HUMAN:FZD2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FZD2
Protein Name(s)	Frizzled-2 Fz-2 hFz2 FzE2
External Links
UniProt	Q14332
EMBL	L37882 AB017364 BC113402 BC113404
CCDS	CCDS11484.1
PIR	JE0338
RefSeq	NP_001457.1
UniGene	Hs.142912 Hs.732654
ProteinModelPortal	Q14332
SMR	Q14332
BioGrid	108811
IntAct	Q14332
STRING	9606.ENSP00000323901
GuidetoPHARMACOLOGY	230
MEROPS	I93.001
PhosphoSite	Q14332
DMDM	17433019
MaxQB	Q14332
PaxDb	Q14332
PRIDE	Q14332
Ensembl	ENST00000315323
GeneID	2535
KEGG	hsa:2535
UCSC	uc002igx.2
CTD	2535
GeneCards	GC17P042645
HGNC	HGNC:4040
HPA	HPA057667
MIM	600667
neXtProt	NX_Q14332
PharmGKB	PA28457
eggNOG	NOG257258
GeneTree	ENSGT00760000118864
HOVERGEN	HBG006977
InParanoid	Q14332
KO	K02235
OMA	SICERAK
OrthoDB	EOG7M3J01
PhylomeDB	Q14332
TreeFam	TF317907
Reactome	REACT_172631 REACT_172638 REACT_172761 REACT_18372 REACT_200610 REACT_200777
ChiTaRS	FZD2
GeneWiki	FZD2
GenomeRNAi	2535
NextBio	10005
PRO	PR:Q14332
Proteomes	UP000005640
Bgee	Q14332
CleanEx	HS_FZD2
ExpressionAtlas	Q14332
Genevestigator	Q14332
GO	GO:0045177 GO:0030669 GO:0005737 GO:0005925 GO:0016021 GO:0032589 GO:0005886 GO:0004930 GO:0030165 GO:0042813 GO:0017147 GO:0007409 GO:0007420 GO:0060070 GO:0007267 GO:0090103 GO:0030855 GO:0007199 GO:0008406 GO:0060022 GO:0060119 GO:0003149 GO:0003150 GO:0030182 GO:0003151 GO:0090179 GO:0030825 GO:0051091 GO:0045893 GO:0007608 GO:0001944 GO:0007223
Gene3D	1.10.2000.10
InterPro	IPR000539 IPR015526 IPR020067 IPR026550 IPR017981
PANTHER	PTHR11309 PTHR11309:SF34
Pfam	PF01534 PF01392
PRINTS	PR00489
SMART	SM00063
SUPFAM	SSF63501
PROSITE	PS50038 PS50261

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0042813	Wnt-activated receptor activity	PMID:28733458^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:28733458^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:24431302^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F	part_of:(GO:0060071) has_direct_input:(UniProtKB:O96014)\|part_of(GO:0060071) has_direct_input:(UniProtKB:P41221)	Seeded From UniProt	complete
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	PMID:24431302^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	PMID:24431302^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F	part_of:(GO:0060071) has_input:(UniProtKB:O96014)\|part_of(GO:0060071) has_input:(UniProtKB:P41221)	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:18215320^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:18929644^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:18929644^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18215320^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18929644^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	PMID:19946729^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18929644^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19038973^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:20802536^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56706	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:19388021^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q92997	F		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:19388021^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14641	F		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:19388021^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14640	F		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001085 FB:FBgn0016797 MGI:MGI:108460 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1196625 PANTHER:PTN000139394 RGD:61916 RGD:71012 UniProtKB:O75084 UniProtKB:Q13467 UniProtKB:Q14332 UniProtKB:Q8N474 UniProtKB:Q9H461 UniProtKB:Q9NPG1 UniProtKB:Q9ULV1 UniProtKB:Q9ULW2 UniProtKB:Q9UP38	P		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001085 FB:FBgn0016797 MGI:MGI:108460 MGI:MGI:108476 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:1313278 MGI:MGI:1888513 PANTHER:PTN000139394 RGD:628817 RGD:71012 UniProtKB:O60353 UniProtKB:O75084 UniProtKB:Q13467 UniProtKB:Q14332 UniProtKB:Q9H461 UniProtKB:Q9ULV1 UniProtKB:Q9ULW2 UniProtKB:Q9UP38	F		Seeded From UniProt	complete
involved_in	GO:0035567	non-canonical Wnt signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108570 PANTHER:PTN000139394 UniProtKB:O60353 ZFIN:ZDB-GENE-990415-218	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001085 FB:FBgn0016797 FB:FBgn0027342 FB:FBgn0027343 MGI:MGI:108078 MGI:MGI:108460 MGI:MGI:108474 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1196625 MGI:MGI:2136761 MGI:MGI:892032 PANTHER:PTN000139394 RGD:621075 RGD:631406 RGD:71017 UniProtKB:O00144 UniProtKB:O75084 UniProtKB:Q13467 UniProtKB:Q6FHJ7 UniProtKB:Q8N474 UniProtKB:Q9NPG1 UniProtKB:Q9UP38	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0016797 MGI:MGI:108075 MGI:MGI:108460 MGI:MGI:108476 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1313278 PANTHER:PTN000139394 RGD:61916 RGD:628817 RGD:71012 UniProtKB:O00144 UniProtKB:O19116 UniProtKB:O60353 UniProtKB:O75084 UniProtKB:Q14332 UniProtKB:Q99835 UniProtKB:Q9NPG1 UniProtKB:Q9ULV1 WB:WBGene00003006 ZFIN:ZDB-GENE-990415-223	C		Seeded From UniProt	complete
involved_in	GO:0090179	planar cell polarity pathway involved in neural tube closure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JIP6 ensembl:ENSMUSP00000091463	P		Seeded From UniProt	complete
involved_in	GO:0090103	cochlea morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JIP6 ensembl:ENSMUSP00000091463	P		Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JIP6 ensembl:ENSMUSP00000091463	P		Seeded From UniProt	complete
involved_in	GO:0060119	inner ear receptor cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JIP6 ensembl:ENSMUSP00000091463	P		Seeded From UniProt	complete
involved_in	GO:0060022	hard palate development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JIP6 ensembl:ENSMUSP00000091463	P		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JIP6 ensembl:ENSMUSP00000091463	F		Seeded From UniProt	complete
involved_in	GO:0030855	epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JIP6 ensembl:ENSMUSP00000091463	P		Seeded From UniProt	complete
involved_in	GO:0007608	sensory perception of smell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JIP6 ensembl:ENSMUSP00000091463	P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JIP6 ensembl:ENSMUSP00000091463	P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JIP6 ensembl:ENSMUSP00000091463	P		Seeded From UniProt	complete
involved_in	GO:0003150	muscular septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JIP6 ensembl:ENSMUSP00000091463	P		Seeded From UniProt	complete
involved_in	GO:0003149	membranous septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JIP6 ensembl:ENSMUSP00000091463	P		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	F		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000539 InterPro:IPR017981	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000539	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026550	P		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026550	F		Seeded From UniProt	complete
involved_in	GO:1904886	beta-catenin destruction complex disassembly	Reactome:R-HSA-4641262	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	Reactome:R-HSA-4086400	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030669	clathrin-coated endocytic vesicle membrane	Reactome:R-HSA-5140747	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007223	Wnt signaling pathway, calcium modulating pathway	Reactome:R-HSA-4086398	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-NUL-1458902 Reactome:R-HSA-5140747 Reactome:R-HSA-5140741 Reactome:R-HSA-3965447 Reactome:R-HSA-3965444 Reactome:R-HSA-201677 Reactome:R-HSA-1504186	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Voloshanenko, O et al. (2017) Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 31 4832-4844 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ ^4.0 ^4.1 Li, C et al. (2008) Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. BMC Mol. Biol. 9 11 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Verkaar, F et al. (2009) Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells. Cell. Signal. 21 22-33 PubMed GONUTS page
↑ Bazhin, AV et al. (2010) cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells. Cell. Mol. Life Sci. 67 817-28 PubMed GONUTS page
↑ Wang, HX et al. (2009) Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. Mol. Hum. Reprod. 15 11-7 PubMed GONUTS page
↑ Wheeler, DS et al. (2011) Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling. Oncogene 30 32-42 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Punchihewa, C et al. (2009) Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins. Protein Sci. 18 994-1002 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:28733458-1] 1.0 ^1.1 Voloshanenko, O et al. (2017) Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 31 4832-4844 PubMed GONUTS page

[PMID:24431302-2] 2.0 ^2.1 ^2.2 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page

[PMID:21423176-3] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:18215320-4] 4.0 ^4.1 Li, C et al. (2008) Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. BMC Mol. Biol. 9 11 PubMed GONUTS page

[PMID:18929644-5] 5.0 ^5.1 ^5.2 ^5.3 Verkaar, F et al. (2009) Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells. Cell. Signal. 21 22-33 PubMed GONUTS page

[PMID:19946729-6] Bazhin, AV et al. (2010) cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells. Cell. Mol. Life Sci. 67 817-28 PubMed GONUTS page

[PMID:19038973-7] Wang, HX et al. (2009) Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. Mol. Hum. Reprod. 15 11-7 PubMed GONUTS page

[PMID:20802536-8] Wheeler, DS et al. (2011) Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling. Oncogene 30 32-42 PubMed GONUTS page

[PMID:19388021-9] 9.0 ^9.1 ^9.2 Punchihewa, C et al. (2009) Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins. Protein Sci. 18 994-1002 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:FZD2

Contents

Annotations

Notes

References

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