HUMAN:FGF8

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FGF8 (synonyms: AIGF)
Protein Name(s)	Fibroblast growth factor 8 FGF-8 Androgen-induced growth factor AIGF Heparin-binding growth factor 8 HBGF-8
External Links
UniProt	P55075
EMBL	S78466 S78462 S78463 S78464 S78465 D38752 U46213 U46212 U46211 U47011 U47009 U47010 U47011 U47009 U47010 U47011 U47009 U47010 U36223 U36228 U36225 U36226 U36227 U47011 U47009 U47010 U56978 AB014615 AF520763 CH471066 BC128235
CCDS	CCDS7515.1 CCDS7516.1 CCDS7517.1 CCDS7518.1
RefSeq	NP_006110.1 NP_149353.1 NP_149354.1 NP_149355.1
UniGene	Hs.57710
PDB	2FDB
PDBsum	2FDB
ProteinModelPortal	P55075
SMR	P55075
BioGrid	108544
DIP	DIP-59630N
IntAct	P55075
STRING	9606.ENSP00000321797
PhosphoSite	P55075
DMDM	1706791
PaxDb	P55075
PRIDE	P55075
Ensembl	ENST00000320185 ENST00000344255 ENST00000346714 ENST00000347978
GeneID	2253
KEGG	hsa:2253
UCSC	uc001ktp.2 uc001ktq.2 uc001ktr.2 uc001kts.2
CTD	2253
GeneCards	GC10M103530
GeneReviews	FGF8
HGNC	HGNC:3686
MIM	600483 612702
neXtProt	NX_P55075
Orphanet	93925 478 93924 280200 93926 432 220386 280195
PharmGKB	PA28125
eggNOG	NOG327940
GeneTree	ENSGT00730000110785
HOGENOM	HOG000115986
HOVERGEN	HBG005659
InParanoid	P55075
KO	K04358
OMA	KGHHTTE
PhylomeDB	P55075
TreeFam	TF331233
Reactome	REACT_111184 REACT_120863 REACT_121153 REACT_121249 REACT_121337 REACT_121398 REACT_147727 REACT_21247 REACT_21270 REACT_21310 REACT_21374 REACT_75829 REACT_9413 REACT_9452 REACT_9508 REACT_9510 REACT_9515 REACT_976
SignaLink	P55075
EvolutionaryTrace	P55075
GeneWiki	FGF8
GenomeRNAi	2253
NextBio	9121
PRO	PR:P55075
Proteomes	UP000005640
Bgee	P55075
CleanEx	HS_FGF8
ExpressionAtlas	P55075
Genevestigator	P55075
GO	GO:0009897 GO:0005576 GO:0005615 GO:0042056 GO:0008083 GO:0005105 GO:0005111 GO:0009653 GO:0035909 GO:0006915 GO:0001974 GO:0030509 GO:0060348 GO:0060445 GO:0001658 GO:0060070 GO:0090134 GO:0021846 GO:0060128 GO:0071542 GO:0033563 GO:0035116 GO:0007173 GO:0003198 GO:0038095 GO:0008543 GO:0021798 GO:0048853 GO:0021884 GO:0007369 GO:0008406 GO:0001947 GO:0045087 GO:0008286 GO:0060425 GO:0030539 GO:0000165 GO:0008078 GO:0001823 GO:0001656 GO:0030917 GO:0008045 GO:0055026 GO:0043524 GO:0001839 GO:0060563 GO:0048011 GO:0042476 GO:0001759 GO:0030916 GO:0003148 GO:0021543 GO:0001569 GO:0060037 GO:0048015 GO:0008284 GO:0010628 GO:0045840 GO:0046622 GO:0042487 GO:0042493 GO:0014070 GO:0006979 GO:0023019 GO:0021544 GO:0030878 GO:0060129
InterPro	IPR008996 IPR028249 IPR002209 IPR028142
PANTHER	PTHR11486 PTHR11486:SF3
PRINTS	PR00262
SMART	SM00442
SUPFAM	SSF50353
PROSITE	PS00247

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0055026	negative regulation of cardiac muscle tissue development	PMID:20702560^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37237	P		Seeded From UniProt	complete
involved_in	GO:0071542	dopaminergic neuron differentiation	PMID:15193767^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060563	neuroepithelial cell differentiation	PMID:17309880^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060348	bone development	PMID:18596921^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042476	odontogenesis	PMID:17394220^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009653	anatomical structure morphogenesis	PMID:8595889^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008406	gonad development	PMID:18596921^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007369	gastrulation	PMID:8700553^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37237	P		Seeded From UniProt	complete
involved_in	GO:0001823	mesonephros development	PMID:18437684^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001656	metanephros development	PMID:18437684^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P22607	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P21802	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0042056	P		Seeded From UniProt	complete
involved_in	GO:0090134	cell migration involved in mesendoderm migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0060445	branching involved in salivary gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0060425	lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0060128	corticotropin hormone secreting cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0048853	forebrain morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0048699	generation of neurons	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0046622	positive regulation of organ growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0045840	positive regulation of mitotic nuclear division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0042487	regulation of odontogenesis of dentin-containing tooth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0042472	inner ear morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0035909	aorta morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0035116	embryonic hindlimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0035108	limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0035050	embryonic heart tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0030917	midbrain-hindbrain boundary development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0030916	otic vesicle formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0030878	thyroid gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0030539	male genitalia development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0023019	signal transduction involved in regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0021846	cell proliferation in forebrain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0021798	forebrain dorsal/ventral pattern formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0021544	subpallium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0021543	pallium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0021537	telencephalon development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0009792	embryo development ending in birth or egg hatching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0008078	mesodermal cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0001839	neural plate morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0001759	organ induction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37237 ensembl:ENSMUSP00000026241	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q76LI5 ensembl:ENSRNOP00000023558	P		Seeded From UniProt	complete
involved_in	GO:0042476	odontogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q76LI5 ensembl:ENSRNOP00000023558	P		Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q76LI5 ensembl:ENSRNOP00000023558	F		Seeded From UniProt	complete
involved_in	GO:0033563	dorsal/ventral axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q76LI5 ensembl:ENSRNOP00000023558	P		Seeded From UniProt	complete
involved_in	GO:0021954	central nervous system neuron development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q76LI5 ensembl:ENSRNOP00000023558	P		Seeded From UniProt	complete
involved_in	GO:0021884	forebrain neuron development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q76LI5 ensembl:ENSRNOP00000023558	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q76LI5 ensembl:ENSRNOP00000023558	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q76LI5 ensembl:ENSRNOP00000023558	C		Seeded From UniProt	complete
involved_in	GO:0008045	motor neuron axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q76LI5 ensembl:ENSRNOP00000023558	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q76LI5 ensembl:ENSRNOP00000023558	P		Seeded From UniProt	complete
enables	GO:0005104	fibroblast growth factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028249	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028249	C		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002209	F		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028249	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:8891346^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:8891346^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:8891346^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:8891346^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:17265164^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:8891346^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:17265164^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:8891346^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005111	type 2 fibroblast growth factor receptor binding	PMID:16384934^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005105	type 1 fibroblast growth factor receptor binding	PMID:16384934^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:22235191^[13] Reactome:R-HSA-5654743 Reactome:R-HSA-5654741 Reactome:R-HSA-5654738 Reactome:R-HSA-5654736 Reactome:R-HSA-190375 Reactome:R-HSA-190373 Reactome:R-HSA-190372 Reactome:R-HSA-190371 Reactome:R-HSA-190322	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_input:(UniProtKB:P22607)	Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	PMID:22235191^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	regulates_o_results_in_acquisition_of_features_of:(CL:0000202) occurs_in:(CL:0000589)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:24431302^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000125084) part_of:(GO:0071542)	Seeded From UniProt	complete
involved_in	GO:0071542	dopaminergic neuron differentiation	PMID:24431302^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	Reactome:R-HSA-2316434	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-5672965 Reactome:R-HSA-5656064 Reactome:R-HSA-5655343 Reactome:R-HSA-5655339 Reactome:R-HSA-5655326 Reactome:R-HSA-5655323 Reactome:R-HSA-5655320 Reactome:R-HSA-5655315 Reactome:R-HSA-5655301 Reactome:R-HSA-5655295 Reactome:R-HSA-5655290 Reactome:R-HSA-5655289 Reactome:R-HSA-5655285 Reactome:R-HSA-5655278 Reactome:R-HSA-5655277 Reactome:R-HSA-5655270 Reactome:R-HSA-5655269 Reactome:R-HSA-5655268 Reactome:R-HSA-5655266 Reactome:R-HSA-5655263 Reactome:R-HSA-5655262 Reactome:R-HSA-5655247 Reactome:R-HSA-5655245 Reactome:R-HSA-5655244 Reactome:R-HSA-5655243 Reactome:R-HSA-5655241 Reactome:R-HSA-5655240 Reactome:R-HSA-5655233 Reactome:R-HSA-5654748 Reactome:R-HSA-5654734 Reactome:R-HSA-5654730 Reactome:R-HSA-5654729 Reactome:R-HSA-5654717 Reactome:R-HSA-5654714 Reactome:R-HSA-5654709 Reactome:R-HSA-5654705 Reactome:R-HSA-5654701 Reactome:R-HSA-5654697 Reactome:R-HSA-5654692 Reactome:R-HSA-5654690 Reactome:R-HSA-5654684 Reactome:R-HSA-5654679 Reactome:R-HSA-5654677 Reactome:R-HSA-5654673 Reactome:R-HSA-5654672 Reactome:R-HSA-5654669 Reactome:R-HSA-5654667 Reactome:R-HSA-5654664 Reactome:R-HSA-5654663 Reactome:R-HSA-5654662 Reactome:R-HSA-5654659 Reactome:R-HSA-5654658 Reactome:R-HSA-5654655 Reactome:R-HSA-5654653 Reactome:R-HSA-5654651 Reactome:R-HSA-5654647 Reactome:R-HSA-5654646 Reactome:R-HSA-5654643 Reactome:R-HSA-5654641 Reactome:R-HSA-5654640 Reactome:R-HSA-5654637 Reactome:R-HSA-5654634 Reactome:R-HSA-5654633 Reactome:R-HSA-5654631 Reactome:R-HSA-5654628 Reactome:R-HSA-5654625 Reactome:R-HSA-5654623 Reactome:R-HSA-5654622 Reactome:R-HSA-5654620 Reactome:R-HSA-5654618 Reactome:R-HSA-5654615 Reactome:R-HSA-5654614 Reactome:R-HSA-5654612 Reactome:R-HSA-5654608 Reactome:R-HSA-5654607 Reactome:R-HSA-5654605 Reactome:R-HSA-5654603 Reactome:R-HSA-5654600 Reactome:R-HSA-5654597 Reactome:R-HSA-5654596 Reactome:R-HSA-5654594 Reactome:R-HSA-5654592 Reactome:R-HSA-5654591 Reactome:R-HSA-5654587 Reactome:R-HSA-5654586 Reactome:R-HSA-5654584 Reactome:R-HSA-5654582 Reactome:R-HSA-5654578 Reactome:R-HSA-5654575 Reactome:R-HSA-5654573 Reactome:R-HSA-5654571 Reactome:R-HSA-5654569 Reactome:R-HSA-5654566 Reactome:R-HSA-5654565 Reactome:R-HSA-5654562 Reactome:R-HSA-5654560 Reactome:R-HSA-5654511 Reactome:R-HSA-5654428 Reactome:R-HSA-5654426 Reactome:R-HSA-5654425 Reactome:R-HSA-5654423 Reactome:R-HSA-5654422 Reactome:R-HSA-5654418 Reactome:R-HSA-5654416 Reactome:R-HSA-5654413 Reactome:R-HSA-5654409 Reactome:R-HSA-5654408 Reactome:R-HSA-5654407 Reactome:R-HSA-5654406 Reactome:R-HSA-5654404 Reactome:R-HSA-5654402 Reactome:R-HSA-5654399 Reactome:R-HSA-5654397 Reactome:R-HSA-5654392 Reactome:R-HSA-5654224 Reactome:R-HSA-5654222 Reactome:R-HSA-5654169 Reactome:R-HSA-5654167 Reactome:R-HSA-5654165 Reactome:R-HSA-5654163 Reactome:R-HSA-5654159 Reactome:R-HSA-5654157 Reactome:R-HSA-5654151 Reactome:R-HSA-5654149 Reactome:R-HSA-5654148 Reactome:R-HSA-5654147 Reactome:R-HSA-2400009 Reactome:R-HSA-2316434 Reactome:R-HSA-2077424 Reactome:R-HSA-2077420 Reactome:R-HSA-2033486 Reactome:R-HSA-2033472 Reactome:R-HSA-2023455 Reactome:R-HSA-2023451 Reactome:R-HSA-2012074 Reactome:R-HSA-2012073 Reactome:R-HSA-190429 Reactome:R-HSA-190413 Reactome:R-HSA-190388 Reactome:R-HSA-190385 Reactome:R-HSA-190326 Reactome:R-HSA-190265 Reactome:R-HSA-190263 Reactome:R-HSA-190261 Reactome:R-HSA-190258 Reactome:R-HSA-190256 Reactome:R-HSA-1839100 Reactome:R-HSA-1839098 Reactome:R-HSA-1839094 Reactome:R-HSA-109699	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0497	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Tirosh-Finkel, L et al. (2010) BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors. Development 137 2989-3000 PubMed GONUTS page
↑ Wang, X et al. (2004) Forskolin cooperating with growth factor on generation of dopaminergic neurons from human fetal mesencephalic neural progenitor cells. Neurosci. Lett. 362 117-21 PubMed GONUTS page
↑ Schneider, BL et al. (2007) Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation. Hum. Mol. Genet. 16 651-66 PubMed GONUTS page
↑ ^4.0 ^4.1 Falardeau, J et al. (2008) Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice. J. Clin. Invest. 118 2822-31 PubMed GONUTS page
↑ Lin, D et al. (2007) Expression survey of genes critical for tooth development in the human embryonic tooth germ. Dev. Dyn. 236 1307-12 PubMed GONUTS page
↑ White, RA et al. (1995) Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region. Genomics 30 109-11 PubMed GONUTS page
↑ Payson, RA et al. (1996) The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells. Oncogene 13 47-53 PubMed GONUTS page
↑ ^8.0 ^8.1 Carev, D et al. (2008) Involvement of FGF and BMP family proteins and VEGF in early human kidney development. Histol. Histopathol. 23 853-62 PubMed GONUTS page
↑ ^9.0 ^9.1 Ornitz, DM et al. (1996) Receptor specificity of the fibroblast growth factor family. J. Biol. Chem. 271 15292-7 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Ghosh, AK et al. (1996) Molecular cloning and characterization of human FGF8 alternative messenger RNA forms. Cell Growth Differ. 7 1425-34 PubMed GONUTS page
↑ ^11.0 ^11.1 Potula, HH et al. (2008) Transient expression, purification and characterization of bioactive human fibroblast growth factor 8b in tobacco plants. Transgenic Res. 17 19-32 PubMed GONUTS page
↑ ^12.0 ^12.1 Olsen, SK et al. (2006) Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain. Genes Dev. 20 185-98 PubMed GONUTS page
↑ ^13.0 ^13.1 Huh, SH et al. (2012) Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal. PLoS Biol. 10 e1001231 PubMed GONUTS page
↑ ^14.0 ^14.1 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page

[PMID:20702560-1] Tirosh-Finkel, L et al. (2010) BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors. Development 137 2989-3000 PubMed GONUTS page

[PMID:15193767-2] Wang, X et al. (2004) Forskolin cooperating with growth factor on generation of dopaminergic neurons from human fetal mesencephalic neural progenitor cells. Neurosci. Lett. 362 117-21 PubMed GONUTS page

[PMID:17309880-3] Schneider, BL et al. (2007) Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation. Hum. Mol. Genet. 16 651-66 PubMed GONUTS page

[PMID:18596921-4] 4.0 ^4.1 Falardeau, J et al. (2008) Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice. J. Clin. Invest. 118 2822-31 PubMed GONUTS page

[PMID:17394220-5] Lin, D et al. (2007) Expression survey of genes critical for tooth development in the human embryonic tooth germ. Dev. Dyn. 236 1307-12 PubMed GONUTS page

[PMID:8595889-6] White, RA et al. (1995) Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region. Genomics 30 109-11 PubMed GONUTS page

[PMID:8700553-7] Payson, RA et al. (1996) The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells. Oncogene 13 47-53 PubMed GONUTS page

[PMID:18437684-8] 8.0 ^8.1 Carev, D et al. (2008) Involvement of FGF and BMP family proteins and VEGF in early human kidney development. Histol. Histopathol. 23 853-62 PubMed GONUTS page

[PMID:8663044-9] 9.0 ^9.1 Ornitz, DM et al. (1996) Receptor specificity of the fibroblast growth factor family. J. Biol. Chem. 271 15292-7 PubMed GONUTS page

[PMID:8891346-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Ghosh, AK et al. (1996) Molecular cloning and characterization of human FGF8 alternative messenger RNA forms. Cell Growth Differ. 7 1425-34 PubMed GONUTS page

[PMID:17265164-11] 11.0 ^11.1 Potula, HH et al. (2008) Transient expression, purification and characterization of bioactive human fibroblast growth factor 8b in tobacco plants. Transgenic Res. 17 19-32 PubMed GONUTS page

[PMID:16384934-12] 12.0 ^12.1 Olsen, SK et al. (2006) Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain. Genes Dev. 20 185-98 PubMed GONUTS page

[PMID:22235191-13] 13.0 ^13.1 Huh, SH et al. (2012) Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal. PLoS Biol. 10 e1001231 PubMed GONUTS page

[PMID:24431302-14] 14.0 ^14.1 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page

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HUMAN:FGF8

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