HUMAN:SHH

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SHH
Protein Name(s)	Sonic hedgehog protein SHH HHG-1 Sonic hedgehog protein N-product Sonic hedgehog protein C-product
External Links
UniProt	Q15465
EMBL	L38518 AY422195 AC002484 AC078834 CH236954
CCDS	CCDS5942.1
RefSeq	NP_000184.1
UniGene	Hs.164537
PDB	3HO5 3M1N 3MXW
PDBsum	3HO5 3M1N 3MXW
ProteinModelPortal	Q15465
SMR	Q15465
BioGrid	112365
STRING	9606.ENSP00000297261
BindingDB	Q15465
ChEMBL	CHEMBL5602
MEROPS	C46.002
PhosphoSite	Q15465
DMDM	6094283
PaxDb	Q15465
PRIDE	Q15465
DNASU	6469
Ensembl	ENST00000297261
GeneID	6469
KEGG	hsa:6469
UCSC	uc003wmj.1
CTD	6469
GeneCards	GC07M155592
GeneReviews	SHH
HGNC	HGNC:10848
HPA	CAB018966
MIM	142945 147250 174500 188740 600725 611638
neXtProt	NX_Q15465
Orphanet	93925 98938 3332 93924 280200 93926 194 295150 295148 295071 295069 799 220386 280195 2286 93405 2950
PharmGKB	PA35752
eggNOG	NOG250647
GeneTree	ENSGT00390000001117
HOGENOM	HOG000233428
HOVERGEN	HBG005480
InParanoid	Q15465
KO	K11988
OMA	HSWAHRA
OrthoDB	EOG779NZ5
PhylomeDB	Q15465
TreeFam	TF106458
Reactome	REACT_18372 REACT_228111 REACT_228209 REACT_228239
SignaLink	Q15465
ChiTaRS	SHH
EvolutionaryTrace	Q15465
GeneWiki	Sonic_hedgehog
GenomeRNAi	6469
NextBio	25129
PRO	PR:Q15465
Proteomes	UP000005640
Bgee	Q15465
CleanEx	HS_SHH
ExpressionAtlas	Q15465
Genevestigator	Q15465
GO	GO:0009986 GO:0031012 GO:0005615 GO:0045121 GO:0005634 GO:0005886 GO:0005509 GO:0005539 GO:0043237 GO:0016015 GO:0005113 GO:0008233 GO:0008270 GO:0008209 GO:0097190 GO:0060840 GO:0007411 GO:0060020 GO:0007596 GO:0060445 GO:0001658 GO:0048754 GO:0060447 GO:0043010 GO:0060070 GO:0043369 GO:0048468 GO:0001708 GO:0007267 GO:0071285 GO:0007417 GO:0021930 GO:0003140 GO:0021904 GO:0009953 GO:0007398 GO:0009790 GO:0048557 GO:0042733 GO:0048617 GO:0035115 GO:0035116 GO:0030326 GO:0009880 GO:0048706 GO:0006897 GO:0060664 GO:0060738 GO:0030010 GO:0030900 GO:0048859 GO:0031069 GO:0007507 GO:0001947 GO:0030902 GO:0007442 GO:0048839 GO:0016539 GO:0045109 GO:0060459 GO:0060174 GO:0030324 GO:0060428 GO:0060463 GO:0060484 GO:0002320 GO:0030539 GO:0060916 GO:0060783 GO:0072136 GO:0001656 GO:0030901 GO:0080125 GO:0045445 GO:0014902 GO:0046639 GO:0043066 GO:0090090 GO:0045596 GO:0030336 GO:0090370 GO:2000357 GO:2001054 GO:0032435 GO:0042130 GO:0034244 GO:0000122 GO:2000062 GO:0045060 GO:0001755 GO:0007405 GO:0048663 GO:0042475 GO:0014003 GO:0048645 GO:0002076 GO:0060021 GO:0031016 GO:0007389 GO:0001569 GO:0009949 GO:0046638 GO:0051781 GO:0008284 GO:0060769 GO:0007228 GO:0033092 GO:2000358 GO:2000729 GO:0002052 GO:0048714 GO:0042307 GO:0061189 GO:0014858 GO:0048643 GO:0045880 GO:0051155 GO:0033089 GO:0045944 GO:0045893 GO:2000063 GO:0030177 GO:0045059 GO:0060516 GO:0060523 GO:0030850 GO:0034504 GO:0042127 GO:0060782 GO:1900175 GO:0042481 GO:0060685 GO:1900180 GO:0030162 GO:0072001 GO:0060458 GO:0060662 GO:0007224 GO:0021938 GO:0061053 GO:0021513 GO:0021522 GO:0048864 GO:0014706 GO:0033077 GO:0021978 GO:0021794 GO:0048538 GO:0030878 GO:0060439 GO:0001570 GO:0007418
Gene3D	2.170.16.10 3.30.1380.10
InterPro	IPR001657 IPR028992 IPR009045 IPR000320 IPR001767 IPR003586 IPR003587 IPR006141
Pfam	PF01085 PF01079
PIRSF	PIRSF009400
PRINTS	PR00632
SMART	SM00305 SM00306
SUPFAM	SSF51294 SSF55166
PROSITE	PS50817

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28344315^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002371)	Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0009949	polarity specification of anterior/posterior axis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:1900180	regulation of protein localization to nucleus	PMID:11331587^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P14635)	Seeded From UniProt	complete
involved_in	GO:1900175	regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	PMID:17507406^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090370	negative regulation of cholesterol efflux	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0061189	positive regulation of sclerotome development	PMID:10654605^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061053	somite development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	PMID:11331587^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P	occurs_in:(UBERON:0008281) has_input:(UniProtKB:Q9CQN4)\|occurs_in(UBERON:0008281) has_input:(UniProtKB:Q7TN16)\|occurs_in(UBERON:0008281) has_input:(UniProtKB:Q61115)\|occurs_in(UBERON:0003856) has_input:(UniProtKB:Q61115)\|occurs_in(UBERON:0003856) has_input:(UniProtKB:Q9CQN4)\|occurs_in(UBERON:0003843) has_input:(UniProtKB:Q61115)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10654605^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045880	positive regulation of smoothened signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0043369	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	PMID:17227833^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042481	regulation of odontogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0033092	positive regulation of immature T cell proliferation in thymus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0033077	T cell differentiation in thymus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
enables	GO:0016015	morphogen activity	PMID:8647801^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:11331587^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007228	positive regulation of hh target transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
enables	GO:0005113	patched binding	PMID:8906787^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003140	determination of left/right asymmetry in lateral mesoderm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0002320	lymphoid progenitor cell differentiation	PMID:14764698^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P	occurs_in:(UBERON:0008281) has_input:(UniProtKB:Q9JHX2)\|occurs_in(UBERON:0008281) has_input:(UniProtKB:P11403)\|occurs_in(UBERON:0008281) has_input:(UniProtKB:Q6NXH9)	Seeded From UniProt	complete
involved_in	GO:2000729	positive regulation of mesenchymal cell proliferation involved in ureter development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:2000358	positive regulation of kidney smooth muscle cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:2000357	negative regulation of kidney smooth muscle cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:2000063	positive regulation of ureter smooth muscle cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:2000062	negative regulation of ureter smooth muscle cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0072136	metanephric mesenchymal cell proliferation involved in metanephros development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0072001	renal system development	PMID:17850284^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048864	stem cell development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0048663	neuron fate commitment	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0048468	cell development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0046638	positive regulation of alpha-beta T cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0045880	positive regulation of smoothened signaling pathway	PMID:19561609^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045596	negative regulation of cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	C		Seeded From UniProt	complete
involved_in	GO:0045060	negative thymic T cell selection	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0045059	positive thymic T cell selection	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
enables	GO:0043237	laminin-1 binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	F		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0033089	positive regulation of T cell differentiation in thymus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0030902	hindbrain development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0030901	midbrain development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0030850	prostate gland development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0030539	male genitalia development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0030162	regulation of proteolysis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0021930	cerebellar granule cell precursor proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	C		Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:19561609^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008209	androgen metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0007405	neuroblast proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:17850284^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:19561609^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:19561609^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001755	neural crest cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0001708	cell fate specification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0001656	metanephros development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0048709	oligodendrocyte differentiation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98297 PANTHER:PTN000223625	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96533 MGI:MGI:98297 PANTHER:PTN001726121 UniProtKB:F1P3J4 UniProtKB:Q15465 UniProtKB:Q91035 UniProtKB:Q98938 ZFIN:ZDB-GENE-980526-166	P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004644 MGI:MGI:94891 MGI:MGI:96533 MGI:MGI:98297 PANTHER:PTN001726121 UniProtKB:Q14623 UniProtKB:Q15465 UniProtKB:Q98938 ZFIN:ZDB-GENE-051010-1 ZFIN:ZDB-GENE-980526-166	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004644 MGI:MGI:98297 PANTHER:PTN001726121 RGD:3673 UniProtKB:F1P3J4 UniProtKB:Q15465 UniProtKB:Q91035 UniProtKB:Q98938	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001726121 UniProtKB:O43323 UniProtKB:Q14623 UniProtKB:Q15465	F		Seeded From UniProt	complete
enables	GO:0005113	patched binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94891 MGI:MGI:96533 MGI:MGI:98297 PANTHER:PTN001726121 UniProtKB:Q14623 UniProtKB:Q15465	F		Seeded From UniProt	complete
involved_in	GO:0001708	cell fate specification	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96533 MGI:MGI:98297 PANTHER:PTN001726121 RGD:3673 ZFIN:ZDB-GENE-980526-166	P		Seeded From UniProt	complete
involved_in	GO:0060738	epithelial-mesenchymal signaling involved in prostate gland development	PMID:12221011^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016015	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016015	P		Seeded From UniProt	complete
involved_in	GO:2001054	negative regulation of mesenchymal cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:2000729	positive regulation of mesenchymal cell proliferation involved in ureter development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:2000358	positive regulation of kidney smooth muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:2000357	negative regulation of kidney smooth muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:2000063	positive regulation of ureter smooth muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:2000062	negative regulation of ureter smooth muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:1905327	tracheoesophageal septum formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:1904339	negative regulation of dopaminergic neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0090370	negative regulation of cholesterol efflux	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0072136	metanephric mesenchymal cell proliferation involved in metanephros development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0071285	cellular response to lithium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0061053	somite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060916	mesenchymal cell proliferation involved in lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060840	artery development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060783	mesenchymal smoothened signaling pathway involved in prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060782	regulation of mesenchymal cell proliferation involved in prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060769	positive regulation of epithelial cell proliferation involved in prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060768	regulation of epithelial cell proliferation involved in prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060738	epithelial-mesenchymal signaling involved in prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060685	regulation of prostatic bud formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060684	epithelial-mesenchymal cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060662	salivary gland cavitation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060523	prostate epithelial cord elongation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060516	primary prostatic bud elongation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060484	lung-associated mesenchyme development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060463	lung lobe morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060459	left lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060458	right lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060447	bud outgrowth involved in lung branching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060445	branching involved in salivary gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060442	branching involved in prostate gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060441	epithelial tube branching involved in lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060439	trachea morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060438	trachea development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060428	lung epithelium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060425	lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060174	limb bud formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060173	limb development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060021	roof of mouth development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0060020	Bergmann glial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0051155	positive regulation of striated muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0051146	striated muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048864	stem cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048859	formation of anatomical boundary	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048856	anatomical structure development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048714	positive regulation of oligodendrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048709	oligodendrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048706	embryonic skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048663	neuron fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048646	anatomical structure formation involved in morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048645	animal organ formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048643	positive regulation of skeletal muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048617	embryonic foregut morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048598	embryonic morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048589	developmental growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048568	embryonic organ development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048557	embryonic digestive tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048546	digestive tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0048468	cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0046639	negative regulation of alpha-beta T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0046638	positive regulation of alpha-beta T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0045880	positive regulation of smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0045596	negative regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0045445	myoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	C		Seeded From UniProt	complete
involved_in	GO:0045109	intermediate filament organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0045060	negative thymic T cell selection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0045059	positive thymic T cell selection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0043588	skin development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0043369	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
enables	GO:0043237	laminin-1 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0043010	camera-type eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0042481	regulation of odontogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0042476	odontogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0042475	odontogenesis of dentin-containing tooth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0042130	negative regulation of T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0035116	embryonic hindlimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0035115	embryonic forelimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0033092	positive regulation of immature T cell proliferation in thymus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0033089	positive regulation of T cell differentiation in thymus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0033077	T cell differentiation in thymus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0031069	hair follicle morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0031016	pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	C		Seeded From UniProt	complete
involved_in	GO:0030902	hindbrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0030901	midbrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0030878	thyroid gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0030850	prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0030539	male genitalia development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0030323	respiratory tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0030178	negative regulation of Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0030177	positive regulation of Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0030162	regulation of proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0030010	establishment of cell polarity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0021978	telencephalon regionalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0021940	positive regulation of cerebellar granule cell precursor proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0021930	cerebellar granule cell precursor proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0021924	cell proliferation in external granule layer	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0021904	dorsal/ventral neural tube patterning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0021871	forebrain regionalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0021794	thalamus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0021522	spinal cord motor neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0021513	spinal cord dorsal/ventral patterning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	C		Seeded From UniProt	complete
involved_in	GO:0014902	myotube differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0014858	positive regulation of skeletal muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0014706	striated muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0014003	oligodendrocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0010463	mesenchymal cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	C		Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0009949	polarity specification of anterior/posterior axis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0008209	androgen metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0007442	hindgut morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0007405	neuroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0007398	ectoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0007228	positive regulation of hh target transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	C		Seeded From UniProt	complete
enables	GO:0005539	glycosaminoglycan binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	F		Seeded From UniProt	complete
enables	GO:0005113	patched binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	F		Seeded From UniProt	complete
involved_in	GO:0003140	determination of left/right asymmetry in lateral mesoderm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0002320	lymphoid progenitor cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0002076	osteoblast development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0002052	positive regulation of neuroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0001944	vasculature development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0001942	hair follicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0001755	neural crest cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0001708	cell fate specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0001656	metanephros development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62226 ensembl:ENSMUSP00000002708	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001767	P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000320 InterPro:IPR001657	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001657	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001767	F		Seeded From UniProt	complete
involved_in	GO:0016539	intein-mediated protein splicing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006141	P		Seeded From UniProt	complete
enables	GO:0016015	morphogen activity	PMID:24431302^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	part_of:(GO:0071542)	Seeded From UniProt	complete
involved_in	GO:0071542	dopaminergic neuron differentiation	PMID:24431302^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007418	ventral midline development	PMID:8896572^[14] PMID:11001584^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009880	embryonic pattern specification	PMID:11001584^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-NUL-5362406 Reactome:R-HSA-5362553 Reactome:R-HSA-5362551 Reactome:R-HSA-5362549 Reactome:R-HSA-5362427	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5387392 Reactome:R-HSA-5387389 Reactome:R-HSA-5362459 Reactome:R-HSA-5362448	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-5483238 Reactome:R-HSA-5483229 Reactome:R-HSA-5387389 Reactome:R-HSA-5387386 Reactome:R-HSA-5362549 Reactome:R-HSA-5362459 Reactome:R-HSA-5362450 Reactome:R-HSA-5362441 Reactome:R-HSA-5362437 Reactome:R-HSA-5362412 Reactome:R-HSA-5362386 Reactome:R-HSA-5358460 Reactome:R-HSA-5358343 Reactome:R-HSA-5358340 Reactome:R-HSA-5358336	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-5632652 Reactome:R-HSA-5632649 Reactome:R-HSA-5362553 Reactome:R-HSA-5362551 Reactome:R-HSA-445448	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Glavey, SV et al. (2017) Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia 31 2426-2434 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Barnes, EA et al. (2001) Patched1 interacts with cyclin B1 to regulate cell cycle progression. EMBO J. 20 2214-23 PubMed GONUTS page
↑ Tavares, AT et al. (2007) Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo. Development 134 2051-60 PubMed GONUTS page
↑ ^4.0 ^4.1 Lee, CS et al. (2000) SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development 127 109-18 PubMed GONUTS page
↑ Rowbotham, NJ et al. (2007) Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation. Blood 109 3757-66 PubMed GONUTS page
↑ Hahn, H et al. (1996) A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities. J. Biol. Chem. 271 12125-8 PubMed GONUTS page
↑ Stone, DM et al. (1996) The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384 129-34 PubMed GONUTS page
↑ Shah, DK et al. (2004) Reduced thymocyte development in sonic hedgehog knockout embryos. J. Immunol. 172 2296-306 PubMed GONUTS page
↑ ^9.0 ^9.1 Jenkins, D et al. (2007) Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development. J. Anat. 211 620-9 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Bosanac, I et al. (2009) The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling. Nat. Struct. Mol. Biol. 16 691-7 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Lamm, ML et al. (2002) Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation. Dev. Biol. 249 349-66 PubMed GONUTS page
↑ ^13.0 ^13.1 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page
↑ Roessler, E et al. (1996) Mutations in the human Sonic Hedgehog gene cause holoprosencephaly. Nat. Genet. 14 357-60 PubMed GONUTS page
↑ ^15.0 ^15.1 Villavicencio, EH et al. (2000) The sonic hedgehog-patched-gli pathway in human development and disease. Am. J. Hum. Genet. 67 1047-54 PubMed GONUTS page

[PMID:28344315-1] Glavey, SV et al. (2017) Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia 31 2426-2434 PubMed GONUTS page

[PMID:11331587-2] 2.0 ^2.1 ^2.2 Barnes, EA et al. (2001) Patched1 interacts with cyclin B1 to regulate cell cycle progression. EMBO J. 20 2214-23 PubMed GONUTS page

[PMID:17507406-3] Tavares, AT et al. (2007) Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo. Development 134 2051-60 PubMed GONUTS page

[PMID:10654605-4] 4.0 ^4.1 Lee, CS et al. (2000) SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development 127 109-18 PubMed GONUTS page

[PMID:17227833-5] Rowbotham, NJ et al. (2007) Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation. Blood 109 3757-66 PubMed GONUTS page

[PMID:8647801-6] Hahn, H et al. (1996) A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities. J. Biol. Chem. 271 12125-8 PubMed GONUTS page

[PMID:8906787-7] Stone, DM et al. (1996) The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384 129-34 PubMed GONUTS page

[PMID:14764698-8] Shah, DK et al. (2004) Reduced thymocyte development in sonic hedgehog knockout embryos. J. Immunol. 172 2296-306 PubMed GONUTS page

[PMID:17850284-9] 9.0 ^9.1 Jenkins, D et al. (2007) Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development. J. Anat. 211 620-9 PubMed GONUTS page

[PMID:19561609-10] 10.0 ^10.1 ^10.2 ^10.3 Bosanac, I et al. (2009) The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling. Nat. Struct. Mol. Biol. 16 691-7 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12221011-12] Lamm, ML et al. (2002) Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation. Dev. Biol. 249 349-66 PubMed GONUTS page

[PMID:24431302-13] 13.0 ^13.1 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page

[PMID:8896572-14] Roessler, E et al. (1996) Mutations in the human Sonic Hedgehog gene cause holoprosencephaly. Nat. Genet. 14 357-60 PubMed GONUTS page

[PMID:11001584-15] 15.0 ^15.1 Villavicencio, EH et al. (2000) The sonic hedgehog-patched-gli pathway in human development and disease. Am. J. Hum. Genet. 67 1047-54 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

HUMAN:SHH

Contents

Annotations

Notes

References

a

b

c

d

e

f

g

h

i

k

l

m

n

o

p

r

s

t

v

z

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools