HUMAN:SFRP4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SFRP4 (synonyms: FRPHE)
Protein Name(s)	Secreted frizzled-related protein 4 sFRP-4 Frizzled protein, human endometrium FrpHE
External Links
UniProt	Q6FHJ7
EMBL	AF026692 DQ420628 AK302357 CR541731 CR541755 BT019679 CH236951 BC047684 BC058911
CCDS	CCDS5453.1
RefSeq	NP_003005.2
UniGene	Hs.658169
ProteinModelPortal	Q6FHJ7
SMR	Q6FHJ7
BioGrid	112322
IntAct	Q6FHJ7
STRING	9606.ENSP00000410715
MEROPS	I93.001
PhosphoSite	Q6FHJ7
DMDM	61216780
PaxDb	Q6FHJ7
PRIDE	Q6FHJ7
DNASU	6424
Ensembl	ENST00000436072
GeneID	6424
KEGG	hsa:6424
UCSC	uc003tfo.4
CTD	6424
GeneCards	GC07M037912
H-InvDB	HIX0033524
HGNC	HGNC:10778
HPA	HPA009712
MIM	606570
neXtProt	NX_Q6FHJ7
PharmGKB	PA35694
eggNOG	NOG304384
GeneTree	ENSGT00760000118864
HOVERGEN	HBG070536
InParanoid	Q6FHJ7
KO	K02185
OMA	NITRMPN
OrthoDB	EOG79PJPC
PhylomeDB	Q6FHJ7
GeneWiki	SFRP4
GenomeRNAi	6424
NextBio	24947
PRO	PR:Q6FHJ7
Proteomes	UP000005640
Bgee	Q6FHJ7
CleanEx	HS_SFRP4
ExpressionAtlas	Q6FHJ7
Genevestigator	Q6FHJ7
GO	GO:0009986 GO:0005737 GO:0005615 GO:0005634 GO:0030165 GO:0042813 GO:0017147 GO:0007420 GO:0030154 GO:0046697 GO:0060429 GO:0008406 GO:0060056 GO:0090090 GO:0008285 GO:0046329 GO:0043433 GO:2000119 GO:0055062 GO:0043065 GO:0090263 GO:0045606 GO:0010628 GO:1902174 GO:0002092 GO:0009725 GO:0001944 GO:0016055
Gene3D	1.10.2000.10
InterPro	IPR015526 IPR020067 IPR001134 IPR018933 IPR026560 IPR008993
PANTHER	PTHR11309 PTHR11309:SF7
Pfam	PF01392 PF01759
SMART	SM00643 SM00063
SUPFAM	SSF50242 SSF63501
PROSITE	PS50038 PS50189

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:2000051	negative regulation of non-canonical Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z1N6	P		Seeded From UniProt	complete
involved_in	GO:0030510	regulation of BMP signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z1N6	P		Seeded From UniProt	complete
involved_in	GO:0060349	bone morphogenesis	PMID:27355534^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:24431302^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F	part_of:(GO:0030178)	Seeded From UniProt	complete
involved_in	GO:0030178	negative regulation of Wnt signaling pathway	PMID:24431302^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:17462603^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P27467	F		Seeded From UniProt	complete
involved_in	GO:2000119	negative regulation of sodium-dependent phosphate transport	PMID:12952927^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000119	negative regulation of sodium-dependent phosphate transport	PMID:16151791^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902174	positive regulation of keratinocyte apoptotic process	PMID:18938133^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:15705870^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:14760084^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:18945944^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055062	phosphate ion homeostasis	PMID:12952927^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055062	phosphate ion homeostasis	PMID:16151791^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045606	positive regulation of epidermal cell differentiation	PMID:18938133^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:18945944^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:15705870^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:18938133^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:14760084^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	PMID:10211996^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:15705870^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:14760084^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14760084^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18938133^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18938133^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:14760084^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	PMID:16151791^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11793365^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:892010 MGI:MGI:892032 PANTHER:PTN000885362 RGD:621075 UniProtKB:Q6FHJ7 UniProtKB:Q92765	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001085 FB:FBgn0016797 MGI:MGI:108460 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1196625 PANTHER:PTN000139394 RGD:61916 RGD:71012 UniProtKB:O75084 UniProtKB:Q13467 UniProtKB:Q14332 UniProtKB:Q8N474 UniProtKB:Q9H461 UniProtKB:Q9NPG1 UniProtKB:Q9ULV1 UniProtKB:Q9ULW2 UniProtKB:Q9UP38	P		Seeded From UniProt	complete
involved_in	GO:0035567	non-canonical Wnt signaling pathway	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108570 PANTHER:PTN000139394 UniProtKB:O60353 ZFIN:ZDB-GENE-990415-218	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001085 FB:FBgn0016797 FB:FBgn0027342 FB:FBgn0027343 MGI:MGI:108078 MGI:MGI:108460 MGI:MGI:108474 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1196625 MGI:MGI:2136761 MGI:MGI:892032 PANTHER:PTN000139394 RGD:621075 RGD:631406 RGD:71017 UniProtKB:O00144 UniProtKB:O75084 UniProtKB:Q13467 UniProtKB:Q6FHJ7 UniProtKB:Q8N474 UniProtKB:Q9NPG1 UniProtKB:Q9UP38	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000139511 RGD:621075 UniProtKB:Q6FHJ7	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000139511 RGD:621075 UniProtKB:Q6FHJ7	C		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:18166153^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P27467	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:17462603^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000051	negative regulation of non-canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1N6 ensembl:ENSMUSP00000002883	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1N6 ensembl:ENSMUSP00000002883	P		Seeded From UniProt	complete
involved_in	GO:0060349	bone morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1N6 ensembl:ENSMUSP00000002883	P		Seeded From UniProt	complete
involved_in	GO:0030510	regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1N6 ensembl:ENSMUSP00000002883	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kiper, POS et al. (2016) Cortical-Bone Fragility--Insights from sFRP4 Deficiency in Pyle's Disease. N. Engl. J. Med. 374 2553-2562 PubMed GONUTS page
↑ ^2.0 ^2.1 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page
↑ ^3.0 ^3.1 Wawrzak, D et al. (2007) Wnt3a binds to several sFRPs in the nanomolar range. Biochem. Biophys. Res. Commun. 357 1119-23 PubMed GONUTS page
↑ ^4.0 ^4.1 Berndt, T et al. (2003) Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. J. Clin. Invest. 112 785-94 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Berndt, TJ et al. (2006) Secreted frizzled-related protein-4 reduces sodium-phosphate co-transporter abundance and activity in proximal tubule cells. Pflugers Arch. 451 579-87 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Maganga, R et al. (2008) Secreted Frizzled related protein-4 (sFRP4) promotes epidermal differentiation and apoptosis. Biochem. Biophys. Res. Commun. 377 606-11 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 He, B et al. (2005) Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells. Cancer Res. 65 743-8 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Horvath, LG et al. (2004) Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro. Clin. Cancer Res. 10 615-25 PubMed GONUTS page
↑ ^9.0 ^9.1 Romaker, D et al. (2009) Increased expression of secreted frizzled-related protein 4 in polycystic kidneys. J. Am. Soc. Nephrol. 20 48-56 PubMed GONUTS page
↑ Abu-Jawdeh, G et al. (1999) Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy. Lab. Invest. 79 439-47 PubMed GONUTS page
↑ Wong, SC et al. (2002) Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours. J. Pathol. 196 145-53 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Cho, SW et al. (2008) Differential effects of secreted frizzled-related proteins (sFRPs) on osteoblastic differentiation of mouse mesenchymal cells and apoptosis of osteoblasts. Biochem. Biophys. Res. Commun. 367 399-405 PubMed GONUTS page

[PMID:27355534-1] Kiper, POS et al. (2016) Cortical-Bone Fragility--Insights from sFRP4 Deficiency in Pyle's Disease. N. Engl. J. Med. 374 2553-2562 PubMed GONUTS page

[PMID:24431302-2] 2.0 ^2.1 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page

[PMID:17462603-3] 3.0 ^3.1 Wawrzak, D et al. (2007) Wnt3a binds to several sFRPs in the nanomolar range. Biochem. Biophys. Res. Commun. 357 1119-23 PubMed GONUTS page

[PMID:12952927-4] 4.0 ^4.1 Berndt, T et al. (2003) Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. J. Clin. Invest. 112 785-94 PubMed GONUTS page

[PMID:16151791-5] 5.0 ^5.1 ^5.2 Berndt, TJ et al. (2006) Secreted frizzled-related protein-4 reduces sodium-phosphate co-transporter abundance and activity in proximal tubule cells. Pflugers Arch. 451 579-87 PubMed GONUTS page

[PMID:18938133-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Maganga, R et al. (2008) Secreted Frizzled related protein-4 (sFRP4) promotes epidermal differentiation and apoptosis. Biochem. Biophys. Res. Commun. 377 606-11 PubMed GONUTS page

[PMID:15705870-7] 7.0 ^7.1 ^7.2 He, B et al. (2005) Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells. Cancer Res. 65 743-8 PubMed GONUTS page

[PMID:14760084-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Horvath, LG et al. (2004) Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro. Clin. Cancer Res. 10 615-25 PubMed GONUTS page

[PMID:18945944-9] 9.0 ^9.1 Romaker, D et al. (2009) Increased expression of secreted frizzled-related protein 4 in polycystic kidneys. J. Am. Soc. Nephrol. 20 48-56 PubMed GONUTS page

[PMID:10211996-10] Abu-Jawdeh, G et al. (1999) Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy. Lab. Invest. 79 439-47 PubMed GONUTS page

[PMID:11793365-11] Wong, SC et al. (2002) Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours. J. Pathol. 196 145-53 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18166153-13] Cho, SW et al. (2008) Differential effects of secreted frizzled-related proteins (sFRPs) on osteoblastic differentiation of mouse mesenchymal cells and apoptosis of osteoblasts. Biochem. Biophys. Res. Commun. 367 399-405 PubMed GONUTS page

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HUMAN:SFRP4

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Annotations

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