CHICK:O93345

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	Lef-1 (ECO:0000313 with EMBL:AAC24524.1)
Protein Name(s)	Lymphiod enhancer binding factor 1 (ECO:0000313 with EMBL:BAE78809.1) Transcription factor LEF-1 (ECO:0000313 with EMBL:AAC24524.1) Uncharacterized protein (ECO:0000313 with Ensembl:ENSGALP00000017123)
External Links
UniProt	O93345
EMBL	AADN03003953 AADN03004031 AF064462 AB188385
RefSeq	NP_990344.1
UniGene	Gga.2694
SMR	O93345
STRING	9031.ENSGALP00000017123
Ensembl	ENSGALT00000017142
GeneID	395865
KEGG	gga:395865
CTD	51176
eggNOG	NOG299161
GeneTree	ENSGT00390000009964
HOGENOM	HOG000116032
HOVERGEN	HBG000419
KO	K04492
OMA	GYSGYIM
OrthoDB	EOG7QNVMG
PhylomeDB	O93345
TreeFam	TF318448
Reactome	REACT_195024 REACT_203085 REACT_203522
NextBio	20815932
PRO	PR:O93345
Proteomes	UP000000539
GO	GO:0005737 GO:0005634 GO:0032993 GO:0005667 GO:0070016 GO:0008013 GO:0003682 GO:0043027 GO:0003677 GO:0008301 GO:0035326 GO:0030284 GO:0030331 GO:0045295 GO:0000978 GO:0001077 GO:0003705 GO:0043565 GO:0003700 GO:0046632 GO:0060033 GO:0060561 GO:1902262 GO:0042100 GO:0030509 GO:0060070 GO:0060326 GO:0048468 GO:0008283 GO:0071353 GO:0060710 GO:0061073 GO:0021542 GO:0030326 GO:0001837 GO:0048069 GO:0060325 GO:0021873 GO:0021879 GO:0021861 GO:0021943 GO:0021766 GO:0043966 GO:0043967 GO:0021854 GO:0061072 GO:0035108 GO:0030879 GO:0048747 GO:0071866 GO:0090090 GO:0022408 GO:0043154 GO:0043392 GO:0071899 GO:0032696 GO:0032713 GO:0032714 GO:0045665 GO:0045843 GO:0000122 GO:0001755 GO:0030223 GO:0071895 GO:0001649 GO:0060021 GO:0048341 GO:0001569 GO:0043923 GO:0090068 GO:0030307 GO:0030335 GO:0071864 GO:0022409 GO:0010718 GO:0030854 GO:0045944 GO:0045893 GO:0022407 GO:0016202 GO:0006357 GO:0050909 GO:0001756 GO:0002040 GO:0033153 GO:0045063 GO:0043586 GO:0061153
Gene3D	1.10.30.10 4.10.900.10
InterPro	IPR027397 IPR013558 IPR009071 IPR028769 IPR024940
PANTHER	PTHR10373 PTHR10373:SF11
Pfam	PF08347 PF00505
SMART	SM00398
SUPFAM	SSF47095
PROSITE	PS50118

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0030178	negative regulation of Wnt receptor signaling pathway	PMID:19850024^[1]	ECO:0000315			P		Figure 1: Negative regulation of Wnt signaling is observed through dominant negative analysis.	complete
	GO:0008134	transcription factor binding	PMID:19850024^[1]	ECO:0000021		UniProtKB:O93385	F		Figure 1: Interaction is observed between Pitx2 and Lef-1 through somitogenesis.	complete
	GO:0090244	Wnt receptor signaling pathway involved in somitogenesis	PMID:19850024^[1]	ECO:0000315			P		Figure 2: Clear involvement of Lef-1 with the Wnt signaling pathway is observed.	complete
	GO:0061055	myotome development	PMID:19850024^[1]	ECO:0000315			P		Figure 2 and 3 show the gene is clearly involved in myotome development.	complete
	GO:0061185	negative regulation of dermatome development	PMID:19850024^[1]	ECO:0000315			P		Figure 3: Misexpression caused an increased development in the dermatome development suggesting the gene to have a negative effect in vivo.	complete
involved_in	GO:0030326	embryonic limb morphogenesis	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0030111	regulation of Wnt signaling pathway	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0022407	regulation of cell-cell adhesion	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0021943	formation of radial glial scaffolds	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0021873	forebrain neuroblast division	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0021861	forebrain radial glial cell differentiation	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0021766	hippocampus development	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0021542	dentate gyrus development	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	F		Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0001944	vasculature development	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:9596583^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9596583^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035108	limb morphogenesis	PMID:9596583^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:9596583^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042100	B cell proliferation	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0033153	T cell receptor V(D)J recombination	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:1902262	apoptotic process involved in blood vessel morphogenesis	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0061153	trachea gland development	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0060561	apoptotic process involved in morphogenesis	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0060325	face morphogenesis	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0060033	anatomical structure regression	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0060021	roof of mouth development	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0050909	sensory perception of taste	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0048341	paraxial mesoderm formation	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0046632	alpha-beta T cell differentiation	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0045843	negative regulation of striated muscle tissue development	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0045063	T-helper 1 cell differentiation	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	F		Seeded From UniProt	complete
involved_in	GO:0043586	tongue development	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:15642085^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	F		Seeded From UniProt	complete
involved_in	GO:0061073	ciliary body morphogenesis	PMID:16854977^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061072	iris morphogenesis	PMID:16854977^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:15254905^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:9596583^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	part_of:(GO:0035108)	Seeded From UniProt	complete
involved_in	GO:0062009	secondary palate development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0048468	cell development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0048341	paraxial mesoderm formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0048069	eye pigmentation	PMID:16854977^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9596583^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q90722)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0045843	negative regulation of striated muscle tissue development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	PMID:12490564^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035108	limb morphogenesis	PMID:9596583^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0021766	hippocampus development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	F		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:12490564^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15254905^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15254905^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	F		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27782	P		Seeded From UniProt	complete
involved_in	GO:0071895	odontoblast differentiation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000042972 RGD:620241	P		Seeded From UniProt	complete
involved_in	GO:0071866	negative regulation of apoptotic process in bone marrow cell	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000042972 UniProtKB:Q9UJU2	P		Seeded From UniProt	complete
involved_in	GO:0071864	positive regulation of cell proliferation in bone marrow	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000042972 UniProtKB:Q9UJU2	P		Seeded From UniProt	complete
enables	GO:0070016	armadillo repeat domain binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000042972 UniProtKB:Q9UJU2	F		Seeded From UniProt	complete
involved_in	GO:0061153	trachea gland development	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972	P		Seeded From UniProt	complete
involved_in	GO:0060710	chorio-allantoic fusion	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042973	P		Seeded From UniProt	complete
involved_in	GO:0060561	apoptotic process involved in morphogenesis	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972	P		Seeded From UniProt	complete
involved_in	GO:0060325	face morphogenesis	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0085432 MGI:MGI:1202879 MGI:MGI:96770 PANTHER:PTN000042967 UniProtKB:O93345 UniProtKB:Q9UJU2 ZFIN:ZDB-GENE-990714-26 ZFIN:ZDB-GENE-991110-8	P		Seeded From UniProt	complete
involved_in	GO:0048341	paraxial mesoderm formation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972	P		Seeded From UniProt	complete
involved_in	GO:0048069	eye pigmentation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000042972 UniProtKB:O93345	P		Seeded From UniProt	complete
involved_in	GO:0046632	alpha-beta T cell differentiation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN002571435 UniProtKB:Q9UJU2	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN002571435 UniProtKB:O93345 UniProtKB:Q9UJU2	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN002571435 UniProtKB:Q9UJU2	P		Seeded From UniProt	complete
enables	GO:0045295	gamma-catenin binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000042972 UniProtKB:Q9UJU2	F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202879 MGI:MGI:96770 PANTHER:PTN000042967 UniProtKB:P36402 UniProtKB:Q9NQB0 UniProtKB:Q9UJU2	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202879 MGI:MGI:96770 PANTHER:PTN000042967 UniProtKB:Q9NQB0 UniProtKB:Q9UJU2 WB:WBGene00004077	F		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000042972 UniProtKB:Q9UJU2	P		Seeded From UniProt	complete
involved_in	GO:0042100	B cell proliferation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972	P		Seeded From UniProt	complete
enables	GO:0035326	enhancer binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000042972 UniProtKB:Q9UJU2	F		Seeded From UniProt	complete
involved_in	GO:0032714	negative regulation of interleukin-5 production	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000042972 UniProtKB:Q9UJU2	P		Seeded From UniProt	complete
involved_in	GO:0032713	negative regulation of interleukin-4 production	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000042972 UniProtKB:Q9UJU2	P		Seeded From UniProt	complete
involved_in	GO:0032696	negative regulation of interleukin-13 production	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000042972 UniProtKB:Q9UJU2	P		Seeded From UniProt	complete
involved_in	GO:0030879	mammary gland development	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972	P		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000042972 UniProtKB:Q9UJU2	F		Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972	P		Seeded From UniProt	complete
involved_in	GO:0030223	neutrophil differentiation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000042972 UniProtKB:Q9UJU2	P		Seeded From UniProt	complete
involved_in	GO:0022407	regulation of cell-cell adhesion	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972	P		Seeded From UniProt	complete
involved_in	GO:0021943	formation of radial glial scaffolds	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972	P		Seeded From UniProt	complete
involved_in	GO:0021873	forebrain neuroblast division	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972	P		Seeded From UniProt	complete
involved_in	GO:0021861	forebrain radial glial cell differentiation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972	P		Seeded From UniProt	complete
involved_in	GO:0021542	dentate gyrus development	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202876 MGI:MGI:1202879 PANTHER:PTN000042967 UniProtKB:P36402 UniProtKB:Q9NQB0 UniProtKB:Q9UJU2 WB:WBGene00004077	F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202879 MGI:MGI:96770 PANTHER:PTN000042967 UniProtKB:Q9NQB0	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0085432 MGI:MGI:1202879 MGI:MGI:98507 PANTHER:PTN000042967	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972 UniProtKB:O93345 UniProtKB:Q9UJU2	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0085432 MGI:MGI:1202879 MGI:MGI:96770 PANTHER:PTN000042967 UniProtKB:Q9UJU2	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0085432 MGI:MGI:1202876 MGI:MGI:1202879 MGI:MGI:96770 MGI:MGI:98507 PANTHER:PTN000042967 RGD:620241 UniProtKB:O93345 UniProtKB:P36402 UniProtKB:Q9HCS4 UniProtKB:Q9NQB0 UniProtKB:Q9UJU2 WB:WBGene00004077 Xenbase:XB-GENE-1031985 ZFIN:ZDB-GENE-980605-30 ZFIN:ZDB-GENE-991110-8	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972 UniProtKB:Q9UJU2	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972	F		Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972	P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972	P		Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972	P		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000042972 UniProtKB:Q9UJU2	P		Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN000042972	P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96770 PANTHER:PTN002571435	F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028769	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028769	F		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024940 InterPro:IPR028769	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000400811	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000400811	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Abu-Elmagd, M et al. (2010) Wnt/Lef1 signaling acts via Pitx2 to regulate somite myogenesis. Dev. Biol. 337 211-9 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 ^2.19 ^2.20 ^2.21 ^2.22 ^2.23 ^2.24 ^2.25 ^2.26 ^2.27 ^2.28 ^2.29 ^2.30 ^2.31 ^2.32 ^2.33 ^2.34 ^2.35 ^2.36 ^2.37 ^2.38 ^2.39 ^2.40 ^2.41 ^2.42 ^2.43 ^2.44 ^2.45 ^2.46 ^2.47 Kuraku, S et al. () Comprehensive survey of carapacial ridge-specific genes in turtle implies co-option of some regulatory genes in carapace evolution. Evol. Dev. 7 3-17 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Kengaku, M et al. (1998) Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud. Science 280 1274-7 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Cho, SH & Cepko, CL (2006) Wnt2b/beta-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye. Development 133 3167-77 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 de Melker, AA et al. (2004) Cellular localization and signaling activity of beta-catenin in migrating neural crest cells. Dev. Dyn. 230 708-26 PubMed GONUTS page
↑ ^6.0 ^6.1 Kubo, F et al. (2003) Wnt2b controls retinal cell differentiation at the ciliary marginal zone. Development 130 587-98 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 ^7.18 ^7.19 ^7.20 ^7.21 ^7.22 ^7.23 ^7.24 ^7.25 ^7.26 ^7.27 ^7.28 ^7.29 ^7.30 ^7.31 ^7.32 ^7.33 ^7.34 ^7.35 ^7.36 ^7.37 ^7.38 ^7.39 ^7.40 ^7.41 ^7.42 ^7.43 ^7.44 ^7.45 ^7.46 ^7.47 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19850024-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Abu-Elmagd, M et al. (2010) Wnt/Lef1 signaling acts via Pitx2 to regulate somite myogenesis. Dev. Biol. 337 211-9 PubMed GONUTS page

[PMID:15642085-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 ^2.19 ^2.20 ^2.21 ^2.22 ^2.23 ^2.24 ^2.25 ^2.26 ^2.27 ^2.28 ^2.29 ^2.30 ^2.31 ^2.32 ^2.33 ^2.34 ^2.35 ^2.36 ^2.37 ^2.38 ^2.39 ^2.40 ^2.41 ^2.42 ^2.43 ^2.44 ^2.45 ^2.46 ^2.47 Kuraku, S et al. () Comprehensive survey of carapacial ridge-specific genes in turtle implies co-option of some regulatory genes in carapace evolution. Evol. Dev. 7 3-17 PubMed GONUTS page

[PMID:9596583-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Kengaku, M et al. (1998) Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud. Science 280 1274-7 PubMed GONUTS page

[PMID:16854977-4] 4.0 ^4.1 ^4.2 Cho, SH & Cepko, CL (2006) Wnt2b/beta-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye. Development 133 3167-77 PubMed GONUTS page

[PMID:15254905-5] 5.0 ^5.1 ^5.2 de Melker, AA et al. (2004) Cellular localization and signaling activity of beta-catenin in migrating neural crest cells. Dev. Dyn. 230 708-26 PubMed GONUTS page

[PMID:12490564-6] 6.0 ^6.1 Kubo, F et al. (2003) Wnt2b controls retinal cell differentiation at the ciliary marginal zone. Development 130 587-98 PubMed GONUTS page

[PMID:21873635-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 ^7.18 ^7.19 ^7.20 ^7.21 ^7.22 ^7.23 ^7.24 ^7.25 ^7.26 ^7.27 ^7.28 ^7.29 ^7.30 ^7.31 ^7.32 ^7.33 ^7.34 ^7.35 ^7.36 ^7.37 ^7.38 ^7.39 ^7.40 ^7.41 ^7.42 ^7.43 ^7.44 ^7.45 ^7.46 ^7.47 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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