HUMAN:FZD5

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FZD5 (synonyms: C2orf31)
Protein Name(s)	Frizzled-5 Fz-5 hFz5 FzE5
External Links
UniProt	Q13467
EMBL	U43318 AB043702 AK290386 AK315338 AC096772
CCDS	CCDS33366.1
RefSeq	NP_003459.2
UniGene	Hs.17631
ProteinModelPortal	Q13467
SMR	Q13467
BioGrid	113609
IntAct	Q13467
MINT	MINT-7005936
STRING	9606.ENSP00000354607
MEROPS	I93.001
PhosphoSite	Q13467
DMDM	116242481
MaxQB	Q13467
PaxDb	Q13467
PRIDE	Q13467
DNASU	7855
Ensembl	ENST00000295417
GeneID	7855
KEGG	hsa:7855
UCSC	uc002vcj.3
CTD	7855
GeneCards	GC02M208628
HGNC	HGNC:4043
HPA	HPA052361 HPA053811
MIM	601723
neXtProt	NX_Q13467
PharmGKB	PA28460
eggNOG	NOG257258
GeneTree	ENSGT00760000118864
HOGENOM	HOG000233236
HOVERGEN	HBG006977
InParanoid	Q13467
KO	K02375
OMA	AATYHKQ
OrthoDB	EOG7M3J01
PhylomeDB	Q13467
TreeFam	TF317907
Reactome	REACT_172631 REACT_172638 REACT_172761 REACT_18372 REACT_200610 REACT_200716 REACT_228188
SignaLink	Q13467
ChiTaRS	FZD5
GeneWiki	FZD5
GenomeRNAi	7855
NextBio	30293
PRO	PR:Q13467
Proteomes	UP000005640
Bgee	Q13467
CleanEx	HS_FZD5
Genevestigator	Q13467
GO	GO:0042995 GO:0009986 GO:0030669 GO:0005737 GO:0005769 GO:0000139 GO:0016021 GO:0048471 GO:0005886 GO:0005923 GO:0004930 GO:0030165 GO:0019901 GO:0031625 GO:0042813 GO:0017147 GO:0001525 GO:0008595 GO:0006915 GO:0060561 GO:0007409 GO:0007420 GO:0060670 GO:0060070 GO:0048469 GO:0071219 GO:0060718 GO:0000578 GO:0031076 GO:0008406 GO:0060716 GO:0008285 GO:0030182 GO:0032729 GO:0043507 GO:0045944 GO:0031077 GO:0060828 GO:1901382 GO:2000810 GO:0060061 GO:0060715 GO:0033077 GO:0044332
Gene3D	1.10.2000.10
InterPro	IPR000539 IPR015526 IPR020067 IPR026547 IPR017981
PANTHER	PTHR11309 PTHR11309:SF29
Pfam	PF01534 PF01392
PRINTS	PR00489
SMART	SM00063
SUPFAM	SSF63501
PROSITE	PS50038 PS50261

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0009986	cell surface	19643732	ECO:0000314			C		Fig 2A. GFP control assay shows Fzd5 localised predominantly at the cell surface.	Missing: reference
	GO:0031623	receptor internalization	19643732	ECO:0000314			P		Fig 2B. When cotransfected with CVAK104, dotlike pattern of Fzd5-GFP is seen throughout in the cell (in control it is localised at edge); Fzd5 has been internalised.	Missing: reference
	GO:0019900	kinase binding	19643732	ECO:0000021		UniProtKB:Q6P3W7	F		Fig 4A. Only Fzd5-GFP co-precipitated with FLAG-CVAK104.	Missing: reference
	GO:0006622	protein targeting to lysosome	19643732	ECO:0000314			P		Fig 5. Collectively shows internalised Fzd5 is sorted to lysosomes for degradation; e.g. treatment with chloroquine (impairs lysosomal function) rescued levels of Fzd5-GFP.	Missing: reference
	GO:0002726	positive regulation of T cell cytokine production	PMID:16601243^[1]	ECO:0000314			P		Figure 6 IFN-gamma release of PBMCs was dose-dependently and significantly decreased with increasing concentrations of the anti-FZD5 antiserum	complete CACAO 6665
involved_in	GO:1904469	positive regulation of tumor necrosis factor secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQD0	P	regulates_o_occurs_in:(CL:0002609) has_regulation_target:(UniProtKB:P01375)	Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQD0	P	regulates_o_occurs_in:(CL:0002609)	Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:12490564^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q98SN7	F		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:18234671^[3]	ECO:0000353	physical interaction evidence used in manual assertion	ComplexPortal:CPX-1134	F		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:18234671^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000093	F		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:18234671^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	F		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:18234671^[3]	ECO:0000353	physical interaction evidence used in manual assertion	CHEBI:64646	F		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	PMID:28733458^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:28733458^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903146	regulation of autophagy of mitochondrion	PMID:24912190^[5]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903955	positive regulation of protein targeting to mitochondrion	PMID:24912190^[5]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O60260)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:24080158^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002726	positive regulation of T cell cytokine production	PMID:16601243^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071219	cellular response to molecule of bacterial origin	PMID:16601243^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:9054360^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:12121999^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:12857724^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060061	Spemann organizer formation	PMID:9054360^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10906785^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P31286	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12857724^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:11029007^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	PMID:9054360^[7]	ECO:0000305	curator inference used in manual assertion	GO:0060070	F		Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	PMID:16601243^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:19643732^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q6P3W7	F		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:12490564^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q98SN7	F		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:12857724^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O00755	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:19643732^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008595	anterior/posterior axis specification, embryo	PMID:9054360^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000578	embryonic axis specification	PMID:12121999^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:22575959^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9ULT6	F		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56706	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:18174455^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P41221	F		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001085 FB:FBgn0016797 MGI:MGI:108460 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1196625 PANTHER:PTN000139394 RGD:61916 RGD:71012 UniProtKB:O75084 UniProtKB:Q13467 UniProtKB:Q14332 UniProtKB:Q8N474 UniProtKB:Q9H461 UniProtKB:Q9NPG1 UniProtKB:Q9ULV1 UniProtKB:Q9ULW2 UniProtKB:Q9UP38	P		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001085 FB:FBgn0016797 MGI:MGI:108460 MGI:MGI:108476 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:1313278 MGI:MGI:1888513 PANTHER:PTN000139394 RGD:628817 RGD:71012 UniProtKB:O60353 UniProtKB:O75084 UniProtKB:Q13467 UniProtKB:Q14332 UniProtKB:Q9H461 UniProtKB:Q9ULV1 UniProtKB:Q9ULW2 UniProtKB:Q9UP38	F		Seeded From UniProt	complete
involved_in	GO:0035567	non-canonical Wnt signaling pathway	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108570 PANTHER:PTN000139394 UniProtKB:O60353 ZFIN:ZDB-GENE-990415-218	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001085 FB:FBgn0016797 FB:FBgn0027342 FB:FBgn0027343 MGI:MGI:108078 MGI:MGI:108460 MGI:MGI:108474 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1196625 MGI:MGI:2136761 MGI:MGI:892032 PANTHER:PTN000139394 RGD:621075 RGD:631406 RGD:71017 UniProtKB:O00144 UniProtKB:O75084 UniProtKB:Q13467 UniProtKB:Q6FHJ7 UniProtKB:Q8N474 UniProtKB:Q9NPG1 UniProtKB:Q9UP38	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0016797 MGI:MGI:108075 MGI:MGI:108460 MGI:MGI:108476 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1313278 PANTHER:PTN000139394 RGD:61916 RGD:628817 RGD:71012 UniProtKB:O00144 UniProtKB:O19116 UniProtKB:O60353 UniProtKB:O75084 UniProtKB:Q14332 UniProtKB:Q99835 UniProtKB:Q9NPG1 UniProtKB:Q9ULV1 WB:WBGene00003006 ZFIN:ZDB-GENE-990415-223	C		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	PMID:15459103^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(FB:FBgn0284084) part_of:(GO:0060070)	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:15459103^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:15459103^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000810	regulation of bicellular tight junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
involved_in	GO:1904469	positive regulation of tumor necrosis factor secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
involved_in	GO:1901382	regulation of chorionic trophoblast cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
involved_in	GO:0060718	chorionic trophoblast cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
involved_in	GO:0060716	labyrinthine layer blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
involved_in	GO:0060715	syncytiotrophoblast cell differentiation involved in labyrinthine layer development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
involved_in	GO:0060670	branching involved in labyrinthine layer morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
involved_in	GO:0060561	apoptotic process involved in morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
involved_in	GO:0048596	embryonic camera-type eye morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	C		Seeded From UniProt	complete
involved_in	GO:0048469	cell maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
involved_in	GO:0033077	T cell differentiation in thymus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
involved_in	GO:0031077	post-embryonic camera-type eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
involved_in	GO:0031076	embryonic camera-type eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	F		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	C		Seeded From UniProt	complete
involved_in	GO:0001944	vasculature development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQD0 ensembl:ENSMUSP00000067783	P		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	F		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000539 InterPro:IPR017981	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000539	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	C		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037441	F		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037441	F		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:18234671^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	PMID:24449494^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	PMID:24449494^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	has_direct_input:(UniProtKB:O00755) part_of:(GO:0007416)	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:24449494^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1904886	beta-catenin destruction complex disassembly	Reactome:R-HSA-4641262	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	Reactome:R-HSA-4086400	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	Reactome:R-HSA-5368596	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030669	clathrin-coated endocytic vesicle membrane	Reactome:R-HSA-5140747	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007223	Wnt signaling pathway, calcium modulating pathway	Reactome:R-HSA-4086398	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-NUL-517516 Reactome:R-NUL-3965440 Reactome:R-HSA-5368596 Reactome:R-HSA-5140747 Reactome:R-HSA-5140741 Reactome:R-HSA-5099886 Reactome:R-HSA-3965447 Reactome:R-HSA-3965444	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0197	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Blumenthal, A et al. (2006) The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood 108 965-73 PubMed GONUTS page
↑ ^2.0 ^2.1 Kubo, F et al. (2003) Wnt2b controls retinal cell differentiation at the ciliary marginal zone. Development 130 587-98 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Magdesian, MH et al. (2008) Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling. J. Biol. Chem. 283 9359-68 PubMed GONUTS page
↑ ^4.0 ^4.1 Voloshanenko, O et al. (2017) Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 31 4832-4844 PubMed GONUTS page
↑ ^5.0 ^5.1 Ivatt, RM et al. (2014) Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy. Proc. Natl. Acad. Sci. U.S.A. 111 8494-9 PubMed GONUTS page
↑ Xavier, CP et al. (2014) Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling. Cell. Signal. 26 94-101 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 He, X et al. (1997) A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science 275 1652-4 PubMed GONUTS page
↑ ^8.0 ^8.1 Holmen, SL et al. (2002) A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. J. Biol. Chem. 277 34727-35 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Caricasole, A et al. (2003) Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. J. Biol. Chem. 278 37024-31 PubMed GONUTS page
↑ Medina, A & Steinbeisser, H (2000) Interaction of Frizzled 7 and Dishevelled in Xenopus. Dev. Dyn. 218 671-80 PubMed GONUTS page
↑ Tamai, K et al. (2000) LDL-receptor-related proteins in Wnt signal transduction. Nature 407 530-5 PubMed GONUTS page
↑ ^12.0 ^12.1 Terabayashi, T et al. (2009) A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5). J. Biol. Chem. 284 26716-24 PubMed GONUTS page
↑ Hao, HX et al. (2012) ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature 485 195-200 PubMed GONUTS page
↑ Pereira, C et al. (2008) Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10. Arterioscler. Thromb. Vasc. Biol. 28 504-10 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Cong, F et al. (2004) Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP. Development 131 5103-15 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Purro, SA et al. (2014) Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases. J Mol Cell Biol 6 75-80 PubMed GONUTS page

[PMID:16601243-1] 1.0 ^1.1 ^1.2 ^1.3 Blumenthal, A et al. (2006) The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood 108 965-73 PubMed GONUTS page

[PMID:12490564-2] 2.0 ^2.1 Kubo, F et al. (2003) Wnt2b controls retinal cell differentiation at the ciliary marginal zone. Development 130 587-98 PubMed GONUTS page

[PMID:18234671-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Magdesian, MH et al. (2008) Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling. J. Biol. Chem. 283 9359-68 PubMed GONUTS page

[PMID:28733458-4] 4.0 ^4.1 Voloshanenko, O et al. (2017) Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 31 4832-4844 PubMed GONUTS page

[PMID:24912190-5] 5.0 ^5.1 Ivatt, RM et al. (2014) Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy. Proc. Natl. Acad. Sci. U.S.A. 111 8494-9 PubMed GONUTS page

[PMID:24080158-6] Xavier, CP et al. (2014) Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling. Cell. Signal. 26 94-101 PubMed GONUTS page

[PMID:9054360-7] 7.0 ^7.1 ^7.2 ^7.3 He, X et al. (1997) A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science 275 1652-4 PubMed GONUTS page

[PMID:12121999-8] 8.0 ^8.1 Holmen, SL et al. (2002) A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. J. Biol. Chem. 277 34727-35 PubMed GONUTS page

[PMID:12857724-9] 9.0 ^9.1 ^9.2 Caricasole, A et al. (2003) Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. J. Biol. Chem. 278 37024-31 PubMed GONUTS page

[PMID:10906785-10] Medina, A & Steinbeisser, H (2000) Interaction of Frizzled 7 and Dishevelled in Xenopus. Dev. Dyn. 218 671-80 PubMed GONUTS page

[PMID:11029007-11] Tamai, K et al. (2000) LDL-receptor-related proteins in Wnt signal transduction. Nature 407 530-5 PubMed GONUTS page

[PMID:19643732-12] 12.0 ^12.1 Terabayashi, T et al. (2009) A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5). J. Biol. Chem. 284 26716-24 PubMed GONUTS page

[PMID:22575959-13] Hao, HX et al. (2012) ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature 485 195-200 PubMed GONUTS page

[PMID:18174455-14] Pereira, C et al. (2008) Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10. Arterioscler. Thromb. Vasc. Biol. 28 504-10 PubMed GONUTS page

[PMID:21873635-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15459103-16] 16.0 ^16.1 ^16.2 Cong, F et al. (2004) Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP. Development 131 5103-15 PubMed GONUTS page

[PMID:24449494-17] 17.0 ^17.1 ^17.2 Purro, SA et al. (2014) Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases. J Mol Cell Biol 6 75-80 PubMed GONUTS page

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