HUMAN:PTEN

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PTEN (synonyms: MMAC1, TEP1)
Protein Name(s)	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Mutated in multiple advanced cancers 1 Phosphatase and tensin homolog
External Links
UniProt	P60484
EMBL	U96180 U92436 U93051 AF143315 AF143312 AF143313 AF143314 AF000734 AF000726 AF000727 AF000728 AF000729 AF000730 AF000731 AF000732 AF000733 AF067844 JF268690 CR450306 AK313581 DQ073384 CH471066 BC005821
CCDS	CCDS31238.1
RefSeq	NP_000305.3 XP_006717990.1
UniGene	Hs.500466
PDB	1D5R 2KYL 4O1V
PDBsum	1D5R 2KYL 4O1V
ProteinModelPortal	P60484
SMR	P60484
BioGrid	111700
DIP	DIP-35019N
IntAct	P60484
MINT	MINT-127351
STRING	9606.ENSP00000361021
BindingDB	P60484
ChEMBL	CHEMBL2052032
DEPOD	P60484
PhosphoSite	P60484
DMDM	42560209
MaxQB	P60484
PaxDb	P60484
PRIDE	P60484
DNASU	5728
Ensembl	ENST00000371953
GeneID	5728
KEGG	hsa:5728
UCSC	uc001kfb.3
CTD	5728
GeneCards	GC10P089613
GeneReviews	PTEN
HGNC	HGNC:9588
HPA	CAB004076 HPA031335
MIM	137800 153480 158350 176807 275355 276950 601728 605309 608089 612242 613028
neXtProt	NX_P60484
Orphanet	109 201 145 79076 65285 210548 744 2969 137608 67037
PharmGKB	PA33942
eggNOG	COG2453
GeneTree	ENSGT00760000119113
HOGENOM	HOG000008008
HOVERGEN	HBG000239
InParanoid	P60484
KO	K01110
OMA	RSINENK
OrthoDB	EOG7R2BJ5
PhylomeDB	P60484
TreeFam	TF324513
BioCyc	MetaCyc:HS10404-MONOMER
Reactome	REACT_121025 REACT_12447 REACT_12555 REACT_147727 REACT_150312 REACT_75829
SignaLink	P60484
ChiTaRS	PTEN
EvolutionaryTrace	P60484
GeneWiki	PTEN_(gene)
GenomeRNAi	5728
NextBio	22282
PMAP-CutDB	P60484
PRO	PR:P60484
Proteomes	UP000005640
Bgee	P60484
CleanEx	HS_PTEN HS_TEP1
ExpressionAtlas	P60484
Genevestigator	P60484
GO	GO:0042995 GO:0005737 GO:0009898 GO:0005829 GO:0043197 GO:0005576 GO:0005739 GO:0035749 GO:0043005 GO:0005634 GO:0005886 GO:0016605 GO:0045211 GO:0043220 GO:0010997 GO:0019899 GO:0051717 GO:0008289 GO:0000287 GO:0030165 GO:0016314 GO:0051800 GO:0004438 GO:0004721 GO:0004722 GO:0004725 GO:0008138 GO:0007092 GO:0007568 GO:0001525 GO:0006915 GO:0048854 GO:0060070 GO:0048738 GO:0016477 GO:0008283 GO:0007417 GO:0032286 GO:0021955 GO:0060997 GO:0021542 GO:0043542 GO:0007173 GO:0038095 GO:0008543 GO:0048853 GO:0007507 GO:0045087 GO:0046855 GO:0043647 GO:0007611 GO:0045475 GO:0007626 GO:0060292 GO:0060291 GO:0060179 GO:0042711 GO:0007613 GO:0033555 GO:0043066 GO:0050771 GO:0090344 GO:0030336 GO:0008285 GO:0045792 GO:0031658 GO:0061002 GO:0050680 GO:0090394 GO:0051895 GO:2000134 GO:0031642 GO:0046621 GO:0050765 GO:0014067 GO:0051898 GO:0001933 GO:0090071 GO:2000808 GO:0007270 GO:0048011 GO:0035335 GO:0006661 GO:0046856 GO:0048015 GO:0006644 GO:0048008 GO:2001235 GO:0008284 GO:2000463 GO:2000060 GO:0051091 GO:0097107 GO:0060134 GO:0097105 GO:0060736 GO:0006470 GO:0043491 GO:0050821 GO:0002902 GO:0032535 GO:0000079 GO:0033032 GO:0010975 GO:0031647 GO:0046685 GO:0033198 GO:0042493 GO:0032355 GO:0045471 GO:0009749 GO:0007584 GO:0010043 GO:0060024 GO:0044281 GO:0035176 GO:0007416 GO:0060074 GO:0050852
Gene3D	3.90.190.10
InterPro	IPR017361 IPR000008 IPR000340 IPR029021 IPR014020 IPR029023 IPR016130
Pfam	PF00782 PF10409
PIRSF	PIRSF038025
SUPFAM	SSF49562 SSF52799
PROSITE	PS51182 PS51181

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	PMID:12622404^[1]	ECO:0000315			F		Figure one shows that Akt activity in hippocampal neurons is regulated by PTEN	complete CACAO 2109
	GO:0046856	phosphatidylinositol dephosphorylation	PMID:21828076^[2]	ECO:0000315			P		Figure 2 showed that mutation to the PTEN (Ala substitution at the P-loop (residue 121 -131) lost the ability to dephosphorylate PIP3.	complete CACAO 2687
	GO:0005737	cytoplasm	PMID:23251242^[3]	ECO:0000314			C		Figure 2B shows increased pten expression in the cytoplasm	complete CACAO 12097
	0051898		3712499:3712499	ECO:0000314					Figure 7	complete CACAO 10941
involved_in	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	PMID:26208095^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_division_of:(CL:0002591)	Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	PMID:28008308^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O54857	P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	PMID:21573166^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	PMID:21573166^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	PMID:22879939^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	PMID:16762633^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903690	negative regulation of wound healing, spreading of epidermal cells	PMID:27919618^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071257	cellular response to electrical stimulus	PMID:27919618^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051548	negative regulation of keratinocyte migration	PMID:27919618^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071257)	Seeded From UniProt	complete
involved_in	GO:0010719	negative regulation of epithelial to mesenchymal transition	PMID:27919618^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000312) part_of:(GO:0071257)	Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	PMID:19962668^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	PMID:19962668^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway	PMID:19962668^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24862762^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002563) exists_during:(GO:0045198) exists_during:(GO:0022612) part_of:(UBERON:0000333)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24862762^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002563) exists_during:(GO:0045198) exists_during:(GO:0022612) part_of:(UBERON:0000333)	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:24862762^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(CL:0002563) exists_during:(GO:0045198) exists_during:(GO:0022612) part_of:(UBERON:0000333)	Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P	occurs_in:(CL:0002548)	Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P	occurs_in:(CL:0002548)	Seeded From UniProt	complete
	GO:0005813	centrosome	PMID:23574721^[12]	ECO:0000314			C		Figure 1	complete CACAO 12098
involved_in	GO:0046856	phosphatidylinositol dephosphorylation	PMID:21828076^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	PMID:25007873^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002188)	Seeded From UniProt	complete
involved_in	GO:2000808	negative regulation of synaptic vesicle clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	PMID:21241890^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	PMID:21241890^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097107	postsynaptic density assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0090394	negative regulation of excitatory postsynaptic potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0061002	negative regulation of dendritic spine morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0060134	prepulse inhibition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0060074	synapse maturation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:20123964^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060024	rhythmic synaptic transmission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:20123964^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:20123964^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050771	negative regulation of axonogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0048854	brain morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0048853	forebrain morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0046856	phosphatidylinositol dephosphorylation	PMID:21828076^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046621	negative regulation of organ growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0045792	negative regulation of cell size	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0045475	locomotor rhythm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
part_of	GO:0043220	Schmidt-Lanterman incisure	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	C		Seeded From UniProt	complete
part_of	GO:0035749	myelin sheath adaxonal region	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	C		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0033555	multicellular organismal response to stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0032535	regulation of cellular component size	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0032286	central nervous system myelin maintenance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	PMID:21241890^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021955	central nervous system neuron axonogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0021542	dentate gyrus development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
enables	GO:0010997	anaphase-promoting complex binding	PMID:21241890^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UJX5	F		Seeded From UniProt	complete
enables	GO:0010997	anaphase-promoting complex binding	PMID:21241890^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UJX4	F		Seeded From UniProt	complete
enables	GO:0010997	anaphase-promoting complex binding	PMID:21241890^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UJX3	F		Seeded From UniProt	complete
enables	GO:0010997	anaphase-promoting complex binding	PMID:21241890^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P30260	F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:19057511^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0007270	neuron-neuron synaptic transmission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:1904668	positive regulation of ubiquitin protein ligase activity	PMID:21241890^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21241890^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21241890^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17218261^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	PMID:21241890^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	PMID:20123964^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	PMID:10760291^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051895	negative regulation of focal adhesion assembly	PMID:9616126^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051800	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	PMID:9811831^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0051717	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	PMID:9593664^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046856	phosphatidylinositol dephosphorylation	PMID:9811831^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046856	phosphatidylinositol dephosphorylation	PMID:9593664^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046855	inositol phosphate dephosphorylation	PMID:9593664^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	PMID:10760291^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	PMID:10866658^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	PMID:17880912^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	PMID:9616126^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:10646847^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q6P0Q8	F		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:10646847^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q12959	F		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:10760291^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q86UL8	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:16845383^[25]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q93009	F		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
enables	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	PMID:9811831^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	PMID:9593664^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010975	regulation of neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	PMID:10940933^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:17880912^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:10468583^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08586	P		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	PMID:9256433^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10760291^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10760291^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10940933^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9187108^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:9256433^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004722	protein serine/threonine phosphatase activity	PMID:9256433^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004438	phosphatidylinositol-3-phosphatase activity	PMID:9811831^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:1990381	ubiquitin-specific protease binding	PMID:26280536^[30]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q92995	F		Seeded From UniProt	complete
enables	GO:1990381	ubiquitin-specific protease binding	PMID:26280536^[30]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q5T2D3	F		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	PMID:26280536^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:24766807^[31]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P60484	F	occurs_in:(GO:0005634)\|occurs_in:(GO:0005737)\|occurs_in:(GO:0016020)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004725	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004725	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004725	P		Seeded From UniProt	complete
involved_in	GO:2001235	positive regulation of apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:2000808	negative regulation of synaptic vesicle clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:1904668	positive regulation of ubiquitin protein ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0097107	postsynaptic density assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0090394	negative regulation of excitatory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0090344	negative regulation of cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0090071	negative regulation of ribosome biogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0061002	negative regulation of dendritic spine morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0060736	prostate gland growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0060341	regulation of cellular localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0060179	male mating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0060134	prepulse inhibition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0060074	synapse maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0060044	negative regulation of cardiac muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0060024	rhythmic synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0050771	negative regulation of axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0048854	brain morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0048853	forebrain morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0048738	cardiac muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0048681	negative regulation of axon regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0048679	regulation of axon regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0046621	negative regulation of organ growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0045792	negative regulation of cell size	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0045475	locomotor rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0043542	endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
part_of	GO:0043220	Schmidt-Lanterman incisure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	C		Seeded From UniProt	complete
involved_in	GO:0042711	maternal behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0036294	cellular response to decreased oxygen levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
part_of	GO:0035749	myelin sheath adaxonal region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	C		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0033555	multicellular organismal response to stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0033032	regulation of myeloid cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0032535	regulation of cellular component size	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0032286	central nervous system myelin maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0032228	regulation of synaptic transmission, GABAergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0031642	negative regulation of myelination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0030534	adult behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0021955	central nervous system neuron axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0021542	dentate gyrus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	F		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
enables	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	F		Seeded From UniProt	complete
involved_in	GO:0010975	regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0007270	neuron-neuron synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	C		Seeded From UniProt	complete
involved_in	GO:0002902	regulation of B cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08586 ensembl:ENSMUSP00000013807	P		Seeded From UniProt	complete
involved_in	GO:2000272	negative regulation of signaling receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	F		Seeded From UniProt	complete
involved_in	GO:1990314	cellular response to insulin-like growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
part_of	GO:0099524	postsynaptic cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	C		Seeded From UniProt	complete
involved_in	GO:0071361	cellular response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0060292	long-term synaptic depression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0050765	negative regulation of phagocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0046856	phosphatidylinositol dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0046685	response to arsenic-containing substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	C		Seeded From UniProt	complete
involved_in	GO:0044320	cellular response to leptin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	C		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	F		Seeded From UniProt	complete
involved_in	GO:0033198	response to ATP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	F		Seeded From UniProt	complete
enables	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	F		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0010043	response to zinc ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0010035	response to inorganic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	C		Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016130	F		Seeded From UniProt	complete
enables	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000340	F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017361	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000340 InterPro:IPR016130	P		Seeded From UniProt	complete
enables	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017361	F		Seeded From UniProt	complete
involved_in	GO:0046855	inositol phosphate dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017361	P		Seeded From UniProt	complete
involved_in	GO:0046856	phosphatidylinositol dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017361	P		Seeded From UniProt	complete
enables	GO:0051717	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017361	F		Seeded From UniProt	complete
enables	GO:0051800	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017361	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F		Seeded From UniProt	complete
enables	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.67	F		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.16	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:26299948^[32]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P60484-1	F		Seeded From UniProt	complete
involved_in	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	PMID:18082964^[33]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:10918569^[34]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	PMID:9367992^[35]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9367992^[35]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	PMID:10918569^[34]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	Reactome:R-HSA-199456	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051800	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	Reactome:R-HSA-1676149	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043647	inositol phosphate metabolic process	Reactome:R-HSA-1855204	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	Reactome:R-HSA-199456	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006661	phosphatidylinositol biosynthetic process	Reactome:R-HSA-1660499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	Reactome:R-HSA-212436	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-9615571 Reactome:R-HSA-8948832 Reactome:R-HSA-8948800 Reactome:R-HSA-8948775 Reactome:R-HSA-8944497 Reactome:R-HSA-8873946 Reactome:R-HSA-8851011 Reactome:R-HSA-8850997 Reactome:R-HSA-8850992 Reactome:R-HSA-8850961 Reactome:R-HSA-8850945 Reactome:R-HSA-8847977 Reactome:R-HSA-8847968 Reactome:R-HSA-6807206 Reactome:R-HSA-6807134 Reactome:R-HSA-6807126 Reactome:R-HSA-6807106 Reactome:R-HSA-6807105 Reactome:R-HSA-2321904 Reactome:R-HSA-199456 Reactome:R-HSA-1855205 Reactome:R-HSA-1676149	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6807126 Reactome:R-HSA-6807118 Reactome:R-HSA-6807105 Reactome:R-HSA-5689950	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Gary, DS & Mattson, MP (2002) PTEN regulates Akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis. Neuromolecular Med. 2 261-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Rodríguez-Escudero, I et al. (2011) A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes. Hum. Mol. Genet. 20 4132-42 PubMed GONUTS page
↑ Zhu, X et al. (2013) Loss and reduced expression of PTEN correlate with advanced-stage gastric carcinoma. Exp Ther Med 5 57-64 PubMed GONUTS page
↑ Green, DE et al. (2015) PPARγ Ligands Attenuate Hypoxia-Induced Proliferation in Human Pulmonary Artery Smooth Muscle Cells through Modulation of MicroRNA-21. PLoS ONE 10 e0133391 PubMed GONUTS page
↑ Wu, Q et al. (2016) The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress. Front Mol Neurosci 9 140 PubMed GONUTS page
↑ ^6.0 ^6.1 Kong, G et al. (2011) Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model. PLoS ONE 6 e19518 PubMed GONUTS page
↑ Dey, N et al. (2012) TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion. PLoS ONE 7 e42316 PubMed GONUTS page
↑ Meng, F et al. (2006) Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology 130 2113-29 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Yan, T et al. (2017) Electric field-induced suppression of PTEN drives epithelial-to-mesenchymal transition via mTORC1 activation. J. Dermatol. Sci. 85 96-105 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Garofalo, M et al. (2009) miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. Cancer Cell 16 498-509 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Georgescu, MM et al. (2014) NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane. Neoplasia 16 365-74.e1-2 PubMed GONUTS page
↑ Leonard, MK et al. (2013) The PTEN-Akt pathway impacts the integrity and composition of mitotic centrosomes. Cell Cycle 12 1406-15 PubMed GONUTS page
↑ Obeidat, M et al. (2014) TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells. Am. J. Physiol. Renal Physiol. 307 F623-33 PubMed GONUTS page
↑ ^14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 Song, MS et al. (2011) Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell 144 187-99 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Humtsoe, JO et al. (2010) Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures. Mol. Cell. Biol. 30 1593-606 PubMed GONUTS page
↑ Yu, J et al. (2009) PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J. 28 21-33 PubMed GONUTS page
↑ Trotman, LC et al. (2007) Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 128 141-56 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 Wu, X et al. (2000) Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. Proc. Natl. Acad. Sci. U.S.A. 97 4233-8 PubMed GONUTS page
↑ ^19.0 ^19.1 Tamura, M et al. (1998) Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280 1614-7 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Myers, MP et al. (1998) The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc. Natl. Acad. Sci. U.S.A. 95 13513-8 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Maehama, T & Dixon, JE (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273 13375-8 PubMed GONUTS page
↑ Vazquez, F et al. (2000) Phosphorylation of the PTEN tail regulates protein stability and function. Mol. Cell. Biol. 20 5010-8 PubMed GONUTS page
↑ ^23.0 ^23.1 Hu, Y et al. (2007) MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells. Arch. Biochem. Biophys. 467 1-9 PubMed GONUTS page
↑ ^24.0 ^24.1 Adey, NB et al. (2000) Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding. Cancer Res. 60 35-7 PubMed GONUTS page
↑ Tang, J et al. (2006) Critical role for Daxx in regulating Mdm2. Nat. Cell Biol. 8 855-62 PubMed GONUTS page
↑ ^26.0 ^26.1 Gjörloff-Wingren, A et al. (2000) Subcellular localization of intracellular protein tyrosine phosphatases in T cells. Eur. J. Immunol. 30 2412-21 PubMed GONUTS page
↑ Georgescu, MM et al. (1999) The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region. Proc. Natl. Acad. Sci. U.S.A. 96 10182-7 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 Myers, MP et al. (1997) P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc. Natl. Acad. Sci. U.S.A. 94 9052-7 PubMed GONUTS page
↑ Li, DM & Sun, H (1997) TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res. 57 2124-9 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Yuan, L et al. (2015) Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. Nat. Cell Biol. 17 1169-81 PubMed GONUTS page
↑ Papa, A et al. (2014) Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function. Cell 157 595-610 PubMed GONUTS page
↑ Heinrich, F et al. (2015) The PTEN Tumor Suppressor Forms Homodimers in Solution. Structure 23 1952-1957 PubMed GONUTS page
↑ Fraser, MM et al. (2008) Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. Neuroscience 151 476-88 PubMed GONUTS page
↑ ^34.0 ^34.1 Bruni, P et al. (2000) PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1. Oncogene 19 3146-55 PubMed GONUTS page
↑ ^35.0 ^35.1 Li, L et al. (1997) A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. J. Biol. Chem. 272 29403-6 PubMed GONUTS page

[PMID:12622404-1] Gary, DS & Mattson, MP (2002) PTEN regulates Akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis. Neuromolecular Med. 2 261-9 PubMed GONUTS page

[PMID:21828076-2] 2.0 ^2.1 ^2.2 Rodríguez-Escudero, I et al. (2011) A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes. Hum. Mol. Genet. 20 4132-42 PubMed GONUTS page

[PMID:23251242-3] Zhu, X et al. (2013) Loss and reduced expression of PTEN correlate with advanced-stage gastric carcinoma. Exp Ther Med 5 57-64 PubMed GONUTS page

[PMID:26208095-4] Green, DE et al. (2015) PPARγ Ligands Attenuate Hypoxia-Induced Proliferation in Human Pulmonary Artery Smooth Muscle Cells through Modulation of MicroRNA-21. PLoS ONE 10 e0133391 PubMed GONUTS page

[PMID:28008308-5] Wu, Q et al. (2016) The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress. Front Mol Neurosci 9 140 PubMed GONUTS page

[PMID:21573166-6] 6.0 ^6.1 Kong, G et al. (2011) Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model. PLoS ONE 6 e19518 PubMed GONUTS page

[PMID:22879939-7] Dey, N et al. (2012) TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion. PLoS ONE 7 e42316 PubMed GONUTS page

[PMID:16762633-8] Meng, F et al. (2006) Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology 130 2113-29 PubMed GONUTS page

[PMID:27919618-9] 9.0 ^9.1 ^9.2 ^9.3 Yan, T et al. (2017) Electric field-induced suppression of PTEN drives epithelial-to-mesenchymal transition via mTORC1 activation. J. Dermatol. Sci. 85 96-105 PubMed GONUTS page

[PMID:19962668-10] 10.0 ^10.1 ^10.2 Garofalo, M et al. (2009) miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. Cancer Cell 16 498-509 PubMed GONUTS page

[PMID:24862762-11] 11.0 ^11.1 ^11.2 Georgescu, MM et al. (2014) NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane. Neoplasia 16 365-74.e1-2 PubMed GONUTS page

[PMID:23574721-12] Leonard, MK et al. (2013) The PTEN-Akt pathway impacts the integrity and composition of mitotic centrosomes. Cell Cycle 12 1406-15 PubMed GONUTS page

[PMID:25007873-13] Obeidat, M et al. (2014) TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells. Am. J. Physiol. Renal Physiol. 307 F623-33 PubMed GONUTS page

[PMID:21241890-14] 14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 Song, MS et al. (2011) Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell 144 187-99 PubMed GONUTS page

[PMID:20123964-15] 15.0 ^15.1 ^15.2 ^15.3 Humtsoe, JO et al. (2010) Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures. Mol. Cell. Biol. 30 1593-606 PubMed GONUTS page

[PMID:19057511-16] Yu, J et al. (2009) PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J. 28 21-33 PubMed GONUTS page

[PMID:17218261-17] Trotman, LC et al. (2007) Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 128 141-56 PubMed GONUTS page

[PMID:10760291-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 Wu, X et al. (2000) Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. Proc. Natl. Acad. Sci. U.S.A. 97 4233-8 PubMed GONUTS page

[PMID:9616126-19] 19.0 ^19.1 Tamura, M et al. (1998) Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280 1614-7 PubMed GONUTS page

[PMID:9811831-20] 20.0 ^20.1 ^20.2 ^20.3 Myers, MP et al. (1998) The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc. Natl. Acad. Sci. U.S.A. 95 13513-8 PubMed GONUTS page

[PMID:9593664-21] 21.0 ^21.1 ^21.2 ^21.3 Maehama, T & Dixon, JE (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273 13375-8 PubMed GONUTS page

[PMID:10866658-22] Vazquez, F et al. (2000) Phosphorylation of the PTEN tail regulates protein stability and function. Mol. Cell. Biol. 20 5010-8 PubMed GONUTS page

[PMID:17880912-23] 23.0 ^23.1 Hu, Y et al. (2007) MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells. Arch. Biochem. Biophys. 467 1-9 PubMed GONUTS page

[PMID:10646847-24] 24.0 ^24.1 Adey, NB et al. (2000) Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding. Cancer Res. 60 35-7 PubMed GONUTS page

[PMID:16845383-25] Tang, J et al. (2006) Critical role for Daxx in regulating Mdm2. Nat. Cell Biol. 8 855-62 PubMed GONUTS page

[PMID:10940933-26] 26.0 ^26.1 Gjörloff-Wingren, A et al. (2000) Subcellular localization of intracellular protein tyrosine phosphatases in T cells. Eur. J. Immunol. 30 2412-21 PubMed GONUTS page

[PMID:10468583-27] Georgescu, MM et al. (1999) The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region. Proc. Natl. Acad. Sci. U.S.A. 96 10182-7 PubMed GONUTS page

[PMID:9256433-28] 28.0 ^28.1 ^28.2 Myers, MP et al. (1997) P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc. Natl. Acad. Sci. U.S.A. 94 9052-7 PubMed GONUTS page

[PMID:9187108-29] Li, DM & Sun, H (1997) TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res. 57 2124-9 PubMed GONUTS page

[PMID:26280536-30] 30.0 ^30.1 ^30.2 Yuan, L et al. (2015) Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. Nat. Cell Biol. 17 1169-81 PubMed GONUTS page

[PMID:24766807-31] Papa, A et al. (2014) Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function. Cell 157 595-610 PubMed GONUTS page

[PMID:26299948-32] Heinrich, F et al. (2015) The PTEN Tumor Suppressor Forms Homodimers in Solution. Structure 23 1952-1957 PubMed GONUTS page

[PMID:18082964-33] Fraser, MM et al. (2008) Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. Neuroscience 151 476-88 PubMed GONUTS page

[PMID:10918569-34] 34.0 ^34.1 Bruni, P et al. (2000) PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1. Oncogene 19 3146-55 PubMed GONUTS page

[PMID:9367992-35] 35.0 ^35.1 Li, L et al. (1997) A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. J. Biol. Chem. 272 29403-6 PubMed GONUTS page

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