GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:8555108
| Citation |
Bally-Cuif, L, Cholley, B and Wassef, M (1995) Involvement of Wnt-1 in the formation of the mes/metencephalic boundary. Mech. Dev. 53:23-34 |
|---|---|
| Abstract |
Wnt-1, a putative signaling molecule, is required before the 7 somite stage (E8.5) for the development of midbrain structures in the mouse. We show here that Wnt-1 is also needed for the formation of a boundary between the mesencephalic and metencephalic domains of the neural tube. In embryos homozygous for the Wnt-1sw allele, mesencephalic and metencephalic markers fail to segregate and the establishment of a straight limit of Otx-2 and Wnt-1 expression at the mid-hindbrain junction is impaired. In addition, as observed previously in heterotopic mes/metencephalic transplantation experiments in avian embryos, Wnt-1 expression is induced at the border of ectopic mes- and metencephalic islands observed in Wnt-1sw/sw mutants, suggesting that, in situ, interactions between mes- and metencephalic cells reinforce Wnt-1 expression at the boundary. |
| Links | |
| Keywords |
Animals; Base Sequence; Cerebellum/embryology; Choroid Plexus/embryology; Drosophila/embryology; Embryonic and Fetal Development/physiology; Gestational Age; Homozygote; Mesencephalon/embryology; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Phenotype; Pons/embryology; Proto-Oncogene Proteins/physiology; Wnt Proteins; Wnt1 Protein; Zebrafish Proteins |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
