HUMAN:EGF

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	EGF
Protein Name(s)	Pro-epidermal growth factor EGF Epidermal growth factor Urogastrone
External Links
UniProt	P01133
EMBL	X04571 AY506357 AK299306 AC004050 AC005509 BC093731 BC113461
CCDS	CCDS3689.1 CCDS54794.1 CCDS54795.1
PIR	A25531
RefSeq	NP_001171601.1 NP_001171602.1 NP_001954.2
UniGene	Hs.419815
PDB	1IVO 1JL9 1NQL 1P9J 2KV4 3NJP
PDBsum	1IVO 1JL9 1NQL 1P9J 2KV4 3NJP
ProteinModelPortal	P01133
SMR	P01133
BioGrid	108270
DIP	DIP-5767N
IntAct	P01133
MINT	MINT-260489
STRING	9606.ENSP00000265171
ChEMBL	CHEMBL5734
DrugBank	DB00364
PhosphoSite	P01133
DMDM	251757262
PaxDb	P01133
PRIDE	P01133
Ensembl	ENST00000265171 ENST00000503392 ENST00000509793
GeneID	1950
KEGG	hsa:1950
UCSC	uc003hzy.4 uc011cfu.2
CTD	1950
GeneCards	GC04P110834
HGNC	HGNC:3229
HPA	CAB017843
MIM	131530 611718
neXtProt	NX_P01133
Orphanet	34527 88673
PharmGKB	PA27664
eggNOG	NOG325841
GeneTree	ENSGT00760000118968
HOGENOM	HOG000112345
HOVERGEN	HBG003858
InParanoid	P01133
KO	K04357
OMA	KIYFAHT
OrthoDB	EOG7Q2N4J
PhylomeDB	P01133
TreeFam	TF315253
Reactome	REACT_115596 REACT_115720 REACT_115755 REACT_115852 REACT_115854 REACT_115993 REACT_116008 REACT_12478 REACT_12484 REACT_12578 REACT_12579 REACT_12606 REACT_147727 REACT_75829 REACT_9417
SignaLink	P01133
ChiTaRS	EGF
EvolutionaryTrace	P01133
GeneWiki	Epidermal_growth_factor
GenomeRNAi	1950
NextBio	7903
PMAP-CutDB	P01133
PRO	PR:P01133
Proteomes	UP000005640
Bgee	P01133
CleanEx	HS_EGF
ExpressionAtlas	P01133
Genevestigator	P01133
GO	GO:0005576 GO:0005615 GO:0070062 GO:0016021 GO:0005765 GO:0005886 GO:0031093 GO:0005509 GO:0005154 GO:0008083 GO:0030297 GO:0000186 GO:0007171 GO:0001525 GO:0007596 GO:0048754 GO:0006260 GO:0007173 GO:0070371 GO:0038095 GO:0008543 GO:0045087 GO:0060749 GO:0090370 GO:0042059 GO:0051048 GO:0048011 GO:0018108 GO:0048015 GO:0030168 GO:0002576 GO:0035413 GO:0008284 GO:0021940 GO:0043388 GO:0045741 GO:1900127 GO:0043406 GO:0045840 GO:0010800 GO:0042327 GO:2000060 GO:0045893 GO:0090279 GO:2000008 GO:0007165 GO:0007262
Gene3D	2.120.10.30 2.40.155.10
InterPro	IPR011042 IPR000742 IPR001881 IPR013032 IPR000152 IPR018097 IPR023413 IPR009030 IPR000033 IPR016317
Pfam	PF00008 PF07645 PF00058
PIRSF	PIRSF001778
SMART	SM00181 SM00179 SM00135
SUPFAM	SSF57184
PROSITE	PS00010 PS00022 PS01186 PS50026 PS01187 PS51120

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	PMID:20353436^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005088	Ras guanyl-nucleotide exchange factor activity	PMID:20353436^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1902966	positive regulation of protein localization to early endosome	PMID:22298428^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P00533)	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:25678558^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:25678558^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:21082674^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16502470^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001914)	Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	PMID:22732145^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P00533)	Seeded From UniProt	complete
involved_in	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	PMID:22732145^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P00533) positively_regulates:(GO:0031623)	Seeded From UniProt	complete
involved_in	GO:2000008	regulation of protein localization to cell surface	PMID:19996314^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090279	regulation of calcium ion import	PMID:19996314^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051048	negative regulation of secretion	PMID:10559227^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:20302655^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:20388803^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045840	positive regulation of mitotic nuclear division	PMID:15611079^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	PMID:15611079^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	PMID:15611079^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	PMID:15611079^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:15611079^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:15611079^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:15611079^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900127	positive regulation of hyaluronan biosynthetic process	PMID:17324121^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002620)	Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	PMID:16314496^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16314496^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q15648)	Seeded From UniProt	complete
involved_in	GO:0043388	positive regulation of DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01132	P		Seeded From UniProt	complete
involved_in	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	PMID:16314496^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q15648)	Seeded From UniProt	complete
involved_in	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01132	P		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	PMID:17897319^[16]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000119 MGI:MGI:1278315 PANTHER:PTN000056248 UniProtKB:O75197 ZFIN:ZDB-GENE-050518-2	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000056261 UniProtKB:O75197	C		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000119 MGI:MGI:1278315 PANTHER:PTN000056248	F		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000119 MGI:MGI:1278315 PANTHER:PTN000056248 UniProtKB:O75197	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95290 PANTHER:PTN000056261 UniProtKB:O75197	C		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:7736574^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:7736574^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030297	P		Seeded From UniProt	complete
involved_in	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01132 ensembl:ENSMUSP00000029653	P		Seeded From UniProt	complete
involved_in	GO:0090370	negative regulation of cholesterol efflux	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01132 ensembl:ENSMUSP00000029653	P		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01132 ensembl:ENSMUSP00000029653	P		Seeded From UniProt	complete
involved_in	GO:0060749	mammary gland alveolus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01132 ensembl:ENSMUSP00000029653	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01132 ensembl:ENSMUSP00000029653	P		Seeded From UniProt	complete
involved_in	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01132 ensembl:ENSMUSP00000029653	P		Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01132 ensembl:ENSMUSP00000029653	P		Seeded From UniProt	complete
involved_in	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01132 ensembl:ENSMUSP00000029653	P		Seeded From UniProt	complete
involved_in	GO:0043388	positive regulation of DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01132 ensembl:ENSMUSP00000029653	P		Seeded From UniProt	complete
involved_in	GO:0021940	positive regulation of cerebellar granule cell precursor proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01132 ensembl:ENSMUSP00000029653	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01132 ensembl:ENSMUSP00000029653	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01132 ensembl:ENSMUSP00000029653	P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01132 ensembl:ENSMUSP00000029653	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01132 ensembl:ENSMUSP00000029653	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01132 ensembl:ENSMUSP00000029653	C		Seeded From UniProt	complete
enables	GO:0005154	epidermal growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01132 ensembl:ENSMUSP00000029653	F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01132 ensembl:ENSMUSP00000029653	P		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01132 ensembl:ENSMUSP00000029653	P		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001881 InterPro:IPR018097	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:3491360^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005154	epidermal growth factor receptor binding	PMID:15611079^[13] PMID:9712850^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	PMID:9712850^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	PMID:9712850^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000145	regulation of cell motility	Reactome:R-HSA-6785631	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901185	negative regulation of ERBB signaling pathway	Reactome:R-HSA-8864125	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061024	membrane organization	Reactome:R-HSA-199991	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	Reactome:R-HSA-2316434	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045746	negative regulation of Notch signaling pathway	Reactome:R-HSA-9018573 Reactome:R-HSA-9018572	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	Reactome:R-HSA-182971	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038128	ERBB2 signaling pathway	Reactome:R-HSA-1227986	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031093	platelet alpha granule lumen	Reactome:R-HSA-481007	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030665	clathrin-coated vesicle membrane	Reactome:R-HSA-8871194 Reactome:R-HSA-8871193 Reactome:R-HSA-8869438 Reactome:R-HSA-8868661 Reactome:R-HSA-8868660 Reactome:R-HSA-8868659 Reactome:R-HSA-8868658	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	Reactome:R-HSA-177929	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	Reactome:R-HSA-212718	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-1251929 Reactome:R-NUL-1251923 Reactome:R-NUL-1248744 Reactome:R-HSA-9018573 Reactome:R-HSA-9018572 Reactome:R-HSA-8951490 Reactome:R-HSA-8868661 Reactome:R-HSA-8868651 Reactome:R-HSA-8868648 Reactome:R-HSA-8868236 Reactome:R-HSA-8868230 Reactome:R-HSA-8868072 Reactome:R-HSA-8868071 Reactome:R-HSA-8867756 Reactome:R-HSA-8867754 Reactome:R-HSA-8867047 Reactome:R-HSA-8867044 Reactome:R-HSA-8867041 Reactome:R-HSA-8866279 Reactome:R-HSA-8864125 Reactome:R-HSA-8864105 Reactome:R-HSA-8864029 Reactome:R-HSA-8863804 Reactome:R-HSA-8848005 Reactome:R-HSA-8847995 Reactome:R-HSA-6785648 Reactome:R-HSA-6785636 Reactome:R-HSA-5672965 Reactome:R-HSA-5638137 Reactome:R-HSA-481007 Reactome:R-HSA-2400009 Reactome:R-HSA-2316434 Reactome:R-HSA-212713 Reactome:R-HSA-212710 Reactome:R-HSA-212706 Reactome:R-HSA-1977959 Reactome:R-HSA-1963589 Reactome:R-HSA-1963586 Reactome:R-HSA-1963582 Reactome:R-HSA-1963581 Reactome:R-HSA-1963563 Reactome:R-HSA-183089 Reactome:R-HSA-183084 Reactome:R-HSA-183072 Reactome:R-HSA-183067 Reactome:R-HSA-183058 Reactome:R-HSA-183055 Reactome:R-HSA-183051 Reactome:R-HSA-183036 Reactome:R-HSA-183002 Reactome:R-HSA-182994 Reactome:R-HSA-182993 Reactome:R-HSA-182990 Reactome:R-HSA-182986 Reactome:R-HSA-182969 Reactome:R-HSA-177945 Reactome:R-HSA-177944 Reactome:R-HSA-177943 Reactome:R-HSA-177942 Reactome:R-HSA-177941 Reactome:R-HSA-177939 Reactome:R-HSA-177938 Reactome:R-HSA-177937 Reactome:R-HSA-177936 Reactome:R-HSA-177935 Reactome:R-HSA-177934 Reactome:R-HSA-177933 Reactome:R-HSA-177930 Reactome:R-HSA-177927 Reactome:R-HSA-177926 Reactome:R-HSA-177925 Reactome:R-HSA-177924 Reactome:R-HSA-177923 Reactome:R-HSA-177922 Reactome:R-HSA-1306965 Reactome:R-HSA-1306963 Reactome:R-HSA-1306957 Reactome:R-HSA-1250195 Reactome:R-HSA-1247844 Reactome:R-HSA-1247842 Reactome:R-HSA-1247841 Reactome:R-HSA-1226016 Reactome:R-HSA-1226014 Reactome:R-HSA-1226012 Reactome:R-HSA-1225978 Reactome:R-HSA-1225961 Reactome:R-HSA-1225960 Reactome:R-HSA-1225957 Reactome:R-HSA-1225956 Reactome:R-HSA-1225952 Reactome:R-HSA-1225951 Reactome:R-HSA-1225950 Reactome:R-HSA-1225949 Reactome:R-HSA-1225947 Reactome:R-HSA-1220613 Reactome:R-HSA-1220612 Reactome:R-HSA-1220611 Reactome:R-HSA-1220610 Reactome:R-HSA-1169421	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002576	platelet degranulation	Reactome:R-HSA-114608	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Sun, Y et al. (2010) Epidermal growth factor's activation of Ras is inhibited by four cardiac hormones. Eur. J. Clin. Invest. 40 408-13 PubMed GONUTS page
↑ Tanno, H et al. (2012) The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane. Mol. Biol. Cell 23 1343-53 PubMed GONUTS page
↑ ^3.0 ^3.1 Cohen-Dvashi, H et al. (2015) Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression. EMBO Mol Med 7 299-314 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Zhang, Y et al. (2010) Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS. Electrophoresis 31 3797-807 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
↑ ^8.0 ^8.1 van Baal, J et al. (2012) Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor. Int. J. Biochem. Cell Biol. 44 1791-9 PubMed GONUTS page
↑ ^9.0 ^9.1 Graziani, A et al. (2010) Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction. J. Biol. Chem. 285 4213-23 PubMed GONUTS page
↑ Keely, SJ & Barrett, KE (1999) ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells. J. Biol. Chem. 274 33449-54 PubMed GONUTS page
↑ Lee, CH et al. (2010) Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer. Mol. Cancer 9 64 PubMed GONUTS page
↑ Hattermann, K et al. (2010) The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects. Cancer Res. 70 3299-308 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Kochupurakkal, BS et al. (2005) Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity. J. Biol. Chem. 280 8503-12 PubMed GONUTS page
↑ Li, L et al. (2007) Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB. Biochem. J. 404 327-36 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Pandey, PK et al. (2005) Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation. Mol. Cell. Biol. 25 10695-710 PubMed GONUTS page
↑ Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^18.0 ^18.1 Miyazaki, T et al. (1995) Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 81 223-31 PubMed GONUTS page
↑ Bell, GI et al. (1986) Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization. Nucleic Acids Res. 14 8427-46 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Lee, NH & Malek, RL (1998) Nerve growth factor regulation of m4 muscarinic receptor mRNA stability but not gene transcription requires mitogen-activated protein kinase activity. J. Biol. Chem. 273 22317-25 PubMed GONUTS page

[PMID:20353436-1] 1.0 ^1.1 Sun, Y et al. (2010) Epidermal growth factor's activation of Ras is inhibited by four cardiac hormones. Eur. J. Clin. Invest. 40 408-13 PubMed GONUTS page

[PMID:22298428-2] Tanno, H et al. (2012) The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane. Mol. Biol. Cell 23 1343-53 PubMed GONUTS page

[PMID:25678558-3] 3.0 ^3.1 Cohen-Dvashi, H et al. (2015) Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression. EMBO Mol Med 7 299-314 PubMed GONUTS page

[PMID:23533145-4] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:21082674-5] Zhang, Y et al. (2010) Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS. Electrophoresis 31 3797-807 PubMed GONUTS page

[PMID:19056867-6] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:16502470-7] Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page

[PMID:22732145-8] 8.0 ^8.1 van Baal, J et al. (2012) Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor. Int. J. Biochem. Cell Biol. 44 1791-9 PubMed GONUTS page

[PMID:19996314-9] 9.0 ^9.1 Graziani, A et al. (2010) Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction. J. Biol. Chem. 285 4213-23 PubMed GONUTS page

[PMID:10559227-10] Keely, SJ & Barrett, KE (1999) ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells. J. Biol. Chem. 274 33449-54 PubMed GONUTS page

[PMID:20302655-11] Lee, CH et al. (2010) Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer. Mol. Cancer 9 64 PubMed GONUTS page

[PMID:20388803-12] Hattermann, K et al. (2010) The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects. Cancer Res. 70 3299-308 PubMed GONUTS page

[PMID:15611079-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Kochupurakkal, BS et al. (2005) Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity. J. Biol. Chem. 280 8503-12 PubMed GONUTS page

[PMID:17324121-14] Li, L et al. (2007) Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB. Biochem. J. 404 327-36 PubMed GONUTS page

[PMID:16314496-15] 15.0 ^15.1 ^15.2 Pandey, PK et al. (2005) Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation. Mol. Cell. Biol. 25 10695-710 PubMed GONUTS page

[PMID:17897319-16] Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page

[PMID:21873635-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7736574-18] 18.0 ^18.1 Miyazaki, T et al. (1995) Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 81 223-31 PubMed GONUTS page

[PMID:3491360-19] Bell, GI et al. (1986) Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization. Nucleic Acids Res. 14 8427-46 PubMed GONUTS page

[PMID:9712850-20] 20.0 ^20.1 ^20.2 Lee, NH & Malek, RL (1998) Nerve growth factor regulation of m4 muscarinic receptor mRNA stability but not gene transcription requires mitogen-activated protein kinase activity. J. Biol. Chem. 273 22317-25 PubMed GONUTS page

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