MOUSE:KLF4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Klf4 (synonyms: Ezf, Gklf, Zie)
Protein Name(s)	Krueppel-like factor 4 Epithelial zinc finger protein EZF Gut-enriched krueppel-like factor
External Links
UniProt	Q60793
EMBL	U20344 U70662 AF117109 AY071827 AK141244 AK144942 AK155343 AL732494 CH466565 BC010301
CCDS	CCDS18195.2
RefSeq	NP_034767.2
UniGene	Mm.4325
PDB	2WBS 2WBU 4M9E
PDBsum	2WBS 2WBU 4M9E
ProteinModelPortal	Q60793
SMR	Q60793
BioGrid	200966
DIP	DIP-59920N
IntAct	Q60793
PhosphoSite	Q60793
PRIDE	Q60793
Ensembl	ENSMUST00000107619
GeneID	16600
KEGG	mmu:16600
UCSC	uc008sxk.2
CTD	9314
MGI	MGI:1342287
eggNOG	COG5048
GeneTree	ENSGT00760000118998
HOGENOM	HOG000060173
HOVERGEN	HBG006220
InParanoid	Q60793
KO	K17846
OMA	CTVGRPL
OrthoDB	EOG747PJ4
PhylomeDB	Q60793
TreeFam	TF350556
Reactome	REACT_216222 REACT_233293 REACT_252217 REACT_27166
EvolutionaryTrace	Q60793
NextBio	290177
PRO	PR:Q60793
Proteomes	UP000000589
Bgee	Q60793
CleanEx	MM_KLF4
ExpressionAtlas	Q60793
Genevestigator	Q60793
GO	GO:0000790 GO:0005634 GO:0005667 GO:0008013 GO:0000987 GO:0003677 GO:0003690 GO:0046872 GO:0035014 GO:0001077 GO:0001085 GO:0001190 GO:0043565 GO:0003700 GO:0001010 GO:0008134 GO:0044212 GO:0030154 GO:0071409 GO:0071363 GO:0070301 GO:0071499 GO:1901653 GO:0009913 GO:0048730 GO:0045444 GO:0090051 GO:0008285 GO:2000342 GO:0043154 GO:0070373 GO:0034115 GO:0045415 GO:0014740 GO:0032088 GO:0014067 GO:0051898 GO:0060761 GO:0048662 GO:0000122 GO:0045892 GO:0032270 GO:0046985 GO:0045429 GO:0045944 GO:0045893 GO:0031077 GO:0035166 GO:0045595 GO:0042127 GO:0006357 GO:0010033 GO:0032526 GO:0019827 GO:0006366
Gene3D	3.30.160.60
InterPro	IPR007087 IPR015880 IPR013087
SMART	SM00355
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:26691508^[1]	ECO:0000314			P		Protein Name: Krueppel-like factor 4; Klf4 Organism: Mus musculus (Mouse) Notes: In Figure 1, more specifically 1C, it is shown how Krueppel-like factor 4/Klf4 in Mus musculus upregulates Wdr5 and Dpy30 expression at the RNA level	complete CACAO 13347
	GO:0030336	negative regulation of cell migration	PMID:22491752^[2]	ECO:0000315			P		Figure 4 shows that knock-out of the KLF4 gene results in increased cell migration.	complete CACAO 4861
	GO:0006351	transcription, DNA-dependent	PMID:23372771^[3]	ECO:0000315			P		As Figure 7A and 7B display, KLF4 is involved in regulation of cell differentiation.	complete CACAO 6408
	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	PMID:28262547^[4]	ECO:0000314			F		MOUSE KLF4 // Fig 4 and "qRT-PCR showed that the high level of KLF4 or expression of exogenous TCL1 in iPSCs(Low-K) is accompanied by increased mRNA expression levels of glucose transporter (Glut1), pyruvate kinase M2 (Pkm2), and lactate dehydrogenase A (Ldha) ( Figure 6F)." KLF4 upregulates Tcl1 expression to enhance AKT activity, thus increasing the expression of other glycolytic protein.	complete CACAO 12382
	GO:0036207	positive regulation of histone gene expression	PMID:26691508^[1]	ECO:0000314			P		Fig. 1C and D shows that Mouse cells treated with Klf4 exhibit increased mRNA levels of histone related genes Wdr5 and Actb relative to the control.	complete CACAO 13355
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O43474	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	PMID:23372771^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	PMID:22491752^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:22723415^[5]	ECO:0000303	author statement without traceable support used in manual assertion		F	has_regulation_target:(ENSEMBL:ENSMUSG00000021611) occurs_in:(CL:0002322) occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22723415^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(ENSEMBL:ENSMUSG00000021611) occurs_in:(CL:0002322)	Seeded From UniProt	complete
involved_in	GO:1904798	positive regulation of core promoter binding	PMID:22723415^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P08775) occurs_in:(CL:0002322) occurs_at:(SO:0000167)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:22723415^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002322)	Seeded From UniProt	complete
part_of	GO:0044798	nuclear transcription factor complex	PMID:22723415^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002322)	Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	PMID:22723415^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002322)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:22723415^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSMUSG00000021611) occurs_in:(CL:0002322) occurs_in:(GO:0005634)	Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:22723415^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q02248	F	occurs_in:(GO:0005634) occurs_in:(CL:0002322) has_direct_input:(UniProtKB:E9PYH6)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18396140^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045444	fat cell differentiation	PMID:18396140^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:18396140^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:18396140^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08152	F		Seeded From UniProt	complete
enables	GO:0001010	RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	PMID:18396140^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19816951^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16954384^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:9422764^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:9422764^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
involved_in	GO:0045595	regulation of cell differentiation	PMID:19816951^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:16954384^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0019827	stem cell population maintenance	PMID:19816951^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:19816951^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P48432	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:19816951^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P20263	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9422764^[9]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338056 MGI:MGI:1342287 MGI:MGI:1354948 MGI:MGI:2153049 MGI:MGI:2153568 MGI:MGI:2181068 MGI:MGI:98968 PANTHER:PTN001145452 RGD:3738 UniProtKB:A0A1D8PNL1 UniProtKB:Q02446 UniProtKB:Q7RTV3 ZFIN:ZDB-GENE-021115-9	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0043364 FB:FBgn0261434 FB:FBgn0263239 MGI:MGI:1101353 MGI:MGI:1277166 MGI:MGI:1333856 MGI:MGI:1338056 MGI:MGI:1342287 MGI:MGI:1342772 MGI:MGI:1346318 MGI:MGI:1929988 MGI:MGI:1932575 MGI:MGI:2153568 MGI:MGI:95295 MGI:MGI:95296 MGI:MGI:98372 MGI:MGI:98968 PANTHER:PTN001145452 RGD:1306768 RGD:2544 RGD:3738 RGD:3741 RGD:3974 RGD:621445 RGD:621652 RGD:62389 UniProtKB:A0A0B4KHC8 UniProtKB:A0A0G2K5M1 UniProtKB:P18146 UniProtKB:P19544 UniProtKB:Q02086 UniProtKB:Q13351 UniProtKB:Q13886 UniProtKB:Q7RTV3 UniProtKB:Q8TDD2 UniProtKB:Q99612 UniProtKB:Q9UIH9 WB:WBGene00007772 WB:WBGene00012735	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001145452 UniProtKB:O14901 UniProtKB:Q9Y5W3 WB:WBGene00012735 ZFIN:ZDB-GENE-021115-9	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990830	cellular response to leukemia inhibitory factor	PMID:20439489^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904998	negative regulation of leukocyte adhesion to arterial endothelial cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903672	positive regulation of sprouting angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071499	cellular response to laminar fluid shear stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621445	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061614	pri-miRNA transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060761	negative regulation of response to cytokine stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051973	positive regulation of telomerase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621445	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051247	positive regulation of protein metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048730	epidermis morphogenesis	PMID:10431239^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183936	P	has_participant:(EMAPA:32787)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048679	regulation of axon regeneration	PMID:24129709^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103038	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048679	regulation of axon regeneration	PMID:24129709^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621445	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046985	positive regulation of hemoglobin biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22306741^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:2146838) occurs_in:(CL:0002334) regulates_o_occurs_in:(CL:0002334)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24161396^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:107405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17130451^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:1274782)\|has_regulation_target:(MGI:MGI:3505689)\|has_regulation_target:(MGI:MGI:1927168)\|has_regulation_target:(MGI:MGI:2685183)\|has_regulation_target:(MGI:MGI:2687035)\|has_regulation_target:(MGI:MGI:95762)\|has_regulation_target:(MGI:MGI:99414)\|has_regulation_target:(MGI:MGI:1342773)\|has_regulation_target:(MGI:MGI:1346336)\|has_regulation_target:(MGI:MGI:97175)\|has_regulation_target:(MGI:MGI:1927578)\|has_regulation_target:(MGI:MGI:1930803)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17060454^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:96687)\|has_regulation_target:(MGI:MGI:106215)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621445	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621445	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045444	fat cell differentiation	PMID:22306741^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045415	negative regulation of interleukin-8 biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:24161396^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621445	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:8940147^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:22306741^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:2146838) occurs_in:(CL:0002334)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621445	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:24129709^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621445	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:17671182^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P	occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035166	post-embryonic hemopoiesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
enables	GO:0035014	phosphatidylinositol 3-kinase regulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621445	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034115	negative regulation of heterotypic cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032526	response to retinoic acid	PMID:18400104^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16039) occurs_in:(CL:0000034)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032270	positive regulation of cellular protein metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031077	post-embryonic camera-type eye development	PMID:17060454^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183917,MGI:MGI:3045749	P	results_in_development_of:(EMAPA:17162)\|results_in_development_of:(EMAPA:17602)\|results_in_development_of:(EMAPA:35935)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:17060454^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183917,MGI:MGI:3045749	P	occurs_in:(EMAPA:18233) results_in_acquisition_of_features_of:(CL:0000160)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019827	stem cell population maintenance	PMID:15358627^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016525	negative regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014740	negative regulation of muscle hyperplasia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621445	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621445	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010033	response to organic substance	PMID:18400104^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009913	epidermal cell differentiation	PMID:10431239^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183936	P	occurs_in:(EMAPA:32786)\|occurs_in:(EMAPA:17881)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:8702718^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:19796622^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24129709^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621445	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24161396^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24129709^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19796622^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621445	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:17130451^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621445	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621445	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15820306^[24]	ECO:0000250	sequence similarity evidence used in manual assertion		F		Seeded From UniProt	Missing: with/from
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:22306741^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:2146838) regulates_o_occurs_in:(CL:0002334) occurs_in:(CL:0002334)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621445	F		Seeded From UniProt	complete
enables	GO:0001221	transcription cofactor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621445	F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:24129709^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42227	F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	F		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621445	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43474	P		Seeded From UniProt	complete
involved_in	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0035014	P		Seeded From UniProt	complete
involved_in	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0035014	P		Seeded From UniProt	complete
involved_in	GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	F		Seeded From UniProt	complete
involved_in	GO:1904998	negative regulation of leukocyte adhesion to arterial endothelial cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0071499	cellular response to laminar fluid shear stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0061614	pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0060761	negative regulation of response to cytokine stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0051247	positive regulation of protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0046985	positive regulation of hemoglobin biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0045415	negative regulation of interleukin-8 biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0035166	post-embryonic hemopoiesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0034115	negative regulation of heterotypic cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0032270	positive regulation of cellular protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	C		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	F		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43474 ensembl:ENSP00000363804	P		Seeded From UniProt	complete
involved_in	GO:1901653	cellular response to peptide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0071409	cellular response to cycloheximide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	F		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	F		Seeded From UniProt	complete
enables	GO:0035014	phosphatidylinositol 3-kinase regulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	F		Seeded From UniProt	complete
involved_in	GO:0014740	negative regulation of muscle hyperplasia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	F		Seeded From UniProt	complete
enables	GO:0001221	transcription cofactor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	F		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	C		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-9625422	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Yang, Z et al. (2015) Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS ONE 10 e0145336 PubMed GONUTS page
↑ ^2.0 ^2.1 Li, J et al. (2012) Deficiency of the Kruppel-like factor KLF4 correlates with increased cell proliferation and enhanced skin tumorigenesis. Carcinogenesis 33 1239-46 PubMed GONUTS page
↑ ^3.0 ^3.1 Jean, JC et al. (2013) Transcription factor Klf4, induced in the lung by oxygen at birth, regulates perinatal fibroblast and myofibroblast differentiation. PLoS ONE 8 e54806 PubMed GONUTS page
↑ Nishimura, K et al. (2017) A Role for KLF4 in Promoting the Metabolic Shift via TCL1 during Induced Pluripotent Stem Cell Generation. Stem Cell Reports 8 787-801 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Hoffmeyer, K et al. (2012) Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science 336 1549-54 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Birsoy, K et al. (2008) Transcriptional regulation of adipogenesis by KLF4. Cell Metab. 7 339-47 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Wei, Z et al. (2009) Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells 27 2969-78 PubMed GONUTS page
↑ ^8.0 ^8.1 Nakatake, Y et al. (2006) Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells. Mol. Cell. Biol. 26 7772-82 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Yet, SF et al. (1998) Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. J. Biol. Chem. 273 1026-31 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page
↑ ^12.0 ^12.1 Segre, JA et al. (1999) Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat. Genet. 22 356-60 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Qin, S et al. (2013) Cross-talk between KLF4 and STAT3 regulates axon regeneration. Nat Commun 4 2633 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Rivero, S et al. (2012) DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis. J. Mol. Biol. 417 36-50 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Fujii, Y et al. (2013) Zfp296 is a novel Klf4-interacting protein and functions as a negative regulator. Biochem. Biophys. Res. Commun. 441 411-7 PubMed GONUTS page
↑ ^16.0 ^16.1 Patel, S et al. (2006) Klf4 and corticosteroids activate an overlapping set of transcriptional targets to accelerate in utero epidermal barrier acquisition. Proc. Natl. Acad. Sci. U.S.A. 103 18668-73 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Swamynathan, SK et al. (2007) Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells. Mol. Cell. Biol. 27 182-94 PubMed GONUTS page
↑ Garrett-Sinha, LA et al. (1996) A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J. Biol. Chem. 271 31384-90 PubMed GONUTS page
↑ Ghaleb, AM et al. (2007) Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res. 67 7147-54 PubMed GONUTS page
↑ ^20.0 ^20.1 Kunarso, G et al. (2008) Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. BMC Genomics 9 155 PubMed GONUTS page
↑ Li, Y et al. (2005) Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. Blood 105 635-7 PubMed GONUTS page
↑ Shields, JM et al. (1996) Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest. J. Biol. Chem. 271 20009-17 PubMed GONUTS page
↑ ^23.0 ^23.1 Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page
↑ Suske, G et al. (2005) Mammalian SP/KLF transcription factors: bring in the family. Genomics 85 551-6 PubMed GONUTS page

[PMID:26691508-1] 1.0 ^1.1 Yang, Z et al. (2015) Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS ONE 10 e0145336 PubMed GONUTS page

[PMID:22491752-2] 2.0 ^2.1 Li, J et al. (2012) Deficiency of the Kruppel-like factor KLF4 correlates with increased cell proliferation and enhanced skin tumorigenesis. Carcinogenesis 33 1239-46 PubMed GONUTS page

[PMID:23372771-3] 3.0 ^3.1 Jean, JC et al. (2013) Transcription factor Klf4, induced in the lung by oxygen at birth, regulates perinatal fibroblast and myofibroblast differentiation. PLoS ONE 8 e54806 PubMed GONUTS page

[PMID:28262547-4] Nishimura, K et al. (2017) A Role for KLF4 in Promoting the Metabolic Shift via TCL1 during Induced Pluripotent Stem Cell Generation. Stem Cell Reports 8 787-801 PubMed GONUTS page

[PMID:22723415-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Hoffmeyer, K et al. (2012) Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science 336 1549-54 PubMed GONUTS page

[PMID:18396140-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Birsoy, K et al. (2008) Transcriptional regulation of adipogenesis by KLF4. Cell Metab. 7 339-47 PubMed GONUTS page

[PMID:19816951-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Wei, Z et al. (2009) Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells 27 2969-78 PubMed GONUTS page

[PMID:16954384-8] 8.0 ^8.1 Nakatake, Y et al. (2006) Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells. Mol. Cell. Biol. 26 7772-82 PubMed GONUTS page

[PMID:9422764-9] 9.0 ^9.1 ^9.2 Yet, SF et al. (1998) Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. J. Biol. Chem. 273 1026-31 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20439489-11] Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page

[PMID:10431239-12] 12.0 ^12.1 Segre, JA et al. (1999) Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat. Genet. 22 356-60 PubMed GONUTS page

[PMID:24129709-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Qin, S et al. (2013) Cross-talk between KLF4 and STAT3 regulates axon regeneration. Nat Commun 4 2633 PubMed GONUTS page

[PMID:22306741-14] 14.0 ^14.1 ^14.2 ^14.3 Rivero, S et al. (2012) DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis. J. Mol. Biol. 417 36-50 PubMed GONUTS page

[PMID:24161396-15] 15.0 ^15.1 ^15.2 Fujii, Y et al. (2013) Zfp296 is a novel Klf4-interacting protein and functions as a negative regulator. Biochem. Biophys. Res. Commun. 441 411-7 PubMed GONUTS page

[PMID:17130451-16] 16.0 ^16.1 Patel, S et al. (2006) Klf4 and corticosteroids activate an overlapping set of transcriptional targets to accelerate in utero epidermal barrier acquisition. Proc. Natl. Acad. Sci. U.S.A. 103 18668-73 PubMed GONUTS page

[PMID:17060454-17] 17.0 ^17.1 ^17.2 Swamynathan, SK et al. (2007) Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells. Mol. Cell. Biol. 27 182-94 PubMed GONUTS page

[PMID:8940147-18] Garrett-Sinha, LA et al. (1996) A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J. Biol. Chem. 271 31384-90 PubMed GONUTS page

[PMID:17671182-19] Ghaleb, AM et al. (2007) Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res. 67 7147-54 PubMed GONUTS page

[PMID:18400104-20] 20.0 ^20.1 Kunarso, G et al. (2008) Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. BMC Genomics 9 155 PubMed GONUTS page

[PMID:15358627-21] Li, Y et al. (2005) Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. Blood 105 635-7 PubMed GONUTS page

[PMID:8702718-22] Shields, JM et al. (1996) Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest. J. Biol. Chem. 271 20009-17 PubMed GONUTS page

[PMID:19796622-23] 23.0 ^23.1 Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page

[PMID:15820306-24] Suske, G et al. (2005) Mammalian SP/KLF transcription factors: bring in the family. Genomics 85 551-6 PubMed GONUTS page

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MOUSE:KLF4

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