HUMAN:WNT4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	WNT4
Protein Name(s)	Protein Wnt-4
External Links
UniProt	P56705
EMBL	AY009398 AF316543 AY358947 AK296058 BT020125 AL445253 AL031281 AL031281 AL445253 BC057781 AF335591 AH010731
CCDS	CCDS223.1
RefSeq	NP_110388.2 XP_005245954.1
UniGene	Hs.25766
ProteinModelPortal	P56705
SMR	P56705
BioGrid	119939
IntAct	P56705
STRING	9606.ENSP00000290167
PhosphoSite	P56705
DMDM	20532425
PaxDb	P56705
PRIDE	P56705
DNASU	54361
Ensembl	ENST00000290167
GeneID	54361
KEGG	hsa:54361
UCSC	uc001bfs.4
CTD	54361
GeneCards	GC01M022443
GeneReviews	WNT4
HGNC	HGNC:12783
HPA	HPA011397
MIM	158330 603490 611812
neXtProt	NX_P56705
Orphanet	247768 139466
PharmGKB	PA37384
eggNOG	NOG284879
GeneTree	ENSGT00760000118943
HOGENOM	HOG000039529
HOVERGEN	HBG001595
InParanoid	P56705
KO	K00408
OMA	RQVQICK
PhylomeDB	P56705
TreeFam	TF105310
Reactome	REACT_163710 REACT_172581 REACT_18372 REACT_200643
SignaLink	P56705
GeneWiki	WNT4
GenomeRNAi	54361
NextBio	35472522
PRO	PR:P56705
Proteomes	UP000005640
Bgee	P56705
CleanEx	HS_WNT4
ExpressionAtlas	P56705
Genevestigator	P56705
GO	GO:0009986 GO:0005737 GO:0005788 GO:0005576 GO:0005615 GO:0005796 GO:0005886 GO:0005578 GO:0005109 GO:0048018 GO:0003714 GO:0030325 GO:0006702 GO:0001658 GO:0060070 GO:0045165 GO:0009267 GO:0071560 GO:0001838 GO:0001837 GO:0090002 GO:0008585 GO:0030237 GO:0033080 GO:0001822 GO:0001889 GO:0008584 GO:0061180 GO:0060231 GO:0072162 GO:0072273 GO:0072174 GO:2001234 GO:0090090 GO:0045596 GO:0030336 GO:0040037 GO:0010629 GO:2000019 GO:0010894 GO:0061369 GO:2000225 GO:0045892 GO:0061045 GO:0030182 GO:0038030 GO:0048599 GO:0061205 GO:0032349 GO:0030501 GO:0090263 GO:0032967 GO:2000066 GO:0061184 GO:0051894 GO:0045836 GO:0045669 GO:0032321 GO:0051496 GO:0045893 GO:0018345 GO:0022407 GO:0072033 GO:0072034 GO:0051145 GO:0060126 GO:0060748 GO:0060129
InterPro	IPR005817 IPR009142 IPR018161
PANTHER	PTHR12027
Pfam	PF00110
PRINTS	PR01844 PR01349
SMART	SM00097
PROSITE	PS00246

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0061184	positive regulation of dermatome development	PMID:10654605^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:16959810^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	PMID:17720811^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0038030	non-canonical Wnt signaling pathway via MAPK cascade	PMID:17720811^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032967	positive regulation of collagen biosynthetic process	PMID:17720811^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	PMID:17720811^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000225	negative regulation of testosterone biosynthetic process	PMID:12949260^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000066	positive regulation of cortisol biosynthetic process	PMID:16981135^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000019	negative regulation of male gonad development	PMID:11283799^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:16959810^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:18182450^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072162	metanephric mesenchymal cell differentiation	PMID:16368682^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	PMID:15040835^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0061369	negative regulation of testicular blood vessel morphogenesis	PMID:12949260^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0061205	paramesonephric duct development	PMID:18182450^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0061180	mammary gland epithelium development	PMID:8168088^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:15317892^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18182450^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16959810^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16981135^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11283799^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22724	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:12949260^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22724	P	Seeded From UniProt	complete
involved_in	GO:0032349	positive regulation of aldosterone biosynthetic process	PMID:16981135^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030325	adrenal gland development	PMID:12844346^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030237	female sex determination	PMID:11283799^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010894	negative regulation of steroid biosynthetic process	PMID:15317892^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000180	negative regulation of androgen biosynthetic process	PMID:16959810^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010894	negative regulation of steroid biosynthetic process	PMID:18182450^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:15317892^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22724	C	Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	PMID:11283799^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	PMID:17848411^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16959810^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16959810^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22724	F	Seeded From UniProt	complete
involved_in	GO:0001889	liver development	PMID:15312687^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:12841867^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	PMID:15312687^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98957 PANTHER:PTN000246517 UniProtKB:P49339 ZFIN:ZDB-GENE-980526-332	P	Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246517 RGD:69250 UniProtKB:P56706 UniProtKB:Q98SN7	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010194 MGI:MGI:108061 MGI:MGI:1197020 MGI:MGI:98953 MGI:MGI:98954 MGI:MGI:98956 MGI:MGI:98958 MGI:MGI:98960 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 UniProtKB:P41221 UniProtKB:Q98SN7 WB:WBGene00000858 WB:WBGene00003029 ZFIN:ZDB-GENE-980526-332	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 MGI:MGI:98956 MGI:MGI:98957 PANTHER:PTN000246517 RGD:1311441 RGD:69250 UniProtKB:P41221 UniProtKB:P56704 UniProtKB:P56705 UniProtKB:Q2LMP1 UniProtKB:Q9UBV4 UniProtKB:Q9YGX6	C	Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 FB:FBgn0004360 FB:FBgn0010453 FB:FBgn0038134 MGI:MGI:98956 MGI:MGI:98957 MGI:MGI:98958 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 RGD:69079 UniProtKB:P09544 UniProtKB:P41221 UniProtKB:P56703 UniProtKB:Q98SN7	F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P	Seeded From UniProt	complete
involved_in	GO:2001234	negative regulation of apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:2000225	negative regulation of testosterone biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0072273	metanephric nephron morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0072210	metanephric nephron development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0072174	metanephric tubule formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0072164	mesonephric tubule development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0072034	renal vesicle induction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0072033	renal vesicle formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0072006	nephron development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0061205	paramesonephric duct development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0061045	negative regulation of wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0060993	kidney morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0060748	tertiary branching involved in mammary gland duct morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0060231	mesenchymal to epithelial transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0060126	somatotropin secreting cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0051145	smooth muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0048856	anatomical structure development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0048599	oocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0045836	positive regulation of meiotic nuclear division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0045596	negative regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0042445	hormone metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0035567	non-canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0035239	tube morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0033080	immature T cell proliferation in thymus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0033077	T cell differentiation in thymus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	C	Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0022407	regulation of cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	C	Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0008585	female gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0007548	sex differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0007276	gamete generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	C	Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	F	Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	F	Seeded From UniProt	complete
involved_in	GO:0001838	embryonic epithelial tube formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0001823	mesonephros development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
involved_in	GO:0001656	metanephros development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22724 ensembl:ENSMUSP00000036580	P	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009142	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009142	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009142	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009142	P	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	Reactome:R-HSA-3781941	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030666	endocytic vesicle membrane	Reactome:R-HSA-3781943 Reactome:R-HSA-3781941	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	Reactome:R-HSA-195721	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-3781943 Reactome:R-HSA-3247844 Reactome:R-HSA-3247843	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005796	Golgi lumen	Reactome:R-HSA-3247844 Reactome:R-HSA-3247840 Reactome:R-HSA-3247837	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-3247837	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-3247843	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lee, CS et al. (2000) SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development 127 109-18 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Biason-Lauber, A et al. (2007) WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report. Hum. Reprod. 22 224-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Chang, J et al. (2007) Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK. J. Biol. Chem. 282 30938-48 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Jordan, BK et al. (2003) Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy. Proc. Natl. Acad. Sci. U.S.A. 100 10866-71 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Chen, M & Hornsby, PJ (2006) Adenovirus-delivered DKK3/WNT4 and steroidogenesis in primary cultures of adrenocortical cells. Horm. Metab. Res. 38 549-55 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Jordan, BK et al. (2001) Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans. Am. J. Hum. Genet. 68 1102-9 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Philibert, P et al. (2008) Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and müllerian duct abnormalities: a French collaborative study. J. Clin. Endocrinol. Metab. 93 895-900 PubMed GONUTS page
↑ Torban, E et al. (2006) PAX2 activates WNT4 expression during mammalian kidney development. J. Biol. Chem. 281 12705-12 PubMed GONUTS page
↑ Zhou, S et al. (2004) Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J. Bone Miner. Res. 19 463-70 PubMed GONUTS page
↑ Huguet, EL et al. (1994) Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res. 54 2615-21 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Biason-Lauber, A et al. (2004) A WNT4 mutation associated with Müllerian-duct regression and virilization in a 46,XX woman. N. Engl. J. Med. 351 792-8 PubMed GONUTS page
↑ Suwa, T et al. (2003) Zonal expression of dickkopf-3 and components of the Wnt signalling pathways in the human adrenal cortex. J. Endocrinol. 178 149-58 PubMed GONUTS page
↑ O'Shaughnessy, PJ et al. (2007) Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester. J. Clin. Endocrinol. Metab. 92 4792-801 PubMed GONUTS page
↑ ^14.0 ^14.1 Peltoketo, H et al. (2004) Characterization and expression of the human WNT4; lack of associated germline mutations in high--to moderate--risk breast and ovarian cancer. Cancer Lett. 213 83-90 PubMed GONUTS page
↑ Taki, M et al. (2003) Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells. Cancer Sci. 94 593-7 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10654605-1] Lee, CS et al. (2000) SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development 127 109-18 PubMed GONUTS page

[PMID:16959810-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Biason-Lauber, A et al. (2007) WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report. Hum. Reprod. 22 224-9 PubMed GONUTS page

[PMID:17720811-3] 3.0 ^3.1 ^3.2 ^3.3 Chang, J et al. (2007) Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK. J. Biol. Chem. 282 30938-48 PubMed GONUTS page

[PMID:12949260-4] 4.0 ^4.1 ^4.2 Jordan, BK et al. (2003) Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy. Proc. Natl. Acad. Sci. U.S.A. 100 10866-71 PubMed GONUTS page

[PMID:16981135-5] 5.0 ^5.1 ^5.2 Chen, M & Hornsby, PJ (2006) Adenovirus-delivered DKK3/WNT4 and steroidogenesis in primary cultures of adrenocortical cells. Horm. Metab. Res. 38 549-55 PubMed GONUTS page

[PMID:11283799-6] 6.0 ^6.1 ^6.2 ^6.3 Jordan, BK et al. (2001) Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans. Am. J. Hum. Genet. 68 1102-9 PubMed GONUTS page

[PMID:18182450-7] 7.0 ^7.1 ^7.2 ^7.3 Philibert, P et al. (2008) Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and müllerian duct abnormalities: a French collaborative study. J. Clin. Endocrinol. Metab. 93 895-900 PubMed GONUTS page

[PMID:16368682-8] Torban, E et al. (2006) PAX2 activates WNT4 expression during mammalian kidney development. J. Biol. Chem. 281 12705-12 PubMed GONUTS page

[PMID:15040835-9] Zhou, S et al. (2004) Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J. Bone Miner. Res. 19 463-70 PubMed GONUTS page

[PMID:8168088-10] Huguet, EL et al. (1994) Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res. 54 2615-21 PubMed GONUTS page

[PMID:15317892-11] 11.0 ^11.1 ^11.2 Biason-Lauber, A et al. (2004) A WNT4 mutation associated with Müllerian-duct regression and virilization in a 46,XX woman. N. Engl. J. Med. 351 792-8 PubMed GONUTS page

[PMID:12844346-12] Suwa, T et al. (2003) Zonal expression of dickkopf-3 and components of the Wnt signalling pathways in the human adrenal cortex. J. Endocrinol. 178 149-58 PubMed GONUTS page

[PMID:17848411-13] O'Shaughnessy, PJ et al. (2007) Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester. J. Clin. Endocrinol. Metab. 92 4792-801 PubMed GONUTS page

[PMID:15312687-14] 14.0 ^14.1 Peltoketo, H et al. (2004) Characterization and expression of the human WNT4; lack of associated germline mutations in high--to moderate--risk breast and ovarian cancer. Cancer Lett. 213 83-90 PubMed GONUTS page

[PMID:12841867-15] Taki, M et al. (2003) Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells. Cancer Sci. 94 593-7 PubMed GONUTS page

[PMID:21873635-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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