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MOUSE:SHH

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Shh (synonyms: Hhg1)
Protein Name(s) Sonic hedgehog protein

SHH HHG-1 Sonic hedgehog protein N-product Sonic hedgehog protein 19 kDa product Sonic hedgehog protein C-product Sonic hedgehog protein 27 kDa product

External Links
UniProt Q62226
EMBL X76290
AK077688
BC063087
CCDS CCDS19146.1
PIR A49425
RefSeq NP_033196.1
UniGene Mm.57202
PDB 1VHH
2WFX
2WG4
3D1M
3N1R
4C4M
4C4N
PDBsum 1VHH
2WFX
2WG4
3D1M
3N1R
4C4M
4C4N
ProteinModelPortal Q62226
SMR Q62226
BioGrid 203220
DIP DIP-48537N
STRING 10090.ENSMUSP00000002708
BindingDB Q62226
ChEMBL CHEMBL5387
MEROPS C46.002
PhosphoSite Q62226
PRIDE Q62226
Ensembl ENSMUST00000002708
GeneID 20423
KEGG mmu:20423
UCSC uc008wua.2
CTD 6469
MGI MGI:98297
eggNOG NOG250647
GeneTree ENSGT00390000001117
HOGENOM HOG000233428
HOVERGEN HBG005480
InParanoid Q62226
KO K11988
OMA HSWAHRA
OrthoDB EOG779NZ5
PhylomeDB Q62226
TreeFam TF106458
Reactome REACT_232469
REACT_233316
REACT_247063
REACT_250061
EvolutionaryTrace Q62226
NextBio 298432
PRO PR:Q62226
Proteomes UP000000589
Bgee Q62226
CleanEx MM_SHH
Genevestigator Q62226
GO GO:0009986
GO:0031012
GO:0005615
GO:0016020
GO:0045121
GO:0005634
GO:0005886
GO:0005509
GO:0001948
GO:0005539
GO:0043237
GO:0005113
GO:0008270
GO:0048856
GO:0048646
GO:0008209
GO:0001525
GO:0009952
GO:0006915
GO:0097190
GO:0060840
GO:0007411
GO:0060020
GO:0007596
GO:0060442
GO:0060445
GO:0001658
GO:0048754
GO:0060447
GO:0043010
GO:0060070
GO:0043369
GO:0048468
GO:0045165
GO:0001708
GO:0008283
GO:0007267
GO:0071285
GO:0007417
GO:0021930
GO:0003140
GO:0007368
GO:0048589
GO:0048546
GO:0021904
GO:0009953
GO:0007398
GO:0048557
GO:0042733
GO:0048617
GO:0035115
GO:0035116
GO:0030326
GO:0048598
GO:0048568
GO:0048706
GO:0006897
GO:0060664
GO:0060441
GO:0060684
GO:0060738
GO:0030010
GO:0030900
GO:0048859
GO:0001942
GO:0031069
GO:0007507
GO:0001947
GO:0030902
GO:0007442
GO:0048839
GO:0016539
GO:0045109
GO:0001822
GO:0060459
GO:0060174
GO:0060173
GO:0030324
GO:0060428
GO:0060463
GO:0060425
GO:0060484
GO:0002320
GO:0030539
GO:0010463
GO:0060916
GO:0060783
GO:0072136
GO:0001656
GO:0030901
GO:0080125
GO:0045445
GO:0014902
GO:0046639
GO:0043066
GO:0090090
GO:0045596
GO:0030336
GO:0090370
GO:0010629
GO:2000357
GO:2001054
GO:0032435
GO:0042177
GO:0042130
GO:0034244
GO:0000122
GO:2000062
GO:0030178
GO:0045060
GO:0001755
GO:0007405
GO:0048663
GO:0042476
GO:0042475
GO:0014003
GO:0048709
GO:0048645
GO:0002076
GO:0060021
GO:0031016
GO:0007389
GO:0001569
GO:0009949
GO:0046638
GO:0045597
GO:0051781
GO:0008284
GO:0021940
GO:0060769
GO:0010628
GO:0007228
GO:0033092
GO:2000358
GO:0002053
GO:2000729
GO:0002052
GO:0048714
GO:0042307
GO:0061189
GO:0014858
GO:0048643
GO:0045880
GO:0051155
GO:0033089
GO:0045944
GO:0045893
GO:2000063
GO:0030177
GO:0045059
GO:0060516
GO:0060523
GO:0030850
GO:0034504
GO:0006508
GO:0042127
GO:0060768
GO:0010468
GO:0060782
GO:0042481
GO:0060685
GO:0030162
GO:0006355
GO:0030323
GO:0060458
GO:0060662
GO:0007165
GO:0043588
GO:0007224
GO:0021938
GO:0061053
GO:0021513
GO:0021522
GO:0048864
GO:0051146
GO:0014706
GO:0033077
GO:0021978
GO:0021794
GO:0048538
GO:0030878
GO:0060438
GO:0060439
GO:0001944
GO:0001570
GO:0060979
Gene3D 2.170.16.10
3.30.1380.10
InterPro IPR001657
IPR028992
IPR009045
IPR000320
IPR001767
IPR003586
IPR003587
IPR006141
Pfam PF01085
PF01079
PIRSF PIRSF009400
PRINTS PR00632
SMART SM00305
SM00306
SUPFAM SSF51294
SSF55166
PROSITE PS50817

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0051236

establishment of RNA localization

PMID:21209331[1]

ECO:0000315

P

Fig 2B shows abnormal patterning of Pax7, FoxA2, Nkx2.2, Hb9 with Shh morphant

complete
CACAO 2905

GO:0021904

dorsal/ventral neural tube patterning

PMID:21209331[1]

ECO:0000315

P

Fig 2B shows abnormal ventralising neural tube expression patterning with morphant compared to WT

complete
CACAO 2906

involved_in

GO:1904339

negative regulation of dopaminergic neuron differentiation

PMID:19122665[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

regulates_o_occurs_in:(UBERON:0003079)

Seeded From UniProt

complete

involved_in

GO:0021930

cerebellar granule cell precursor proliferation

PMID:22095825[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090370

negative regulation of cholesterol efflux

PMID:21931618[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061053

somite development

PMID:11517919[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048864

stem cell development

PMID:12843296[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048538

thymus development

PMID:19109233[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046638

positive regulation of alpha-beta T cell differentiation

PMID:14764698[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21447550[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045880

positive regulation of smoothened signaling pathway

PMID:11517919[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045060

negative thymic T cell selection

PMID:17227833[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045059

positive thymic T cell selection

PMID:17227833[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043369

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment

PMID:17227833[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042481

regulation of odontogenesis

PMID:21447550[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033092

positive regulation of immature T cell proliferation in thymus

PMID:14764698[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033092

positive regulation of immature T cell proliferation in thymus

PMID:19273836[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033089

positive regulation of T cell differentiation in thymus

PMID:19109233[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033077

T cell differentiation in thymus

PMID:19273836[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0021904

dorsal/ventral neural tube patterning

PMID:21209331[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007228

positive regulation of hh target transcription factor activity

PMID:11517919[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005113

patched binding

PMID:9811851[12]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13635

F

Seeded From UniProt

complete

enables

GO:0005113

patched binding

PMID:9811851[12]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9Y6C5

F

Seeded From UniProt

complete

involved_in

GO:0003140

determination of left/right asymmetry in lateral mesoderm

PMID:11517919[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002320

lymphoid progenitor cell differentiation

PMID:14764698[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001947

heart looping

PMID:11517919[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:21447550[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097190

apoptotic signaling pathway

PMID:11044396[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:11044396[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042733

embryonic digit morphogenesis

PMID:11044396[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|enables

GO:0016787

hydrolase activity

PMID:10500113[14]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0009949

polarity specification of anterior/posterior axis

PMID:11044396[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005113

patched binding

PMID:10500113[14]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q61115

F

Seeded From UniProt

complete

involved_in

GO:2000729

positive regulation of mesenchymal cell proliferation involved in ureter development

PMID:12399320[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000358

positive regulation of kidney smooth muscle cell differentiation

PMID:12399320[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000357

negative regulation of kidney smooth muscle cell differentiation

PMID:12399320[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000063

positive regulation of ureter smooth muscle cell differentiation

PMID:12399320[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000062

negative regulation of ureter smooth muscle cell differentiation

PMID:12399320[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072136

metanephric mesenchymal cell proliferation involved in metanephros development

PMID:12399320[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:12399320[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045880

positive regulation of smoothened signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q15465

P

Seeded From UniProt

complete

involved_in

GO:0021930

cerebellar granule cell precursor proliferation

PMID:14687547[16]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P51448

P

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:16396903[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:16396903[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q15465

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q15465

F

Seeded From UniProt

complete

involved_in

GO:0001656

metanephros development

PMID:12399320[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048709

oligodendrocyte differentiation

PMID:21873635[18]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98297
PANTHER:PTN000223625

P

Seeded From UniProt

complete

involved_in

GO:0010468

regulation of gene expression

PMID:21873635[18]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96533
MGI:MGI:98297
PANTHER:PTN001726121
UniProtKB:F1P3J4
UniProtKB:Q15465
UniProtKB:Q91035
UniProtKB:Q98938
ZFIN:ZDB-GENE-980526-166

P

Seeded From UniProt

complete

involved_in

GO:0007224

smoothened signaling pathway

PMID:21873635[18]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004644
MGI:MGI:94891
MGI:MGI:96533
MGI:MGI:98297
PANTHER:PTN001726121
UniProtKB:Q14623
UniProtKB:Q15465
UniProtKB:Q98938
ZFIN:ZDB-GENE-051010-1
ZFIN:ZDB-GENE-980526-166

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[18]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004644
MGI:MGI:98297
PANTHER:PTN001726121
RGD:3673
UniProtKB:F1P3J4
UniProtKB:Q15465
UniProtKB:Q91035
UniProtKB:Q98938

C

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:21873635[18]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001726121
UniProtKB:O43323
UniProtKB:Q14623
UniProtKB:Q15465

F

Seeded From UniProt

complete

enables

GO:0005113

patched binding

PMID:21873635[18]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:94891
MGI:MGI:96533
MGI:MGI:98297
PANTHER:PTN001726121
UniProtKB:Q14623
UniProtKB:Q15465

F

Seeded From UniProt

complete

involved_in

GO:0001708

cell fate specification

PMID:21873635[18]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96533
MGI:MGI:98297
PANTHER:PTN001726121
RGD:3673
ZFIN:ZDB-GENE-980526-166

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060840

artery development

PMID:16968815[19]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95729

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060840

artery development

PMID:16968815[19]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1861186

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060783

mesenchymal smoothened signaling pathway involved in prostate gland development

PMID:12221011[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(EMAPA:18995)
  • occurs_in:(CL:0000134)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060782

regulation of mesenchymal cell proliferation involved in prostate gland development

PMID:12221011[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060769

positive regulation of epithelial cell proliferation involved in prostate gland development

PMID:12221011[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060768

regulation of epithelial cell proliferation involved in prostate gland development

PMID:12221011[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060738

epithelial-mesenchymal signaling involved in prostate gland development

PMID:15987773[21]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1347472

P

occurs_in:(EMAPA:19287)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060738

epithelial-mesenchymal signaling involved in prostate gland development

PMID:12221011[20]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15465

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060685

regulation of prostatic bud formation

PMID:12221011[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • regulates_o_results_in_formation_of:(EMAPA:18995)
  • regulates_o_has_participant:(CL:0000066)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060685

regulation of prostatic bud formation

PMID:18393306[22]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060684

epithelial-mesenchymal cell signaling

PMID:19304890[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060664

epithelial cell proliferation involved in salivary gland morphogenesis

PMID:15042696[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060662

salivary gland cavitation

PMID:16332353[25]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060523

prostate epithelial cord elongation

PMID:15013801[26]

ECO:0000314

direct assay evidence used in manual assertion

P

has_participant:(EMAPA:32290)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060516

primary prostatic bud elongation

PMID:10208740[27]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060484

lung-associated mesenchyme development

PMID:9731532[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060463

lung lobe morphogenesis

PMID:9731532[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060459

left lung development

PMID:10500184[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

results_in_development_of:(EMAPA:17653)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060458

right lung development

PMID:10500184[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

results_in_development_of:(EMAPA:17661)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060447

bud outgrowth involved in lung branching

PMID:9731532[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060445

branching involved in salivary gland morphogenesis

PMID:15042696[24]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99604

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060445

branching involved in salivary gland morphogenesis

PMID:15042696[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

has_participant:(EMAPA:17756)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060442

branching involved in prostate gland morphogenesis

PMID:10208740[27]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060441

epithelial tube branching involved in lung morphogenesis

PMID:9731532[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060441

epithelial tube branching involved in lung morphogenesis

PMID:10500184[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

occurs_in:(EMAPA:16728)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060439

trachea morphogenesis

PMID:9731532[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060438

trachea development

PMID:9731532[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060428

lung epithelium development

PMID:9731532[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060425

lung morphogenesis

PMID:10500184[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

has_participant:(EMAPA:16728)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060406

positive regulation of penile erection

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060174

limb bud formation

PMID:11118883[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060173

limb development

PMID:19223390[31]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1329045

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060173

limb development

PMID:19223390[31]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060070

canonical Wnt signaling pathway

PMID:17284610[32]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060021

roof of mouth development

PMID:19304890[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2176256

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060021

roof of mouth development

PMID:19304890[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060020

Bergmann glial cell differentiation

PMID:10375501[33]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(EMAPA:17787)
  • results_in_acquisition_of_features_of:(CL:0000644)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051781

positive regulation of cell division

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15465

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051155

positive regulation of striated muscle cell differentiation

PMID:11171399[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796
MGI:MGI:1861186

P

occurs_in:(EMAPA:16405)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051146

striated muscle cell differentiation

PMID:15238161[35]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

  • occurs_in:(EMAPA:16405)
  • results_in_acquisition_of_features_of:(CL:0000189)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051146

striated muscle cell differentiation

PMID:15238161[35]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048859

formation of anatomical boundary

PMID:9731532[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048856

anatomical structure development

PMID:11485934[36]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

results_in_development_of:(EMAPA:18256)|results_in_development_of:(EMAPA:18692)|results_in_development_of:(EMAPA:16832)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048839

inner ear development

PMID:17395647[37]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95729

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048839

inner ear development

PMID:17395647[37]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934261

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048808

male genitalia morphogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048754

branching morphogenesis of an epithelial tube

PMID:9768363[38]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934261

P

has_participant:(EMAPA:17653)|has_participant:(EMAPA:17661)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048754

branching morphogenesis of an epithelial tube

PMID:15305287[39]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268,MGI:MGI:2679524

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048754

branching morphogenesis of an epithelial tube

PMID:15042696[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

has_participant:(EMAPA:17756)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048714

positive regulation of oligodendrocyte differentiation

PMID:11171336[40]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(EMAPA:16525)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048709

oligodendrocyte differentiation

PMID:15880651[41]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95729

P

  • occurs_in:(EMAPA:17577)
  • results_in_acquisition_of_features_of:(CL:0000128)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048709

oligodendrocyte differentiation

PMID:11493571[42]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:108067

P

  • occurs_in:(EMAPA:16910)
  • results_in_acquisition_of_features_of:(CL:0000128)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048709

oligodendrocyte differentiation

PMID:11171336[40]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:108067

P

  • occurs_in:(EMAPA:16910)
  • results_in_acquisition_of_features_of:(CL:0000128)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048706

embryonic skeletal system development

PMID:17504941[43]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95655

P

results_in_development_of:(EMAPA:17928)|results_in_development_of:(EMAPA:18715)|results_in_development_of:(EMAPA:19197)|results_in_development_of:(EMAPA:18290)|results_in_development_of:(EMAPA:17214)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048678

response to axon injury

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048663

neuron fate commitment

PMID:16221724[44]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268

P

  • has_participant:(EMAPA:17544)
  • results_in_commitment_to:(CL:0000099)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048646

anatomical structure formation involved in morphogenesis

PMID:9768363[38]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934261

P

results_in_formation_of:(EMAPA:16853)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048645

animal organ formation

PMID:15013801[26]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

results_in_formation_of:(EMAPA:19180)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048643

positive regulation of skeletal muscle tissue development

PMID:11171399[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796
MGI:MGI:1861186

P

regulates_o_results_in_development_of:(EMAPA:16405)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048617

embryonic foregut morphogenesis

PMID:9731532[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048617

embryonic foregut morphogenesis

PMID:9731532[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048598

embryonic morphogenesis

PMID:17881493[45]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048598

embryonic morphogenesis

PMID:16492970[46]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

has_participant:(EMAPA:16118)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048589

developmental growth

PMID:11044393[47]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268,MGI:MGI:2445832

P

occurs_in:(EMAPA:17921)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048568

embryonic organ development

PMID:15680353[48]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048557

embryonic digestive tract morphogenesis

PMID:10821773[49]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934261

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048546

digestive tract morphogenesis

PMID:9731532[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048468

cell development

PMID:16236765[50]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268,MGI:MGI:3052661

P

  • occurs_in:(EMAPA:17168)
  • occurs_in:(CL:0000573)|occurs_in:(EMAPA:17168)
  • occurs_in:(CL:0000561)|occurs_in:(EMAPA:17168)
  • occurs_in:(CL:0000745)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048468

cell development

PMID:15183722[51]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268
MGI:MGI:2387802

P

  • occurs_in:(EMAPA:17787)
  • occurs_in:(CL:0000121)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046639

negative regulation of alpha-beta T cell differentiation

PMID:10981962[52]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(EMAPA:17523)
  • regulates_o_results_in_acquisition_of_features_of:(CL:0000809)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046534

positive regulation of photoreceptor cell differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:9585504[53]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:104327

P

has_regulation_target:(MGI:MGI:97485)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:17881493[45]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96533

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:16880529[54]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95728

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:10340755[55]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97168

P

has_regulation_target:(MGI:MGI:105373)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:9731532[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

has_regulation_target:(MGI:MGI:105373)|has_regulation_target:(MGI:MGI:95727)|has_regulation_target:(MGI:MGI:88180)|has_regulation_target:(MGI:MGI:95729)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:19304890[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268

P

has_regulation_target:(MGI:MGI:105373)|has_regulation_target:(MGI:MGI:95727)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:10340755[55]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:105373)|has_regulation_target:(MGI:MGI:95727)|has_regulation_target:(MGI:MGI:95727)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:9769173[56]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:9769173[56]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:105373)|has_regulation_target:(MGI:MGI:95727)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:9585504[53]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:97485)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:9006067[57]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:105373)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:23740243[58]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:11493558[59]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:1347470)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

PMID:9356179[60]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15465

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045880

positive regulation of smoothened signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15465

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045666

positive regulation of neuron differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045597

positive regulation of cell differentiation

PMID:10357934[61]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

regulates_o_results_in_acquisition_of_features_of:(CL:0000127)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045596

negative regulation of cell differentiation

PMID:16236765[50]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268,MGI:MGI:3052661

P

  • occurs_in:(EMAPA:17171)
  • regulates_o_results_in_acquisition_of_features_of:(CL:0000740)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045596

negative regulation of cell differentiation

PMID:15337776[62]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(EMAPA:16247)
  • regulates_o_results_in_acquisition_of_features_of:(CL:0000029)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045471

response to ethanol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045445

myoblast differentiation

PMID:15238161[35]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045165

cell fate commitment

PMID:17504941[43]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95655

P

occurs_in:(EMAPA:16531)

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

PMID:15075292[63]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045109

intermediate filament organization

PMID:11171399[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1861186

P

occurs_in:(EMAPA:16405)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043588

skin development

PMID:10331973[64]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

results_in_development_of:(EMAPA:17527)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043587

tongue morphogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043586

tongue development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043369

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15465

P

Seeded From UniProt

complete

enables

GO:0043237

laminin-1 binding

PMID:15056720[65]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:19029980[66]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95728

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:9731532[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043010

camera-type eye development

PMID:18582859[67]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95729

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043010

camera-type eye development

PMID:16236765[50]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268,MGI:MGI:3052661

P

results_in_development_of:(EMAPA:17168)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043010

camera-type eye development

PMID:12756179[68]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268

P

results_in_development_of:(EMAPA:16678)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043010

camera-type eye development

PMID:12195432[69]

ECO:0000314

direct assay evidence used in manual assertion

P

results_in_development_of:(EMAPA:18592)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042733

embryonic digit morphogenesis

PMID:17504941[43]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95655

P

has_participant:(EMAPA:17432)|has_participant:(EMAPA:17435)|has_participant:(EMAPA:17463)|has_participant:(EMAPA:17466)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042733

embryonic digit morphogenesis

PMID:17504940[70]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95655

P

has_participant:(EMAPA:17463)|has_participant:(EMAPA:17432)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042733

embryonic digit morphogenesis

PMID:15930098[71]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:98715

P

has_participant:(EMAPA:17428)|has_participant:(EMAPA:17459)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042733

embryonic digit morphogenesis

PMID:20660756[72]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042476

odontogenesis

PMID:10781055[73]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042475

odontogenesis of dentin-containing tooth

PMID:11044393[47]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268,MGI:MGI:2445832

P

has_participant:(EMAPA:17921)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042307

positive regulation of protein import into nucleus

PMID:17043310[74]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:108075

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042177

negative regulation of protein catabolic process

PMID:16611981[75]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042130

negative regulation of T cell proliferation

PMID:10981962[52]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042127

regulation of cell population proliferation

PMID:12756179[68]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042127

regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035116

embryonic hindlimb morphogenesis

PMID:11118883[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035115

embryonic forelimb morphogenesis

PMID:11476582[76]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035115

embryonic forelimb morphogenesis

PMID:11118883[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034504

protein localization to nucleus

PMID:19952108[77]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0000047)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034244

negative regulation of transcription elongation from RNA polymerase II promoter

PMID:17284610[32]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:98297)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032901

positive regulation of neurotrophin production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032435

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

PMID:16611981[75]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031069

hair follicle morphogenesis

PMID:9768360[78]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934261

P

has_participant:(EMAPA:18771)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031069

hair follicle morphogenesis

PMID:14623238[79]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

has_participant:(EMAPA:18771)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031069

hair follicle morphogenesis

PMID:11520664[80]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031016

pancreas development

PMID:11044404[81]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96533

P

results_in_development_of:(EMAPA:17503)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031016

pancreas development

PMID:11044404[81]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934261

P

results_in_development_of:(EMAPA:17503)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031016

pancreas development

PMID:10821773[49]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934261

P

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

PMID:11476578[82]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:32906)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030902

hindbrain development

PMID:15496441[83]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95728

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030902

hindbrain development

PMID:15183722[51]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268
MGI:MGI:2387802

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030901

midbrain development

PMID:16020517[84]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:104719

P

results_in_development_of:(EMAPA:16974)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030900

forebrain development

PMID:16020517[84]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:104719

P

results_in_development_of:(EMAPA:16895)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030878

thyroid gland development

PMID:16968815[19]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1861186

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030850

prostate gland development

PMID:15013801[26]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

results_in_development_of:(EMAPA:19287)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030850

prostate gland development

PMID:10208740[27]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030539

male genitalia development

PMID:11684660[85]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

results_in_development_of:(EMAPA:17382)

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030336

negative regulation of cell migration

PMID:15337776[62]

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_o_occurs_in:(EMAPA:16247)
  • regulates_o_results_in_movement_of:(CL:0000011)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030326

embryonic limb morphogenesis

PMID:19422820[86]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95729
MGI:MGI:97168
MGI:MGI:97169

P

has_participant:(EMAPA:16405)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030326

embryonic limb morphogenesis

PMID:11389830[87]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:105373

P

occurs_in:(EMAPA:17428)|occurs_in:(EMAPA:17459)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030326

embryonic limb morphogenesis

PMID:15315763[88]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3053959,MGI:MGI:3053960

P

has_participant:(EMAPA:16405)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030324

lung development

PMID:15136151[89]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95729

P

results_in_development_of:(EMAPA:16728)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030324

lung development

PMID:9768363[38]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934261

P

results_in_development_of:(EMAPA:17653)|results_in_development_of:(EMAPA:17661)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030324

lung development

PMID:9731532[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030324

lung development

PMID:17187775[90]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030324

lung development

PMID:15305287[39]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268,MGI:MGI:2679524

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030324

lung development

PMID:15136151[89]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

results_in_development_of:(EMAPA:16728)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030323

respiratory tube development

PMID:9731532[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030178

negative regulation of Wnt signaling pathway

PMID:9356179[60]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030177

positive regulation of Wnt signaling pathway

PMID:11520664[80]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030162

regulation of proteolysis

PMID:15136151[89]

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_o_occurs_in:(EMAPA:16728)
  • regulates_o_has_input:(MGI:MGI:95729)

Seeded From UniProt

complete

part_of

GO:0030133

transport vesicle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030010

establishment of cell polarity

PMID:16332353[25]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(EMAPA:17755)
  • occurs_in:(CL:0000066)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0022006

zona limitans intrathalamica formation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021978

telencephalon regionalization

PMID:11060228[91]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

has_participant:(EMAPA:16895)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021978

telencephalon regionalization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021940

positive regulation of cerebellar granule cell precursor proliferation

PMID:10027293[92]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021938

smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

PMID:10375501[33]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(EMAPA:17787)
  • occurs_in:(CL:0000120)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021938

smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

PMID:10375501[33]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(EMAPA:17787)
  • occurs_in:(CL:0000120)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021924

cell proliferation in external granule layer

PMID:10970885[93]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021904

dorsal/ventral neural tube patterning

PMID:17504941[43]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95655

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021904

dorsal/ventral neural tube patterning

PMID:18590716[94]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021904

dorsal/ventral neural tube patterning

PMID:17442700[95]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021871

forebrain regionalization

PMID:24528677[96]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3775846
MGI:MGI:3840448

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021794

thalamus development

PMID:19357274[97]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:108075

P

results_in_development_of:(EMAPA:16754)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021794

thalamus development

PMID:19357274[97]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268,MGI:MGI:2176173

P

results_in_development_of:(EMAPA:16754)|results_in_development_of:(EMAPA:17540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021522

spinal cord motor neuron differentiation

PMID:21552265[98]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:107736

P

  • occurs_in:(EMAPA:16530)
  • results_in_acquisition_of_features_of:(CL:0000100)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021521

ventral spinal cord interneuron specification

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q63673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021513

spinal cord dorsal/ventral patterning

PMID:11748151[99]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

has_participant:(EMAPA:16531)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021513

spinal cord dorsal/ventral patterning

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q63673

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:18477453[100]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0014902

myotube differentiation

PMID:11171399[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796
MGI:MGI:1861186

P

occurs_in:(EMAPA:16405)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0014858

positive regulation of skeletal muscle cell proliferation

PMID:11171399[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1861186

P

regulates_o_occurs_in:(EMAPA:16405)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0014706

striated muscle tissue development

PMID:11171399[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1861186

P

results_in_development_of:(EMAPA:16405)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0014003

oligodendrocyte development

PMID:8660874[101]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010628

positive regulation of gene expression

PMID:11118883[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

has_regulation_target:(MGI:MGI:99604)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010468

regulation of gene expression

PMID:18799682[102]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95729

P

  • occurs_in:(EMAPA:16039)
  • has_regulation_target:(MGI:MGI:2151153)|occurs_in(EMAPA:16039)
  • has_regulation_target:(MGI:MGI:108460)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010468

regulation of gene expression

PMID:18799682[102]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(EMAPA:16039)
  • has_regulation_target:(MGI:MGI:2151153)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010468

regulation of gene expression

PMID:11476582[76]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010468

regulation of gene expression

PMID:22179047[103]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010468

regulation of gene expression

PMID:10021344[104]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q92008

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010463

mesenchymal cell proliferation

PMID:9731532[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:15576403[105]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009953

dorsal/ventral pattern formation

PMID:21552265[98]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1932386

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009952

anterior/posterior pattern specification

PMID:11118883[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

PMID:16054035[106]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95728

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

PMID:15496441[83]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95728

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

PMID:16396903[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

regulates_o_occurs_in:(EMAPA:36437)|regulates_o_occurs_in:(EMAPA:17950)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

PMID:16236765[50]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268,MGI:MGI:3052661

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

PMID:16054035[106]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

PMID:15183722[51]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268
MGI:MGI:2387802

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

PMID:11748155[107]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15465

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008283

cell population proliferation

PMID:19056373[108]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95728

P

  • acts_on_population_of:(CL:0000047)
  • occurs_in:(EMAPA:16164)

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15465

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008209

androgen metabolic process

PMID:15013801[26]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

part_of

GO:0008021

synaptic vesicle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007596

blood coagulation

PMID:8835524[109]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1860897

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007507

heart development

PMID:15936751[110]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

results_in_development_of:(EMAPA:16346)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007507

heart development

PMID:11172440[111]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

results_in_development_of:(EMAPA:16346)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007507

heart development

PMID:10500184[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

results_in_development_of:(EMAPA:16105)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007502

digestive tract mesoderm development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007442

hindgut morphogenesis

PMID:11485934[36]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

has_participant:(EMAPA:17896)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007417

central nervous system development

PMID:12435628[112]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

results_in_development_of:(EMAPA:16525)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007411

axon guidance

PMID:15065125[113]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007411

axon guidance

PMID:12756179[68]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007411

axon guidance

PMID:12679031[114]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007405

neuroblast proliferation

PMID:15337776[62]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(EMAPA:16247)
  • acts_on_population_of:(CL:0000011)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007398

ectoderm development

PMID:11118883[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007389

pattern specification process

PMID:14602680[115]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95729

P

occurs_in:(EMAPA:16184)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007389

pattern specification process

PMID:12231626[116]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

occurs_in:(EMAPA:17597)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007368

determination of left/right symmetry

PMID:10500184[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007368

determination of left/right symmetry

PMID:10411502[117]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

has_participant:(EMAPA:16105)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007368

determination of left/right symmetry

PMID:10385121[118]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

has_participant:(EMAPA:16039)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007267

cell-cell signaling

PMID:16492970[46]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007267

cell-cell signaling

PMID:15199404[119]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934268

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007228

positive regulation of hh target transcription factor activity

PMID:16880529[54]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95728

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007228

positive regulation of hh target transcription factor activity

PMID:10340755[55]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:105373)|has_regulation_target:(MGI:MGI:95727)|has_regulation_target:(MGI:MGI:95727)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007228

positive regulation of hh target transcription factor activity

PMID:16611981[75]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:95728)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007224

smoothened signaling pathway

PMID:17043310[74]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:108075

P

occurs_in:(EMAPA:16674)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007224

smoothened signaling pathway

PMID:11118883[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007224

smoothened signaling pathway

PMID:8906787[120]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007224

smoothened signaling pathway

PMID:25639508[121]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006897

endocytosis

PMID:18477453[100]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006355

regulation of transcription, DNA-templated

PMID:11412027[122]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006355

regulation of transcription, DNA-templated

PMID:11171399[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1861186

P

has_regulation_target:(MGI:MGI:88180)|has_regulation_target:(MGI:MGI:97252)

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:7891723[123]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:25639508[121]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:10027293[92]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15465

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

C

Seeded From UniProt

complete

enables

GO:0005539

glycosaminoglycan binding

PMID:11476578[82]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(EMAPA:32906)

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15465

F

Seeded From UniProt

complete

enables

GO:0005113

patched binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15465

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002320

lymphoid progenitor cell differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15465

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002076

osteoblast development

PMID:16880529[54]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002053

positive regulation of mesenchymal cell proliferation

PMID:9731532[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002052

positive regulation of neuroblast proliferation

PMID:11748155[107]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002052

positive regulation of neuroblast proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001947

heart looping

PMID:10500184[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

has_participant:(EMAPA:16105)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001947

heart looping

PMID:10411502[117]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

has_participant:(EMAPA:16105)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001944

vasculature development

PMID:17881493[45]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001942

hair follicle development

PMID:16054035[106]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

results_in_development_of:(EMAPA:16039)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001841

neural tube formation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001822

kidney development

PMID:11172440[111]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

results_in_development_of:(EMAPA:17373)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001755

neural crest cell migration

PMID:15936751[110]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

  • occurs_in:(EMAPA:16039)
  • results_in_movement_of:(CL:0000333)|occurs_in(EMAPA:16039)
  • results_in_movement_of:(CL:0000333)|occurs_in(EMAPA:16039)
  • results_in_movement_of:(CL:0000333)|occurs_in(EMAPA:16039)
  • results_in_movement_of:(CL:0000333)|occurs_in(EMAPA:16039)
  • results_in_movement_of:(CL:0000333)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001708

cell fate specification

PMID:16647304[124]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1926387

P

has_participant:(EMAPA:16903)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001708

cell fate specification

PMID:12231626[116]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

has_participant:(EMAPA:16669)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001708

cell fate specification

PMID:18076286[125]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001658

branching involved in ureteric bud morphogenesis

PMID:16396903[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

has_participant:(EMAPA:17950)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001570

vasculogenesis

PMID:15294868[126]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001569

branching involved in blood vessel morphogenesis

PMID:15936751[110]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

occurs_in:(EMAPA:16685)|occurs_in:(EMAPA:16686)|occurs_in:(EMAPA:16687)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001525

angiogenesis

PMID:17187775[90]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95516

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001525

angiogenesis

PMID:17187775[90]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001525

angiogenesis

PMID:16778080[127]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:9769173[56]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:9769173[56]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:108061)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001054

negative regulation of mesenchymal cell apoptotic process

PMID:19422820[86]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934261

P

  • regulates_o_occurs_in:(EMAPA:16781)
  • regulates_o_occurs_in:(CL:0000134)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001028

positive regulation of endothelial cell chemotaxis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1905327

tracheoesophageal septum formation

PMID:9731532[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903672

positive regulation of sprouting angiogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901215

negative regulation of neuron death

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1900180

regulation of protein localization to nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15465

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090090

negative regulation of canonical Wnt signaling pathway

PMID:17284610[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

regulates_o_occurs_in:(EMAPA:18272)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071679

commissural neuron axon guidance

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071285

cellular response to lithium ion

PMID:17284610[32]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070447

positive regulation of oligodendrocyte progenitor proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061198

fungiform papilla formation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061197

fungiform papilla morphogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061196

fungiform papilla development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3673

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061189

positive regulation of sclerotome development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15465

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060916

mesenchymal cell proliferation involved in lung development

PMID:9006067[57]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1900180

regulation of protein localization to nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15465
ensembl:ENSP00000297261

P

Seeded From UniProt

complete

involved_in

GO:0072001

renal system development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15465
ensembl:ENSP00000297261

P

Seeded From UniProt

complete

involved_in

GO:0061189

positive regulation of sclerotome development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15465
ensembl:ENSP00000297261

P

Seeded From UniProt

complete

involved_in

GO:0060738

epithelial-mesenchymal signaling involved in prostate gland development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15465
ensembl:ENSP00000297261

P

Seeded From UniProt

complete

involved_in

GO:0051781

positive regulation of cell division

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15465
ensembl:ENSP00000297261

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15465
ensembl:ENSP00000297261

P

Seeded From UniProt

complete

involved_in

GO:0045880

positive regulation of smoothened signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15465
ensembl:ENSP00000297261

P

Seeded From UniProt

complete

involved_in

GO:0043369

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15465
ensembl:ENSP00000297261

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15465
ensembl:ENSP00000297261

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15465
ensembl:ENSP00000297261

F

Seeded From UniProt

complete

involved_in

GO:0007224

smoothened signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15465
ensembl:ENSP00000297261

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15465
ensembl:ENSP00000297261

C

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15465
ensembl:ENSP00000297261

F

Seeded From UniProt

complete

enables

GO:0005113

patched binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15465
ensembl:ENSP00000297261

F

Seeded From UniProt

complete

involved_in

GO:0002320

lymphoid progenitor cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15465
ensembl:ENSP00000297261

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001767

P

Seeded From UniProt

complete

involved_in

GO:0007267

cell-cell signaling

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000320
InterPro:IPR001657

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001657

P

Seeded From UniProt

complete

involved_in

GO:0016539

intein-mediated protein splicing

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006141

P

Seeded From UniProt

complete

involved_in

GO:0071542

dopaminergic neuron differentiation

PMID:16243425[128]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060979

vasculogenesis involved in coronary vascular morphogenesis

PMID:20299672[129]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048557

embryonic digestive tract morphogenesis

PMID:11001584[130]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-NUL-5362792

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-NUL-5362792
Reactome:R-MMU-5632654

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007165

signal transduction

PMID:11684660[85]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page
  2. ↑ Joksimovic, M et al. (2009) Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. Nat. Neurosci. 12 125-31 PubMed GONUTS page
  3. ↑ Lee, HY et al. (2012) Reciprocal actions of ATF5 and Shh in proliferation of cerebellar granule neuron progenitor cells. Dev Neurobiol 72 789-804 PubMed GONUTS page
  4. ↑ Bidet, M et al. (2011) The hedgehog receptor patched is involved in cholesterol transport. PLoS ONE 6 e23834 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Zhang, XM et al. (2001) Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell 106 781-92 PubMed GONUTS page
  6. ↑ Viti, J et al. (2003) Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2. J. Neurosci. 23 5919-27 PubMed GONUTS page
  7. ↑ 7.0 7.1 Outram, SV et al. (2009) Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation. Blood 113 2217-28 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 Shah, DK et al. (2004) Reduced thymocyte development in sonic hedgehog knockout embryos. J. Immunol. 172 2296-306 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 Cho, SW et al. (2011) Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth. Development 138 1807-16 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 Rowbotham, NJ et al. (2007) Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation. Blood 109 3757-66 PubMed GONUTS page
  11. ↑ 11.0 11.1 Rowbotham, NJ et al. (2009) Sonic hedgehog negatively regulates pre-TCR-induced differentiation by a Gli2-dependent mechanism. Blood 113 5144-56 PubMed GONUTS page
  12. ↑ 12.0 12.1 Carpenter, D et al. (1998) Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc. Natl. Acad. Sci. U.S.A. 95 13630-4 PubMed GONUTS page
  13. ↑ 13.0 13.1 13.2 13.3 Sanz-Ezquerro, JJ & Tickle, C (2000) Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development. Development 127 4811-23 PubMed GONUTS page
  14. ↑ 14.0 14.1 Fuse, N et al. (1999) Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. Proc. Natl. Acad. Sci. U.S.A. 96 10992-9 PubMed GONUTS page
  15. ↑ 15.0 15.1 15.2 15.3 15.4 15.5 15.6 15.7 Yu, J et al. (2002) Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 129 5301-12 PubMed GONUTS page
  16. ↑ Gold, DA et al. (2003) RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron 40 1119-31 PubMed GONUTS page
  17. ↑ 17.0 17.1 17.2 17.3 Hu, MC et al. (2006) GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133 569-78 PubMed GONUTS page
  18. ↑ 18.0 18.1 18.2 18.3 18.4 18.5 18.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  19. ↑ 19.0 19.1 19.2 Alt, B et al. (2006) Arteries define the position of the thyroid gland during its developmental relocalisation. Development 133 3797-804 PubMed GONUTS page
  20. ↑ 20.0 20.1 20.2 20.3 20.4 20.5 Lamm, ML et al. (2002) Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation. Dev. Biol. 249 349-66 PubMed GONUTS page
  21. ↑ Gao, N et al. (2005) Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation. Development 132 3431-43 PubMed GONUTS page
  22. ↑ Vezina, CM et al. (2008) Retinoic acid induces prostatic bud formation. Dev. Dyn. 237 1321-33 PubMed GONUTS page
  23. ↑ 23.0 23.1 23.2 23.3 Lan, Y & Jiang, R (2009) Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development 136 1387-96 PubMed GONUTS page
  24. ↑ 24.0 24.1 24.2 24.3 Jaskoll, T et al. (2004) Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis. Dev. Dyn. 229 722-32 PubMed GONUTS page
  25. ↑ 25.0 25.1 Hashizume, A & Hieda, Y (2006) Hedgehog peptide promotes cell polarization and lumen formation in developing mouse submandibular gland. Biochem. Biophys. Res. Commun. 339 996-1000 PubMed GONUTS page
  26. ↑ 26.0 26.1 26.2 26.3 Berman, DM et al. (2004) Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis. Dev. Biol. 267 387-98 PubMed GONUTS page
  27. ↑ 27.0 27.1 27.2 Podlasek, CA et al. (1999) Prostate development requires Sonic hedgehog expressed by the urogenital sinus epithelium. Dev. Biol. 209 28-39 PubMed GONUTS page
  28. ↑ 28.00 28.01 28.02 28.03 28.04 28.05 28.06 28.07 28.08 28.09 28.10 28.11 28.12 28.13 28.14 28.15 28.16 28.17 Litingtung, Y et al. (1998) Sonic hedgehog is essential to foregut development. Nat. Genet. 20 58-61 PubMed GONUTS page
  29. ↑ 29.0 29.1 29.2 29.3 29.4 29.5 29.6 Tsukui, T et al. (1999) Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Proc. Natl. Acad. Sci. U.S.A. 96 11376-81 PubMed GONUTS page
  30. ↑ 30.0 30.1 30.2 30.3 30.4 30.5 30.6 Kraus, P et al. (2001) Some distal limb structures develop in mice lacking Sonic hedgehog signaling. Mech. Dev. 100 45-58 PubMed GONUTS page
  31. ↑ 31.0 31.1 Patterson, VL et al. (2009) Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway. Hum. Mol. Genet. 18 1719-39 PubMed GONUTS page
  32. ↑ 32.0 32.1 32.2 32.3 Iwatsuki, K et al. (2007) Wnt signaling interacts with Shh to regulate taste papilla development. Proc. Natl. Acad. Sci. U.S.A. 104 2253-8 PubMed GONUTS page
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  34. ↑ 34.0 34.1 34.2 34.3 34.4 34.5 34.6 Krüger, M et al. (2001) Sonic hedgehog is a survival factor for hypaxial muscles during mouse development. Development 128 743-52 PubMed GONUTS page
  35. ↑ 35.0 35.1 35.2 Li, X et al. (2004) Hedgehog can drive terminal differentiation of amniote slow skeletal muscle. BMC Dev. Biol. 4 9 PubMed GONUTS page
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  37. ↑ 37.0 37.1 Bok, J et al. (2007) Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear. Development 134 1713-22 PubMed GONUTS page
  38. ↑ 38.0 38.1 38.2 Pepicelli, CV et al. (1998) Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr. Biol. 8 1083-6 PubMed GONUTS page
  39. ↑ 39.0 39.1 Miller, LA et al. (2004) Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung. Dev. Dyn. 231 57-71 PubMed GONUTS page
  40. ↑ 40.0 40.1 Nery, S et al. (2001) Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain. Development 128 527-40 PubMed GONUTS page
  41. ↑ Oh, S et al. (2005) Specific requirements of sonic hedgehog signaling during oligodendrocyte development. Dev. Dyn. 234 489-96 PubMed GONUTS page
  42. ↑ Tekki-Kessaris, N et al. (2001) Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon. Development 128 2545-54 PubMed GONUTS page
  43. ↑ 43.0 43.1 43.2 43.3 Allen, BL et al. (2007) The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev. 21 1244-57 PubMed GONUTS page
  44. ↑ Xu, Q et al. (2005) Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon. Development 132 4987-98 PubMed GONUTS page
  45. ↑ 45.0 45.1 45.2 Astorga, J & Carlsson, P (2007) Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Development 134 3753-61 PubMed GONUTS page
  46. ↑ 46.0 46.1 Yamagishi, C et al. (2006) Sonic hedgehog is essential for first pharyngeal arch development. Pediatr. Res. 59 349-54 PubMed GONUTS page
  47. ↑ 47.0 47.1 Dassule, HR et al. (2000) Sonic hedgehog regulates growth and morphogenesis of the tooth. Development 127 4775-85 PubMed GONUTS page
  48. ↑ Moore-Scott, BA & Manley, NR (2005) Differential expression of Sonic hedgehog along the anterior-posterior axis regulates patterning of pharyngeal pouch endoderm and pharyngeal endoderm-derived organs. Dev. Biol. 278 323-35 PubMed GONUTS page
  49. ↑ 49.0 49.1 Ramalho-Santos, M et al. (2000) Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127 2763-72 PubMed GONUTS page
  50. ↑ 50.0 50.1 50.2 50.3 Wang, Y et al. (2005) Retinal ganglion cell-derived sonic hedgehog locally controls proliferation and the timing of RGC development in the embryonic mouse retina. Development 132 5103-13 PubMed GONUTS page
  51. ↑ 51.0 51.1 51.2 Lewis, PM et al. (2004) Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev. Biol. 270 393-410 PubMed GONUTS page
  52. ↑ 52.0 52.1 Outram, SV et al. (2000) Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte. Immunity 13 187-97 PubMed GONUTS page
  53. ↑ 53.0 53.1 McMahon, JA et al. (1998) Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev. 12 1438-52 PubMed GONUTS page
  54. ↑ 54.0 54.1 54.2 Zhao, M et al. (2006) The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling. Mol. Cell. Biol. 26 6197-208 PubMed GONUTS page
  55. ↑ 55.0 55.1 55.2 Zhang, Y et al. (1999) Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ. Dev. Dyn. 215 45-53 PubMed GONUTS page
  56. ↑ 56.0 56.1 56.2 56.3 Dassule, HR & McMahon, AP (1998) Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev. Biol. 202 215-27 PubMed GONUTS page
  57. ↑ 57.0 57.1 Bellusci, S et al. (1997) Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development 124 53-63 PubMed GONUTS page
  58. ↑ Nakamura, I et al. (2013) Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration. J. Biol. Chem. 288 21389-98 PubMed GONUTS page
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  60. ↑ 60.0 60.1 Fan, CM et al. (1997) A role for WNT proteins in induction of dermomyotome. Dev. Biol. 191 160-5 PubMed GONUTS page
  61. ↑ Wallace, VA & Raff, MC (1999) A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve. Development 126 2901-9 PubMed GONUTS page
  62. ↑ 62.0 62.1 62.2 Fu, M et al. (2004) Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut. J. Cell Biol. 166 673-84 PubMed GONUTS page
  63. ↑ Chen, MH et al. (2004) Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev. 18 641-59 PubMed GONUTS page
  64. ↑ Karlsson, L et al. (1999) Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. Development 126 2611-21 PubMed GONUTS page
  65. ↑ Blaess, S et al. (2004) Beta1-integrins are critical for cerebellar granule cell precursor proliferation. J. Neurosci. 24 3402-12 PubMed GONUTS page
  66. ↑ Nasr, R et al. (2008) Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation. Nat. Med. 14 1333-42 PubMed GONUTS page
  67. ↑ Dakubo, GD et al. (2008) Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye. Dev. Biol. 320 242-55 PubMed GONUTS page
  68. ↑ 68.0 68.1 68.2 Dakubo, GD et al. (2003) Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development. Development 130 2967-80 PubMed GONUTS page
  69. ↑ Wang, YP et al. (2002) Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells. Nat. Neurosci. 5 831-2 PubMed GONUTS page
  70. ↑ Martinelli, DC & Fan, CM (2007) Gas1 extends the range of Hedgehog action by facilitating its signaling. Genes Dev. 21 1231-43 PubMed GONUTS page
  71. ↑ Liu, A et al. (2005) Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development 132 3103-11 PubMed GONUTS page
  72. ↑ Witte, F et al. (2010) Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region. Proc. Natl. Acad. Sci. U.S.A. 107 14211-6 PubMed GONUTS page
  73. ↑ Sarkar, L et al. (2000) Wnt/Shh interactions regulate ectodermal boundary formation during mammalian tooth development. Proc. Natl. Acad. Sci. U.S.A. 97 4520-4 PubMed GONUTS page
  74. ↑ 74.0 74.1 Kim, JW & Lemke, G (2006) Hedgehog-regulated localization of Vax2 controls eye development. Genes Dev. 20 2833-47 PubMed GONUTS page
  75. ↑ 75.0 75.1 75.2 Pan, Y et al. (2006) Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol. Cell. Biol. 26 3365-77 PubMed GONUTS page
  76. ↑ 76.0 76.1 Chiang, C et al. (2001) Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev. Biol. 236 421-35 PubMed GONUTS page
  77. ↑ Fernandez-L, A et al. (2009) YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes Dev. 23 2729-41 PubMed GONUTS page
  78. ↑ St-Jacques, B et al. (1998) Sonic hedgehog signaling is essential for hair development. Curr. Biol. 8 1058-68 PubMed GONUTS page
  79. ↑ Michno, K et al. (2003) Shh expression is required for embryonic hair follicle but not mammary gland development. Dev. Biol. 264 153-65 PubMed GONUTS page
  80. ↑ 80.0 80.1 Reddy, S et al. (2001) Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis. Mech. Dev. 107 69-82 PubMed GONUTS page
  81. ↑ 81.0 81.1 Hebrok, M et al. (2000) Regulation of pancreas development by hedgehog signaling. Development 127 4905-13 PubMed GONUTS page
  82. ↑ 82.0 82.1 Gritli-Linde, A et al. (2001) The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev. Biol. 236 364-86 PubMed GONUTS page
  83. ↑ 83.0 83.1 Corrales, JD et al. (2004) Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development. Development 131 5581-90 PubMed GONUTS page
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  85. ↑ 85.0 85.1 Haraguchi, R et al. (2001) Unique functions of Sonic hedgehog signaling during external genitalia development. Development 128 4241-50 PubMed GONUTS page
  86. ↑ 86.0 86.1 Lallemand, Y et al. (2009) Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb. Dev. Biol. 331 189-98 PubMed GONUTS page
  87. ↑ Lewis, PM et al. (2001) Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell 105 599-612 PubMed GONUTS page
  88. ↑ Harfe, BD et al. (2004) Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell 118 517-28 PubMed GONUTS page
  89. ↑ 89.0 89.1 89.2 Li, Y et al. (2004) Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis. Dev. Biol. 270 214-31 PubMed GONUTS page
  90. ↑ 90.0 90.1 90.2 van Tuyl, M et al. (2007) Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs. Dev. Biol. 303 514-26 PubMed GONUTS page
  91. ↑ Corbin, JG et al. (2000) The Gsh2 homeodomain gene controls multiple aspects of telencephalic development. Development 127 5007-20 PubMed GONUTS page
  92. ↑ 92.0 92.1 Wechsler-Reya, RJ & Scott, MP (1999) Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22 103-14 PubMed GONUTS page
  93. ↑ Bhatt, RS et al. (2000) Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons. Genes Dev. 14 2216-28 PubMed GONUTS page
  94. ↑ Cho, A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev. Biol. 321 27-39 PubMed GONUTS page
  95. ↑ Vokes, SA et al. (2007) Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development 134 1977-89 PubMed GONUTS page
  96. ↑ Chatterjee, M et al. (2014) Pax6 regulates the formation of the habenular nuclei by controlling the temporospatial expression of Shh in the diencephalon in vertebrates. BMC Biol. 12 13 PubMed GONUTS page
  97. ↑ 97.0 97.1 Vue, TY et al. (2009) Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice. J. Neurosci. 29 4484-97 PubMed GONUTS page
  98. ↑ 98.0 98.1 Ocbina, PJ et al. (2011) Complex interactions between genes controlling trafficking in primary cilia. Nat. Genet. 43 547-53 PubMed GONUTS page
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  100. ↑ 100.0 100.1 Capurro, MI et al. (2008) Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding. Dev. Cell 14 700-11 PubMed GONUTS page
  101. ↑ Pringle, NP et al. (1996) Determination of neuroepithelial cell fate: induction of the oligodendrocyte lineage by ventral midline cells and sonic hedgehog. Dev. Biol. 177 30-42 PubMed GONUTS page
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  105. ↑ Jeong, J & McMahon, AP (2005) Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development 132 143-54 PubMed GONUTS page
  106. ↑ 106.0 106.1 106.2 Mill, P et al. (2005) Shh controls epithelial proliferation via independent pathways that converge on N-Myc. Dev. Cell 9 293-303 PubMed GONUTS page
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  114. ↑ Charron, F et al. (2003) The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell 113 11-23 PubMed GONUTS page
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