MOUSE:GLI1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Gli1 (synonyms: Gli)
Protein Name(s)	Zinc finger protein GLI1 Glioma-associated oncogene homolog
External Links
UniProt	P47806
EMBL	AF026305 AB025922 AC114678 CH466578
CCDS	CCDS24238.1
RefSeq	NP_034426.2
UniGene	Mm.391450
ProteinModelPortal	P47806
SMR	P47806
BioGrid	199942
IntAct	P47806
STRING	10090.ENSMUSP00000026474
ChEMBL	CHEMBL5007
PhosphoSite	P47806
PaxDb	P47806
PRIDE	P47806
Ensembl	ENSMUST00000026474
GeneID	14632
KEGG	mmu:14632
UCSC	uc007hjf.1
CTD	2735
MGI	MGI:95727
eggNOG	COG5048
GeneTree	ENSGT00760000118771
HOGENOM	HOG000290688
HOVERGEN	HBG080668
InParanoid	P47806
KO	K16797
OMA	CPRLEHY
OrthoDB	EOG7X6KZ8
TreeFam	TF350216
Reactome	REACT_268705 REACT_269412
NextBio	286482
PRO	PR:P47806
Proteomes	UP000000589
CleanEx	MM_GLI1
ExpressionAtlas	P47806
Genevestigator	P47806
GO	GO:0005929 GO:0005737 GO:0005829 GO:0005634 GO:0072372 GO:0003682 GO:0003677 GO:0046872 GO:0008017 GO:0003705 GO:0044212 GO:0021696 GO:0009953 GO:0009913 GO:0030324 GO:0090090 GO:0060032 GO:0001649 GO:0021983 GO:0045740 GO:0045880 GO:0045944 GO:0045893 GO:0009954 GO:0007165 GO:0007224 GO:0021938 GO:0007283 GO:0006366 GO:0007418
Gene3D	3.30.160.60
InterPro	IPR007087 IPR015880 IPR013087
Pfam	PF00096
SMART	SM00355
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045667	regulation of osteoblast differentiation	PMID:22493482^[1]	ECO:0000315			P		Figure 2 shows how osteoblast differentiation is altered by defects in Gli1.	complete CACAO 4856
	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16254602^[2]	ECO:0000314			P		Gli1 increased transcription of Ptch1 compared to the GFP control in limb bud cells (Figure 3A).	complete CACAO 10671
	GO:0005930	axoneme	PMID:16254602^[2]	ECO:0000314			C		Figure 5A shows Gli1 localization in the cilium axoneme.	complete CACAO 10699
Colocalizes with	GO:0097542	ciliary tip	PMID:16254602^[2]	ECO:0000314			C		Figure 5 shows ciliary tip localization due to failure of GFP to colocalize with gamma-tubulin in addition to colocalizing within a domain of Polaris.	complete CACAO 10718
colocalizes_with	GO:0097542	ciliary tip	PMID:16254602^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005930	axoneme	PMID:16254602^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16254602^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08151-1	F		Seeded From UniProt	complete
involved_in	GO:0045667	regulation of osteoblast differentiation	PMID:22493482^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17035233^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007418	ventral midline development	PMID:10725236^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P	results_in_development_of:(EMAPA:16903)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	PMID:11717126^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:18449196^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P	occurs_in:(EMAPA:17168)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:9769173^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:19124651^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17168)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:19684112^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:16254602^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16316410^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1345643	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19684112^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11821712^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11717126^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19684112^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)\|part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17442700^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16489008^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17528)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16316410^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16254602^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11717126^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:17442700^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16396903^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:17373) has_participant:(MGI:MGI:97486)\|occurs_in(EMAPA:17373) has_participant:(MGI:MGI:1889585)\|occurs_in(EMAPA:17373) has_participant:(MGI:MGI:97357)\|occurs_in(EMAPA:17373) has_participant:(MGI:MGI:88313)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15614767^[15]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:1096383)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:17442700^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:23740243^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000345	regulation of hepatocyte proliferation	PMID:23740243^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902808	positive regulation of cell cycle G1/S phase transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097421	liver regeneration	PMID:23740243^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:23740243^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060045	positive regulation of cardiac muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060032	notochord regression	PMID:10725236^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P	has_participant:(EMAPA:16191)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23740243^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17442700^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:105373)\|has_regulation_target:(MGI:MGI:97347)\|has_regulation_target:(MGI:MGI:108067)\|has_regulation_target:(MGI:MGI:104606)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16611981^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16936075^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15614767^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045880	positive regulation of smoothened signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045740	positive regulation of DNA replication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:10725236^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P	results_in_development_of:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021983	pituitary gland development	PMID:10725236^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P	results_in_development_of:(EMAPA:16898)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	PMID:16571625^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P	occurs_in:(EMAPA:17787) occurs_in:(CL:0000120)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021696	cerebellar cortex morphogenesis	PMID:16571625^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P	has_participant:(EMAPA:17787)\|has_participant:(EMAPA:17787)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009954	proximal/distal pattern formation	PMID:16342201^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:16342201^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009913	epidermal cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009611	response to wounding	PMID:23740243^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009611	response to wounding	PMID:23740243^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08151	P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:11717126^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6X8 ensembl:ENSRNOP00000009803	P		Seeded From UniProt	complete
involved_in	GO:0030850	prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6X8 ensembl:ENSRNOP00000009803	P		Seeded From UniProt	complete
involved_in	GO:0060045	positive regulation of cardiac muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08151 ensembl:ENSP00000228682	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08151 ensembl:ENSP00000228682	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08151 ensembl:ENSP00000228682	P		Seeded From UniProt	complete
involved_in	GO:0045880	positive regulation of smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08151 ensembl:ENSP00000228682	P		Seeded From UniProt	complete
involved_in	GO:0045740	positive regulation of DNA replication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08151 ensembl:ENSP00000228682	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08151 ensembl:ENSP00000228682	F		Seeded From UniProt	complete
involved_in	GO:0009913	epidermal cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08151 ensembl:ENSP00000228682	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08151 ensembl:ENSP00000228682	P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08151 ensembl:ENSP00000228682	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08151 ensembl:ENSP00000228682	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08151 ensembl:ENSP00000228682	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08151 ensembl:ENSP00000228682	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08151 ensembl:ENSP00000228682	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08151 ensembl:ENSP00000228682	F		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08151 ensembl:ENSP00000228682	P		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08151 ensembl:ENSP00000228682	F		Seeded From UniProt	complete
involved_in	GO:1902808	positive regulation of cell cycle G1/S phase transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08151 ensembl:ENSP00000228682	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08151 ensembl:ENSP00000228682	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032850	F		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032850	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032850	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032850	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007165	signal transduction	PMID:11717126^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Hojo, H et al. (2012) Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification. J. Biol. Chem. 287 17860-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Haycraft, CJ et al. (2005) Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet. 1 e53 PubMed GONUTS page
↑ He, J et al. (2006) Suppressing Wnt signaling by the hedgehog pathway through sFRP-1. J. Biol. Chem. 281 35598-602 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Park, HL et al. (2000) Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development 127 1593-605 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Kroft, TL et al. (2001) GLI1 localization in the germinal epithelial cells alternates between cytoplasm and nucleus: upregulation in transgenic mice blocks spermatogenesis in pachytene. Biol. Reprod. 65 1663-71 PubMed GONUTS page
↑ Mariani, FV et al. (2008) Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning. Nature 453 401-5 PubMed GONUTS page
↑ Dassule, HR & McMahon, AP (1998) Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev. Biol. 202 215-27 PubMed GONUTS page
↑ Wall, DS et al. (2009) Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J. Cell Biol. 184 101-12 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Chen, MH et al. (2009) Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 23 1910-28 PubMed GONUTS page
↑ ^10.0 ^10.1 Barnfield, PC et al. (2005) Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation 73 397-405 PubMed GONUTS page
↑ Kubis, N et al. (2002) Decreased arteriolar density in endothelial nitric oxide synthase knockout mice is due to hypertension, not to the constitutive defect in endothelial nitric oxide synthase enzyme. J. Hypertens. 20 273-80 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Vokes, SA et al. (2007) Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development 134 1977-89 PubMed GONUTS page
↑ Adolphe, C et al. (2006) Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res. 66 2081-8 PubMed GONUTS page
↑ Hu, MC et al. (2006) GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133 569-78 PubMed GONUTS page
↑ ^15.0 ^15.1 Saitsu, H et al. (2005) Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain. Dev. Dyn. 232 282-92 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Nakamura, I et al. (2013) Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration. J. Biol. Chem. 288 21389-98 PubMed GONUTS page
↑ Pan, Y et al. (2006) Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol. Cell. Biol. 26 3365-77 PubMed GONUTS page
↑ Borello, U et al. (2006) The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis. Development 133 3723-32 PubMed GONUTS page
↑ ^19.0 ^19.1 Corrales, JD et al. (2006) The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation. Development 133 1811-21 PubMed GONUTS page
↑ ^20.0 ^20.1 Furimsky, M & Wallace, VA (2006) Complementary Gli activity mediates early patterning of the mouse visual system. Dev. Dyn. 235 594-605 PubMed GONUTS page

[PMID:22493482-1] 1.0 ^1.1 Hojo, H et al. (2012) Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification. J. Biol. Chem. 287 17860-9 PubMed GONUTS page

[PMID:16254602-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Haycraft, CJ et al. (2005) Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet. 1 e53 PubMed GONUTS page

[PMID:17035233-3] He, J et al. (2006) Suppressing Wnt signaling by the hedgehog pathway through sFRP-1. J. Biol. Chem. 281 35598-602 PubMed GONUTS page

[PMID:10725236-4] 4.0 ^4.1 ^4.2 ^4.3 Park, HL et al. (2000) Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development 127 1593-605 PubMed GONUTS page

[PMID:11717126-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Kroft, TL et al. (2001) GLI1 localization in the germinal epithelial cells alternates between cytoplasm and nucleus: upregulation in transgenic mice blocks spermatogenesis in pachytene. Biol. Reprod. 65 1663-71 PubMed GONUTS page

[PMID:18449196-6] Mariani, FV et al. (2008) Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning. Nature 453 401-5 PubMed GONUTS page

[PMID:9769173-7] Dassule, HR & McMahon, AP (1998) Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev. Biol. 202 215-27 PubMed GONUTS page

[PMID:19124651-8] Wall, DS et al. (2009) Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J. Cell Biol. 184 101-12 PubMed GONUTS page

[PMID:19684112-9] 9.0 ^9.1 ^9.2 Chen, MH et al. (2009) Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 23 1910-28 PubMed GONUTS page

[PMID:16316410-10] 10.0 ^10.1 Barnfield, PC et al. (2005) Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation 73 397-405 PubMed GONUTS page

[PMID:11821712-11] Kubis, N et al. (2002) Decreased arteriolar density in endothelial nitric oxide synthase knockout mice is due to hypertension, not to the constitutive defect in endothelial nitric oxide synthase enzyme. J. Hypertens. 20 273-80 PubMed GONUTS page

[PMID:17442700-12] 12.0 ^12.1 ^12.2 ^12.3 Vokes, SA et al. (2007) Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development 134 1977-89 PubMed GONUTS page

[PMID:16489008-13] Adolphe, C et al. (2006) Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res. 66 2081-8 PubMed GONUTS page

[PMID:16396903-14] Hu, MC et al. (2006) GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133 569-78 PubMed GONUTS page

[PMID:15614767-15] 15.0 ^15.1 Saitsu, H et al. (2005) Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain. Dev. Dyn. 232 282-92 PubMed GONUTS page

[PMID:23740243-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Nakamura, I et al. (2013) Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration. J. Biol. Chem. 288 21389-98 PubMed GONUTS page

[PMID:16611981-17] Pan, Y et al. (2006) Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol. Cell. Biol. 26 3365-77 PubMed GONUTS page

[PMID:16936075-18] Borello, U et al. (2006) The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis. Development 133 3723-32 PubMed GONUTS page

[PMID:16571625-19] 19.0 ^19.1 Corrales, JD et al. (2006) The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation. Development 133 1811-21 PubMed GONUTS page

[PMID:16342201-20] 20.0 ^20.1 Furimsky, M & Wallace, VA (2006) Complementary Gli activity mediates early patterning of the mouse visual system. Dev. Dyn. 235 594-605 PubMed GONUTS page

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