HUMAN:WNT1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	WNT1 (synonyms: INT1)
Protein Name(s)	Proto-oncogene Wnt-1 Proto-oncogene Int-1 homolog
External Links
UniProt	P04628
EMBL	X03072 BT019429 CH471111 BC074798 BC074799
CCDS	CCDS8776.1
PIR	A24674
RefSeq	NP_005421.1
UniGene	Hs.248164
ProteinModelPortal	P04628
SMR	P04628
BioGrid	113308
STRING	9606.ENSP00000293549
PhosphoSite	P04628
DMDM	139743
PaxDb	P04628
PRIDE	P04628
DNASU	7471
Ensembl	ENST00000293549
GeneID	7471
KEGG	hsa:7471
UCSC	uc001rsu.3
CTD	7471
GeneCards	GC12P049372
HGNC	HGNC:12774
MIM	164820 166710 615220 615221
neXtProt	NX_P04628
Orphanet	85193 216812 216820
PharmGKB	PA37376
eggNOG	NOG284879
GeneTree	ENSGT00760000118943
HOGENOM	HOG000039528
HOVERGEN	HBG001595
InParanoid	P04628
KO	K03209
OMA	AIKECKW
OrthoDB	EOG7C8GJ8
PhylomeDB	P04628
TreeFam	TF105310
Reactome	REACT_163710 REACT_172581 REACT_18372 REACT_200610 REACT_200777 REACT_27161
SignaLink	P04628
GeneWiki	WNT1
GenomeRNAi	7471
NextBio	29264
PRO	PR:P04628
Proteomes	UP000005640
Bgee	P04628
CleanEx	HS_WNT1
Genevestigator	P04628
GO	GO:0009986 GO:0005737 GO:0005788 GO:0005576 GO:0005615 GO:0005796 GO:0005886 GO:0005578 GO:0005125 GO:0005109 GO:0048018 GO:0044212 GO:0060348 GO:0001658 GO:0060070 GO:0044336 GO:0045165 GO:0007267 GO:0071375 GO:0021551 GO:0021588 GO:0021536 GO:0000578 GO:0021797 GO:0071425 GO:0070365 GO:0042472 GO:0030901 GO:0022004 GO:0007520 GO:0030514 GO:0090344 GO:0022408 GO:0010812 GO:0045599 GO:2000059 GO:0030512 GO:0030182 GO:0048664 GO:0031100 GO:0008284 GO:0061184 GO:0048146 GO:0043568 GO:0010592 GO:0045747 GO:0001934 GO:0051091 GO:0045944 GO:0045893 GO:0009611 GO:0042770 GO:0060061 GO:0021527 GO:0033077 GO:0030579 GO:0016055
InterPro	IPR005817 IPR009139 IPR018161
PANTHER	PTHR12027
Pfam	PF00110
PRINTS	PR01841 PR01349
SMART	SM00097
PROSITE	PS00246

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:12154096^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:28733458^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:28733458^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:23461676^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F	part_of:(GO:0060070) has_input:(UniProtKB:Q9UP38)	Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:23461676^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F	has_direct_input:(UniProtKB:Q9UP38) part_of:(GO:0060070)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:23461676^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	part_of:(GO:0071542)	Seeded From UniProt	complete
involved_in	GO:1904953	Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	PMID:23461676^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	PMID:16194878^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090344	negative regulation of cell aging	PMID:16501043^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061184	positive regulation of dermatome development	PMID:10654605^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:19756656^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:19778454^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060061	Spemann organizer formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04426	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04426	P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	PMID:19734317^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:19778454^[8]	ECO:0000305	curator inference used in manual assertion	GO:0060070	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10644691^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04426	P		Seeded From UniProt	complete
involved_in	GO:0045747	positive regulation of Notch signaling pathway	PMID:16501043^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04426	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:12154096^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0043066)	Seeded From UniProt	complete
involved_in	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	PMID:12154096^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042770	signal transduction in response to DNA damage	PMID:16501043^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030901	midbrain development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04426	P		Seeded From UniProt	complete
involved_in	GO:0022408	negative regulation of cell-cell adhesion	PMID:17072303^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021588	cerebellum formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04426	P		Seeded From UniProt	complete
involved_in	GO:0021551	central nervous system morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04426	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:10644691^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010812	negative regulation of cell-substrate adhesion	PMID:16501043^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010592	positive regulation of lamellipodium assembly	PMID:19756656^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:19778454^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:16501043^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04426	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19756656^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04426	F		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:19756656^[7]	ECO:0000305	curator inference used in manual assertion	GO:0060070	F		Seeded From UniProt	complete
involved_in	GO:0000578	embryonic axis specification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04426	P		Seeded From UniProt	complete
involved_in	GO:0060348	bone development	PMID:23499309^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19847889^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:19847889^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	PMID:17982423^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11793365^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98957 PANTHER:PTN000246517 UniProtKB:P49339 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246517 RGD:69250 UniProtKB:P56706 UniProtKB:Q98SN7	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010194 MGI:MGI:108061 MGI:MGI:1197020 MGI:MGI:98953 MGI:MGI:98954 MGI:MGI:98956 MGI:MGI:98958 MGI:MGI:98960 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 UniProtKB:P41221 UniProtKB:Q98SN7 WB:WBGene00000858 WB:WBGene00003029 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 MGI:MGI:98956 MGI:MGI:98957 PANTHER:PTN000246517 RGD:1311441 RGD:69250 UniProtKB:P41221 UniProtKB:P56704 UniProtKB:P56705 UniProtKB:Q2LMP1 UniProtKB:Q9UBV4 UniProtKB:Q9YGX6	C		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 FB:FBgn0004360 FB:FBgn0010453 FB:FBgn0038134 MGI:MGI:98956 MGI:MGI:98957 MGI:MGI:98958 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 RGD:69079 UniProtKB:P09544 UniProtKB:P41221 UniProtKB:P56703 UniProtKB:Q98SN7	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016015	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0071375	cellular response to peptide hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A9J2 ensembl:ENSRNOP00000071688	P		Seeded From UniProt	complete
involved_in	GO:0070365	hepatocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A9J2 ensembl:ENSRNOP00000071688	P		Seeded From UniProt	complete
involved_in	GO:0031100	animal organ regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A9J2 ensembl:ENSRNOP00000071688	P		Seeded From UniProt	complete
involved_in	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:1990403	embryonic brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:1904954	canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:1904948	midbrain dopaminergic neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:1903204	negative regulation of oxidative stress-induced neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0071542	dopaminergic neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0071425	hematopoietic stem cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0060061	Spemann organizer formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0048664	neuron fate determination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0048663	neuron fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0045596	negative regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0042472	inner ear morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0036520	astrocyte-dopaminergic neuron signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0033278	cell proliferation in midbrain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0033077	T cell differentiation in thymus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0030917	midbrain-hindbrain boundary development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0030901	midbrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0030579	ubiquitin-dependent SMAD protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0022037	metencephalon development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0022008	neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0022004	midbrain-hindbrain boundary maturation during brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0021797	forebrain anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0021588	cerebellum formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0021551	central nervous system morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0021549	cerebellum development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0021536	diencephalon development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0021527	spinal cord association neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	F		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0014902	myotube differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	C		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0007520	myoblast fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
involved_in	GO:0000578	embryonic axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04426 ensembl:ENSMUSP00000023734	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009139	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009139	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009139	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009139	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:26049140^[17] PMID:24431302^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:2000097)	Seeded From UniProt	complete
enables	GO:0016015	morphogen activity	PMID:24431302^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	part_of:(GO:0071542)	Seeded From UniProt	complete
involved_in	GO:1904953	Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	PMID:24431302^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904954	canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	PMID:22988876^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904886	beta-catenin destruction complex disassembly	Reactome:R-HSA-4641262	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	Reactome:R-HSA-3781941	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	Reactome:R-HSA-4086400	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030666	endocytic vesicle membrane	Reactome:R-HSA-3781943 Reactome:R-HSA-3781941	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	Reactome:R-HSA-195721	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-3781943 Reactome:R-HSA-3247844 Reactome:R-HSA-3247843	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005796	Golgi lumen	Reactome:R-HSA-3247844 Reactome:R-HSA-3247840 Reactome:R-HSA-3247837	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-3247837	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-209104 Reactome:R-NUL-1458902 Reactome:R-HSA-5323545 Reactome:R-HSA-3858482 Reactome:R-HSA-3247843 Reactome:R-HSA-201677 Reactome:R-HSA-1504186	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Longo, KA et al. (2002) Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. J. Biol. Chem. 277 38239-44 PubMed GONUTS page
↑ ^2.0 ^2.1 Voloshanenko, O et al. (2017) Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 31 4832-4844 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Marchetti, B et al. (2013) Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair. Eur. J. Neurosci. 37 1550-63 PubMed GONUTS page
↑ Zhang, WV & Stott, NS () BMP-2-modulated chondrogenic differentiation in vitro involves down-regulation of membrane-bound beta-catenin. Cell Commun. Adhes. 11 89-102 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Ayyanan, A et al. (2006) Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc. Natl. Acad. Sci. U.S.A. 103 3799-804 PubMed GONUTS page
↑ Lee, CS et al. (2000) SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development 127 109-18 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Zhang, L et al. (2009) The effect on cell growth by Wnt1 RNAi in human neuroblastoma SH-SY5Y cell line. Pediatr. Surg. Int. 25 1065-71 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Wei, W et al. (2009) Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells. Mol. Cancer 8 76 PubMed GONUTS page
↑ Salazar, KD et al. (2009) Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. Am. J. Physiol. Lung Cell Mol. Physiol. 297 L1002-11 PubMed GONUTS page
↑ ^10.0 ^10.1 Strovel, ET et al. (2000) Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription. J. Biol. Chem. 275 2399-403 PubMed GONUTS page
↑ Yook, JI et al. (2006) A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat. Cell Biol. 8 1398-406 PubMed GONUTS page
↑ Keupp, K et al. (2013) Mutations in WNT1 cause different forms of bone fragility. Am. J. Hum. Genet. 92 565-74 PubMed GONUTS page
↑ ^13.0 ^13.1 Pizzatti, L et al. (2010) SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia. Genes Chromosomes Cancer 49 107-18 PubMed GONUTS page
↑ McGowan, SL et al. (2007) Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas. Mol. Vis. 13 1984-2000 PubMed GONUTS page
↑ Wong, SC et al. (2002) Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours. J. Pathol. 196 145-53 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Zhang, J et al. (2015) A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice. Neurobiol. Dis. 82 32-45 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page
↑ Berwick, DC & Harvey, K (2012) The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem. Soc. Trans. 40 1123-8 PubMed GONUTS page

[PMID:12154096-1] 1.0 ^1.1 ^1.2 Longo, KA et al. (2002) Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. J. Biol. Chem. 277 38239-44 PubMed GONUTS page

[PMID:28733458-2] 2.0 ^2.1 Voloshanenko, O et al. (2017) Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 31 4832-4844 PubMed GONUTS page

[PMID:23461676-3] 3.0 ^3.1 ^3.2 ^3.3 Marchetti, B et al. (2013) Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair. Eur. J. Neurosci. 37 1550-63 PubMed GONUTS page

[PMID:16194878-4] Zhang, WV & Stott, NS () BMP-2-modulated chondrogenic differentiation in vitro involves down-regulation of membrane-bound beta-catenin. Cell Commun. Adhes. 11 89-102 PubMed GONUTS page

[PMID:16501043-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Ayyanan, A et al. (2006) Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc. Natl. Acad. Sci. U.S.A. 103 3799-804 PubMed GONUTS page

[PMID:10654605-6] Lee, CS et al. (2000) SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development 127 109-18 PubMed GONUTS page

[PMID:19756656-7] 7.0 ^7.1 ^7.2 ^7.3 Zhang, L et al. (2009) The effect on cell growth by Wnt1 RNAi in human neuroblastoma SH-SY5Y cell line. Pediatr. Surg. Int. 25 1065-71 PubMed GONUTS page

[PMID:19778454-8] 8.0 ^8.1 ^8.2 Wei, W et al. (2009) Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells. Mol. Cancer 8 76 PubMed GONUTS page

[PMID:19734317-9] Salazar, KD et al. (2009) Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. Am. J. Physiol. Lung Cell Mol. Physiol. 297 L1002-11 PubMed GONUTS page

[PMID:10644691-10] 10.0 ^10.1 Strovel, ET et al. (2000) Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription. J. Biol. Chem. 275 2399-403 PubMed GONUTS page

[PMID:17072303-11] Yook, JI et al. (2006) A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat. Cell Biol. 8 1398-406 PubMed GONUTS page

[PMID:23499309-12] Keupp, K et al. (2013) Mutations in WNT1 cause different forms of bone fragility. Am. J. Hum. Genet. 92 565-74 PubMed GONUTS page

[PMID:19847889-13] 13.0 ^13.1 Pizzatti, L et al. (2010) SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia. Genes Chromosomes Cancer 49 107-18 PubMed GONUTS page

[PMID:17982423-14] McGowan, SL et al. (2007) Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas. Mol. Vis. 13 1984-2000 PubMed GONUTS page

[PMID:11793365-15] Wong, SC et al. (2002) Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours. J. Pathol. 196 145-53 PubMed GONUTS page

[PMID:21873635-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26049140-17] Zhang, J et al. (2015) A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice. Neurobiol. Dis. 82 32-45 PubMed GONUTS page

[PMID:24431302-18] 18.0 ^18.1 ^18.2 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page

[PMID:22988876-19] Berwick, DC & Harvey, K (2012) The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem. Soc. Trans. 40 1123-8 PubMed GONUTS page

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