 18 5959-66 PubMed GONUTS page

[PMID:11336703-9] Mao, J et al. (2001) Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol. Cell 7 801-9 PubMed GONUTS page

[PMID:19951692-10] 10.0 ^10.1 Chung, S et al. (2009) Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway. Cell Stem Cell 5 646-58 PubMed GONUTS page

[PMID:9473323-11] Capdevila, J et al. (1998) Control of dorsoventral somite patterning by Wnt-1 and beta-catenin. Dev. Biol. 193 182-94 PubMed GONUTS page

[PMID:15265686-12] Lyons, JP et al. (2004) Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells. Exp. Cell Res. 298 369-87 PubMed GONUTS page

[PMID:12121999-13] Holmen, SL et al. (2002) A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. J. Biol. Chem. 277 34727-35 PubMed GONUTS page

[PMID:9192640-14] Finch, PW et al. (1997) Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. Proc. Natl. Acad. Sci. U.S.A. 94 6770-5 PubMed GONUTS page

[PMID:15035989-15] Xu, Q et al. (2004) Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell 116 883-95 PubMed GONUTS page

[PMID:10937998-16] 16.0 ^16.1 ^16.2 Ross, SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289 950-3 PubMed GONUTS page

[PMID:2202907-17] 17.0 ^17.1 ^17.2 Thomas, KR & Capecchi, MR (1990) Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 346 847-50 PubMed GONUTS page

[PMID:2534596-18] McMahon, AP & Moon, RT (1989) int-1--a proto-oncogene involved in cell signalling. Development 107 Suppl 161-7 PubMed GONUTS page

[PMID:12937339-19] Ohira, T et al. (2003) WNT7a induces E-cadherin in lung cancer cells. Proc. Natl. Acad. Sci. U.S.A. 100 10429-34 PubMed GONUTS page

[PMID:15454084-20] Lu, W et al. (2004) Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119 97-108 PubMed GONUTS page

[PMID:21873635-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16601693-22] 22.0 ^22.1 ^22.2 Liu, W et al. (2006) Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J. 25 1646-58 PubMed GONUTS page

[PMID:9160667-23] 23.0 ^23.1 Austin, TW et al. (1997) A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells. Blood 89 3624-35 PubMed GONUTS page

[PMID:15143170-24] 24.0 ^24.1 González-Sancho, JM et al. (2004) Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol. Cell. Biol. 24 4757-68 PubMed GONUTS page

[PMID:9652750-25] Bafico, A et al. (1998) Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts. Oncogene 16 2819-25 PubMed GONUTS page

[PMID:20383322-26] Dietrich, MF et al. (2010) Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo. PLoS ONE 5 e9960 PubMed GONUTS page

[PMID:16543246-27] Nam, JS et al. (2006) Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. J. Biol. Chem. 281 13247-57 PubMed GONUTS page

[PMID:16207730-28] Johnson, EB et al. (2005) Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice. Hum. Mol. Genet. 14 3523-38 PubMed GONUTS page

[PMID:15282335-29] 29.0 ^29.1 ^29.2 ^29.3 Rochat, A et al. (2004) Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy. Mol. Biol. Cell 15 4544-55 PubMed GONUTS page

[PMID:15064719-30] Brennan, K et al. (2004) Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins. Oncogene 23 4873-84 PubMed GONUTS page

[PMID:11265645-31] 31.0 ^31.1 Staal, FJ et al. (2001) Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription. Eur. J. Immunol. 31 285-93 PubMed GONUTS page

[PMID:16339193-32] 32.0 ^32.1 Prakash, N et al. (2006) A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development 133 89-98 PubMed GONUTS page

[PMID:15574752-33] 33.0 ^33.1 Adachi, S et al. (2004) Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. Cancer Res. 64 8496-501 PubMed GONUTS page

[PMID:9769173-34] Dassule, HR & McMahon, AP (1998) Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev. Biol. 202 215-27 PubMed GONUTS page

[PMID:9356179-35] Fan, CM et al. (1997) A role for WNT proteins in induction of dermomyotome. Dev. Biol. 191 160-5 PubMed GONUTS page

[PMID:15728361-36] Bennett, CN et al. (2005) Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc. Natl. Acad. Sci. U.S.A. 102 3324-9 PubMed GONUTS page

[PMID:15961523-37] Riccomagno, MM et al. (2005) Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh. Genes Dev. 19 1612-23 PubMed GONUTS page

[PMID:2205396-38] 38.0 ^38.1 ^38.2 McMahon, AP & Bradley, A (1990) The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62 1073-85 PubMed GONUTS page

[PMID:19850029-39] Misra, K & Matise, MP (2010) A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev. Biol. 337 74-83 PubMed GONUTS page

[PMID:8555108-40] Bally-Cuif, L et al. (1995) Involvement of Wnt-1 in the formation of the mes/metencephalic boundary. Mech. Dev. 53 23-34 PubMed GONUTS page

[PMID:18094027-41] 41.0 ^41.1 Lavado, A et al. (2008) Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon. Development 135 441-50 PubMed GONUTS page

[PMID:11877374-42] Muroyama, Y et al. (2002) Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. Genes Dev. 16 548-53 PubMed GONUTS page

[PMID:8710372-43] Schryver, B et al. (1996) Properties of Wnt-1 protein that enable cell surface association. Oncogene 13 333-42 PubMed GONUTS page

[PMID:16054034-44] Carroll, TJ et al. (2005) Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev. Cell 9 283-92 PubMed GONUTS page

[PMID:26049140-45] 45.0 ^45.1 ^45.2 ^45.3 Zhang, J et al. (2015) A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice. Neurobiol. Dis. 82 32-45 PubMed GONUTS page

[PMID:16243425-46] Jankovic, J et al. () The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Prog. Neurobiol. 77 128-38 PubMed GONUTS page

[PMID:9889131-47] 47.0 ^47.1 ^47.2 ^47.3 Loureiro, JJ (1999) The Wnts. Curr. Biol. 9 R4 PubMed GONUTS page

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