HUMAN:KLF4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	KLF4 (synonyms: EZF, GKLF)
Protein Name(s)	Krueppel-like factor 4 Epithelial zinc finger protein EZF Gut-enriched krueppel-like factor
External Links
UniProt	O43474
EMBL	AF022184 AF105036 HF546201 HF546202 U70663 AK095134 AK313489 DQ658241 AL360218 CH471105 CH471105 BC029923 BC030811
CCDS	CCDS6770.2
RefSeq	NP_004226.3 XP_005252362.1
UniGene	Hs.376206
ProteinModelPortal	O43474
SMR	O43474
BioGrid	114726
DIP	DIP-57667N
IntAct	O43474
MINT	MINT-7261942
STRING	9606.ENSP00000363804
PhosphoSite	O43474
MaxQB	O43474
PaxDb	O43474
PRIDE	O43474
DNASU	9314
Ensembl	ENST00000374672
GeneID	9314
KEGG	hsa:9314
UCSC	uc004bdf.2 uc004bdg.3 uc004bdh.3
CTD	9314
GeneCards	GC09M110247
HGNC	HGNC:6348
HPA	HPA002926
MIM	602253
neXtProt	NX_O43474
PharmGKB	PA30138
eggNOG	COG5048
GeneTree	ENSGT00760000118998
HOVERGEN	HBG006220
InParanoid	O43474
KO	K17846
OMA	CTVGRPL
PhylomeDB	O43474
TreeFam	TF350556
Reactome	REACT_19189 REACT_200812 REACT_27161
SignaLink	O43474
ChiTaRS	KLF4
GeneWiki	KLF4
GenomeRNAi	9314
NextBio	34891
PRO	PR:O43474
Proteomes	UP000005640
Bgee	O43474
CleanEx	HS_KLF4
ExpressionAtlas	O43474
Genevestigator	O43474
GO	GO:0000790 GO:0005634 GO:0005667 GO:0000987 GO:0003690 GO:0035014 GO:0001077 GO:0001085 GO:0001190 GO:0003700 GO:0001010 GO:0044212 GO:0008270 GO:0071409 GO:0071363 GO:0070301 GO:0071499 GO:1901653 GO:0009913 GO:0048730 GO:0045444 GO:0007500 GO:0090051 GO:0008285 GO:2000342 GO:0043154 GO:0070373 GO:0034115 GO:0050728 GO:0045415 GO:0014740 GO:0032088 GO:0014067 GO:0051898 GO:0060761 GO:0048662 GO:0000122 GO:0045892 GO:0032270 GO:0046985 GO:0045429 GO:0051247 GO:0045944 GO:0045893 GO:0031077 GO:0035166 GO:0045595 GO:0032526 GO:0019827 GO:0006366
Gene3D	3.30.160.60
InterPro	IPR007087 IPR015880 IPR013087
SMART	SM00355
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:22267480^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS00003768C5_9606	P	regulates_expression_of:(ENSEMBL:ENSG00000164867) part_of:(GO:0071356) occurs_in:(CL:1000413)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:22267480^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS00003768C5_9606	P	part_of:(GO:0071356) regulates_expression_of:(ENSEMBL:ENSG00000007908) regulates:(GO:0050901) occurs_in:(CL:1000413)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:22267480^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS00003768C5_9606	P	part_of:(GO:0071356) regulates_expression_of:(ENSEMBL:ENSG00000108691) occurs_in:(CL:1000413)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:27907090^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	PMID:27907090^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061614	pri-miRNA transcription by RNA polymerase II	PMID:23867820^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000283785)	Seeded From UniProt	complete
involved_in	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	PMID:23867820^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618) negatively_regulates:(GO:0001525)	Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:23867820^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:22267480^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS00003768C5_9606	P	part_of:(GO:0071356) regulates_expression_of:(ENSEMBL:ENSG00000162692) occurs_in:(CL:1000413)	Seeded From UniProt	complete
involved_in	GO:1904998	negative regulation of leukocyte adhesion to arterial endothelial cell	PMID:22267480^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS00003768C5_9606	P	part_of:(GO:0071356)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22723415^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(ENSEMBL:ENSG00000164362)	Seeded From UniProt	complete
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	PMID:27431648^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS0000591950_9606	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:27431648^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618) regulates_transcription_of:(ENSEMBL:ENSG00000112715)	Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	PMID:20629177^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071499	cellular response to laminar fluid shear stress	PMID:22430140^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22430140^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P00966) occurs_in:(CL:0002618)\|has_input(UniProtKB:P29474) occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:22430140^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618) part_of:(GO:0071499)	Seeded From UniProt	complete
involved_in	GO:0032270	positive regulation of cellular protein metabolic process	PMID:22430140^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P00966) occurs_in:(CL:0002618)\|has_input(UniProtKB:P29474) occurs_in:(CL:0002618)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q9JHX2	F		Seeded From UniProt	complete
involved_in	GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production	PMID:20551324^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	PMID:20551324^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	PMID:20551324^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P15692)	Seeded From UniProt	complete
involved_in	GO:0060761	negative regulation of response to cytokine stimulus	PMID:20551324^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P01375)	Seeded From UniProt	complete
involved_in	GO:0051247	positive regulation of protein metabolic process	PMID:20551324^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q62862	P	has_regulation_target:(UniProtKB:P29474)	Seeded From UniProt	complete
involved_in	GO:0046985	positive regulation of hemoglobin biosynthetic process	PMID:21539536^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000764)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20551324^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q62862	P	part_of:(GO:0060761) has_output:(UniProtKB:P29474)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60793	P		Seeded From UniProt	complete
involved_in	GO:0045444	fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60793	P		Seeded From UniProt	complete
involved_in	GO:0045415	negative regulation of interleukin-8 biosynthetic process	PMID:20551324^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:20551324^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035166	post-embryonic hemopoiesis	PMID:21539536^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000764)	Seeded From UniProt	complete
involved_in	GO:0034115	negative regulation of heterotypic cell-cell adhesion	PMID:20551324^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PMID:20551324^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60793	P		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:21539536^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q92793	F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60793	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:21539536^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0001010	RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60793	F		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	PMID:21539536^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21539536^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20551324^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000162692)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9422764^[11]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60793	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:9422764^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045595	regulation of cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60793	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60793	F		Seeded From UniProt	complete
involved_in	GO:0019827	stem cell population maintenance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60793	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:9422764^[11]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:9422764^[11]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338056 MGI:MGI:1342287 MGI:MGI:1354948 MGI:MGI:2153049 MGI:MGI:2153568 MGI:MGI:2181068 MGI:MGI:98968 PANTHER:PTN001145452 RGD:3738 UniProtKB:A0A1D8PNL1 UniProtKB:Q02446 UniProtKB:Q7RTV3 ZFIN:ZDB-GENE-021115-9	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0043364 FB:FBgn0261434 FB:FBgn0263239 MGI:MGI:1101353 MGI:MGI:1277166 MGI:MGI:1333856 MGI:MGI:1338056 MGI:MGI:1342287 MGI:MGI:1342772 MGI:MGI:1346318 MGI:MGI:1929988 MGI:MGI:1932575 MGI:MGI:2153568 MGI:MGI:95295 MGI:MGI:95296 MGI:MGI:98372 MGI:MGI:98968 PANTHER:PTN001145452 RGD:1306768 RGD:2544 RGD:3738 RGD:3741 RGD:3974 RGD:621445 RGD:621652 RGD:62389 UniProtKB:A0A0B4KHC8 UniProtKB:A0A0G2K5M1 UniProtKB:P18146 UniProtKB:P19544 UniProtKB:Q02086 UniProtKB:Q13351 UniProtKB:Q13886 UniProtKB:Q7RTV3 UniProtKB:Q8TDD2 UniProtKB:Q99612 UniProtKB:Q9UIH9 WB:WBGene00007772 WB:WBGene00012735	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001145452 UniProtKB:O14901 UniProtKB:Q9Y5W3 WB:WBGene00012735 ZFIN:ZDB-GENE-021115-9	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0035014	P		Seeded From UniProt	complete
involved_in	GO:1990830	cellular response to leukemia inhibitory factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
involved_in	GO:1904798	positive regulation of core promoter binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
involved_in	GO:0048730	epidermis morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
involved_in	GO:0048679	regulation of axon regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
involved_in	GO:0045595	regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
involved_in	GO:0045444	fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
part_of	GO:0044798	nuclear transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	C		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	F		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
involved_in	GO:0031077	post-embryonic camera-type eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
involved_in	GO:0019827	stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
involved_in	GO:0009913	epidermal cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	F		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	C		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	F		Seeded From UniProt	complete
enables	GO:0001010	RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60793 ensembl:ENSMUSP00000103245	F		Seeded From UniProt	complete
involved_in	GO:1901653	cellular response to peptide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0071409	cellular response to cycloheximide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	F		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	F		Seeded From UniProt	complete
enables	GO:0035014	phosphatidylinositol 3-kinase regulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	F		Seeded From UniProt	complete
involved_in	GO:0014740	negative regulation of muscle hyperplasia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
involved_in	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	F		Seeded From UniProt	complete
enables	GO:0001221	transcription cofactor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	F		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q923V7 ensembl:ENSRNOP00000022255	C		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:8702718^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007500	mesodermal cell fate determination	PMID:8940147^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:10431239^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:20551324^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035019	somatic stem cell population maintenance	Reactome:R-HSA-452723	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-480204	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Fang, Y & Davies, PF (2012) Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium. Arterioscler. Thromb. Vasc. Biol. 32 979-87 PubMed GONUTS page
↑ ^3.0 ^3.1 Bin, L et al. (2016) Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation. PLoS ONE 11 e0167392 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Zheng, X et al. (2013) Key role of microRNA-15a in the KLF4 suppressions of proliferation and angiogenesis in endothelial and vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 437 625-31 PubMed GONUTS page
↑ Hoffmeyer, K et al. (2012) Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science 336 1549-54 PubMed GONUTS page
↑ ^6.0 ^6.1 Li, YZ et al. (2016) Inhibition of miR-7 promotes angiogenesis in human umbilical vein endothelial cells by upregulating VEGF via KLF4. Oncol. Rep. 36 1569-75 PubMed GONUTS page
↑ Wong, CW et al. (2010) Krüppel-like transcription factor 4 contributes to maintenance of telomerase activity in stem cells. Stem Cells 28 1510-7 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Mun, GI & Boo, YC (2012) A regulatory role of Kruppel-like factor 4 in endothelial argininosuccinate synthetase 1 expression in response to laminar shear stress. Biochem. Biophys. Res. Commun. 420 450-5 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 Ohnesorge, N et al. (2010) Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4). J. Biol. Chem. 285 26199-210 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Kalra, IS et al. (2011) Krüppel-like Factor 4 activates HBG gene expression in primary erythroid cells. Br. J. Haematol. 154 248-59 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Yet, SF et al. (1998) Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. J. Biol. Chem. 273 1026-31 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Shields, JM et al. (1996) Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest. J. Biol. Chem. 271 20009-17 PubMed GONUTS page
↑ Garrett-Sinha, LA et al. (1996) A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J. Biol. Chem. 271 31384-90 PubMed GONUTS page
↑ Segre, JA et al. (1999) Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat. Genet. 22 356-60 PubMed GONUTS page

[PMID:19274049-1] Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:22267480-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Fang, Y & Davies, PF (2012) Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium. Arterioscler. Thromb. Vasc. Biol. 32 979-87 PubMed GONUTS page

[PMID:27907090-3] 3.0 ^3.1 Bin, L et al. (2016) Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation. PLoS ONE 11 e0167392 PubMed GONUTS page

[PMID:23867820-4] 4.0 ^4.1 ^4.2 Zheng, X et al. (2013) Key role of microRNA-15a in the KLF4 suppressions of proliferation and angiogenesis in endothelial and vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 437 625-31 PubMed GONUTS page

[PMID:22723415-5] Hoffmeyer, K et al. (2012) Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science 336 1549-54 PubMed GONUTS page

[PMID:27431648-6] 6.0 ^6.1 Li, YZ et al. (2016) Inhibition of miR-7 promotes angiogenesis in human umbilical vein endothelial cells by upregulating VEGF via KLF4. Oncol. Rep. 36 1569-75 PubMed GONUTS page

[PMID:20629177-7] Wong, CW et al. (2010) Krüppel-like transcription factor 4 contributes to maintenance of telomerase activity in stem cells. Stem Cells 28 1510-7 PubMed GONUTS page

[PMID:22430140-8] 8.0 ^8.1 ^8.2 ^8.3 Mun, GI & Boo, YC (2012) A regulatory role of Kruppel-like factor 4 in endothelial argininosuccinate synthetase 1 expression in response to laminar shear stress. Biochem. Biophys. Res. Commun. 420 450-5 PubMed GONUTS page

[PMID:20551324-9] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 Ohnesorge, N et al. (2010) Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4). J. Biol. Chem. 285 26199-210 PubMed GONUTS page

[PMID:21539536-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Kalra, IS et al. (2011) Krüppel-like Factor 4 activates HBG gene expression in primary erythroid cells. Br. J. Haematol. 154 248-59 PubMed GONUTS page

[PMID:9422764-11] 11.0 ^11.1 ^11.2 ^11.3 Yet, SF et al. (1998) Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. J. Biol. Chem. 273 1026-31 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8702718-13] Shields, JM et al. (1996) Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest. J. Biol. Chem. 271 20009-17 PubMed GONUTS page

[PMID:8940147-14] Garrett-Sinha, LA et al. (1996) A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J. Biol. Chem. 271 31384-90 PubMed GONUTS page

[PMID:10431239-15] Segre, JA et al. (1999) Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat. Genet. 22 356-60 PubMed GONUTS page

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HUMAN:KLF4

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