PMID:12195432

Citation	Wang, YP, Dakubo, G, Howley, P, Campsall, KD, Mazarolle, CJ, Shiga, SA, Lewis, PM, McMahon, AP and Wallace, VA (2002) Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells. Nat. Neurosci. 5:831-2
Abstract	The adult retina is organized into three cellular layers--an outer photoreceptor, a middle interneuron and an inner retinal ganglion cell (RGC) layer. Although the retinal pigment epithelium (RPE) and Müller cells are important in the establishment and maintenance of this organization, the signals involved are unknown. Here we show that Sonic hedgehog signaling from RGCs is required for the normal laminar organization in the vertebrate retina.
Links	PubMed Online version:10.1038/nn911
Keywords	Animals; Body Patterning/drug effects; Body Patterning/genetics; Cell Communication/drug effects; Cell Communication/genetics; Cell Differentiation/drug effects; Cell Differentiation/genetics; Cell Division/drug effects; Cell Division/genetics; Female; Gene Expression Regulation, Developmental/drug effects; Gene Expression Regulation, Developmental/physiology; Growth Substances/diagnostic use; Growth Substances/pharmacology; Hedgehog Proteins; Male; Mice; Mice, Knockout; Neuroglia/cytology; Neuroglia/drug effects; Neuroglia/metabolism; Phenotype; Recombinant Fusion Proteins/diagnostic use; Recombinant Fusion Proteins/pharmacology; Retina/abnormalities; Retina/cytology; Retina/metabolism; Retinal Ganglion Cells/cytology; Retinal Ganglion Cells/drug effects; Retinal Ganglion Cells/metabolism; Signal Transduction/drug effects; Signal Transduction/genetics; Stem Cells/cytology; Stem Cells/metabolism; Trans-Activators/deficiency; Trans-Activators/genetics; Trans-Activators/pharmacology
edit table

Annotations

Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
edit table

References

See Help:References for how to manage references in GONUTS.