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PMID:10411502

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Citation

Meyers, EN and Martin, GR (1999) Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH. Science 285:403-6

Abstract

A molecular pathway leading to left-right asymmetry in the chick embryo has been described, in which FGF8 is a right determinant and Sonic Hedgehog a left determinant. Here evidence is presented that the Fgf8 and Sonic Hedgehog genes are required for left-right axis determination in the mouse embryo, but that they have different functions from those previously reported in the chick. In the mouse FGF8 is a left determinant and Sonic Hedgehog is required to prevent left determinants from being expressed on the right.

Links

PubMed

Keywords

Animals; Body Patterning; Chick Embryo/growth & development; Chick Embryo/metabolism; Embryo, Mammalian/metabolism; Embryonic Induction; Embryonic and Fetal Development; Fibroblast Growth Factor 8; Fibroblast Growth Factors/genetics; Fibroblast Growth Factors/physiology; Gene Expression Regulation, Developmental; Heart/embryology; Heart Defects, Congenital/embryology; Hedgehog Proteins; Homeodomain Proteins/genetics; Homeodomain Proteins/physiology; Left-Right Determination Factors; Lung/abnormalities; Lung/embryology; Mesoderm/metabolism; Mice; Mutation; Nodal Protein; Nuclear Proteins; Paired Box Transcription Factors; Proteins/genetics; Proteins/physiology; Recombinant Proteins/metabolism; Trans-Activators; Transcription Factors/genetics; Transcription Factors/physiology; Transforming Growth Factor beta/genetics; Transforming Growth Factor beta/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:FGF8

acts_upstream_of_or_within

GO:0030324: lung development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857843

P

  • results_in_development_of:(EMAPA:16728)

Seeded From UniProt

complete

MOUSE:FGF8

acts_upstream_of_or_within

GO:0001947: heart looping

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857843

P

Seeded From UniProt

complete

MOUSE:FGF8

acts_upstream_of_or_within

GO:0007368: determination of left/right symmetry

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857843

P

Seeded From UniProt

complete

MOUSE:FGF8

acts_upstream_of_or_within

GO:0010628: positive regulation of gene expression

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857843

P

  • has_input:(MGI:MGI:97359)

Seeded From UniProt

complete

MOUSE:FGF8

acts_upstream_of_or_within

GO:0060425: lung morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857843

P

Seeded From UniProt

complete

MOUSE:SHH

acts_upstream_of_or_within

GO:0001947: heart looping

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

MOUSE:SHH

acts_upstream_of_or_within

GO:0007368: determination of left/right symmetry

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

Seeded From UniProt

complete

MOUSE:SHH

acts_upstream_of_or_within

GO:0007368: determination of left/right symmetry

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

has_participant:(EMAPA:16105)

Seeded From UniProt

complete

MOUSE:SHH

acts_upstream_of_or_within

GO:0001947: heart looping

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857796

P

has_participant:(EMAPA:16105)

Seeded From UniProt

complete


See also

References

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Backtrace:

#0 /usr/local/github/wiki-extensions/wiki-extensions-hulab/AnnotationLinks/AnnotationLinks.php(70): AnnotationLinks::getQuickGOannotations(string, array)
#1 /var/www/html/go/wiki/includes/parser/Parser.php(3888): AnnotationLinks::renderAnnotations(NULL, array, Parser, PPFrame_DOM)
#2 /var/www/html/go/wiki/includes/parser/Preprocessor_DOM.php(1362): Parser->extensionSubstitution(array, PPFrame_DOM)
#3 /var/www/html/go/wiki/includes/parser/Parser.php(2942): PPFrame_DOM->expand(DOMElement, integer)
#4 /var/www/html/go/wiki/includes/parser/Parser.php(1293): Parser->replaceVariables(string)
#5 /var/www/html/go/wiki/includes/parser/Parser.php(443): Parser->internalParse(string)
#6 /var/www/html/go/wiki/includes/content/WikitextContent.php(323): Parser->parse(string, Title, ParserOptions, boolean, boolean, integer)
#7 /var/www/html/go/wiki/includes/content/AbstractContent.php(516): WikitextContent->fillParserOutput(Title, integer, ParserOptions, boolean, ParserOutput)
#8 /var/www/html/go/wiki/includes/jobqueue/jobs/RefreshLinksJob.php(231): AbstractContent->getParserOutput(Title, integer, ParserOptions, boolean)
#9 /var/www/html/go/wiki/includes/jobqueue/jobs/RefreshLinksJob.php(126): RefreshLinksJob->runForTitle(Title)
#10 /var/www/html/go/wiki/includes/jobqueue/JobRunner.php(296): RefreshLinksJob->run()
#11 /var/www/html/go/wiki/includes/jobqueue/JobRunner.php(193): JobRunner->executeJob(RefreshLinksJob, Wikimedia\Rdbms\LBFactorySimple, BufferingStatsdDataFactory, integer)
#12 /var/www/html/go/wiki/includes/MediaWiki.php(1002): JobRunner->run(array)
#13 /var/www/html/go/wiki/includes/MediaWiki.php(988): MediaWiki->triggerSyncJobs(integer, MediaWiki\Logger\LegacyLogger)
#14 /var/www/html/go/wiki/includes/MediaWiki.php(912): MediaWiki->triggerJobs()
#15 /var/www/html/go/wiki/includes/MediaWiki.php(727): MediaWiki->restInPeace(string, boolean)
#16 /var/www/html/go/wiki/includes/MediaWiki.php(750): MediaWiki->{closure}()
#17 /var/www/html/go/wiki/includes/MediaWiki.php(557): MediaWiki->doPostOutputShutdown(string)
#18 /var/www/html/go/wiki/index.php(42): MediaWiki->run()
#19 {main}

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