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MOUSE:FZD2
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Fzd2 (synonyms: Fzd10) | |
| Protein Name(s) | Frizzled-2
Fz-2 mFz2 Frizzled-10 Fz-10 mFz10 | |
| External Links | ||
| UniProt | Q9JIP6 | |
| EMBL | AF206321 AF206322 BC049774 BC055727 AF139183 | |
| CCDS | CCDS25501.1 | |
| RefSeq | NP_065256.1 | |
| UniGene | Mm.36416 | |
| ProteinModelPortal | Q9JIP6 | |
| SMR | Q9JIP6 | |
| IntAct | Q9JIP6 | |
| MINT | MINT-1779244 | |
| GuidetoPHARMACOLOGY | 230 | |
| MEROPS | I93.001 | |
| PhosphoSite | Q9JIP6 | |
| PaxDb | Q9JIP6 | |
| PRIDE | Q9JIP6 | |
| Ensembl | ENSMUST00000057893 | |
| GeneID | 57265 | |
| KEGG | mmu:57265 | |
| UCSC | uc011yft.1 | |
| CTD | 2535 | |
| MGI | MGI:1888513 | |
| eggNOG | NOG257258 | |
| GeneTree | ENSGT00760000118864 | |
| HOGENOM | HOG000233237 | |
| HOVERGEN | HBG006977 | |
| InParanoid | Q9JIP6 | |
| KO | K02235 | |
| OMA | SICERAK | |
| OrthoDB | EOG7M3J01 | |
| PhylomeDB | Q9JIP6 | |
| TreeFam | TF317907 | |
| Reactome | REACT_207044 REACT_216784 REACT_221970 REACT_222715 | |
| ChiTaRS | Fzd2 | |
| NextBio | 313595 | |
| PRO | PR:Q9JIP6 | |
| Proteomes | UP000000589 | |
| Bgee | Q9JIP6 | |
| CleanEx | MM_FZD10 MM_FZD2 | |
| ExpressionAtlas | Q9JIP6 | |
| Genevestigator | Q9JIP6 | |
| GO | GO:0045177 GO:0005737 GO:0016021 GO:0032589 GO:0004930 GO:0030165 GO:0042813 GO:0017147 GO:0007409 GO:0007420 GO:0060070 GO:0007267 GO:0090103 GO:0030855 GO:0007199 GO:0008406 GO:0060022 GO:0060119 GO:0003149 GO:0003150 GO:0003151 GO:0090179 GO:0030825 GO:0051091 GO:0045893 GO:0006357 GO:0007608 GO:0001944 GO:0060412 GO:0007223 | |
| Gene3D | 1.10.2000.10 | |
| InterPro | IPR000539 IPR015526 IPR020067 IPR026550 IPR017981 | |
| PANTHER | PTHR11309 PTHR11309:SF34 | |
| Pfam | PF01534 PF01392 | |
| PRINTS | PR00489 | |
| SMART | SM00063 | |
| SUPFAM | SSF63501 | |
| PROSITE | PS50038 PS50261 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0001085 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042813 |
Wnt-activated receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0001085 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035567 |
non-canonical Wnt signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108570 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017147 |
Wnt-protein binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0001085 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0016797 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0090179 |
planar cell polarity pathway involved in neural tube closure |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1196625 |
P |
occurs_in:(EMAPA:16530) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0090103 |
cochlea morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2135272 |
P |
has_participant:(EMAPA:19061) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060412 |
ventricular septum morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1196625 |
P |
has_participant:(EMAPA:17333) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060119 |
inner ear receptor cell development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2135272 |
P |
occurs_in:(EMAPA:19061) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:71012 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060022 |
hard palate development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1196625 |
P |
results_in_development_of:(EMAPA:18952) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060022 |
hard palate development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4442611 |
P |
results_in_development_of:(EMAPA:18952) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:71012 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045745 |
positive regulation of G protein-coupled receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042813 |
Wnt-activated receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042813 |
Wnt-activated receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042813 |
Wnt-activated receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:71012 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:71012 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0030855 |
epithelial cell differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:103124 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0030855 |
epithelial cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
enables |
GO:0030165 |
PDZ domain binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007608 |
sensory perception of smell |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4442611 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007267 |
cell-cell signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007223 |
Wnt signaling pathway, calcium modulating pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:71012 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:71012 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007199 |
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:71012 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:71012 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0003151 |
outflow tract morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1196625 |
P |
has_participant:(EMAPA:16105) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0003150 |
muscular septum morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1196625 |
P |
has_participant:(EMAPA:18247) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0003149 |
membranous septum morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1196625 |
P |
has_participant:(EMAPA:18246) |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14332 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14332 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14332 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045745 |
positive regulation of G protein-coupled receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14332 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042813 |
Wnt-activated receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14332 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030165 |
PDZ domain binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14332 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14332 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14332 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004888 |
transmembrane signaling receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007166 |
cell surface receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042813 |
Wnt-activated receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Yu, H et al. (2010) Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes. Development 137 3707-17 PubMed GONUTS page
- ↑ Toyofuku, T et al. (2000) Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex. J. Cell Biol. 150 225-41 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Kim, BM et al. (2005) The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling. Dev. Cell 8 611-22 PubMed GONUTS page
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- GO:0030165 ! PDZ domain binding
- GO:0090179 ! planar cell polarity pathway involved in neural tube closure
- GO:0005886 ! plasma membrane
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0007204 ! positive regulation of cytosolic calcium ion concentration
- GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway
- GO:0051091 ! positive regulation of DNA-binding transcription factor activity
- GO:0046982 ! protein heterodimerization activity
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