MOUSE:WNT2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Wnt2 (synonyms: Irp, Wnt-2)
Protein Name(s)	Protein Wnt-2 INT-1-related protein IRP
External Links
UniProt	P21552
EMBL	AK012093 CH466533 BC026373
CCDS	CCDS19928.1
PIR	B36470
RefSeq	NP_076142.3
UniGene	Mm.33653
ProteinModelPortal	P21552
SMR	P21552
BioGrid	204572
STRING	10090.ENSMUSP00000010941
PhosphoSite	P21552
PaxDb	P21552
PRIDE	P21552
Ensembl	ENSMUST00000010941
GeneID	22413
KEGG	mmu:22413
UCSC	uc009bag.2
CTD	7472
MGI	MGI:98954
eggNOG	NOG284879
GeneTree	ENSGT00760000118943
HOGENOM	HOG000039529
HOVERGEN	HBG001595
InParanoid	P21552
KO	K00182
OMA	GYDTSRI
OrthoDB	EOG7C8GJ8
TreeFam	TF105310
Reactome	REACT_213918 REACT_250061
NextBio	302821
PRO	PR:P21552
Proteomes	UP000000589
Bgee	P21552
CleanEx	MM_WNT2
ExpressionAtlas	P21552
Genevestigator	P21552
GO	GO:0005737 GO:0005615 GO:0005886 GO:0005578 GO:0005109 GO:0055009 GO:0060070 GO:0060317 GO:0071560 GO:0060716 GO:0030324 GO:0060492 GO:0061180 GO:0030182 GO:0090263 GO:0060045 GO:0001938 GO:0060501 GO:0048146 GO:0002053 GO:0051091 GO:0045944 GO:0016055
InterPro	IPR005817 IPR009140 IPR018161
PANTHER	PTHR12027
Pfam	PF00110
PRINTS	PR01842 PR01349
SMART	SM00097
PROSITE	PS00246

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0033278	cell proliferation in midbrain	PMID:20018874^[1]	ECO:0000315			P		Figure 5 shows lack of Wnt2 gene results in a decrease in midbrain length.	complete CACAO 6646
	GO:0050769	positive regulation of neurogenesis	PMID:20018874^[1]	ECO:0000314			P		Figure 3 shows increased Wnt2 leads to increased number of DA neurons from precursor cells.	complete CACAO 6811
	GO:0016055	Wnt receptor signaling pathway	PMID:20018874^[1]	ECO:0000314			P		Figure 2 shows Wnt2 activates the Beta-catenin/Wnt receptor signal pathway.	complete CACAO 6814
	GO:0050769	positive regulation of neurogenesis	PMID:20018874^[1]	ECO:0000315			P		Figure 5 shows knockout of Wnt2 gene leads to decreased neurogenesis.	complete CACAO 6816
involved_in	GO:0045165	cell fate commitment	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98957 PANTHER:PTN000246517 UniProtKB:P49339 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246517 RGD:69250 UniProtKB:P56706 UniProtKB:Q98SN7	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010194 MGI:MGI:108061 MGI:MGI:1197020 MGI:MGI:98953 MGI:MGI:98954 MGI:MGI:98956 MGI:MGI:98958 MGI:MGI:98960 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 UniProtKB:P41221 UniProtKB:Q98SN7 WB:WBGene00000858 WB:WBGene00003029 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 MGI:MGI:98956 MGI:MGI:98957 PANTHER:PTN000246517 RGD:1311441 RGD:69250 UniProtKB:P41221 UniProtKB:P56704 UniProtKB:P56705 UniProtKB:Q2LMP1 UniProtKB:Q9UBV4 UniProtKB:Q9YGX6	C		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 FB:FBgn0004360 FB:FBgn0010453 FB:FBgn0038134 MGI:MGI:98956 MGI:MGI:98957 MGI:MGI:98958 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 RGD:69079 UniProtKB:P09544 UniProtKB:P41221 UniProtKB:P56703 UniProtKB:Q98SN7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09544	P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09544	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20159597^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:107516)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033278	cell proliferation in midbrain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09544	P		Seeded From UniProt	complete
part_of	GO:0031232	extrinsic component of external side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09544	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016055	Wnt signaling pathway	PMID:11092808^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108571	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007267	cell-cell signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09544	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23610556^[5]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09544	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09544	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621346	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09544	F		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09544	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002053	positive regulation of mesenchymal cell proliferation	PMID:19686689^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4361155	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621346	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904954	canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904948	midbrain dopaminergic neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09544	P		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09544	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060716	labyrinthine layer blood vessel development	PMID:8951051^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177935	P	results_in_development_of:(EMAPA:16042)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	PMID:19686689^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4361155	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060492	lung induction	PMID:19686689^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1261834	P	has_participant:(EMAPA:16548)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060317	cardiac epithelial to mesenchymal transition	PMID:20159597^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4361155	P	occurs_in:(EMAPA:16546)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:19686689^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1261834	P	occurs_in:(EMAPA:16548)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:20159597^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4361155	P	occurs_in:(EMAPA:16546)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:9652750^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060045	positive regulation of cardiac muscle cell proliferation	PMID:20159597^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4361155	P	regulates_o_occurs_in:(EMAPA:17320)\|regulates_o_occurs_in:(EMAPA:17326)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055009	atrial cardiac muscle tissue morphogenesis	PMID:20159597^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4361155	P	has_participant:(EMAPA:17320)\|has_participant:(EMAPA:17326)	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:1904954	canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P		Seeded From UniProt	complete
involved_in	GO:1904948	midbrain dopaminergic neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	C		Seeded From UniProt	complete
involved_in	GO:0061180	mammary gland epithelium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P		Seeded From UniProt	complete
involved_in	GO:0033278	cell proliferation in midbrain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P		Seeded From UniProt	complete
part_of	GO:0031232	extrinsic component of external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	C		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	F		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	F		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q2IBD1 ensembl:ENSRNOP00000071025	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q2IBD1 ensembl:ENSRNOP00000071025	C		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q2IBD1 ensembl:ENSRNOP00000071025	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009140	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009140	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009140	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009140	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Sousa, KM et al. (2010) Wnt2 regulates progenitor proliferation in the developing ventral midbrain. J. Biol. Chem. 285 7246-53 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Tian, Y et al. (2010) Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. Dev. Cell 18 275-87 PubMed GONUTS page
↑ Ishikawa, T et al. (2001) Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development 128 25-33 PubMed GONUTS page
↑ Lu, J et al. (2013) A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 11 e1001536 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Goss, AM et al. (2009) Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev. Cell 17 290-8 PubMed GONUTS page
↑ Monkley, SJ et al. (1996) Targeted disruption of the Wnt2 gene results in placentation defects. Development 122 3343-53 PubMed GONUTS page
↑ Bafico, A et al. (1998) Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts. Oncogene 16 2819-25 PubMed GONUTS page

[PMID:20018874-1] 1.0 ^1.1 ^1.2 ^1.3 Sousa, KM et al. (2010) Wnt2 regulates progenitor proliferation in the developing ventral midbrain. J. Biol. Chem. 285 7246-53 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20159597-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Tian, Y et al. (2010) Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. Dev. Cell 18 275-87 PubMed GONUTS page

[PMID:11092808-4] Ishikawa, T et al. (2001) Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development 128 25-33 PubMed GONUTS page

[PMID:23610556-5] Lu, J et al. (2013) A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 11 e1001536 PubMed GONUTS page

[PMID:19686689-6] 6.0 ^6.1 ^6.2 ^6.3 Goss, AM et al. (2009) Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev. Cell 17 290-8 PubMed GONUTS page

[PMID:8951051-7] Monkley, SJ et al. (1996) Targeted disruption of the Wnt2 gene results in placentation defects. Development 122 3343-53 PubMed GONUTS page

[PMID:9652750-8] Bafico, A et al. (1998) Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts. Oncogene 16 2819-25 PubMed GONUTS page

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MOUSE:WNT2

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