MOUSE:FZD8

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Fzd8
Protein Name(s)	Frizzled-8 Fz-8 mFz8
External Links
UniProt	Q61091
EMBL	U43321 CH466592 BC132543 BC138062
CCDS	CCDS29048.1
RefSeq	NP_032084.2
UniGene	Mm.184289
PDB	1IJY 4F0A
PDBsum	1IJY 4F0A
ProteinModelPortal	Q61091
SMR	Q61091
BioGrid	199781
DIP	DIP-41258N
IntAct	Q61091
MINT	MINT-1782989
STRING	10090.ENSMUSP00000039660
MEROPS	I93.001
PhosphoSite	Q61091
PRIDE	Q61091
Ensembl	ENSMUST00000041080
GeneID	14370
KEGG	mmu:14370
UCSC	uc008eag.2
CTD	8325
MGI	MGI:108460
eggNOG	NOG257258
GeneTree	ENSGT00760000118864
HOGENOM	HOG000233236
HOVERGEN	HBG006977
InParanoid	Q61091
KO	K02375
OMA	HEKVACN
OrthoDB	EOG7M3J01
TreeFam	TF317907
Reactome	REACT_250061
EvolutionaryTrace	Q61091
NextBio	285853
PRO	PR:Q61091
Proteomes	UP000000589
Bgee	Q61091
CleanEx	MM_FZD8
Genevestigator	Q61091
GO	GO:0042995 GO:0005737 GO:0005794 GO:0016021 GO:0005886 GO:0004930 GO:0030165 GO:0005102 GO:0042813 GO:0017147 GO:0001525 GO:0007409 GO:0007420 GO:0060070 GO:0008406 GO:0000122 GO:0043507 GO:0001934 GO:0045944 GO:0006357 GO:0033077 GO:0001944 GO:0016055
Gene3D	1.10.2000.10
InterPro	IPR000539 IPR015526 IPR020067 IPR017981
PANTHER	PTHR11309
Pfam	PF01534 PF01392
PRINTS	PR00489
SMART	SM00063
SUPFAM	SSF63501
PROSITE	PS50038 PS50261

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0016055	Wnt signaling pathway	PMID:11357136^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:11357136^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P28026	F		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:20093360^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P22726	F		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:20093360^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P22725	F		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:20093360^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O35468	F		Seeded From UniProt	complete
part_of	GO:1990851	Wnt-Frizzled-LRP5/6 complex	PMID:11029007^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75581	C		Seeded From UniProt	complete
part_of	GO:1990851	Wnt-Frizzled-LRP5/6 complex	PMID:11448771^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75581	C		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:22653731^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P28026	F		Seeded From UniProt	complete
part_of	GO:1990851	Wnt-Frizzled-LRP5/6 complex	PMID:20093360^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:20093360^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P56704	F		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:11520064^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8BH60	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15035989^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:11029007^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75581	F		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001085 FB:FBgn0016797 MGI:MGI:108460 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1196625 PANTHER:PTN000139394 RGD:61916 RGD:71012 UniProtKB:O75084 UniProtKB:Q13467 UniProtKB:Q14332 UniProtKB:Q8N474 UniProtKB:Q9H461 UniProtKB:Q9NPG1 UniProtKB:Q9ULV1 UniProtKB:Q9ULW2 UniProtKB:Q9UP38	P		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001085 FB:FBgn0016797 MGI:MGI:108460 MGI:MGI:108476 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:1313278 MGI:MGI:1888513 PANTHER:PTN000139394 RGD:628817 RGD:71012 UniProtKB:O60353 UniProtKB:O75084 UniProtKB:Q13467 UniProtKB:Q14332 UniProtKB:Q9H461 UniProtKB:Q9ULV1 UniProtKB:Q9ULW2 UniProtKB:Q9UP38	F		Seeded From UniProt	complete
involved_in	GO:0035567	non-canonical Wnt signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108570 PANTHER:PTN000139394 UniProtKB:O60353 ZFIN:ZDB-GENE-990415-218	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001085 FB:FBgn0016797 FB:FBgn0027342 FB:FBgn0027343 MGI:MGI:108078 MGI:MGI:108460 MGI:MGI:108474 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1196625 MGI:MGI:2136761 MGI:MGI:892032 PANTHER:PTN000139394 RGD:621075 RGD:631406 RGD:71017 UniProtKB:O00144 UniProtKB:O75084 UniProtKB:Q13467 UniProtKB:Q6FHJ7 UniProtKB:Q8N474 UniProtKB:Q9NPG1 UniProtKB:Q9UP38	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0016797 MGI:MGI:108075 MGI:MGI:108460 MGI:MGI:108476 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1313278 PANTHER:PTN000139394 RGD:61916 RGD:628817 RGD:71012 UniProtKB:O00144 UniProtKB:O19116 UniProtKB:O60353 UniProtKB:O75084 UniProtKB:Q14332 UniProtKB:Q99835 UniProtKB:Q9NPG1 UniProtKB:Q9ULV1 WB:WBGene00003006 ZFIN:ZDB-GENE-990415-223	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:16115200^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98956	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:15143170^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:15064719^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:11265645^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:16543246^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H461	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17360443^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043507	positive regulation of JUN kinase activity	PMID:15195140^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	PMID:15454084^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04426	F		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H461	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033077	T cell differentiation in thymus	PMID:11265645^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H461	F		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H461	F		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:15454084^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04426	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016055	Wnt signaling pathway	PMID:19129494^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	PMID:15143170^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:19129494^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17360443^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002322) has_regulation_target:(MGI:MGI:107543)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H461 ensembl:ENSP00000363826	P		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H461 ensembl:ENSP00000363826	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H461 ensembl:ENSP00000363826	F		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H461 ensembl:ENSP00000363826	F		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	F		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000539 InterPro:IPR017981	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000539	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-NUL-517516 Reactome:R-NUL-3858478	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-1458871	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Mao, B et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411 321-5 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Bourhis, E et al. (2010) Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. J. Biol. Chem. 285 9172-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Tamai, K et al. (2000) LDL-receptor-related proteins in Wnt signal transduction. Nature 407 530-5 PubMed GONUTS page
↑ Semënov, MV et al. (2001) Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr. Biol. 11 951-61 PubMed GONUTS page
↑ Janda, CY et al. (2012) Structural basis of Wnt recognition by Frizzled. Science 337 59-64 PubMed GONUTS page
↑ Yao, R et al. (2001) Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled. Biochem. Biophys. Res. Commun. 286 771-8 PubMed GONUTS page
↑ Xu, Q et al. (2004) Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell 116 883-95 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Takada, R et al. (2005) Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation. Genes Cells 10 919-28 PubMed GONUTS page
↑ ^10.0 ^10.1 González-Sancho, JM et al. (2004) Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol. Cell. Biol. 24 4757-68 PubMed GONUTS page
↑ Brennan, K et al. (2004) Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins. Oncogene 23 4873-84 PubMed GONUTS page
↑ ^12.0 ^12.1 Staal, FJ et al. (2001) Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription. Eur. J. Immunol. 31 285-93 PubMed GONUTS page
↑ Nam, JS et al. (2006) Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. J. Biol. Chem. 281 13247-57 PubMed GONUTS page
↑ ^14.0 ^14.1 Liu, Y et al. (2007) Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 104 3859-64 PubMed GONUTS page
↑ Yao, R et al. (2004) MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap. Oncogene 23 6023-30 PubMed GONUTS page
↑ ^16.0 ^16.1 Lu, W et al. (2004) Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119 97-108 PubMed GONUTS page
↑ ^17.0 ^17.1 Daneman, R et al. (2009) Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 106 641-6 PubMed GONUTS page

[PMID:11357136-1] 1.0 ^1.1 Mao, B et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411 321-5 PubMed GONUTS page

[PMID:20093360-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Bourhis, E et al. (2010) Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. J. Biol. Chem. 285 9172-9 PubMed GONUTS page

[PMID:11029007-3] 3.0 ^3.1 Tamai, K et al. (2000) LDL-receptor-related proteins in Wnt signal transduction. Nature 407 530-5 PubMed GONUTS page

[PMID:11448771-4] Semënov, MV et al. (2001) Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr. Biol. 11 951-61 PubMed GONUTS page

[PMID:22653731-5] Janda, CY et al. (2012) Structural basis of Wnt recognition by Frizzled. Science 337 59-64 PubMed GONUTS page

[PMID:11520064-6] Yao, R et al. (2001) Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled. Biochem. Biophys. Res. Commun. 286 771-8 PubMed GONUTS page

[PMID:15035989-7] Xu, Q et al. (2004) Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell 116 883-95 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16115200-9] Takada, R et al. (2005) Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation. Genes Cells 10 919-28 PubMed GONUTS page

[PMID:15143170-10] 10.0 ^10.1 González-Sancho, JM et al. (2004) Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol. Cell. Biol. 24 4757-68 PubMed GONUTS page

[PMID:15064719-11] Brennan, K et al. (2004) Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins. Oncogene 23 4873-84 PubMed GONUTS page

[PMID:11265645-12] 12.0 ^12.1 Staal, FJ et al. (2001) Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription. Eur. J. Immunol. 31 285-93 PubMed GONUTS page

[PMID:16543246-13] Nam, JS et al. (2006) Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. J. Biol. Chem. 281 13247-57 PubMed GONUTS page

[PMID:17360443-14] 14.0 ^14.1 Liu, Y et al. (2007) Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 104 3859-64 PubMed GONUTS page

[PMID:15195140-15] Yao, R et al. (2004) MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap. Oncogene 23 6023-30 PubMed GONUTS page

[PMID:15454084-16] 16.0 ^16.1 Lu, W et al. (2004) Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119 97-108 PubMed GONUTS page

[PMID:19129494-17] 17.0 ^17.1 Daneman, R et al. (2009) Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 106 641-6 PubMed GONUTS page

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MOUSE:FZD8

Contents

Annotations

Notes

References

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