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MOUSE:WNT2

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Wnt2 (synonyms: Irp, Wnt-2)
Protein Name(s) Protein Wnt-2

INT-1-related protein IRP

External Links
UniProt P21552
EMBL AK012093
CH466533
BC026373
CCDS CCDS19928.1
PIR B36470
RefSeq NP_076142.3
UniGene Mm.33653
ProteinModelPortal P21552
SMR P21552
BioGrid 204572
STRING 10090.ENSMUSP00000010941
PhosphoSite P21552
PaxDb P21552
PRIDE P21552
Ensembl ENSMUST00000010941
GeneID 22413
KEGG mmu:22413
UCSC uc009bag.2
CTD 7472
MGI MGI:98954
eggNOG NOG284879
GeneTree ENSGT00760000118943
HOGENOM HOG000039529
HOVERGEN HBG001595
InParanoid P21552
KO K00182
OMA GYDTSRI
OrthoDB EOG7C8GJ8
TreeFam TF105310
Reactome REACT_213918
REACT_250061
NextBio 302821
PRO PR:P21552
Proteomes UP000000589
Bgee P21552
CleanEx MM_WNT2
ExpressionAtlas P21552
Genevestigator P21552
GO GO:0005737
GO:0005615
GO:0005886
GO:0005578
GO:0005109
GO:0055009
GO:0060070
GO:0060317
GO:0071560
GO:0060716
GO:0030324
GO:0060492
GO:0061180
GO:0030182
GO:0090263
GO:0060045
GO:0001938
GO:0060501
GO:0048146
GO:0002053
GO:0051091
GO:0045944
GO:0016055
InterPro IPR005817
IPR009140
IPR018161
PANTHER PTHR12027
Pfam PF00110
PRINTS PR01842
PR01349
SMART SM00097
PROSITE PS00246

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0033278

cell proliferation in midbrain

PMID:20018874[1]

ECO:0000315

P

Figure 5 shows lack of Wnt2 gene results in a decrease in midbrain length.

complete
CACAO 6646

GO:0050769

positive regulation of neurogenesis

PMID:20018874[1]

ECO:0000314

P

Figure 3 shows increased Wnt2 leads to increased number of DA neurons from precursor cells.

complete
CACAO 6811

GO:0016055

Wnt receptor signaling pathway

PMID:20018874[1]

ECO:0000314

P

Figure 2 shows Wnt2 activates the Beta-catenin/Wnt receptor signal pathway.

complete
CACAO 6814

GO:0050769

positive regulation of neurogenesis

PMID:20018874[1]

ECO:0000315

P

Figure 5 shows knockout of Wnt2 gene leads to decreased neurogenesis.

complete
CACAO 6816

involved_in

GO:0045165

cell fate commitment

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98957
PANTHER:PTN000246517
UniProtKB:P49339
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000246517
RGD:69250
UniProtKB:P56706
UniProtKB:Q98SN7

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010194
MGI:MGI:108061
MGI:MGI:1197020
MGI:MGI:98953
MGI:MGI:98954
MGI:MGI:98956
MGI:MGI:98958
MGI:MGI:98960
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
UniProtKB:P41221
UniProtKB:Q98SN7
WB:WBGene00000858
WB:WBGene00003029
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
MGI:MGI:98956
MGI:MGI:98957
PANTHER:PTN000246517
RGD:1311441
RGD:69250
UniProtKB:P41221
UniProtKB:P56704
UniProtKB:P56705
UniProtKB:Q2LMP1
UniProtKB:Q9UBV4
UniProtKB:Q9YGX6

C

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
FB:FBgn0004360
FB:FBgn0010453
FB:FBgn0038134
MGI:MGI:98956
MGI:MGI:98957
MGI:MGI:98958
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
RGD:69079
UniProtKB:P09544
UniProtKB:P41221
UniProtKB:P56703
UniProtKB:Q98SN7

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051091

positive regulation of DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048146

positive regulation of fibroblast proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

enables

GO:0048018

receptor ligand activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:20159597[3]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:107516)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033278

cell proliferation in midbrain

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

part_of

GO:0031232

extrinsic component of external side of plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016055

Wnt signaling pathway

PMID:11092808[4]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:108571

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007267

cell-cell signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:23610556[5]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621346

C

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

F

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002053

positive regulation of mesenchymal cell proliferation

PMID:19686689[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4361155

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001938

positive regulation of endothelial cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621346

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1904954

canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1904948

midbrain dopaminergic neuron differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060716

labyrinthine layer blood vessel development

PMID:8951051[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2177935

P

results_in_development_of:(EMAPA:16042)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060501

positive regulation of epithelial cell proliferation involved in lung morphogenesis

PMID:19686689[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4361155

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060492

lung induction

PMID:19686689[6]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1261834

P

has_participant:(EMAPA:16548)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060317

cardiac epithelial to mesenchymal transition

PMID:20159597[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4361155

P

occurs_in:(EMAPA:16546)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060070

canonical Wnt signaling pathway

PMID:19686689[6]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1261834

P

occurs_in:(EMAPA:16548)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060070

canonical Wnt signaling pathway

PMID:20159597[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4361155

P

occurs_in:(EMAPA:16546)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060070

canonical Wnt signaling pathway

PMID:9652750[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060070

canonical Wnt signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060045

positive regulation of cardiac muscle cell proliferation

PMID:20159597[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4361155

P

regulates_o_occurs_in:(EMAPA:17320)|regulates_o_occurs_in:(EMAPA:17326)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0055009

atrial cardiac muscle tissue morphogenesis

PMID:20159597[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4361155

P

has_participant:(EMAPA:17320)|has_participant:(EMAPA:17326)

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048018

P

Seeded From UniProt

complete

involved_in

GO:1904954

canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

involved_in

GO:1904948

midbrain dopaminergic neuron differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

involved_in

GO:0071560

cellular response to transforming growth factor beta stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

C

Seeded From UniProt

complete

involved_in

GO:0061180

mammary gland epithelium development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

involved_in

GO:0051091

positive regulation of DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

involved_in

GO:0048146

positive regulation of fibroblast proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

enables

GO:0048018

receptor ligand activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

involved_in

GO:0033278

cell proliferation in midbrain

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

part_of

GO:0031232

extrinsic component of external side of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

C

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

involved_in

GO:0007267

cell-cell signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

C

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

F

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

F

Seeded From UniProt

complete

involved_in

GO:0030324

lung development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q2IBD1
ensembl:ENSRNOP00000071025

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q2IBD1
ensembl:ENSRNOP00000071025

C

Seeded From UniProt

complete

involved_in

GO:0001938

positive regulation of endothelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q2IBD1
ensembl:ENSRNOP00000071025

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009140

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009140

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009140

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009140

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Sousa, KM et al. (2010) Wnt2 regulates progenitor proliferation in the developing ventral midbrain. J. Biol. Chem. 285 7246-53 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Tian, Y et al. (2010) Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. Dev. Cell 18 275-87 PubMed GONUTS page
  4. Ishikawa, T et al. (2001) Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development 128 25-33 PubMed GONUTS page
  5. Lu, J et al. (2013) A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 11 e1001536 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Goss, AM et al. (2009) Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev. Cell 17 290-8 PubMed GONUTS page
  7. Monkley, SJ et al. (1996) Targeted disruption of the Wnt2 gene results in placentation defects. Development 122 3343-53 PubMed GONUTS page
  8. Bafico, A et al. (1998) Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts. Oncogene 16 2819-25 PubMed GONUTS page