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PMID:15880651

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Citation

Oh, S, Huang, X and Chiang, C (2005) Specific requirements of sonic hedgehog signaling during oligodendrocyte development. Dev. Dyn. 234:489-96

Abstract

Oligodendrocyte precursors (OLPs) in the developing spinal cord are generated from the same part of the ventral neuroepithelium as motor neurons, by inductive processes that include a temporal switch from neuronal to glial cell fate. Recent studies have implicated Shh as a key signal in the generation of both OLPs and ventral neurons. In this study, we used Shh(-/-), Gli3(-/-), and Shh(-/-);Gli3(-/-) mutants to address the role of Shh signaling during oligodendrocyte development. We find that, in the absence of Gli3, Shh signaling is dispensable for the generation and maintenance of OLPs. However, Shh is required for OLPs to emerge at the appropriate developmental stages and for subsequent differentiation of OLPs into mature oligodendrocytes. The initial delay and reduction in OLP generation in Shh(-/-);Gli3(-/-) mutants are accompanied by extended neurogenesis and persistent expression of Neurogenin 2 in the Olig2 progenitor domain, suggesting that Shh signaling influences the timing of neuron-glia fate switching. Thus, our studies suggest that Shh signaling plays multiple roles during development of oligodendrocytes.

Links

PubMed Online version:10.1002/dvdy.20422

Keywords

Animals; Basic Helix-Loop-Helix Transcription Factors/genetics; Basic Helix-Loop-Helix Transcription Factors/metabolism; Cell Differentiation; Gene Expression Regulation, Developmental; Hedgehog Proteins; Kruppel-Like Transcription Factors/deficiency; Kruppel-Like Transcription Factors/genetics; Kruppel-Like Transcription Factors/metabolism; Mice; Mice, Knockout; Mutation/genetics; Nerve Tissue Proteins/deficiency; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Oligodendroglia/cytology; Oligodendroglia/metabolism; Signal Transduction; Trans-Activators/deficiency; Trans-Activators/genetics; Trans-Activators/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:SHH

acts_upstream_of_or_within

GO:0048709: oligodendrocyte differentiation

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:95729

P

  • occurs_in:(EMAPA:17577)
  • results_in_acquisition_of_features_of:(CL:0000128)

Seeded From UniProt

complete

MOUSE:GLI3

acts_upstream_of_or_within

GO:0048709: oligodendrocyte differentiation

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:98297

P

  • occurs_in:(EMAPA:17577)
  • results_in_acquisition_of_features_of:(CL:0000128)

Seeded From UniProt

complete


See also

References

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