HUMAN:A4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	APP (synonyms: A4, AD1)
Protein Name(s)	Amyloid beta A4 protein ABPP APPI APP Alzheimer disease amyloid protein Cerebral vascular amyloid peptide CVAP PreA4 Protease nexin-II PN-II N-APP Soluble APP-alpha S-APP-alpha Soluble APP-beta S-APP-beta C99 Beta-amyloid protein 42 Beta-APP42 Beta-amyloid protein 40 Beta-APP40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 Amyloid intracellular domain 59 AICD-59 AID(59) Gamma-CTF(59) Gamma-secretase C-terminal fragment 57 Amyloid intracellular domain 57 AICD-57 AID(57) Gamma-CTF(57) Gamma-secretase C-terminal fragment 50 Amyloid intracellular domain 50 AICD-50 AID(50) Gamma-CTF(50) C31
External Links
UniProt	P05067
EMBL	Y00264 X13466 X13467 X13468 X13469 X13470 X13471 X13472 X13473 X13474 X13475 X13476 X13477 X13478 X13479 X13487 X13488 X06989 M33112 M34862 M34863 M34864 M34865 M34866 M34867 M34868 M34869 M34870 M34871 M34872 M34873 M34874 M34876 M34877 M34878 M34879 M34875 M34862 M34863 M34864 M34865 M34866 M34867 M34868 M34869 M34870 M34871 M34872 M34873 D87675 AK312326 AK295621 AY919674 AP001439 AP001440 AP001441 AP001442 AP001443 CH471079 CH471079 CH471079 CH471079 CH471079 CH471079 BC004369 BC065529 M35675 M24547 M24546 M28373 X06982 X06981 M18734 M29270 M29269 AB066441 M15533 M15532 M37896 M37895 S45136 S60317 AF282245 S60721 S61380 S61383 M16765
CCDS	CCDS13576.1 CCDS13577.1 CCDS33523.1 CCDS46638.1 CCDS56212.1 CCDS56213.1
PIR	S01442 S02260
RefSeq	NP_000475.1 NP_001129488.1 NP_001129601.1 NP_001129602.1 NP_001129603.1 NP_001191230.1 NP_001191231.1 NP_001191232.1 NP_958816.1 NP_958817.1
UniGene	Hs.434980
PDB	1AAP 1AMB 1AMC 1AML 1BA4 1BA6 1BJB 1BJC 1BRC 1CA0 1HZ3 1IYT 1MWP 1OWT 1QCM 1QWP 1QXC 1QYT 1TAW 1TKN 1UO7 1UO8 1UOA 1UOI 1X11 1Z0Q 1ZE7 1ZE9 1ZJD 2BEG 2BOM 2BP4 2FJZ 2FK1 2FK2 2FK3 2FKL 2FMA 2G47 2IPU 2LFM 2LLM 2LMN 2LMO 2LMP 2LMQ 2LNQ 2LOH 2LP1 2LZ3 2LZ4 2M4J 2M9R 2M9S 2MJ1 2OTK 2R0W 2WK3 2Y29 2Y2A 2Y3J 2Y3K 2Y3L 3AYU 3BAE 3BKJ 3DXC 3DXD 3DXE 3GCI 3IFL 3IFN 3IFO 3IFP 3JQ5 3JQL 3JTI 3KTM 3L33 3L81 3MOQ 3MXC 3MXY 3NYJ 3NYL 3OVJ 3OW9 3SV1 3U0T 3UMH 3UMI 3UMK 4HIX 4JFN 4M1C 4MDR 4NGE 4ONF 4ONG
PDBsum	1AAP 1AMB 1AMC 1AML 1BA4 1BA6 1BJB 1BJC 1BRC 1CA0 1HZ3 1IYT 1MWP 1OWT 1QCM 1QWP 1QXC 1QYT 1TAW 1TKN 1UO7 1UO8 1UOA 1UOI 1X11 1Z0Q 1ZE7 1ZE9 1ZJD 2BEG 2BOM 2BP4 2FJZ 2FK1 2FK2 2FK3 2FKL 2FMA 2G47 2IPU 2LFM 2LLM 2LMN 2LMO 2LMP 2LMQ 2LNQ 2LOH 2LP1 2LZ3 2LZ4 2M4J 2M9R 2M9S 2MJ1 2OTK 2R0W 2WK3 2Y29 2Y2A 2Y3J 2Y3K 2Y3L 3AYU 3BAE 3BKJ 3DXC 3DXD 3DXE 3GCI 3IFL 3IFN 3IFO 3IFP 3JQ5 3JQL 3JTI 3KTM 3L33 3L81 3MOQ 3MXC 3MXY 3NYJ 3NYL 3OVJ 3OW9 3SV1 3U0T 3UMH 3UMI 3UMK 4HIX 4JFN 4M1C 4MDR 4NGE 4ONF 4ONG
ProteinModelPortal	P05067
SMR	P05067
BioGrid	106848
DIP	DIP-574N
IntAct	P05067
MINT	MINT-150767
BindingDB	P05067
ChEMBL	CHEMBL2487
MEROPS	I02.015
TCDB	1.C.50.1.2
PhosphoSite	P05067
UniCarbKB	P05067
DMDM	112927
SWISS-2DPAGE	P05067
MaxQB	P05067
PaxDb	P05067
PRIDE	P05067
DNASU	351
Ensembl	ENST00000346798 ENST00000348990 ENST00000354192 ENST00000357903 ENST00000358918 ENST00000440126
GeneID	351
KEGG	hsa:351
UCSC	uc002ylz.3 uc002yma.3 uc002ymb.3 uc010glj.3 uc010glk.3 uc011acj.2 uc021whz.1 uc021wia.1 uc021wib.1
CTD	351
GeneCards	GC21M027252
GeneReviews	APP
HGNC	HGNC:620
HPA	CAB000157 HPA001462
MIM	104300 104760 605714
neXtProt	NX_P05067
Orphanet	1020 324723 100006 324718 324708 324713 324703
PharmGKB	PA24910
eggNOG	NOG289770
GeneTree	ENSGT00530000063252
HOVERGEN	HBG000051
InParanoid	P05067
KO	K04520
OMA	TKTCIGT
OrthoDB	EOG7RNJZP
PhylomeDB	P05067
TreeFam	TF317274
BioCyc	MetaCyc:ENSG00000142192-MONOMER
Reactome	REACT_118563 REACT_163906 REACT_18283 REACT_19231 REACT_21264 REACT_21281 REACT_24969 REACT_25195 REACT_75808 REACT_75925
SABIO-RK	P05067
ChiTaRS	APP
EvolutionaryTrace	P05067
GeneWiki	Amyloid_precursor_protein
GenomeRNAi	351
NextBio	1445
PMAP-CutDB	P05067
PRO	PR:P05067
Proteomes	UP000005640
Bgee	P05067
ExpressionAtlas	P05067
Genevestigator	P05067
GO	GO:0045177 GO:0030424 GO:0009986 GO:0005911 GO:0035253 GO:0005905 GO:0005737 GO:0005829 GO:0043198 GO:0043197 GO:0005768 GO:0030134 GO:0005576 GO:0005615 GO:0070062 GO:0005794 GO:0016021 GO:0005887 GO:0043231 GO:0045121 GO:0031594 GO:0005641 GO:0048471 GO:0005886 GO:0031093 GO:0043235 GO:0051233 GO:0045202 GO:0033130 GO:0003677 GO:0019899 GO:0008201 GO:0042802 GO:0016504 GO:0051425 GO:0005102 GO:0004867 GO:0046914 GO:0008344 GO:0008088 GO:0016199 GO:0007409 GO:0007596 GO:0007155 GO:0006878 GO:0008203 GO:0048669 GO:0016358 GO:0006897 GO:0030198 GO:0030900 GO:0045087 GO:0035235 GO:0007626 GO:0007617 GO:0006378 GO:0010951 GO:0045665 GO:0050885 GO:0051402 GO:0031175 GO:0016322 GO:0007219 GO:0035872 GO:0030168 GO:0002576 GO:0010971 GO:0045931 GO:0045944 GO:0006468 GO:0007176 GO:0040014 GO:0043393 GO:0050803 GO:0006417 GO:0006979 GO:0051563 GO:0001967 GO:0051124 GO:0008542
Gene3D	3.30.1490.140 3.90.570.10 4.10.230.10 4.10.410.10
InterPro	IPR008155 IPR013803 IPR011178 IPR024329 IPR008154 IPR019744 IPR015849 IPR019745 IPR028866 IPR019543 IPR002223 IPR020901
PANTHER	PTHR23103:SF7
Pfam	PF10515 PF12924 PF12925 PF02177 PF03494 PF00014
PRINTS	PR00203 PR00759 PR00204
SMART	SM00006 SM00131
SUPFAM	SSF109843 SSF56491 SSF57362 SSF89811
PROSITE	PS00319 PS00320 PS00280 PS50279

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0016322	transmembrane receptor protein tyrosine kinase activity	PMID:8234269^[1]	ECO:0000314			F		Figure 5: Neurite production by APP antisense cell lines - APP funciton in neurite outgrowth	complete
part_of	GO:0005769	early endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050890	cognition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:1900272	negative regulation of long-term synaptic potentiation	PMID:16636059^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q61391	P	occurs_in:(UBERON:0001885) regulates_o_occurs_in:(UBERON:0001885)\|occurs_in(UBERON:0003881) regulates_o_occurs_in:(UBERON:0003881)	Seeded From UniProt	complete
involved_in	GO:0045080	positive regulation of chemokine biosynthetic process	PMID:22406537^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q62151	P	occurs_in:(UBERON:0000955) regulates_o_occurs_in:(UBERON:0000955) has_regulation_target:(UniProtKB:P13500)	Seeded From UniProt	complete
involved_in	GO:0045410	positive regulation of interleukin-6 biosynthetic process	PMID:22406537^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q62151	P	occurs_in:(UBERON:0000955) regulates_o_occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0050725	positive regulation of interleukin-1 beta biosynthetic process	PMID:22406537^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q62151	P	occurs_in:(UBERON:0000956) regulates_o_occurs_in:(UBERON:0000956)\|occurs_in(UBERON:0002421) regulates_o_occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	PMID:22406537^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q62151	P	occurs_in:(UBERON:0000956) regulates_o_occurs_in:(UBERON:0000956)\|occurs_in(UBERON:0002421) regulates_o_occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:1903980	positive regulation of microglial cell activation	PMID:22406537^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q62151	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:27853422^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49768	P	regulates_expression_of:(ENSEMBL:ENSG00000126581) regulates:(GO:0006914)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:27853422^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49768	P	regulates_expression_of:(ENSEMBL:ENSG00000067900) regulates:(GO:0006914)	Seeded From UniProt	complete
involved_in	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	PMID:21857966^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49768	P	has_regulation_target:(UniProtKB:Q9UQM7)	Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08592	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:28008308^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49768	P	happens_during:(GO:0007568) regulates_expression_of:(ENSEMBL:ENSG00000171862) occurs_in:(UBERON:0000956) occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:28008308^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49768	P	happens_during:(GO:0007568) regulates_expression_of:(ENSEMBL:ENSG00000207713) occurs_in:(UBERON:0000956) occurs_in:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	C		Seeded From UniProt	complete
part_of	GO:0005798	Golgi-associated vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	C		Seeded From UniProt	complete
involved_in	GO:0030111	regulation of Wnt signaling pathway	PMID:21857966^[5]	ECO:0000305	curator inference used in manual assertion	GO:0010468	P	occurs_in:(UBERON:0002421) regulates_o_occurs_in:(UBERON:0002421) causally_upstream_of:(GO:0070997)	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21857966^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49768	P	regulates_expression_of:(ENSEMBL:ENSG00000163251) regulates:(GO:0018108) occurs_in:(UBERON:0002421) regulates_o_occurs_in:(UBERON:0002421)\|regulates_expression_of(ENSEMBL:ENSG00000114251) regulates:(GO:0018108) occurs_in:(UBERON:0002421) regulates_o_occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:15457210^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15109	P	happens_during:(UBERON:0007222) positively_regulates:(GO:0004683) occurs_in:(UBERON:0002421) regulates_o_occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:15457210^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15109	P	happens_during:(UBERON:0018241)	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:15457210^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15109	P	has_regulation_target:(UniProtKB:Q16539) happens_during:(UBERON:0018241)	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:15457210^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15109	P	part_of:(GO:0032793) happens_during:(UBERON:0018241)	Seeded From UniProt	complete
involved_in	GO:0150003	regulation of spontaneous synaptic transmission	PMID:15457210^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15109	P	happens_during:(UBERON:0018241) occurs_in:(UBERON:0014554)\|happens_during(GO:0007568) occurs_in:(UBERON:0014554)	Seeded From UniProt	complete
involved_in	GO:1900272	negative regulation of long-term synaptic potentiation	PMID:15457210^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15109	P	occurs_in:(UBERON:6003624) regulates_o_occurs_in:(UBERON:0014554) happens_during:(GO:0007568)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:15457210^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15109	P	happens_during:(UBERON:0018241)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:15457210^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(UBERON:0018241)	Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	PMID:15457210^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15109	P		Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	PMID:15457210^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903980	positive regulation of microglial cell activation	PMID:15457210^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15109	P	regulates_o_occurs_in:(UBERON:0000956) occurs_in:(UBERON:0000956) happens_during:(UBERON:0007222)\|regulates_o_occurs_in(UBERON:0002421) occurs_in:(UBERON:0002421) happens_during:(UBERON:0007222)	Seeded From UniProt	complete
involved_in	GO:0061890	positive regulation of astrocyte activation	PMID:15457210^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15109	P	regulates_o_occurs_in:(UBERON:0000956) occurs_in:(UBERON:0000956) happens_during:(UBERON:0007222)\|regulates_o_occurs_in(UBERON:0002421) occurs_in:(UBERON:0002421) happens_during:(UBERON:0007222)	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:15457210^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15109	P	regulates_o_occurs_in:(UBERON:0000956) occurs_in:(UBERON:0000956) regulates_o_occurs_in:(GO:0005634) regulates_o_occurs_in:(UBERON:6003624)	Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:15457210^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15109	P	regulates_o_occurs_in:(UBERON:0000956) occurs_in:(UBERON:0000956) regulates_o_occurs_in:(UBERON:6003624)	Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:15457210^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15109	P	regulates_o_occurs_in:(UBERON:0000956) occurs_in:(UBERON:0000956) regulates_o_occurs_in:(GO:0005634) regulates_o_occurs_in:(UBERON:6003624)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:15457210^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000204305) regulates_o_occurs_in:(UBERON:0000956) occurs_in:(UBERON:0000956) regulates_o_occurs_in:(UBERON:6003624)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:24052308^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49768,UniProtKB:P97484	P	happens_during:(UBERON:0018241) occurs_in:(UBERON:0007023)	Seeded From UniProt	complete
NOT\|involved_in	GO:1905598	negative regulation of low-density lipoprotein receptor activity	PMID:20005821^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P35951,UniProtKB:P49768	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:22944668^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:21113149^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P54763	P	occurs_in:(UBERON:0001885)	Seeded From UniProt	complete
involved_in	GO:1902004	positive regulation of amyloid-beta formation	PMID:23640054^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49768	P	part_of:(GO:0007568) has_output:(UniProtKB:P05067:PRO_0000000092) has_output:(UniProtKB:P05067:PRO_0000000093) regulates_o_occurs_in:(UBERON:0000955) occurs_in:(UBERON:0000955) has_output:(ComplexPortal:CPX-1120)\|part_of(GO:0007568) has_output:(UniProtKB:P05067:PRO_0000000092) has_output:(UniProtKB:P05067:PRO_0000000093) regulates_o_occurs_in:(UBERON:0000913) occurs_in:(UBERON:0000955) has_output:(ComplexPortal:CPX-1120)	Seeded From UniProt	complete
involved_in	GO:2000406	positive regulation of T cell migration	PMID:19660551^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002421) part_of:(GO:0007568) regulates_o_occurs_in:(CL:0000813)\|occurs_in(UBERON:0000956) part_of:(GO:0007568) regulates_o_occurs_in:(CL:0000813)	Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:19660551^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002421) part_of:(GO:0007568) has_input:(UniProtKB:P10636)\|occurs_in(UBERON:0000956) part_of:(GO:0007568) has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
involved_in	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	PMID:19660551^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002421) part_of:(GO:0007568) has_input:(UniProtKB:P10636)\|occurs_in(UBERON:0000956) part_of:(GO:0007568) has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
involved_in	GO:1905908	positive regulation of amyloid fibril formation	PMID:19660551^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002421) part_of:(GO:0007568)\|occurs_in(UBERON:0000956) part_of:(GO:0007568)	Seeded From UniProt	complete
involved_in	GO:0007612	learning	PMID:11140684^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0090647)	Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	PMID:11140684^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:11880515^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0090647)	Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	PMID:11880515^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	PMID:25707991^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49768	P	occurs_in:(UBERON:0002421) has_regulation_target:(UniProtKB:Q14289) regulates_o_occurs_in:(UBERON:0003881)\|occurs_in(UBERON:0000956) has_regulation_target:(UniProtKB:Q14289)	Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	PMID:19587288^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49582	P	occurs_in:(UBERON:0001870) happens_during:(UBERON:0007222) has_input:(UniProtKB:P36544)\|occurs_in(UBERON:0002421) happens_during:(UBERON:0007222) has_input:(UniProtKB:P36544)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:19587288^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49582	P	has_input:(UniProtKB:P36544) happens_during:(UBERON:0007222)	Seeded From UniProt	complete
involved_in	GO:0048169	regulation of long-term neuronal synaptic plasticity	PMID:23921129^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	regulates_o_occurs_in:(UBERON:0001954) occurs_in:(UBERON:0001954)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23921129^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	part_of:(GO:1904646) regulates_transcription_of:(ENSEMBL:ENSG00000072694)	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:23921129^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	regulates_o_occurs_in:(CL:0002609) part_of:(GO:1904646) regulates_activity_of:(UniProtKB:P05412)	Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:23921129^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	regulates_o_occurs_in:(CL:0002609) part_of:(GO:1904646) part_of:(GO:1901216)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:23921129^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001954)	Seeded From UniProt	complete
involved_in	GO:0051247	positive regulation of protein metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08592	P	occurs_in:(UBERON:0002421) has_regulation_target:(UniProtKB:P36544)	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:11404397^[19]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0001885) has_regulation_target:(UniProtKB:P16220)\|occurs_in(UBERON:0003881) has_regulation_target:(UniProtKB:P16220) happens_during:(UBERON:0018241)	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:11404397^[19]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0001885) has_regulation_target:(UniProtKB:P28482) happens_during:(UBERON:0018241)\|occurs_in(UBERON:0003881) has_regulation_target:(UniProtKB:P28482) happens_during:(UBERON:0018241)	Seeded From UniProt	complete
involved_in	GO:0051247	positive regulation of protein metabolic process	PMID:11404397^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001885) has_regulation_target:(UniProtKB:P36544) happens_during:(GO:0007568)\|occurs_in(UBERON:0003881) has_regulation_target:(UniProtKB:P36544) happens_during:(GO:0007568)	Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	PMID:23152628^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:A0A0R4J0I9,UniProtKB:P49768	P	occurs_in:(CL:0002590)	Seeded From UniProt	complete
involved_in	GO:0002265	astrocyte activation involved in immune response	PMID:23152628^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:A0A0R4J0I9,UniProtKB:P49768	P	part_of:(GO:1904646) occurs_in:(CL:0002590)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20164328^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(UBERON:0018241) part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:20164328^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49582	P	has_input:(UniProtKB:P36544) happens_during:(UBERON:0018241)	Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	PMID:20445063^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04156,UniProtKB:P49768	P	happens_during:(GO:0007568)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:20445063^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04156,UniProtKB:P49768	P	part_of:(GO:0090647) happens_during:(GO:0007568)	Seeded From UniProt	complete
involved_in	GO:1990535	neuron projection maintenance	PMID:20445063^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04156,UniProtKB:P49768	P	occurs_in:(CL:0000850) occurs_in:(GO:0030424)	Seeded From UniProt	complete
involved_in	GO:0048143	astrocyte activation	PMID:20445063^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49768	P	occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:22198949^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49768	P	regulates_expression_of:(ENSEMBL:ENSG00000232810) occurs_in:(UBERON:0000955)\|regulates_expression_of(ENSEMBL:ENSG00000125538) occurs_in:(UBERON:0000955)\|regulates_expression_of(ENSEMBL:ENSG00000108691) occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:22198949^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49768	P	regulates_expression_of:(ENSEMBL:ENSG00000136634) occurs_in:(UBERON:0000955)\|regulates_expression_of(ENSEMBL:ENSG00000118520) occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0032640	tumor necrosis factor production	PMID:22198949^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49768,UniProtKB:Q9QUN7	P	has_agent:(CL:0002092) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0014005	microglia development	PMID:22198949^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49768,UniProtKB:Q9QUN7	P	has_agent:(CL:0002092) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	PMID:24012003^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P41594,UniProtKB:P49768	P	part_of:(GO:0090647) happens_during:(GO:0007568) occurs_in:(UBERON:0001885)	Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	PMID:24012003^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P41594,UniProtKB:P49768	P	happens_during:(GO:0007568)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:24012003^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P41594,UniProtKB:P49768	P	part_of:(GO:0090647) happens_during:(GO:0007568)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23164821^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000956) regulates_expression_of:(ENSEMBL:ENSG00000155090)\|occurs_in(UBERON:0000956) regulates_expression_of:(ENSEMBL:ENSG00000110092)\|occurs_in(UBERON:0000956) regulates_expression_of:(ENSEMBL:ENSG00000170345)\|occurs_in(UBERON:0000956) regulates_expression_of:(ENSEMBL:ENSG00000120738)	Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	PMID:20974225^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49582	P	occurs_in:(UBERON:0003881) happens_during:(UBERON:0018241)	Seeded From UniProt	complete
involved_in	GO:0098815	modulation of excitatory postsynaptic potential	PMID:20974225^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49582	P	occurs_in:(UBERON:0003881) happens_during:(UBERON:0018241)	Seeded From UniProt	complete
involved_in	GO:0009987	cellular process	PMID:25620700^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990000	amyloid fibril formation	PMID:25620700^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:18353773^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:18353773^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005641	nuclear envelope lumen	PMID:21989385^[29]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0005794)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:24499793^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:24499793^[30]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P62942	F		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[31]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:20427278^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16502470^[33]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001914)	Seeded From UniProt	complete
enables	GO:0051425	PTB domain binding	PMID:12805363^[34]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q5SW96	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12805363^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:19849849^[35]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04233	F		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	PMID:24052308^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49768,UniProtKB:P97484	P	has_regulation_target:(UniProtKB:P97484) has_regulation_target:(UniProtKB:P18760) regulates_o_occurs_in:(UBERON:0001890) occurs_in:(UBERON:0001890)	Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	PMID:19225519^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050803	regulation of synapse structure or activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0048669	collateral sprouting in absence of injury	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0045931	positive regulation of mitotic cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0040014	regulation of multicellular organism growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	C		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0016358	dendrite development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0016322	neuron remodeling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0016199	axon midline choice point recognition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:7593229^[37]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008542	visual learning	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0008344	adult locomotory behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0008088	axo-dendritic transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0007617	mating behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0007176	regulation of epidermal growth factor-activated receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0006878	cellular copper ion homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0006378	mRNA polyadenylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20427278^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:20427278^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18509662^[38]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	C		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:10652580^[39]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023	F		Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	PMID:19726636^[40]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	PMID:19726636^[40]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	PMID:19726636^[40]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:11988176^[41]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:23382219^[42]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	PMID:11988176^[41]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:11988176^[41]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:24720730^[43]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:24065130^[44]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23907009^[45]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23603391^[46]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23551356^[47]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23416305^[48]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23353684^[49]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23103738^[50]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22584060^[51]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22200570^[52]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21527912^[53]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21320494^[54]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21205198^[55]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21113149^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20818335^[56]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20573181^[57]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19754881^[58]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19549187^[59]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18805418^[60]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16286452^[61]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067	F		Seeded From UniProt	complete
part_of	GO:0005790	smooth endoplasmic reticulum	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0051563	C		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004867	P		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004867	P		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004867	P		Seeded From UniProt	complete
involved_in	GO:0010952	positive regulation of peptidase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016504	P		Seeded From UniProt	complete
involved_in	GO:2000273	positive regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0030546	P		Seeded From UniProt	complete
part_of	GO:1990812	growth cone filopodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
part_of	GO:1990761	growth cone lamellipodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	P		Seeded From UniProt	complete
part_of	GO:0097449	astrocyte projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
involved_in	GO:0071874	cellular response to norepinephrine stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	P		Seeded From UniProt	complete
involved_in	GO:0071320	cellular response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	P		Seeded From UniProt	complete
involved_in	GO:0071287	cellular response to manganese ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	P		Seeded From UniProt	complete
involved_in	GO:0071280	cellular response to copper ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	P		Seeded From UniProt	complete
enables	GO:0070851	growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	F		Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	P		Seeded From UniProt	complete
involved_in	GO:0051247	positive regulation of protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
part_of	GO:0044304	main axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
enables	GO:0016504	peptidase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	F		Seeded From UniProt	complete
involved_in	GO:0010288	response to lead ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
part_of	GO:0005791	rough endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08592 ensembl:ENSRNOP00000041613	C		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
involved_in	GO:0051563	smooth endoplasmic reticulum calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
part_of	GO:0051233	spindle midzone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
involved_in	GO:0051124	synaptic growth at neuromuscular junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0050890	cognition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0050885	neuromuscular process controlling balance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0050803	regulation of synapse structure or activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
part_of	GO:0048786	presynaptic active zone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
involved_in	GO:0048669	collateral sprouting in absence of injury	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0045931	positive regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
involved_in	GO:0043393	regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
involved_in	GO:0040014	regulation of multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
part_of	GO:0035253	ciliary rootlet	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
enables	GO:0030546	receptor activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	F		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
part_of	GO:0030134	COPII-coated ER to Golgi transport vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
involved_in	GO:0016358	dendrite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0016322	neuron remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0016199	axon midline choice point recognition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
involved_in	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
involved_in	GO:0008542	visual learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0008344	adult locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0008088	axo-dendritic transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0007617	mating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0007176	regulation of epidermal growth factor-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0006878	cellular copper ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
involved_in	GO:0006378	mRNA polyadenylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
part_of	GO:0005798	Golgi-associated vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	F		Seeded From UniProt	complete
involved_in	GO:0001967	suckling behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12023 ensembl:ENSMUSP00000005406	P		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002223 InterPro:IPR036880	F		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028866	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015849 InterPro:IPR036454	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008155 InterPro:IPR013803 InterPro:IPR037071	C		Seeded From UniProt	complete
enables	GO:0046914	transition metal ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011178 InterPro:IPR036669	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:24462250^[62]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067-4	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20212142^[63]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067-4	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16193067^[64]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067-4	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:20164328^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(UBERON:0018241) part_of:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	PMID:11316806^[65]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O88536	F		Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	PMID:11316806^[65]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P25090	F	occurs_in:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	PMID:29371969^[66]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000031)	Seeded From UniProt	complete
involved_in	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	PMID:24827165^[67]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000283242)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:24827165^[67]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001969)\|part_of:(UBERON:0001359)	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:29518356^[68]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NZC2	F		Seeded From UniProt	complete
involved_in	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	PMID:25152461^[69]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000207730) occurs_in:(CL:0000031)	Seeded From UniProt	complete
colocalizes_with	GO:0009986	cell surface	PMID:15457210^[7]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	PMID:23164821^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P10909	P	occurs_in:(GO:0005622)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23164821^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O94907	P	regulates_o_occurs_in:(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000166886)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000155090)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000110092)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000170345)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000120738)	Seeded From UniProt	complete
enables	GO:0043395	heparan sulfate proteoglycan binding	PMID:21289173^[70]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
colocalizes_with	GO:0005764	lysosome	PMID:21289173^[70]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
NOT\|involved_in	GO:1902003	regulation of amyloid-beta formation	PMID:26005850^[71]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q7M6Y3	P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:26005850^[71]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q7M6Y3	P		Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	PMID:26005850^[71]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q7M6Y3	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:23921129^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P31994	F		Seeded From UniProt	complete
involved_in	GO:0090026	positive regulation of monocyte chemotaxis	PMID:11160457^[72]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P25090	P	part_of:(GO:1904646) occurs_in:(CL:0000576)	Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	PMID:11160457^[72]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P25090	P	part_of:(GO:1904646) occurs_in:(CL:0000576) positively_regulates:(GO:0002548)	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:11160457^[72]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P25090	P	part_of:(GO:1904646) occurs_in:(CL:0000576) part_of:(GO:0019722) positively_regulates:(GO:0002548)	Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	PMID:15190117^[73]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	occurs_in:(UBERON:0002421) part_of:(GO:0045666) has_agent:(GO:0106003)	Seeded From UniProt	complete
involved_in	GO:0000185	activation of MAPKKK activity	PMID:15190117^[73]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	occurs_in:(UBERON:0002421) part_of:(GO:0045666) has_agent:(GO:0106003)	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:15190117^[73]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	occurs_in:(UBERON:0002421) part_of:(GO:0045666) has_agent:(GO:0106003)	Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:18234671^[74]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13467 UniProtKB:Q9ULV1	F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23164821^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:D3Z9J1	P	regulates_o_occurs_in:(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000166886)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000155090)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000110092)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000170345)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000120738)	Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	PMID:22138302^[75]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0034185	apolipoprotein binding	PMID:22138302^[75]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02649	F	occurs_in:(UBERON:0001359)	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:20141570^[76]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:F1M670	P	regulates_o_occurs_in:(CL:0000127)\|regulates_o_occurs_in:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:1900122	positive regulation of receptor binding	PMID:20141570^[76]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000127) occurs_in:(GO:0016020) has_regulation_target:(UniProtKB:F1M670) has_regulation_target:(UniProtKB:M0R9F7)\|occurs_in(CL:0000129) occurs_in:(GO:0016020) has_regulation_target:(UniProtKB:F1M670) has_regulation_target:(UniProtKB:M0R9F7)	Seeded From UniProt	complete
involved_in	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	PMID:20141570^[76]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:F1M670	P	regulates_o_occurs_in:(CL:0000127)\|regulates_o_occurs_in:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:20141570^[76]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:F1M670	P	regulates_o_occurs_in:(CL:0000127)\|regulates_o_occurs_in:(CL:0000129)	Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	PMID:21113149^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P54763	F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23164821^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05371	P	regulates_o_occurs_in:(CL:0002609) regulates_expression_of:(ENSEMBL:ENSRNOG00000011692)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSRNOG00000008415)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSRNOG00000006118)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSRNOG00000020918)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSRNOG00000008015)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSRNOG00000019422)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23164821^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P10909	P	regulates_expression_of:(ENSEMBL:ENSRNOG00000011692) occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:18568035^[77]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092 UniProtKB:P05067:PRO_0000000093	C		Seeded From UniProt	complete
part_of	GO:0106003	amyloid-beta complex	PMID:23386614^[78]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:18568035^[77]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000093	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:18568035^[77]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	F		Seeded From UniProt	complete
part_of	GO:0106003	amyloid-beta complex	PMID:23640054^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(UBERON:0000955) part_of:(UBERON:0000913)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:23640054^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(UBERON:0000955) part_of:(UBERON:0000913) part_of:(GO:0106003)	Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	PMID:19660551^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(UBERON:0000955) part_of:(GO:0007568) has_output:(ComplexPortal:CPX-1120) has_output:(ComplexPortal:CPX-1062) has_input:(UniProtKB:P05067:PRO_0000000093)	Seeded From UniProt	complete
involved_in	GO:0070206	protein trimerization	PMID:19660551^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000955) part_of:(GO:0007568) has_input:(UniProtKB:P05067:PRO_0000000093) has_output:(ComplexPortal:CPX-1120) has_output:(ComplexPortal:CPX-1062)	Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	PMID:19660551^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000955) part_of:(GO:0007568) has_input:(UniProtKB:P05067:PRO_0000000093) has_output:(ComplexPortal:CPX-1120) has_output:(ComplexPortal:CPX-1062)	Seeded From UniProt	complete
involved_in	GO:1905906	regulation of amyloid fibril formation	PMID:11140685^[79]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	occurs_in:(UBERON:0002421)\|occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:11140685^[79]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	part_of:(GO:0090647)	Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	PMID:11140685^[79]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P		Seeded From UniProt	complete
involved_in	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	PMID:22500019^[80]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-3187 UniProtKB:O60896,UniProtKB:P30988	P		Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:16541076^[81]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16541076^[81]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
NOT\|involved_in	GO:1902514	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	PMID:21883149^[82]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0007268	chemical synaptic transmission	PMID:18216187^[83]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:26005850^[71]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000913)\|part_of:(UBERON:0001969)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23164821^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P10361	P	regulates_o_occurs_in:(CL:0002609) regulates_expression_of:(ENSEMBL:ENSRNOG00000008015)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSRNOG00000019422)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSRNOG00000011692)	Seeded From UniProt	complete
involved_in	GO:1903048	regulation of acetylcholine-gated cation channel activity	PMID:19118188^[84]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134,UniProtKB:P49582	P	occurs_in:(UBERON:0002421) has_regulation_target:(UniProtKB:P49582) part_of:(GO:1900273)	Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:19118188^[84]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134,UniProtKB:P49582	P	occurs_in:(UBERON:0002421) happens_during:(GO:1903048)	Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	PMID:19118188^[84]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134,UniProtKB:P49582	P	occurs_in:(UBERON:0002421) happens_during:(GO:1903048)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:19118188^[84]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134,UniProtKB:P49582	P	occurs_in:(UBERON:0002421) happens_during:(GO:1903048)	Seeded From UniProt	complete
NOT\|involved_in	GO:0010996	response to auditory stimulus	PMID:19118188^[84]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P		Seeded From UniProt	complete
involved_in	GO:0008306	associative learning	PMID:19118188^[84]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:19118188^[84]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	PMID:19118188^[84]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	occurs_in:(UBERON:0003881)	Seeded From UniProt	complete
involved_in	GO:1900272	negative regulation of long-term synaptic potentiation	PMID:19118188^[84]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	occurs_in:(UBERON:0003881)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08592:PRO_0000000163	P	occurs_in:(UBERON:0002421) has_regulation_target:(UniProtKB:P28482)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08592:PRO_0000000163	P	occurs_in:(UBERON:0002421) has_regulation_target:(UniProtKB:P28482) part_of:(GO:0051592)	Seeded From UniProt	complete
involved_in	GO:1905945	regulation of response to calcium ion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08592:PRO_0000000163	P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08592:PRO_0000000163	P	occurs_in:(UBERON:0002421) has_regulation_target:(UniProtKB:P28482)	Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08592:PRO_0000000163	P	occurs_in:(UBERON:0002421) has_regulation_target:(UniProtKB:P28482) activated_by:(CHEBI:39124)	Seeded From UniProt	complete
colocalizes_with	GO:0005764	lysosome	PMID:23152628^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002590)	Seeded From UniProt	complete
involved_in	GO:0048143	astrocyte activation	PMID:18723082^[85]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:F1M670	P		Seeded From UniProt	complete
involved_in	GO:0050867	positive regulation of cell activation	PMID:11689470^[86]	ECO:0000303	author statement without traceable support used in manual assertion		P	regulates_o_occurs_in:(CL:0000234)	Seeded From UniProt	complete
NOT\|part_of	GO:0031232	extrinsic component of external side of plasma membrane	PMID:15537891^[87]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
NOT\|colocalizes_with	GO:0032590	dendrite membrane	PMID:15537891^[87]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	PMID:25015123^[88]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P02649	P	has_regulation_target:(UniProtKB:P01130) regulates_o_occurs_in:(CL:2000044)\|has_regulation_target(UniProtKB:Q07954) regulates_o_occurs_in:(CL:2000044)	Seeded From UniProt	complete
involved_in	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	PMID:25015123^[88]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P01130) regulates_o_occurs_in:(CL:2000044)\|has_regulation_target(UniProtKB:Q07954) regulates_o_occurs_in:(CL:2000044)	Seeded From UniProt	complete
involved_in	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	PMID:20141570^[76]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P25090,UniProtKB:Q9UEW3	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:20141570^[76]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P25090,UniProtKB:Q9UEW3	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:20141570^[76]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P25090,UniProtKB:Q9UEW3	P	part_of:(GO:0001934)	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:23386614^[78]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:23386614^[78]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P05067)	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:22500019^[80]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:22500019^[80]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010739	positive regulation of protein kinase A signaling	PMID:22500019^[80]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:22500019^[80]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:26005850^[71]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1001602)	Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	PMID:15190117^[73]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	occurs_in:(UBERON:0002421) has_agent:(GO:0106003)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:18723082^[85]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:F1M670	P	regulates_o_occurs_in:(CL:0000129)\|regulates_o_occurs_in:(CL:0000127)	Seeded From UniProt	complete
involved_in	GO:1904022	positive regulation of G protein-coupled receptor internalization	PMID:18723082^[85]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000129) has_regulation_target:(UniProtKB:P25090)\|regulates_o_occurs_in(CL:0000127) has_regulation_target:(UniProtKB:P25090)	Seeded From UniProt	complete
involved_in	GO:0032930	positive regulation of superoxide anion generation	PMID:11316806^[65]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O88536	P	occurs_in:(CL:0000775)	Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:11316806^[65]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O88536	F	results_in_movement_of:(CL:0000775)\|results_in_movement_of:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	PMID:11316806^[65]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O88536) occurs_in:(CL:0000129)\|has_regulation_target(UniProtKB:P25090)\|has_regulation_target(UniProtKB:O88536) occurs_in:(CL:0000775)	Seeded From UniProt	complete
enables	GO:0030546	receptor activator activity	PMID:11316806^[65]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:P25090) positively_regulates:(GO:0007186)	Seeded From UniProt	complete
part_of	GO:0070381	endosome to plasma membrane transport vesicle	PMID:26005850^[71]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1001602)	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:11689470^[86]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P25090	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:11689470^[86]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
colocalizes_with	GO:0005886	plasma membrane	PMID:11689470^[86]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
colocalizes_with	GO:0005737	cytoplasm	PMID:11689470^[86]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0061903	positive regulation of 1-phosphatidylinositol-3-kinase activity	PMID:18723082^[85]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:F1M670	P	regulates_o_occurs_in:(CL:0000129) positively_regulates:(GO:0070371)\|regulates_o_occurs_in(CL:0000127) positively_regulates:(GO:0070371)	Seeded From UniProt	complete
involved_in	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	PMID:18723082^[85]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:F1M670	P	regulates_o_occurs_in:(CL:0000129)\|regulates_o_occurs_in:(CL:0000127)	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:11160457^[72]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:1904646) regulates_o_occurs_in:(CL:0000576) part_of:(GO:0019722) part_of:(GO:0097237)	Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	PMID:11160457^[72]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:1904646) occurs_in:(CL:0000576)	Seeded From UniProt	complete
involved_in	GO:0090026	positive regulation of monocyte chemotaxis	PMID:11160457^[72]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:1904646)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18723082^[85]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000129)\|part_of:(CL:0000127)	Seeded From UniProt	complete
involved_in	GO:0001774	microglial cell activation	PMID:18723082^[85]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:F1M670	P		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	PMID:19406747^[89]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06213	F	part_of:(GO:0008286)	Seeded From UniProt	complete
colocalizes_with	GO:0043005	neuron projection	PMID:25390368^[90]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608)	Seeded From UniProt	complete
colocalizes_with	GO:0044297	cell body	PMID:25390368^[90]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000125) part_of:(UBERON:0002421)\|part_of:(CL:0002608)	Seeded From UniProt	complete
colocalizes_with	GO:0098793	presynapse	PMID:25390368^[90]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000125) part_of:(UBERON:0002421)\|part_of:(CL:0002608)	Seeded From UniProt	complete
colocalizes_with	GO:0098794	postsynapse	PMID:25390368^[90]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000125) part_of:(UBERON:0002421)\|part_of:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:1900122	positive regulation of receptor binding	PMID:20037584^[91]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O00206) has_regulation_target:(UniProtKB:P16671) has_regulation_target:(UniProtKB:Q9Y2C9) occurs_in:(CL:0000576)	Seeded From UniProt	complete
involved_in	GO:1903223	positive regulation of oxidative stress-induced neuron death	PMID:20037584^[91]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9EPW9 UniProtKB:Q9QUK6	P	regulates_o_occurs_in:(CL:0000540) occurs_in:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:20037584^[91]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q80UF7 UniProtKB:Q9EPW9 UniProtKB:Q9QUK6	P	regulates_o_occurs_in:(CL:0000129) regulates_expression_of:(ENSEMBL:ENSMUSG00000035042)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:20037584^[91]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P22366 UniProtKB:Q9EPW9 UniProtKB:Q9QUK6	P	regulates_o_occurs_in:(CL:0000129) regulates_expression_of:(ENSEMBL:ENSMUSG00000027398)	Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:20037584^[91]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P16671	P	regulates_o_occurs_in:(CL:0000129) positively_regulates:(GO:0070997)	Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:20037584^[91]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O00206	P	regulates_o_occurs_in:(CL:0000129) positively_regulates:(GO:0070997)	Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:20037584^[91]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O00206,UniProtKB:P16671,UniProtKB:Q9Y2C9	P	regulates_o_occurs_in:(CL:0000129) positively_regulates:(GO:0070997)	Seeded From UniProt	complete
involved_in	GO:0034121	regulation of toll-like receptor signaling pathway	PMID:20037584^[91]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P16671	P	has_regulation_target:(UniProtKB:O00206) has_regulation_target:(UniProtKB:Q9Y2C9)	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:20037584^[91]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O00206,UniProtKB:P16671,UniProtKB:Q9Y2C9	P		Seeded From UniProt	complete
part_of	GO:1990777	lipoprotein particle	PMID:22138302^[75]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001359)	Seeded From UniProt	complete
NOT\|involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:22635104^[92]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:15447668^[93]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:15447668^[93]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	PMID:23921129^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	occurs_in:(CL:0002609)\|occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:1902950	regulation of dendritic spine maintenance	PMID:23921129^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	occurs_in:(CL:0002608) part_of:(GO:1904646) regulates_o_occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	PMID:23921129^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	regulates_o_occurs_in:(CL:0002609) part_of:(GO:1904646)	Seeded From UniProt	complete
enables	GO:0033130	acetylcholine receptor binding	PMID:10681545^[94]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P36544	F		Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:16541076^[81]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:29990310^[95]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:28750690^[96]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:28650319^[97]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:28219245^[98]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25938662^[99]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25732184^[100]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25686087^[101]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:24052308^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23907583^[102]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21949245^[103]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19264960^[104]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16492752^[105]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	F		Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0042056	P		Seeded From UniProt	complete
involved_in	GO:2000273	positive regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030549	P		Seeded From UniProt	complete
involved_in	GO:2000273	positive regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030546	P		Seeded From UniProt	complete
involved_in	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	PMID:12808450^[106]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q62151	P	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:1903523	negative regulation of blood circulation	PMID:12808450^[106]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P22387,UniProtKB:Q62151	P	occurs_in:(UBERON:0000956) regulates_o_occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
involved_in	GO:1904472	positive regulation of endothelin secretion	PMID:12808450^[106]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q62151	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:27853422^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000067900)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:23525105^[107]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:18602473^[108]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_output:(ComplexPortal:CPX-1180)	Seeded From UniProt	complete
involved_in	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	PMID:22406537^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15109	P	occurs_in:(UBERON:0000956) regulates_o_occurs_in:(UBERON:0000956)\|occurs_in(UBERON:0002421) regulates_o_occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:22406537^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050786	RAGE receptor binding	PMID:22406537^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15109	F		Seeded From UniProt	complete
colocalizes_with	GO:0009986	cell surface	PMID:15457210^[7]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0050750	low-density lipoprotein particle receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12023:PRO_0000000119	F		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	PMID:23164821^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P10909	P	occurs_in:(GO:0005622)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23164821^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O94907	P	regulates_o_occurs_in:(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000166886)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000155090)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000110092)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000170345)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000120738)	Seeded From UniProt	complete
enables	GO:0043395	heparan sulfate proteoglycan binding	PMID:21289173^[70]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	PMID:26005850^[71]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O95782) has_regulation_target:(UniProtKB:Q07954) regulates_o_occurs_in:(UBERON:0013694)\|has_regulation_target(UniProtKB:Q00610) has_regulation_target:(UniProtKB:Q07954) regulates_o_occurs_in:(UBERON:0013694)\|has_regulation_target(UniProtKB:Q13492) has_regulation_target:(UniProtKB:Q07954) regulates_o_occurs_in:(UBERON:0013694)	Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:18234671^[74]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13467 UniProtKB:Q9ULV1	F		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	PMID:22138302^[75]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0034185	apolipoprotein binding	PMID:22138302^[75]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02649	F	occurs_in:(UBERON:0001359)	Seeded From UniProt	complete
involved_in	GO:1902949	positive regulation of tau-protein kinase activity	PMID:23164821^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:D4A4F4	P	regulates_o_occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:1904591	positive regulation of protein import	PMID:23164821^[25]	ECO:0000314	direct assay evidence used in manual assertion		P	positively_regulates:(GO:0098776) has_regulation_target:(UniProtKB:P05371) occurs_in:(CL:0002609)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:18568035^[77]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:18568035^[77]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	F		Seeded From UniProt	complete
part_of	GO:0106003	amyloid-beta complex	PMID:23640054^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(UBERON:0000955) part_of:(UBERON:0000913)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:23640054^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(UBERON:0000955) part_of:(UBERON:0000913) part_of:(GO:0106003)	Seeded From UniProt	complete
involved_in	GO:0070206	protein trimerization	PMID:19660551^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000955) part_of:(GO:0007568) has_input:(UniProtKB:P05067:PRO_0000000092) has_output:(ComplexPortal:CPX-1120) has_output:(ComplexPortal:CPX-1062)	Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	PMID:19660551^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000955) part_of:(GO:0007568) has_input:(UniProtKB:P05067:PRO_0000000092) has_output:(ComplexPortal:CPX-1120) has_output:(ComplexPortal:CPX-1062)	Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	PMID:19660551^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(UBERON:0000955) part_of:(GO:0007568) has_output:(ComplexPortal:CPX-1120) has_output:(ComplexPortal:CPX-1062) has_input:(UniProtKB:P05067:PRO_0000000092)	Seeded From UniProt	complete
NOT\|colocalizes_with	GO:0030425	dendrite	PMID:17251419^[109]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:26005850^[71]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000913)\|part_of:(UBERON:0001969)	Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	PMID:23164821^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:D3Z9J1	P	regulates_o_occurs_in:(CL:0002609)	Seeded From UniProt	complete
colocalizes_with	GO:0005764	lysosome	PMID:23152628^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002590)	Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:22138302^[75]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034363	intermediate-density lipoprotein particle	PMID:22138302^[75]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
NOT\|colocalizes_with	GO:0097060	synaptic membrane	PMID:17308309^[110]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:21126803^[111]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000066) occurs_in:(GO:0009897)	Seeded From UniProt	complete
part_of	GO:0070381	endosome to plasma membrane transport vesicle	PMID:26005850^[71]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1001602)	Seeded From UniProt	complete
enables	GO:0034185	apolipoprotein binding	PMID:9211985^[112]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P18287	F	occurs_in:(GO:0034362)\|occurs_in:(GO:0034363)\|occurs_in:(GO:0034361)	Seeded From UniProt	complete
involved_in	GO:0042157	lipoprotein metabolic process	PMID:9211985^[112]	ECO:0000305	curator inference used in manual assertion	GO:0034185,GO:0034361,GO:0034362,GO:0034363,GO:0034364	P		Seeded From UniProt	complete
enables	GO:0034185	apolipoprotein binding	PMID:9211985^[112]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P09809	F	occurs_in:(GO:0034364)	Seeded From UniProt	complete
colocalizes_with	GO:0034361	very-low-density lipoprotein particle	PMID:9211985^[112]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02649	C		Seeded From UniProt	complete
colocalizes_with	GO:0034363	intermediate-density lipoprotein particle	PMID:9211985^[112]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02649	C		Seeded From UniProt	complete
colocalizes_with	GO:0034362	low-density lipoprotein particle	PMID:9211985^[112]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02649	C		Seeded From UniProt	complete
colocalizes_with	GO:0034364	high-density lipoprotein particle	PMID:9211985^[112]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02647	C		Seeded From UniProt	complete
enables	GO:0034185	apolipoprotein binding	PMID:9211985^[112]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04639	F	occurs_in:(GO:0034362)\|occurs_in:(GO:0034363)\|occurs_in:(GO:0034361)\|occurs_in:(GO:0034364)	Seeded From UniProt	complete
enables	GO:0034185	apolipoprotein binding	PMID:9211985^[112]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02647	F	occurs_in:(GO:0034364)	Seeded From UniProt	complete
enables	GO:0034185	apolipoprotein binding	PMID:9211985^[112]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02649	F	occurs_in:(GO:0034362)\|occurs_in:(GO:0034363)\|occurs_in:(GO:0034361)	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:26005850^[71]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1001602)	Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	PMID:2218531^[113]	ECO:0000314	direct assay evidence used in manual assertion		P	happens_during:(GO:0007416) happens_during:(GO:0016358) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	PMID:2218531^[113]	ECO:0000314	direct assay evidence used in manual assertion		P	happens_during:(GO:0030182) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:9228033^[114]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:18234671^[74]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P56704	P	occurs_in:(CL:0000540) regulates_expression_of:(ENSEMBL:ENSG00000168646) part_of:(GO:0090090)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:18234671^[74]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P56704	P	occurs_in:(CL:0000540) regulates_expression_of:(ENSEMBL:ENSG00000138795) part_of:(GO:0090090)	Seeded From UniProt	complete
involved_in	GO:1900181	negative regulation of protein localization to nucleus	PMID:18234671^[74]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P56704	P	occurs_in:(CL:0000540) has_regulation_target:(UniProtKB:P35222)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:18234671^[74]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P56704	P	occurs_in:(CL:0000540) regulates_expression_of:(ENSEMBL:ENSG00000110092) part_of:(GO:0090090)	Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:18234671^[74]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:9228033^[114]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10909	F		Seeded From UniProt	complete
part_of	GO:1990777	lipoprotein particle	PMID:22138302^[75]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001359)	Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:23106396^[115]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02511 UniProtKB:P10909	F		Seeded From UniProt	complete
part_of	GO:0106003	amyloid-beta complex	PMID:22179788^[116]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000093	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:22179788^[116]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:22179788^[116]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P05067:PRO_0000000093)	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:15447668^[93]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:15447668^[93]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P05067:PRO_0000000093)	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25543257^[117]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000093	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22179788^[116]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000093	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22036569^[118]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000093	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20133839^[119]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000093	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19841277^[120]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000093	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19706519^[121]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000093	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19706468^[122]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000093	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19458258^[123]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000093	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19304802^[124]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000093	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18499799^[125]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000093	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18483195^[126]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000093	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18059284^[127]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000093	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17116874^[128]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000093	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20164328^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:16541076^[81]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:20209079^[129]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:20209079^[129]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019731	antibacterial humoral response	PMID:20209079^[129]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:20209079^[129]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:20209079^[129]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001871) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0019732	antifungal humoral response	PMID:20209079^[129]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001871) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0001878	response to yeast	PMID:20209079^[129]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001871) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:20209079^[129]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:20209079^[129]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019731	antibacterial humoral response	PMID:20209079^[129]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:20209079^[129]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:20209079^[129]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001871) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0001878	response to yeast	PMID:20209079^[129]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001871) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0019732	antifungal humoral response	PMID:20209079^[129]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001871) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:1900221	regulation of amyloid-beta clearance	PMID:19057576^[130]	ECO:0000305	curator inference used in manual assertion	GO:0000979,GO:0006357	P		Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	PMID:19057576^[130]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000098,UniProtKB:P05067:PRO_0000000099	P	has_regulation_target:(ENSEMBL:ENSG00000196549) occurs_at:(SO:0000170)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19057576^[130]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000098,UniProtKB:P05067:PRO_0000000099	C	part_of:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:19057576^[130]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000098,UniProtKB:P05067:PRO_0000000099	P	has_input:(ENSEMBL:ENSG00000196549) occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	PMID:19057576^[130]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000098,UniProtKB:P05067:PRO_0000000099	F	has_input:(ENSEMBL:ENSG00000196549) occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:1900221	regulation of amyloid-beta clearance	PMID:19057576^[130]	ECO:0000305	curator inference used in manual assertion	GO:0000979,GO:0006357	P		Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	PMID:19057576^[130]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000097,UniProtKB:P05067:PRO_0000000099	P	has_regulation_target:(ENSEMBL:ENSG00000196549) occurs_at:(SO:0000170)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19057576^[130]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000097,UniProtKB:P05067:PRO_0000000099	C	part_of:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:19057576^[130]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000097,UniProtKB:P05067:PRO_0000000099	P	has_input:(ENSEMBL:ENSG00000196549) occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	PMID:19057576^[130]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000097,UniProtKB:P05067:PRO_0000000099	F	has_input:(ENSEMBL:ENSG00000196549) occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:1900221	regulation of amyloid-beta clearance	PMID:19057576^[130]	ECO:0000305	curator inference used in manual assertion	GO:0000979,GO:0006357	P		Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	PMID:19057576^[130]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000097,UniProtKB:P05067:PRO_0000000098	P	has_regulation_target:(ENSEMBL:ENSG00000196549) occurs_at:(SO:0000170)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19057576^[130]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000097,UniProtKB:P05067:PRO_0000000098	C	part_of:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:19057576^[130]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000097,UniProtKB:P05067:PRO_0000000098	P	has_input:(ENSEMBL:ENSG00000196549) occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	PMID:19057576^[130]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000097,UniProtKB:P05067:PRO_0000000098	F	has_input:(ENSEMBL:ENSG00000196549) occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21803450^[131]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O00213	P	regulates_transcription_of:(ENSEMBL:ENSG00000120885)	Seeded From UniProt	complete
NOT\|involved_in	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	PMID:21803450^[131]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905898	positive regulation of response to endoplasmic reticulum stress	PMID:21803450^[131]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905893	positive regulation of cellular response to thapsigargin	PMID:21803450^[131]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905896	positive regulation of cellular response to tunicamycin	PMID:21803450^[131]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:21803450^[131]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:1905893)\|part_of:(GO:1905896)\|part_of:(GO:1905898)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20164328^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(UBERON:0018241) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:16541076^[81]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	PMID:25390368^[90] PMID:24012003^[24] PMID:16541076^[81] PMID:16541076^[81] PMID:16541076^[81]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	causally_upstream_of:(GO:0007611)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:24012003^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	part_of:(GO:0090647) happens_during:(GO:0007568)	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:10806211^[132]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	PMID:17360908^[133]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	regulates_o_occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	Reactome:R-HSA-168249	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032588	trans-Golgi network membrane	Reactome:R-HSA-5229132 Reactome:R-HSA-5229111	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031904	endosome lumen	Reactome:R-HSA-9010096 Reactome:R-HSA-9010091 Reactome:R-HSA-8871506 Reactome:R-HSA-8871494 Reactome:R-HSA-6783332 Reactome:R-HSA-5692495 Reactome:R-HSA-5229111 PMID:24305806^[134] PMID:24305806^[134]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031093	platelet alpha granule lumen	Reactome:R-HSA-481007	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	Reactome:R-HSA-1474244	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-9010091 Reactome:R-HSA-9010034	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-844612 Reactome:R-HSA-844610 Reactome:R-HSA-844440 Reactome:R-HSA-1296421	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005796	Golgi lumen	Reactome:R-HSA-8871506	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-8952289	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-997411 Reactome:R-HSA-977136 Reactome:R-HSA-976734 Reactome:R-HSA-9010034 Reactome:R-HSA-8870710 Reactome:R-HSA-879411 Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-749452 Reactome:R-HSA-749448 Reactome:R-HSA-6783332 Reactome:R-HSA-481007 Reactome:R-HSA-391913 Reactome:R-HSA-380073 Reactome:R-HSA-379048 Reactome:R-HSA-2467665	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002576	platelet degranulation	Reactome:R-HSA-114608	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0914	P		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0722	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0168 UniProtKB-SubCell:SL-0069	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
enables	GO:0030414	peptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
involved_in	GO:0010466	negative regulation of peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0310	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0288	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0197	C		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:27853422^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	causally_upstream_of:(GO:0099177)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23164821^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000107984) regulates_o_occurs_in:(CL:0000540) negatively_regulates:(GO:0060070)	Seeded From UniProt	complete
NOT\|colocalizes_with	GO:0032590	dendrite membrane	PMID:20032460^[135] PMID:20032460^[135]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:1904399	heparan sulfate binding	PMID:21289173^[70] PMID:21289173^[70]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0030549	acetylcholine receptor activator activity	PMID:19118188^[84]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:11404397^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0002609)\|occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0010823	negative regulation of mitochondrion organization	PMID:22500019^[80]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097645	amylin binding	PMID:22500019^[80] PMID:22500019^[80]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:22500019^[80] PMID:22500019^[80]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:22500019^[80]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051247	positive regulation of protein metabolic process	PMID:20005821^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_input:(UniProtKB:P02649)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:20005821^[9] PMID:21803450^[131]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000123384) causally_upstream_of:(GO:0048259)	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kibbey, MC et al. (1993) beta-Amyloid precursor protein binds to the neurite-promoting IKVAV site of laminin. Proc. Natl. Acad. Sci. U.S.A. 90 10150-3 PubMed GONUTS page
↑ Huang, SM et al. (2006) Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function. J. Biol. Chem. 281 17941-51 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Deane, R et al. (2012) A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J. Clin. Invest. 122 1377-92 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Hu, YB et al. (2016) ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance. Front Cell Neurosci 10 253 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Li, B et al. (2011) WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity. PLoS ONE 6 e22920 PubMed GONUTS page
↑ ^6.0 ^6.1 Wu, Q et al. (2016) The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress. Front Mol Neurosci 9 140 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 Arancio, O et al. (2004) RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice. EMBO J. 23 4096-105 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Kim, T et al. (2013) Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Science 341 1399-404 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Kim, J et al. (2009) Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron 64 632-44 PubMed GONUTS page
↑ Wang, L et al. (2012) Antimicrobial activity of human islet amyloid polypeptides: an insight into amyloid peptides' connection with antimicrobial peptides. Biol. Chem. 393 641-6 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Cissé, M et al. (2011) Reversing EphB2 depletion rescues cognitive functions in Alzheimer model. Nature 469 47-52 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Takeda, S et al. (2013) Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease. FASEB J. 27 3239-48 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 ^13.8 ^13.9 Shankar, GM et al. (2009) Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiol. Dis. 36 293-302 PubMed GONUTS page
↑ ^14.0 ^14.1 Chen, G et al. () A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease. Nature 408 975-9 PubMed GONUTS page
↑ ^15.0 ^15.1 Westerman, MA et al. (2002) The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J. Neurosci. 22 1858-67 PubMed GONUTS page
↑ Kaufman, AC et al. (2015) Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. Ann. Neurol. 77 953-71 PubMed GONUTS page
↑ ^17.0 ^17.1 Dziewczapolski, G et al. (2009) Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease. J. Neurosci. 29 8805-15 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 ^18.8 Kam, TI et al. (2013) FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease. J. Clin. Invest. 123 2791-802 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Dineley, KT et al. (2001) Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. J. Neurosci. 21 4125-33 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Kanekiyo, T et al. (2012) LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β. J. Neurosci. 32 16458-65 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 Hernandez, CM et al. (2010) Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease. J. Neurosci. 30 2442-53 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 Gimbel, DA et al. (2010) Memory impairment in transgenic Alzheimer mice requires cellular prion protein. J. Neurosci. 30 6367-74 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 Liu, S et al. (2012) TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation. J. Immunol. 188 1098-107 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 Um, JW et al. (2013) Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein. Neuron 79 887-902 PubMed GONUTS page
↑ ^25.00 ^25.01 ^25.02 ^25.03 ^25.04 ^25.05 ^25.06 ^25.07 ^25.08 ^25.09 ^25.10 ^25.11 ^25.12 Killick, R et al. (2014) Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol. Psychiatry 19 88-98 PubMed GONUTS page
↑ ^26.0 ^26.1 Söderman, A et al. (2011) Activation of nicotinic α(7) acetylcholine receptor enhances long term potentation in wild type mice but not in APP(swe)/PS1ΔE9 mice. Neurosci. Lett. 487 325-9 PubMed GONUTS page
↑ ^27.0 ^27.1 Matarin, M et al. (2015) A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology. Cell Rep 10 633-44 PubMed GONUTS page
↑ ^28.0 ^28.1 Schöbel, S et al. (2008) A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. J. Biol. Chem. 283 14257-68 PubMed GONUTS page
↑ Schmidt, V et al. (2012) Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease. EMBO J. 31 187-200 PubMed GONUTS page
↑ ^30.0 ^30.1 Liu, FL et al. (2014) FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines. J. Biosci. 39 85-95 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 Ullrich, S et al. (2010) The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein. J. Biol. Chem. 285 20664-74 PubMed GONUTS page
↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
↑ ^34.0 ^34.1 Noviello, C et al. (2003) Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor protein. J. Biol. Chem. 278 31843-7 PubMed GONUTS page
↑ Matsuda, S et al. (2009) CD74 interacts with APP and suppresses the production of Abeta. Mol Neurodegener 4 41 PubMed GONUTS page
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HUMAN:A4

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