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PMID:28750690
| Citation |
Wang, HY, Trocmé-Thibierge, C, Stucky, A, Shah, SM, Kvasic, J, Khan, A, Morain, P, Guignot, I, Bouguen, E, Deschet, K, Pueyo, M, Mocaer, E, Ousset, PJ, Vellas, B and Kiyasova, V (2017) Increased Aβ-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer's disease pathogenesis. Alzheimers Res Ther 9:54 |
|---|---|
| Abstract |
The apolipoprotein E ε4 (APOE4) genotype is a prominent late-onset Alzheimer's disease (AD) risk factor. ApoE4 disrupts memory function in rodents and may contribute to both plaque and tangle formation. |
| Links |
PubMed PMC5530996 Online version:10.1186/s13195-017-0280-8 |
| Keywords |
Aged; Aged, 80 and over; Alzheimer Disease/genetics; Alzheimer Disease/pathology; Amyloid beta-Peptides/metabolism; Amyloid beta-Peptides/pharmacology; Animals; Cognitive Dysfunction/genetics; Cognitive Dysfunction/pathology; Dose-Response Relationship, Drug; Female; Frontal Lobe/ultrastructure; Humans; Lymphocytes/drug effects; Lymphocytes/metabolism; Male; Peptide Fragments/metabolism; Peptide Fragments/pharmacology; Phosphorylation/drug effects; Protein Binding/drug effects; Rats; Rats, Sprague-Dawley; Receptors, LDL/metabolism; Statistics as Topic; Synaptosomes/metabolism; Synaptosomes/ultrastructure; alpha7 Nicotinic Acetylcholine Receptor/metabolism; tau Proteins/metabolism |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0042802: identical protein binding |
ECO:0000353: physical interaction evidence used in manual assertion |
UniProtKB:P05067:PRO_0000000092 |
F |
Seeded From UniProt |
complete | ||
Notes
See also
References
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