CHICK:Q4R0X9

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	FGF8 (ECO:0000313 with EMBL:CAG28796.1)
Protein Name(s)	Fibroblast growth factor (ECO:0000256 with RuleBase:RU049442) FGF (ECO:0000256 with RuleBase:RU049442)
External Links
UniProt	Q4R0X9
EMBL	AJ704621
UniGene	Gga.661
ProteinModelPortal	Q4R0X9
SMR	Q4R0X9
HOVERGEN	HBG005659
OrthoDB	EOG7DFXD5
Reactome	REACT_197153 REACT_198076 REACT_198103 REACT_198105 REACT_198138 REACT_198173 REACT_198174 REACT_205965 REACT_207556 REACT_212391 REACT_216625 REACT_224574 REACT_224844 REACT_231139 REACT_244511 REACT_244793 REACT_254131 REACT_94545
GO	GO:0005615 GO:0035909 GO:0006915 GO:0001974 GO:0030509 GO:0060348 GO:0060445 GO:0001658 GO:0060070 GO:0090134 GO:0021846 GO:0060128 GO:0071542 GO:0035116 GO:0003198 GO:0008543 GO:0021798 GO:0048853 GO:0008406 GO:0001947 GO:0060425 GO:0030539 GO:0000165 GO:0008078 GO:0001656 GO:0030917 GO:0055026 GO:0043524 GO:0001839 GO:0001759 GO:0030916 GO:0003148 GO:0021543 GO:0001569 GO:0060037 GO:0008284 GO:0010628 GO:0045840 GO:0046622 GO:0042487 GO:0023019 GO:0021544 GO:0030878 GO:0060129
InterPro	IPR008996 IPR028249 IPR002209 IPR028142
PANTHER	PTHR11486 PTHR11486:SF3
PRINTS	PR00262
SMART	SM00442
SUPFAM	SSF50353
PROSITE	PS00247

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0071774	response to fibroblast growth factor	PMID:17889828^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060684	epithelial-mesenchymal cell signaling	PMID:9187149^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060173	limb development	PMID:9187149^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	PMID:17889828^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	PMID:17889828^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	PMID:8674413^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:17889828^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:8674413^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009880	embryonic pattern specification	PMID:9187149^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0090134	cell migration involved in mesendoderm migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0060445	branching involved in salivary gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0060425	lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0060128	corticotropin hormone secreting cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0048853	forebrain morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0048699	generation of neurons	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0046622	positive regulation of organ growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0045840	positive regulation of mitotic nuclear division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0042487	regulation of odontogenesis of dentin-containing tooth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0042472	inner ear morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0035909	aorta morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0035116	embryonic hindlimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0035108	limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0035050	embryonic heart tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0030917	midbrain-hindbrain boundary development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0030916	otic vesicle formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0030878	thyroid gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0030539	male genitalia development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0023019	signal transduction involved in regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0021846	cell proliferation in forebrain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0021798	forebrain dorsal/ventral pattern formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0021544	subpallium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0021543	pallium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0021537	telencephalon development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0009792	embryo development ending in birth or egg hatching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0008078	mesodermal cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0001839	neural plate morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0001759	organ induction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P	Seeded From UniProt	complete
involved_in	GO:0071542	dopaminergic neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55075 ensembl:ENSP00000321797	P	Seeded From UniProt	complete
involved_in	GO:0060563	neuroepithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55075 ensembl:ENSP00000321797	P	Seeded From UniProt	complete
involved_in	GO:0060348	bone development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55075 ensembl:ENSP00000321797	P	Seeded From UniProt	complete
involved_in	GO:0055026	negative regulation of cardiac muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55075 ensembl:ENSP00000321797	P	Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55075 ensembl:ENSP00000321797	P	Seeded From UniProt	complete
involved_in	GO:0008406	gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55075 ensembl:ENSP00000321797	P	Seeded From UniProt	complete
involved_in	GO:0001823	mesonephros development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55075 ensembl:ENSP00000321797	P	Seeded From UniProt	complete
involved_in	GO:0001656	metanephros development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55075 ensembl:ENSP00000321797	P	Seeded From UniProt	complete
enables	GO:0005104	fibroblast growth factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028249	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028249	C	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002209	F	Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028249	P	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Zhou, J et al. (2007) IHH and FGF8 coregulate elongation of digit primordia. Biochem. Biophys. Res. Commun. 363 513-8 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Ohuchi, H et al. (1997) The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor. Development 124 2235-44 PubMed GONUTS page
↑ ^3.0 ^3.1 Vogel, A et al. (1996) Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb. Development 122 1737-50 PubMed GONUTS page

[PMID:17889828-1] 1.0 ^1.1 ^1.2 ^1.3 Zhou, J et al. (2007) IHH and FGF8 coregulate elongation of digit primordia. Biochem. Biophys. Res. Commun. 363 513-8 PubMed GONUTS page

[PMID:9187149-2] 2.0 ^2.1 ^2.2 Ohuchi, H et al. (1997) The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor. Development 124 2235-44 PubMed GONUTS page

[PMID:8674413-3] 3.0 ^3.1 Vogel, A et al. (1996) Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb. Development 122 1737-50 PubMed GONUTS page

[1]

[2]

[3]

CHICK:Q4R0X9

Contents

Annotations

Notes

References

a

b

c

d

e

f

g

h

i

k

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools