HUMAN:WNT7B

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	WNT7B
Protein Name(s)	Protein Wnt-7b
External Links
UniProt	P56706
EMBL	AB062766 AF416743 BX511035 CR536603 CR536603 BX511035 BC034923
CCDS	CCDS33667.1
RefSeq	NP_478679.1
UniGene	Hs.512714
ProteinModelPortal	P56706
SMR	P56706
BioGrid	113314
IntAct	P56706
STRING	9606.ENSP00000341032
PhosphoSite	P56706
DMDM	20532426
MaxQB	P56706
PaxDb	P56706
PRIDE	P56706
DNASU	7477
Ensembl	ENST00000339464
GeneID	7477
KEGG	hsa:7477
UCSC	uc003bgo.2
CTD	7477
GeneCards	GC22M046316
HGNC	HGNC:12787
HPA	CAB025665
MIM	601967
neXtProt	NX_P56706
PharmGKB	PA37388
eggNOG	NOG284879
GeneTree	ENSGT00760000118943
HOGENOM	HOG000039528
HOVERGEN	HBG001595
InParanoid	P56706
KO	K00572
OrthoDB	EOG7C8GJ8
PhylomeDB	P56706
TreeFam	TF105310
Reactome	REACT_163710 REACT_18372
ChiTaRS	WNT7B
GeneWiki	WNT7B
GenomeRNAi	7477
NextBio	29288
PRO	PR:P56706
Proteomes	UP000005640
Bgee	P56706
CleanEx	HS_WNT7B
ExpressionAtlas	P56706
Genevestigator	P56706
GO	GO:0005788 GO:0005576 GO:0005615 GO:0005796 GO:0005886 GO:0005578 GO:0005109 GO:0007257 GO:0060033 GO:1902262 GO:0060070 GO:0045165 GO:0044237 GO:0071300 GO:0022009 GO:0060710 GO:0060560 GO:0048568 GO:0060669 GO:0016332 GO:0048144 GO:0021871 GO:0042592 GO:0001701 GO:0072061 GO:0070307 GO:0060482 GO:0030324 GO:0060428 GO:0060425 GO:0060484 GO:0061180 GO:0072205 GO:0072207 GO:0072236 GO:0003338 GO:0045879 GO:0030182 GO:0048812 GO:0042475 GO:0072060 GO:0032364 GO:0008284 GO:0010628 GO:0046330 GO:0045669 GO:0032536 GO:0072053 GO:0072054 GO:0051384 GO:0051145 GO:0072089 GO:0050808 GO:0060535 GO:0016055
InterPro	IPR005817 IPR013300 IPR018161
PANTHER	PTHR12027
Pfam	PF00110
PRINTS	PR01891 PR01349
SMART	SM00097
PROSITE	PS00246

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0048018	receptor ligand activity	PMID:28733458^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:28733458^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070307	lens fiber cell development	PMID:16258938^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3L254	P	Seeded From UniProt	complete
involved_in	GO:0072236	metanephric loop of Henle development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0072207	metanephric epithelium development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0072205	metanephric collecting duct development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0072089	stem cell proliferation	PMID:19734317^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072061	inner medullary collecting duct development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0072060	outer medullary collecting duct development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0072054	renal outer medulla development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0072053	renal inner medulla development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	PMID:12239632^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	PMID:12429992^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0061180	mammary gland epithelium development	PMID:8168088^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060710	chorio-allantoic fusion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0060669	embryonic placenta morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0060560	developmental growth involved in morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0060535	trachea cartilage morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0060482	lobar bronchus development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0060428	lung epithelium development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0060425	lung morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0048568	embryonic organ development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0048144	fibroblast proliferation	PMID:19734317^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0044237	cellular metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0042592	homeostatic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0032364	oxygen homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:12429992^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0022009	central nervous system vasculogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0021871	forebrain regionalization	PMID:15164427^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016332	establishment or maintenance of polarity of embryonic epithelium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0003338	metanephros morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28047	P	Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246746 RGD:1311441	P	Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98957 PANTHER:PTN000246517 UniProtKB:P49339 ZFIN:ZDB-GENE-980526-332	P	Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246517 RGD:69250 UniProtKB:P56706 UniProtKB:Q98SN7	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010194 MGI:MGI:108061 MGI:MGI:1197020 MGI:MGI:98953 MGI:MGI:98954 MGI:MGI:98956 MGI:MGI:98958 MGI:MGI:98960 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 UniProtKB:P41221 UniProtKB:Q98SN7 WB:WBGene00000858 WB:WBGene00003029 ZFIN:ZDB-GENE-980526-332	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 MGI:MGI:98956 MGI:MGI:98957 PANTHER:PTN000246517 RGD:1311441 RGD:69250 UniProtKB:P41221 UniProtKB:P56704 UniProtKB:P56705 UniProtKB:Q2LMP1 UniProtKB:Q9UBV4 UniProtKB:Q9YGX6	C	Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 FB:FBgn0004360 FB:FBgn0010453 FB:FBgn0038134 MGI:MGI:98956 MGI:MGI:98957 MGI:MGI:98958 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 RGD:69079 UniProtKB:P09544 UniProtKB:P41221 UniProtKB:P56703 UniProtKB:Q98SN7	F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P	Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K3B7 ensembl:ENSRNOP00000072573	P	Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K3B7 ensembl:ENSRNOP00000072573	P	Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K3B7 ensembl:ENSRNOP00000072573	P	Seeded From UniProt	complete
involved_in	GO:0032536	regulation of cell projection size	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K3B7 ensembl:ENSRNOP00000072573	P	Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K3B7 ensembl:ENSRNOP00000072573	P	Seeded From UniProt	complete
involved_in	GO:0007257	activation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K3B7 ensembl:ENSRNOP00000072573	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K3B7 ensembl:ENSRNOP00000072573	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K3B7 ensembl:ENSRNOP00000072573	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K3B7 ensembl:ENSRNOP00000072573	C	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR013300	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR013300	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR013300	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR013300	P	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	Reactome:R-HSA-3781941	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030666	endocytic vesicle membrane	Reactome:R-HSA-3781943 Reactome:R-HSA-3781941	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	Reactome:R-HSA-195721	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-3781943 Reactome:R-HSA-3247844 Reactome:R-HSA-3247843	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005796	Golgi lumen	Reactome:R-HSA-3247844 Reactome:R-HSA-3247840 Reactome:R-HSA-3247837	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-3247837	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-3247843	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Voloshanenko, O et al. (2017) Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 31 4832-4844 PubMed GONUTS page
↑ Fokina, VM & Frolova, EI (2006) Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Dev. Dyn. 235 496-505 PubMed GONUTS page
↑ ^3.0 ^3.1 Salazar, KD et al. (2009) Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. Am. J. Physiol. Lung Cell Mol. Physiol. 297 L1002-11 PubMed GONUTS page
↑ Kirikoshi, H & Katoh, M (2002) Expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B in human cancer. Int. J. Oncol. 21 895-900 PubMed GONUTS page
↑ ^5.0 ^5.1 Katoh, M (2002) Regulation of WNT signaling molecules by retinoic acid during neuronal differentiation in NT2 cells: threshold model of WNT action (review). Int. J. Mol. Med. 10 683-7 PubMed GONUTS page
↑ Huguet, EL et al. (1994) Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res. 54 2615-21 PubMed GONUTS page
↑ Abu-Khalil, A et al. (2004) Wnt genes define distinct boundaries in the developing human brain: implications for human forebrain patterning. J. Comp. Neurol. 474 276-88 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:28733458-1] 1.0 ^1.1 Voloshanenko, O et al. (2017) Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 31 4832-4844 PubMed GONUTS page

[PMID:16258938-2] Fokina, VM & Frolova, EI (2006) Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Dev. Dyn. 235 496-505 PubMed GONUTS page

[PMID:19734317-3] 3.0 ^3.1 Salazar, KD et al. (2009) Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. Am. J. Physiol. Lung Cell Mol. Physiol. 297 L1002-11 PubMed GONUTS page

[PMID:12239632-4] Kirikoshi, H & Katoh, M (2002) Expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B in human cancer. Int. J. Oncol. 21 895-900 PubMed GONUTS page

[PMID:12429992-5] 5.0 ^5.1 Katoh, M (2002) Regulation of WNT signaling molecules by retinoic acid during neuronal differentiation in NT2 cells: threshold model of WNT action (review). Int. J. Mol. Med. 10 683-7 PubMed GONUTS page

[PMID:8168088-6] Huguet, EL et al. (1994) Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res. 54 2615-21 PubMed GONUTS page

[PMID:15164427-7] Abu-Khalil, A et al. (2004) Wnt genes define distinct boundaries in the developing human brain: implications for human forebrain patterning. J. Comp. Neurol. 474 276-88 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:WNT7B

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