GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:WNT2
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Wnt2 (synonyms: Irp, Wnt-2) | |
Protein Name(s) | Protein Wnt-2
INT-1-related protein IRP | |
External Links | ||
UniProt | P21552 | |
EMBL | AK012093 CH466533 BC026373 | |
CCDS | CCDS19928.1 | |
PIR | B36470 | |
RefSeq | NP_076142.3 | |
UniGene | Mm.33653 | |
ProteinModelPortal | P21552 | |
SMR | P21552 | |
BioGrid | 204572 | |
STRING | 10090.ENSMUSP00000010941 | |
PhosphoSite | P21552 | |
PaxDb | P21552 | |
PRIDE | P21552 | |
Ensembl | ENSMUST00000010941 | |
GeneID | 22413 | |
KEGG | mmu:22413 | |
UCSC | uc009bag.2 | |
CTD | 7472 | |
MGI | MGI:98954 | |
eggNOG | NOG284879 | |
GeneTree | ENSGT00760000118943 | |
HOGENOM | HOG000039529 | |
HOVERGEN | HBG001595 | |
InParanoid | P21552 | |
KO | K00182 | |
OMA | GYDTSRI | |
OrthoDB | EOG7C8GJ8 | |
TreeFam | TF105310 | |
Reactome | REACT_213918 REACT_250061 | |
NextBio | 302821 | |
PRO | PR:P21552 | |
Proteomes | UP000000589 | |
Bgee | P21552 | |
CleanEx | MM_WNT2 | |
ExpressionAtlas | P21552 | |
Genevestigator | P21552 | |
GO | GO:0005737 GO:0005615 GO:0005886 GO:0005578 GO:0005109 GO:0055009 GO:0060070 GO:0060317 GO:0071560 GO:0060716 GO:0030324 GO:0060492 GO:0061180 GO:0030182 GO:0090263 GO:0060045 GO:0001938 GO:0060501 GO:0048146 GO:0002053 GO:0051091 GO:0045944 GO:0016055 | |
InterPro | IPR005817 IPR009140 IPR018161 | |
PANTHER | PTHR12027 | |
Pfam | PF00110 | |
PRINTS | PR01842 PR01349 | |
SMART | SM00097 | |
PROSITE | PS00246 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0033278 |
cell proliferation in midbrain |
ECO:0000315 |
P |
Figure 5 shows lack of Wnt2 gene results in a decrease in midbrain length. |
complete | |||||
GO:0050769 |
positive regulation of neurogenesis |
ECO:0000314 |
P |
Figure 3 shows increased Wnt2 leads to increased number of DA neurons from precursor cells. |
complete | |||||
GO:0016055 |
Wnt receptor signaling pathway |
ECO:0000314 |
P |
Figure 2 shows Wnt2 activates the Beta-catenin/Wnt receptor signal pathway. |
complete | |||||
GO:0050769 |
positive regulation of neurogenesis |
ECO:0000315 |
P |
Figure 5 shows knockout of Wnt2 gene leads to decreased neurogenesis. |
complete | |||||
involved_in |
GO:0045165 |
cell fate commitment |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98957 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030182 |
neuron differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000246517 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0010194 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004009 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005109 |
frizzled binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004009 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0048146 |
positive regulation of fibroblast proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0048018 |
receptor ligand activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(MGI:MGI:107516) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0033278 |
cell proliferation in midbrain |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0031232 |
extrinsic component of external side of plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0016055 |
Wnt signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:108571 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007267 |
cell-cell signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621346 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005125 |
cytokine activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005109 |
frizzled binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0002053 |
positive regulation of mesenchymal cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4361155 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001938 |
positive regulation of endothelial cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621346 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:1904954 |
canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1904948 |
midbrain dopaminergic neuron differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0060716 |
labyrinthine layer blood vessel development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2177935 |
P |
results_in_development_of:(EMAPA:16042) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0060501 |
positive regulation of epithelial cell proliferation involved in lung morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4361155 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0060492 |
lung induction |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1261834 |
P |
has_participant:(EMAPA:16548) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0060317 |
cardiac epithelial to mesenchymal transition |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4361155 |
P |
occurs_in:(EMAPA:16546) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1261834 |
P |
occurs_in:(EMAPA:16548) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4361155 |
P |
occurs_in:(EMAPA:16546) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0060045 |
positive regulation of cardiac muscle cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4361155 |
P |
regulates_o_occurs_in:(EMAPA:17320)|regulates_o_occurs_in:(EMAPA:17326) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0055009 |
atrial cardiac muscle tissue morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4361155 |
P |
has_participant:(EMAPA:17320)|has_participant:(EMAPA:17326) |
Seeded From UniProt |
complete | |
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0048018 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1904954 |
canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09544 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1904948 |
midbrain dopaminergic neuron differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09544 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071560 |
cellular response to transforming growth factor beta stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09544 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09544 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0061180 |
mammary gland epithelium development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09544 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09544 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09544 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048146 |
positive regulation of fibroblast proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09544 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0048018 |
receptor ligand activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09544 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09544 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033278 |
cell proliferation in midbrain |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09544 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0031232 |
extrinsic component of external side of plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09544 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09544 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007267 |
cell-cell signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09544 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09544 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005125 |
cytokine activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09544 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005109 |
frizzled binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09544 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030324 |
lung development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q2IBD1 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q2IBD1 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001938 |
positive regulation of endothelial cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q2IBD1 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Sousa, KM et al. (2010) Wnt2 regulates progenitor proliferation in the developing ventral midbrain. J. Biol. Chem. 285 7246-53 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Tian, Y et al. (2010) Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. Dev. Cell 18 275-87 PubMed GONUTS page
- ↑ Ishikawa, T et al. (2001) Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development 128 25-33 PubMed GONUTS page
- ↑ Lu, J et al. (2013) A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 11 e1001536 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Goss, AM et al. (2009) Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev. Cell 17 290-8 PubMed GONUTS page
- ↑ Monkley, SJ et al. (1996) Targeted disruption of the Wnt2 gene results in placentation defects. Development 122 3343-53 PubMed GONUTS page
- ↑ Bafico, A et al. (1998) Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts. Oncogene 16 2819-25 PubMed GONUTS page
c
- GO:0060070 ! canonical Wnt signaling pathway
- GO:0060317 ! cardiac epithelial to mesenchymal transition
- GO:0007267 ! cell-cell signaling
- GO:0071560 ! cellular response to transforming growth factor beta stimulus
- GO:0045165 ! cell fate commitment
- GO:0033278 ! cell proliferation in midbrain
- Chordata
- Craniata
- GO:0005125 ! cytokine activity
- GO:0005737 ! cytoplasm
e
g
l
m
o
p
- GO:0060045 ! positive regulation of cardiac muscle cell proliferation
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0051091 ! positive regulation of DNA-binding transcription factor activity
- GO:0048146 ! positive regulation of fibroblast proliferation
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0002053 ! positive regulation of mesenchymal cell proliferation
- GO:0001938 ! positive regulation of endothelial cell proliferation
- GO:0060501 ! positive regulation of epithelial cell proliferation involved in lung morphogenesis
- GO:0050769 ! positive regulation of neurogenesis
r