MOUSE:SFRP2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Sfrp2 (synonyms: Sarp1, Sdf5)
Protein Name(s)	Secreted frizzled-related protein 2 sFRP-2 Protein SDF5 Secreted apoptosis-related protein 1 SARP-1
External Links
UniProt	P97299
EMBL	D50462 U88567 AF017989 BC014722
CCDS	CCDS17434.1
RefSeq	NP_033170.1
UniGene	Mm.19155
ProteinModelPortal	P97299
SMR	P97299
BioGrid	203142
DIP	DIP-59486N
MEROPS	I93.001
PhosphoSite	P97299
PRIDE	P97299
Ensembl	ENSMUST00000029625
GeneID	20319
KEGG	mmu:20319
UCSC	uc008ppl.2
CTD	6423
MGI	MGI:108078
eggNOG	NOG240950
HOGENOM	HOG000231058
HOVERGEN	HBG052928
InParanoid	P97299
KO	K02176
OMA	TSLKRWQ
OrthoDB	EOG789CBZ
PhylomeDB	P97299
TreeFam	TF350133
Reactome	REACT_210612
ChiTaRS	Sfrp2
NextBio	298111
PRO	PR:P97299
Proteomes	UP000000589
Bgee	P97299
CleanEx	MM_SFRP2
ExpressionAtlas	P97299
Genevestigator	P97299
GO	GO:0005737 GO:0005615 GO:0005886 GO:0061133 GO:0010577 GO:0030165 GO:0048018 GO:0042813 GO:0017147 GO:0009952 GO:0006915 GO:0060349 GO:0007420 GO:0003214 GO:0051216 GO:0031668 GO:0071481 GO:0002063 GO:0030199 GO:0060028 GO:0046546 GO:0048546 GO:0042733 GO:0071425 GO:0008584 GO:0030514 GO:0090090 GO:0010667 GO:0030308 GO:0030336 GO:0043154 GO:0061185 GO:0050680 GO:0010719 GO:1902042 GO:0010629 GO:0043508 GO:0042662 GO:0050732 GO:2000041 GO:0045892 GO:0030178 GO:0001843 GO:0021915 GO:0003151 GO:0001569 GO:0090179 GO:0045766 GO:0043065 GO:0090263 GO:0035413 GO:0030307 GO:0008284 GO:0010950 GO:0045600 GO:0045669 GO:0033138 GO:0045944 GO:0036342 GO:0042981 GO:0042127 GO:0090175 GO:2000035 GO:0030111 GO:0042493 GO:0007584 GO:0061056 GO:0001756 GO:0090244
Gene3D	1.10.2000.10
InterPro	IPR015526 IPR020067 IPR001134 IPR018933 IPR026558 IPR008993
PANTHER	PTHR11309 PTHR11309:SF45
Pfam	PF01392 PF01759
SMART	SM00643 SM00063
SUPFAM	SSF50242 SSF63501
PROSITE	PS50038 PS50189

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0035413	positive regulation of catenin protein nuclear translocation	PMID:20723538^[1]	ECO:0000314			P		Figure 1B: induction of beta-catenin protein level upon Wnt3a/sFRP2 showed increased beta-catenin nuclear translocation	complete
	GO:0001934	positive regulation of protein phosphorylation	PMID:20723538^[1]	ECO:0000314			P		Figure 1D: Treatment with both Wnt3a and sFRP2 augmented the LRP6 phosphorylation in HEK293A cells.	complete
	GO:0045941	positive regulation of transcription	PMID:20723538^[1]	ECO:0000314			P		Figure 3:When Wnt3a plus sFRP2 were used for treatment of Wnt11 showed enhanced mRNA expression.	complete
involved_in	GO:0030178	negative regulation of Wnt signaling pathway	PMID:11357136^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904956	regulation of midbrain dopaminergic neuron differentiation	PMID:22290867^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8C4U3	P		Seeded From UniProt	complete
involved_in	GO:0010975	regulation of neuron projection development	PMID:22290867^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000700)	Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:19001373^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0002563)	Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	PMID:9391078^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:20723538^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061185	negative regulation of dermatome development	PMID:10654605^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061056	sclerotome development	PMID:10654605^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:20723538^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20723538^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:19458075^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:20723538^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030178	negative regulation of Wnt signaling pathway	PMID:10654605^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10654605^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	PMID:19458075^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000035	regulation of stem cell division	PMID:19778523^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071481	cellular response to X-ray	PMID:19778523^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071425	hematopoietic stem cell proliferation	PMID:19778523^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	PMID:10980594^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:19778523^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	PMID:10980594^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	PMID:10980594^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030111	regulation of Wnt signaling pathway	PMID:9391078^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:10980594^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:10980594^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10980594^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:9391078^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108078 MGI:MGI:892014 PANTHER:PTN002259328 RGD:621074 RGD:735163 UniProtKB:Q5T4F7 UniProtKB:Q8N474 UniProtKB:Q96HF1	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001085 FB:FBgn0016797 MGI:MGI:108460 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1196625 PANTHER:PTN000139394 RGD:61916 RGD:71012 UniProtKB:O75084 UniProtKB:Q13467 UniProtKB:Q14332 UniProtKB:Q8N474 UniProtKB:Q9H461 UniProtKB:Q9NPG1 UniProtKB:Q9ULV1 UniProtKB:Q9ULW2 UniProtKB:Q9UP38	P		Seeded From UniProt	complete
involved_in	GO:0035567	non-canonical Wnt signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108570 PANTHER:PTN000139394 UniProtKB:O60353 ZFIN:ZDB-GENE-990415-218	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001085 FB:FBgn0016797 FB:FBgn0027342 FB:FBgn0027343 MGI:MGI:108078 MGI:MGI:108460 MGI:MGI:108474 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1196625 MGI:MGI:2136761 MGI:MGI:892032 PANTHER:PTN000139394 RGD:621075 RGD:631406 RGD:71017 UniProtKB:O00144 UniProtKB:O75084 UniProtKB:Q13467 UniProtKB:Q6FHJ7 UniProtKB:Q8N474 UniProtKB:Q9NPG1 UniProtKB:Q9UP38	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108078 PANTHER:PTN002259328 UniProtKB:O19116 UniProtKB:Q863H1 UniProtKB:Q8N474 UniProtKB:Q96HF1	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation	PMID:18257070^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1860298 MGI:MGI:2135272 MGI:MGI:892014	P	regulates_o_occurs_in:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:18166153^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98956	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735163	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090244	Wnt signaling pathway involved in somitogenesis	PMID:18257070^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1329040 MGI:MGI:892014	P	occurs_in:(EMAPA:16171)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090179	planar cell polarity pathway involved in neural tube closure	PMID:18257070^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1860298 MGI:MGI:2135272 MGI:MGI:892014	P	occurs_in:(EMAPA:16164)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090175	regulation of establishment of planar polarity	PMID:19300477^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1860298 MGI:MGI:2135272 MGI:MGI:892014	P	regulates_o_occurs_in:(EMAPA:17888) regulates_o_has_participant:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:19896444^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:892014 MGI:MGI:98956	P	regulates_o_occurs_in:(CL:0000337) occurs_in:(CL:0000337)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:19850029^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:892014	P	regulates_o_occurs_in:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:18257070^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1329040 MGI:MGI:892014	P	regulates_o_occurs_in:(EMAPA:16171)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:17462603^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98956	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:17804636^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96HF1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735163	P		Seeded From UniProt	complete
enables	GO:0061133	endopeptidase activator activity	PMID:19079247^[18]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:88176)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060349	bone morphogenesis	PMID:18729207^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3810257	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060028	convergent extension involved in axis elongation	PMID:18257070^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108078 MGI:MGI:1860298	P	has_participant:(EMAPA:16183)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051216	cartilage development	PMID:18729207^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3810257	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96HF1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048546	digestive tract morphogenesis	PMID:19300477^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1860298 MGI:MGI:2135272 MGI:MGI:892014	P	has_participant:(EMAPA:16247)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046546	development of primary male sexual characteristics	PMID:19100252^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:892014	P	has_participant:(EMAPA:18681)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96HF1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	PMID:18166153^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98956	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045600	positive regulation of fat cell differentiation	PMID:12055200^[21]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96HF1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043508	negative regulation of JUN kinase activity	PMID:19300477^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1860298 MGI:MGI:892014	P	regulates_o_occurs_in:(EMAPA:16255) regulates_o_occurs_in:(CL:0000066)\|regulates_o_occurs_in:(EMAPA:16255) regulates_o_occurs_in:(CL:0000134)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:17251350^[22]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96HF1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	PMID:18729207^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3810257	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:18729207^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3810257	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042662	negative regulation of mesodermal cell fate specification	PMID:17462603^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98956	P	regulates_o_results_in_specification_of:(CL:0000352)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:18729207^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3810257	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036342	post-anal tail morphogenesis	PMID:18729207^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3810257	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031668	cellular response to extracellular stimulus	PMID:10322635^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030514	negative regulation of BMP signaling pathway	PMID:19850029^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:892014	P	regulates_o_occurs_in:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030514	negative regulation of BMP signaling pathway	PMID:19850029^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030308	negative regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96HF1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030199	collagen fibril organization	PMID:19079247^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3664776	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030178	negative regulation of Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96HF1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021915	neural tube development	PMID:19850029^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:892014	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:17462603^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P22725 UniProtKB:P27467	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010950	positive regulation of endopeptidase activity	PMID:19079247^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:88176)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010719	negative regulation of epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96HF1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	PMID:17251350^[22]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:16467359^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:892014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008584	male gonad development	PMID:19100252^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:892014	P	results_in_development_of:(EMAPA:17972)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96HF1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96HF1	P		Seeded From UniProt	complete
enables	GO:0008047	enzyme activator activity	PMID:19079247^[18]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:88176)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	PMID:18729207^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3810257	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96HF1	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003214	cardiac left ventricle morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96HF1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003151	outflow tract morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96HF1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002063	chondrocyte development	PMID:18729207^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3810257	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001843	neural tube closure	PMID:19850029^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:892014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001756	somitogenesis	PMID:16467359^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:892014	P	has_participant:(EMAPA:16315)\|has_participant:(EMAPA:16316)\|has_participant:(EMAPA:16317)\|has_participant:(EMAPA:16441)\|has_participant:(EMAPA:16445)\|has_participant:(EMAPA:16449)\|has_participant:(EMAPA:16453)\|has_participant:(EMAPA:16457)\|has_participant:(EMAPA:16461)\|has_participant:(EMAPA:16465)\|has_participant:(EMAPA:16600)\|has_participant:(EMAPA:16604)\|has_participant:(EMAPA:16608)	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B1WBV2 ensembl:ENSRNOP00000012659	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B1WBV2 ensembl:ENSRNOP00000012659	P		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B1WBV2 ensembl:ENSRNOP00000012659	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96HF1 ensembl:ENSP00000274063	P		Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96HF1 ensembl:ENSP00000274063	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96HF1 ensembl:ENSP00000274063	P		Seeded From UniProt	complete
involved_in	GO:0045600	positive regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96HF1 ensembl:ENSP00000274063	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96HF1 ensembl:ENSP00000274063	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96HF1 ensembl:ENSP00000274063	P		Seeded From UniProt	complete
involved_in	GO:0030178	negative regulation of Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96HF1 ensembl:ENSP00000274063	P		Seeded From UniProt	complete
involved_in	GO:0010719	negative regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96HF1 ensembl:ENSP00000274063	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96HF1 ensembl:ENSP00000274063	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96HF1 ensembl:ENSP00000274063	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96HF1 ensembl:ENSP00000274063	C		Seeded From UniProt	complete
involved_in	GO:0003214	cardiac left ventricle morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96HF1 ensembl:ENSP00000274063	P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96HF1 ensembl:ENSP00000274063	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-3772439	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 von Marschall, Z & Fisher, LW (2010) Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling. Biochem. Biophys. Res. Commun. 400 299-304 PubMed GONUTS page
↑ Mao, B et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411 321-5 PubMed GONUTS page
↑ ^3.0 ^3.1 Kele, J et al. (2012) SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells. Stem Cells 30 865-75 PubMed GONUTS page
↑ Kress, E et al. (2009) The frizzled-related sFRP2 gene is a target of thyroid hormone receptor alpha1 and activates beta-catenin signaling in mouse intestine. J. Biol. Chem. 284 1234-41 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Melkonyan, HS et al. (1997) SARPs: a family of secreted apoptosis-related proteins. Proc. Natl. Acad. Sci. U.S.A. 94 13636-41 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Lee, CS et al. (2000) SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development 127 109-18 PubMed GONUTS page
↑ ^7.0 ^7.1 Courtwright, A et al. (2009) Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway. Cancer Res. 69 4621-8 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Nakajima, H et al. (2009) Wnt modulators, SFRP-1, and SFRP-2 are expressed in osteoblasts and differentially regulate hematopoietic stem cells. Biochem. Biophys. Res. Commun. 390 65-70 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Roth, W et al. (2000) Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells. Oncogene 19 4210-20 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Satoh, W et al. (2008) Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse. Genesis 46 92-103 PubMed GONUTS page
↑ ^12.0 ^12.1 Cho, SW et al. (2008) Differential effects of secreted frizzled-related proteins (sFRPs) on osteoblastic differentiation of mouse mesenchymal cells and apoptosis of osteoblasts. Biochem. Biophys. Res. Commun. 367 399-405 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Matsuyama, M et al. (2009) Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium. PLoS Genet. 5 e1000427 PubMed GONUTS page
↑ Paik, JH et al. (2009) FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5 540-53 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Misra, K & Matise, MP (2010) A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev. Biol. 337 74-83 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Wawrzak, D et al. (2007) Wnt3a binds to several sFRPs in the nanomolar range. Biochem. Biophys. Res. Commun. 357 1119-23 PubMed GONUTS page
↑ Zaghetto, AA et al. (2007) Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections. J. Neurosci. 27 9757-68 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Kobayashi, K et al. (2009) Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction. Nat. Cell Biol. 11 46-55 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 ^19.7 Ikegawa, M et al. (2008) Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice. Dev. Dyn. 237 2506-17 PubMed GONUTS page
↑ ^20.0 ^20.1 Warr, N et al. (2009) Sfrp1 and Sfrp2 are required for normal male sexual development in mice. Dev. Biol. 326 273-84 PubMed GONUTS page
↑ Bennett, CN et al. (2002) Regulation of Wnt signaling during adipogenesis. J. Biol. Chem. 277 30998-1004 PubMed GONUTS page
↑ ^22.0 ^22.1 Mirotsou, M et al. (2007) Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc. Natl. Acad. Sci. U.S.A. 104 1643-8 PubMed GONUTS page
↑ Leimeister, C et al. (1999) Screen for genes regulated during early kidney morphogenesis. Dev. Genet. 24 273-83 PubMed GONUTS page
↑ ^24.0 ^24.1 Satoh, W et al. (2006) Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Development 133 989-99 PubMed GONUTS page

[PMID:20723538-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 von Marschall, Z & Fisher, LW (2010) Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling. Biochem. Biophys. Res. Commun. 400 299-304 PubMed GONUTS page

[PMID:11357136-2] Mao, B et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411 321-5 PubMed GONUTS page

[PMID:22290867-3] 3.0 ^3.1 Kele, J et al. (2012) SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells. Stem Cells 30 865-75 PubMed GONUTS page

[PMID:19001373-4] Kress, E et al. (2009) The frizzled-related sFRP2 gene is a target of thyroid hormone receptor alpha1 and activates beta-catenin signaling in mouse intestine. J. Biol. Chem. 284 1234-41 PubMed GONUTS page

[PMID:9391078-5] 5.0 ^5.1 ^5.2 Melkonyan, HS et al. (1997) SARPs: a family of secreted apoptosis-related proteins. Proc. Natl. Acad. Sci. U.S.A. 94 13636-41 PubMed GONUTS page

[PMID:10654605-6] 6.0 ^6.1 ^6.2 ^6.3 Lee, CS et al. (2000) SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development 127 109-18 PubMed GONUTS page

[PMID:19458075-7] 7.0 ^7.1 Courtwright, A et al. (2009) Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway. Cancer Res. 69 4621-8 PubMed GONUTS page

[PMID:19778523-8] 8.0 ^8.1 ^8.2 ^8.3 Nakajima, H et al. (2009) Wnt modulators, SFRP-1, and SFRP-2 are expressed in osteoblasts and differentially regulate hematopoietic stem cells. Biochem. Biophys. Res. Commun. 390 65-70 PubMed GONUTS page

[PMID:10980594-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Roth, W et al. (2000) Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells. Oncogene 19 4210-20 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18257070-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Satoh, W et al. (2008) Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse. Genesis 46 92-103 PubMed GONUTS page

[PMID:18166153-12] 12.0 ^12.1 Cho, SW et al. (2008) Differential effects of secreted frizzled-related proteins (sFRPs) on osteoblastic differentiation of mouse mesenchymal cells and apoptosis of osteoblasts. Biochem. Biophys. Res. Commun. 367 399-405 PubMed GONUTS page

[PMID:19300477-13] 13.0 ^13.1 ^13.2 Matsuyama, M et al. (2009) Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium. PLoS Genet. 5 e1000427 PubMed GONUTS page

[PMID:19896444-14] Paik, JH et al. (2009) FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5 540-53 PubMed GONUTS page

[PMID:19850029-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Misra, K & Matise, MP (2010) A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev. Biol. 337 74-83 PubMed GONUTS page

[PMID:17462603-16] 16.0 ^16.1 ^16.2 Wawrzak, D et al. (2007) Wnt3a binds to several sFRPs in the nanomolar range. Biochem. Biophys. Res. Commun. 357 1119-23 PubMed GONUTS page

[PMID:17804636-17] Zaghetto, AA et al. (2007) Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections. J. Neurosci. 27 9757-68 PubMed GONUTS page

[PMID:19079247-18] 18.0 ^18.1 ^18.2 ^18.3 Kobayashi, K et al. (2009) Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction. Nat. Cell Biol. 11 46-55 PubMed GONUTS page

[PMID:18729207-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 ^19.7 Ikegawa, M et al. (2008) Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice. Dev. Dyn. 237 2506-17 PubMed GONUTS page

[PMID:19100252-20] 20.0 ^20.1 Warr, N et al. (2009) Sfrp1 and Sfrp2 are required for normal male sexual development in mice. Dev. Biol. 326 273-84 PubMed GONUTS page

[PMID:12055200-21] Bennett, CN et al. (2002) Regulation of Wnt signaling during adipogenesis. J. Biol. Chem. 277 30998-1004 PubMed GONUTS page

[PMID:17251350-22] 22.0 ^22.1 Mirotsou, M et al. (2007) Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc. Natl. Acad. Sci. U.S.A. 104 1643-8 PubMed GONUTS page

[PMID:10322635-23] Leimeister, C et al. (1999) Screen for genes regulated during early kidney morphogenesis. Dev. Genet. 24 273-83 PubMed GONUTS page

[PMID:16467359-24] 24.0 ^24.1 Satoh, W et al. (2006) Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Development 133 989-99 PubMed GONUTS page

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MOUSE:SFRP2

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