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HUMAN:WN10A

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) WNT10A
Protein Name(s) Protein Wnt-10a
External Links
UniProt Q9GZT5
EMBL AY009400
AF315943
AB059569
AK024363
AK315081
AC073128
CH471063
BC052234
CCDS CCDS2426.1
PIR JC7693
RefSeq NP_079492.2
UniGene Hs.121540
ProteinModelPortal Q9GZT5
SMR Q9GZT5
IntAct Q9GZT5
STRING 9606.ENSP00000258411
PhosphoSite Q9GZT5
DMDM 14424011
PaxDb Q9GZT5
PRIDE Q9GZT5
DNASU 80326
Ensembl ENST00000258411
GeneID 80326
KEGG hsa:80326
UCSC uc002vjd.1
CTD 80326
GeneCards GC02P219745
HGNC HGNC:13829
HPA HPA013898
MIM 150400
224750
257980
606268
neXtProt NX_Q9GZT5
Orphanet 248
2227
2721
99798
50944
PharmGKB PA37817
eggNOG NOG240772
GeneTree ENSGT00690000101857
HOGENOM HOG000039528
HOVERGEN HBG001595
InParanoid Q9GZT5
KO K01357
OMA GMDNCES
OrthoDB EOG7C8GJ8
PhylomeDB Q9GZT5
TreeFam TF105310
Reactome REACT_163710
REACT_18372
GeneWiki WNT10A
GenomeRNAi 80326
NextBio 70863
PRO PR:Q9GZT5
Proteomes UP000005640
Bgee Q9GZT5
CleanEx HS_WNT10A
ExpressionAtlas Q9GZT5
Genevestigator Q9GZT5
GO GO:0005576
GO:0005615
GO:0005578
GO:0005109
GO:0045165
GO:0071560
GO:0048730
GO:0001942
GO:0031069
GO:0014033
GO:0030182
GO:0042476
GO:0010628
GO:0042487
GO:0048733
GO:0043588
GO:0043586
GO:0016055
InterPro IPR005817
IPR013302
IPR018161
PANTHER PTHR12027
Pfam PF00110
PRINTS PR01893
PR01349
SMART SM00097
PROSITE PS00246

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0048018

receptor ligand activity

PMID:28733458[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

PMID:28733458[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048733

sebaceous gland development

PMID:19559398[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048730

epidermis morphogenesis

PMID:20163410[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043588

skin development

PMID:19559398[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043588

skin development

PMID:17847007[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043586

tongue development

PMID:17847007[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043586

tongue development

PMID:19559398[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042476

odontogenesis

PMID:19559398[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042476

odontogenesis

PMID:17847007[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031069

hair follicle morphogenesis

PMID:20163410[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001942

hair follicle development

PMID:19559398[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001942

hair follicle development

PMID:17847007[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071560

cellular response to transforming growth factor beta stimulus

PMID:15040835[5]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045165

cell fate commitment

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98957
PANTHER:PTN000246517
UniProtKB:P49339
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000246517
RGD:69250
UniProtKB:P56706
UniProtKB:Q98SN7

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010194
MGI:MGI:108061
MGI:MGI:1197020
MGI:MGI:98953
MGI:MGI:98954
MGI:MGI:98956
MGI:MGI:98958
MGI:MGI:98960
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
UniProtKB:P41221
UniProtKB:Q98SN7
WB:WBGene00000858
WB:WBGene00003029
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
MGI:MGI:98956
MGI:MGI:98957
PANTHER:PTN000246517
RGD:1311441
RGD:69250
UniProtKB:P41221
UniProtKB:P56704
UniProtKB:P56705
UniProtKB:Q2LMP1
UniProtKB:Q9UBV4
UniProtKB:Q9YGX6

C

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
FB:FBgn0004360
FB:FBgn0010453
FB:FBgn0038134
MGI:MGI:98956
MGI:MGI:98957
MGI:MGI:98958
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
RGD:69079
UniProtKB:P09544
UniProtKB:P41221
UniProtKB:P56703
UniProtKB:Q98SN7

F

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048018

P

Seeded From UniProt

complete

involved_in

GO:0042487

regulation of odontogenesis of dentin-containing tooth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70701
ensembl:ENSMUSP00000006718

P

Seeded From UniProt

complete

involved_in

GO:0014033

neural crest cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70701
ensembl:ENSMUSP00000006718

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70701
ensembl:ENSMUSP00000006718

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR013302

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR013302

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR013302

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR013302

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

Reactome:R-HSA-195721

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-3247843

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Voloshanenko, O et al. (2017) Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 31 4832-4844 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Bohring, A et al. (2009) WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes. Am. J. Hum. Genet. 85 97-105 PubMed GONUTS page
  3. ↑ 3.0 3.1 Van Geel, M et al. (2010) Phenotypic variability associated with WNT10A nonsense mutations. Br. J. Dermatol. 162 1403-6 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Adaimy, L et al. (2007) Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia. Am. J. Hum. Genet. 81 821-8 PubMed GONUTS page
  5. ↑ Zhou, S et al. (2004) Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J. Bone Miner. Res. 19 463-70 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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