GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:20940229

From GONUTS
Jump to: navigation, search
Citation

Yu, H, Smallwood, PM, Wang, Y, Vidaltamayo, R, Reed, R and Nathans, J (2010) Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes. Development 137:3707-17

Abstract

The closure of an open anatomical structure by the directed growth and fusion of two tissue masses is a recurrent theme in mammalian embryology, and this process plays an integral role in the development of the palate, ventricular septum, neural tube, urethra, diaphragm and eye. In mice, targeted mutations of the genes encoding frizzled 1 (Fz1) and frizzled 2 (Fz2) show that these highly homologous integral membrane receptors play an essential and partially redundant role in closure of the palate and ventricular septum, and in the correct positioning of the cardiac outflow tract. When combined with a mutant allele of the planar cell polarity gene Vangl2 (Vangl2(Lp)), Fz1 and/or Fz2 mutations also cause defects in neural tube closure and misorientation of inner ear sensory hair cells. These observations indicate that frizzled signaling is involved in diverse tissue closure processes, defects in which account for some of the most common congenital anomalies in humans.

Links

PubMed PMC2964100 Online version:10.1242/dev.052001

Keywords

Animals; Animals, Newborn; Cell Fusion; Epistasis, Genetic/physiology; Female; Frizzled Receptors/genetics; Frizzled Receptors/metabolism; Frizzled Receptors/physiology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Biological; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/physiology; Neural Tube/embryology; Neural Tube/metabolism; Neural Tube/physiology; Palate/embryology; Palate/metabolism; Pregnancy; Receptors, G-Protein-Coupled/genetics; Receptors, G-Protein-Coupled/metabolism; Receptors, G-Protein-Coupled/physiology; Ventricular Septum/embryology; Ventricular Septum/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:FZD1

acts_upstream_of_or_within

GO:0003151: outflow tract morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1888513

P

Seeded From UniProt

complete

MOUSE:FZD1

acts_upstream_of_or_within

GO:0003150: muscular septum morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1888513
MGI:MGI:2135272

P

Seeded From UniProt

complete

MOUSE:FZD1

acts_upstream_of_or_within

GO:0003149: membranous septum morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1888513
MGI:MGI:2135272

P

Seeded From UniProt

complete

MOUSE:FZD1

acts_upstream_of_or_within

GO:0060412: ventricular septum morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1888513

P

Seeded From UniProt

complete

MOUSE:FZD1

acts_upstream_of_or_within

GO:0060022: hard palate development

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1888513

P

  • results_in_development_of:(EMAPA:18952)

Seeded From UniProt

complete

MOUSE:FZD1

acts_upstream_of_or_within

GO:0090179: planar cell polarity pathway involved in neural tube closure

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1888513
MGI:MGI:2135272

P

  • occurs_in:(EMAPA:16530)

Seeded From UniProt

complete

MOUSE:VANG2

acts_upstream_of_or_within

GO:0003150: muscular septum morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1196625
MGI:MGI:1888513

P

Seeded From UniProt

complete

MOUSE:VANG2

acts_upstream_of_or_within

GO:0003149: membranous septum morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1196625
MGI:MGI:1888513

P

Seeded From UniProt

complete

MOUSE:VANG2

acts_upstream_of_or_within

GO:0060119: inner ear receptor cell development

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1888513

P

  • occurs_in:(EMAPA:19061)

Seeded From UniProt

complete

MOUSE:VANG2

acts_upstream_of_or_within

GO:0090179: planar cell polarity pathway involved in neural tube closure

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1196625
MGI:MGI:1888513

P

  • occurs_in:(EMAPA:16530)

Seeded From UniProt

complete

MOUSE:VANG2

acts_upstream_of_or_within

GO:0090103: cochlea morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1888513

P

Seeded From UniProt

complete

MOUSE:FZD2

acts_upstream_of_or_within

GO:0003151: outflow tract morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1196625

P

Seeded From UniProt

complete

MOUSE:FZD2

acts_upstream_of_or_within

GO:0003150: muscular septum morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1196625
MGI:MGI:2135272

P

Seeded From UniProt

complete

MOUSE:FZD2

acts_upstream_of_or_within

GO:0003149: membranous septum morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1196625
MGI:MGI:2135272

P

Seeded From UniProt

complete

MOUSE:FZD2

acts_upstream_of_or_within

GO:0060412: ventricular septum morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1196625

P

Seeded From UniProt

complete

MOUSE:FZD2

acts_upstream_of_or_within

GO:0060119: inner ear receptor cell development

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:2135272

P

  • occurs_in:(EMAPA:19061)

Seeded From UniProt

complete

MOUSE:FZD2

acts_upstream_of_or_within

GO:0060022: hard palate development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:4442611

P

  • results_in_development_of:(EMAPA:18952)

Seeded From UniProt

complete

MOUSE:FZD2

acts_upstream_of_or_within

GO:0060022: hard palate development

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1196625

P

  • results_in_development_of:(EMAPA:18952)

Seeded From UniProt

complete

MOUSE:FZD2

acts_upstream_of_or_within

GO:0090179: planar cell polarity pathway involved in neural tube closure

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1196625
MGI:MGI:2135272

P

  • occurs_in:(EMAPA:16530)

Seeded From UniProt

complete

MOUSE:FZD2

acts_upstream_of_or_within

GO:0090103: cochlea morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:2135272

P

Seeded From UniProt

complete

MOUSE:FZD2

acts_upstream_of_or_within

GO:0007608: sensory perception of smell

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:4442611

P

Seeded From UniProt

complete

MOUSE:FZD2

acts_upstream_of_or_within

GO:0003151: outflow tract morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1196625

P

has_participant:(EMAPA:16105)

Seeded From UniProt

complete

MOUSE:FZD2

acts_upstream_of_or_within

GO:0003150: muscular septum morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1196625
MGI:MGI:2135272

P

has_participant:(EMAPA:18247)

Seeded From UniProt

complete

MOUSE:FZD2

acts_upstream_of_or_within

GO:0003149: membranous septum morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1196625
MGI:MGI:2135272

P

has_participant:(EMAPA:18246)

Seeded From UniProt

complete

MOUSE:FZD2

acts_upstream_of_or_within

GO:0060022: hard palate development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:4442611

P

results_in_development_of:(EMAPA:18952)

Seeded From UniProt

complete

MOUSE:FZD2

acts_upstream_of_or_within

GO:0060022: hard palate development

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1196625

P

results_in_development_of:(EMAPA:18952)

Seeded From UniProt

complete

MOUSE:FZD2

acts_upstream_of_or_within

GO:0060119: inner ear receptor cell development

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:2135272

P

occurs_in:(EMAPA:19061)

Seeded From UniProt

complete

MOUSE:FZD2

acts_upstream_of_or_within

GO:0060412: ventricular septum morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1196625

P

has_participant:(EMAPA:17333)

Seeded From UniProt

complete

MOUSE:FZD2

acts_upstream_of_or_within

GO:0090103: cochlea morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:2135272

P

has_participant:(EMAPA:19061)

Seeded From UniProt

complete

MOUSE:FZD2

acts_upstream_of_or_within

GO:0090179: planar cell polarity pathway involved in neural tube closure

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1196625
MGI:MGI:2135272

P

occurs_in:(EMAPA:16530)

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.