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PMID:8299937

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Citation

Takada, S, Stark, KL, Shea, MJ, Vassileva, G, McMahon, JA and McMahon, AP (1994) Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev. 8:174-89

Abstract

Amphibian studies have implicated Wnt signaling in the regulation of mesoderm formation, although direct evidence is lacking. We have characterized the expression of 12 mammalian Wnt-genes, identifying three that are expressed during gastrulation. Only one of these, Wnt-3a, is expressed extensively in cells fated to give rise to embryonic mesoderm, at egg cylinder stages. A likely null allele of Wnt-3a was generated by gene targeting. All Wnt-3a-/Wnt-3a- embryos lack caudal somites, have a disrupted notochord, and fail to form a tailbud. Thus, Wnt-3a may regulate dorsal (somitic) mesoderm fate and is required, by late primitive steak stages, for generation of all new embryonic mesoderm. Wnt-3a is also expressed in the dorsal CNS. Mutant embryos show CNS dysmorphology and ectopic expression of a dorsal CNS marker. We suggest that dysmorphology is secondary to the mesodermal and axial defects and that dorsal patterning of the CNS may be regulated by inductive signals arising from surface ectoderm.

Links

PubMed

Keywords

Animals; Base Sequence; Central Nervous System/embryology; Embryonic and Fetal Development/genetics; Gastrula; Mesoderm; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Proteins/genetics; Tail/embryology; Wnt Proteins; Wnt3 Protein; Wnt3A Protein

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:WNT3A

acts_upstream_of_or_within

GO:0021904: dorsal/ventral neural tube patterning

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857489

P

  • occurs_in:(EMAPA:16530)

Seeded From UniProt

complete

MOUSE:WNT3A

acts_upstream_of_or_within

GO:0001756: somitogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857489

P

Seeded From UniProt

complete

MOUSE:WNT3A

acts_upstream_of_or_within

GO:0007498: mesoderm development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857489

P

  • results_in_development_of:(EMAPA:16039)

Seeded From UniProt

complete

MOUSE:WNT3A

acts_upstream_of_or_within

GO:0036342: post-anal tail morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857489

P

Seeded From UniProt

complete

MOUSE:WNT3A

acts_upstream_of_or_within

GO:0001756: somitogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857489

P

has_participant:(EMAPA:16184)

Seeded From UniProt

complete

MOUSE:WNT3A

acts_upstream_of_or_within

GO:0007498: mesoderm development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857489

P

results_in_development_of:(EMAPA:16039)

Seeded From UniProt

complete

MOUSE:WNT3A

acts_upstream_of_or_within

GO:0021904: dorsal/ventral neural tube patterning

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857489

P

Seeded From UniProt

complete

MOUSE:WNT3A

acts_upstream_of_or_within

GO:0036342: post-anal tail morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857489

P

has_participant:(EMAPA:16748)

Seeded From UniProt

complete


See also

References

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