HUMAN:WNT7A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	WNT7A
Protein Name(s)	Protein Wnt-7a
External Links
UniProt	O00755
EMBL	U53476 D83175 CH471055 BC008811
CCDS	CCDS2616.1
RefSeq	NP_004616.2
UniGene	Hs.72290
ProteinModelPortal	O00755
SMR	O00755
IntAct	O00755
MINT	MINT-1379349
STRING	9606.ENSP00000285018
PhosphoSite	O00755
MaxQB	O00755
PaxDb	O00755
PRIDE	O00755
DNASU	7476
Ensembl	ENST00000285018
GeneID	7476
KEGG	hsa:7476
UCSC	uc003bye.1
CTD	7476
GeneCards	GC03M013835
HGNC	HGNC:12786
HPA	CAB025894 HPA015719
MIM	228930 276820 601570
neXtProt	NX_O00755
Orphanet	2854 2879
PharmGKB	PA37387
eggNOG	NOG284879
GeneTree	ENSGT00760000118943
HOGENOM	HOG000039528
HOVERGEN	HBG001595
InParanoid	O00755
KO	K00572
OMA	YIDKSPN
OrthoDB	EOG7C8GJ8
PhylomeDB	O00755
TreeFam	TF105310
Reactome	REACT_163710 REACT_18372
SignaLink	O00755
ChiTaRS	WNT7A
GeneWiki	WNT7A
GenomeRNAi	7476
NextBio	29284
PRO	PR:O00755
Proteomes	UP000005640
Bgee	O00755
CleanEx	HS_WNT7A
Genevestigator	O00755
GO	GO:0009986 GO:0005788 GO:0005576 GO:0005615 GO:0005796 GO:0005886 GO:0005578 GO:0005125 GO:0005109 GO:0048018 GO:0005102 GO:0008105 GO:0060070 GO:0001502 GO:0045165 GO:0021846 GO:0071560 GO:0022009 GO:0021707 GO:0002062 GO:0009953 GO:0000578 GO:0042733 GO:0035115 GO:0035116 GO:0030010 GO:0070307 GO:0043066 GO:0050768 GO:0030182 GO:0007269 GO:0035567 GO:0060066 GO:0060021 GO:0090263 GO:0060054 GO:0046330 GO:0051965 GO:0045944 GO:0045893 GO:0031133 GO:0032355 GO:0007548 GO:0014719 GO:0014834 GO:0048103 GO:0035019 GO:0048864 GO:0050808 GO:0061038 GO:0035659
InterPro	IPR005817 IPR013300 IPR018161
PANTHER	PTHR12027
Pfam	PF00110
PRINTS	PR01891 PR01349
SMART	SM00097
PROSITE	PS00246

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005102	receptor binding		ECO:0000303			F		Source: ProtInc	Missing: reference
	GO:0007548	sex differentiation		ECO:0000304			P		Source: ProtInc	Missing: reference
	GO:0007165	signal transduction		ECO:0000303			P		Source: ProtInc	Missing: reference
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	PMID:15802269^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0035313) occurs_in:(CL:0000575)\|positively_regulates(GO:0060054) occurs_in:(CL:0000575)	Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:28733458^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:28733458^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:21670302^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:1904891	positive regulation of excitatory synapse assembly	PMID:21670302^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	PMID:21670302^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:16805831^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032270	positive regulation of cellular protein metabolic process	PMID:16805831^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9WU82) regulates_o_occurs_in:(GO:0005634)	Seeded From UniProt	complete
involved_in	GO:0002062	chondrocyte differentiation	PMID:17202865^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001502	cartilage condensation	PMID:17202865^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:8893824^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070307	lens fiber cell development	PMID:16258938^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9DEB8	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:18986540^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:15802269^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0035313) occurs_in:(CL:0000575)\|positively_regulates(GO:0060054) occurs_in:(CL:0000575)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:12857724^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing	PMID:15802269^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000575)	Seeded From UniProt	complete
involved_in	GO:0062009	secondary palate development	PMID:18413325^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	PMID:18986540^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050768	negative regulation of neurogenesis	PMID:12843296^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048864	stem cell development	PMID:12843296^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:18986540^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:15802269^[1]	ECO:0000305	curator inference used in manual assertion	GO:0060070	F	occurs_in:(CL:0000575)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12857724^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15802269^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0035313) occurs_in:(CL:0000575)\|positively_regulates(GO:0060054) occurs_in:(CL:0000575)	Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	PMID:16826533^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035313	wound healing, spreading of epidermal cells	PMID:15802269^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000575)	Seeded From UniProt	complete
involved_in	GO:0035116	embryonic hindlimb morphogenesis	PMID:16826533^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035115	embryonic forelimb morphogenesis	PMID:16826533^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021846	cell proliferation in forebrain	PMID:12843296^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:18986540^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:12857724^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13467	F		Seeded From UniProt	complete
involved_in	GO:0000578	embryonic axis specification	PMID:16826533^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	PMID:15040835^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	PMID:20530549^[14]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	PMID:20530549^[14]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	PMID:20530549^[14]	ECO:0006052	RNAi evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	PMID:20530549^[14]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:20530549^[14]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:20530549^[14]	ECO:0006054	pharmacological assay evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:20530549^[14]	ECO:0006052	RNAi evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:20530549^[14]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246719 RGD:69079	P		Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98957 PANTHER:PTN000246517 UniProtKB:P49339 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246517 RGD:69250 UniProtKB:P56706 UniProtKB:Q98SN7	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010194 MGI:MGI:108061 MGI:MGI:1197020 MGI:MGI:98953 MGI:MGI:98954 MGI:MGI:98956 MGI:MGI:98958 MGI:MGI:98960 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 UniProtKB:P41221 UniProtKB:Q98SN7 WB:WBGene00000858 WB:WBGene00003029 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 MGI:MGI:98956 MGI:MGI:98957 PANTHER:PTN000246517 RGD:1311441 RGD:69250 UniProtKB:P41221 UniProtKB:P56704 UniProtKB:P56705 UniProtKB:Q2LMP1 UniProtKB:Q9UBV4 UniProtKB:Q9YGX6	C		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 FB:FBgn0004360 FB:FBgn0010453 FB:FBgn0038134 MGI:MGI:98956 MGI:MGI:98957 MGI:MGI:98958 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 RGD:69079 UniProtKB:P09544 UniProtKB:P41221 UniProtKB:P56703 UniProtKB:Q98SN7	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0007269	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0036465	C		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:M0R9D3 ensembl:ENSRNOP00000066101	P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:M0R9D3 ensembl:ENSRNOP00000066101	P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:M0R9D3 ensembl:ENSRNOP00000066101	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:M0R9D3 ensembl:ENSRNOP00000066101	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:M0R9D3 ensembl:ENSRNOP00000066101	P		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:M0R9D3 ensembl:ENSRNOP00000066101	F		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0099175	regulation of postsynapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	C		Seeded From UniProt	complete
involved_in	GO:0061038	uterus morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0060173	limb development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0060066	oviduct development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0060065	uterus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0050770	regulation of axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0048103	somatic stem cell division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0045167	asymmetric protein localization involved in cell fate determination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0035567	non-canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0035116	embryonic hindlimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0035115	embryonic forelimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0035019	somatic stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0031133	regulation of axon diameter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	C		Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0030010	establishment of cell polarity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0022009	central nervous system vasculogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0021707	cerebellar granule cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0014719	skeletal muscle satellite cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	C		Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
involved_in	GO:0007269	neurotransmitter secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P24383 ensembl:ENSMUSP00000032180	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR013300	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR013300	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR013300	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR013300	P		Seeded From UniProt	complete
involved_in	GO:0099068	postsynapse assembly	PMID:24449494^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0099054	presynapse assembly	PMID:24449494^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:1904861	excitatory synapse assembly	PMID:24449494^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905386	positive regulation of protein localization to presynapse	PMID:24449494^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	part_of:(GO:0007416)	Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	PMID:24449494^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	part_of:(GO:0007416) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0036465	synaptic vesicle recycling	PMID:22988876^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_at:(GO:0098793)	Seeded From UniProt	complete
involved_in	GO:0007548	sex differentiation	PMID:9790192^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	Reactome:R-HSA-3781941	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030666	endocytic vesicle membrane	Reactome:R-HSA-3781943 Reactome:R-HSA-3781941	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	Reactome:R-HSA-195721	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-3781943 Reactome:R-HSA-3247844 Reactome:R-HSA-3247843	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005796	Golgi lumen	Reactome:R-HSA-3247844 Reactome:R-HSA-3247840 Reactome:R-HSA-3247837	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-3247837	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-3247843	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Lyu, J & Joo, CK (2005) Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing. J. Biol. Chem. 280 21653-60 PubMed GONUTS page
↑ ^2.0 ^2.1 Voloshanenko, O et al. (2017) Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 31 4832-4844 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Ciani, L et al. (2011) Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca²⁺/Calmodulin-dependent protein kinase II. Proc. Natl. Acad. Sci. U.S.A. 108 10732-7 PubMed GONUTS page
↑ ^4.0 ^4.1 Caruso, A et al. (2006) Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells. J. Neurochem. 98 364-71 PubMed GONUTS page
↑ ^5.0 ^5.1 Jin, EJ et al. (2006) BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway. Mol. Cells 22 353-9 PubMed GONUTS page
↑ Ikegawa, S et al. (1996) Isolation, characterization and chromosomal assignment of the human WNT7A gene. Cytogenet. Cell Genet. 74 149-52 PubMed GONUTS page
↑ Fokina, VM & Frolova, EI (2006) Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Dev. Dyn. 235 496-505 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Davis, EK et al. (2008) Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation. Neural Dev 3 32 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Caricasole, A et al. (2003) Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. J. Biol. Chem. 278 37024-31 PubMed GONUTS page
↑ Chiquet, BT et al. (2008) Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. Hum. Mol. Genet. 17 2212-8 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Viti, J et al. (2003) Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2. J. Neurosci. 23 5919-27 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Woods, CG et al. (2006) Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome. Am. J. Hum. Genet. 79 402-8 PubMed GONUTS page
↑ Zhou, S et al. (2004) Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J. Bone Miner. Res. 19 463-70 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 Sahores, M et al. (2010) Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis. Development 137 2215-25 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 Purro, SA et al. (2014) Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases. J Mol Cell Biol 6 75-80 PubMed GONUTS page
↑ Berwick, DC & Harvey, K (2012) The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem. Soc. Trans. 40 1123-8 PubMed GONUTS page
↑ Parr, BA & McMahon, AP (1998) Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. Nature 395 707-10 PubMed GONUTS page

[PMID:15802269-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Lyu, J & Joo, CK (2005) Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing. J. Biol. Chem. 280 21653-60 PubMed GONUTS page

[PMID:28733458-2] 2.0 ^2.1 Voloshanenko, O et al. (2017) Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 31 4832-4844 PubMed GONUTS page

[PMID:21670302-3] 3.0 ^3.1 ^3.2 Ciani, L et al. (2011) Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca²⁺/Calmodulin-dependent protein kinase II. Proc. Natl. Acad. Sci. U.S.A. 108 10732-7 PubMed GONUTS page

[PMID:16805831-4] 4.0 ^4.1 Caruso, A et al. (2006) Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells. J. Neurochem. 98 364-71 PubMed GONUTS page

[PMID:17202865-5] 5.0 ^5.1 Jin, EJ et al. (2006) BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway. Mol. Cells 22 353-9 PubMed GONUTS page

[PMID:8893824-6] Ikegawa, S et al. (1996) Isolation, characterization and chromosomal assignment of the human WNT7A gene. Cytogenet. Cell Genet. 74 149-52 PubMed GONUTS page

[PMID:16258938-7] Fokina, VM & Frolova, EI (2006) Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Dev. Dyn. 235 496-505 PubMed GONUTS page

[PMID:18986540-8] 8.0 ^8.1 ^8.2 ^8.3 Davis, EK et al. (2008) Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation. Neural Dev 3 32 PubMed GONUTS page

[PMID:12857724-9] 9.0 ^9.1 ^9.2 Caricasole, A et al. (2003) Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. J. Biol. Chem. 278 37024-31 PubMed GONUTS page

[PMID:18413325-10] Chiquet, BT et al. (2008) Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. Hum. Mol. Genet. 17 2212-8 PubMed GONUTS page

[PMID:12843296-11] 11.0 ^11.1 ^11.2 Viti, J et al. (2003) Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2. J. Neurosci. 23 5919-27 PubMed GONUTS page

[PMID:16826533-12] 12.0 ^12.1 ^12.2 ^12.3 Woods, CG et al. (2006) Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome. Am. J. Hum. Genet. 79 402-8 PubMed GONUTS page

[PMID:15040835-13] Zhou, S et al. (2004) Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J. Bone Miner. Res. 19 463-70 PubMed GONUTS page

[PMID:20530549-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 Sahores, M et al. (2010) Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis. Development 137 2215-25 PubMed GONUTS page

[PMID:21873635-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24449494-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 Purro, SA et al. (2014) Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases. J Mol Cell Biol 6 75-80 PubMed GONUTS page

[PMID:22988876-17] Berwick, DC & Harvey, K (2012) The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem. Soc. Trans. 40 1123-8 PubMed GONUTS page

[PMID:9790192-18] Parr, BA & McMahon, AP (1998) Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. Nature 395 707-10 PubMed GONUTS page

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