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PMID:15238161
| Citation |
Li, X, Blagden, CS, Bildsoe, H, Bonnin, MA, Duprez, D and Hughes, SM (2004) Hedgehog can drive terminal differentiation of amniote slow skeletal muscle. BMC Dev. Biol. 4:9 |
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| Abstract |
Secreted Hedgehog (Hh) signalling molecules have profound influences on many developing and regenerating tissues. Yet in most vertebrate tissues it is unclear which Hh-responses are the direct result of Hh action on a particular cell type because Hhs frequently elicit secondary signals. In developing skeletal muscle, Hhs promote slow myogenesis in zebrafish and are involved in specification of medial muscle cells in amniote somites. However, the extent to which non-myogenic cells, myoblasts or differentiating myocytes are direct or indirect targets of Hh signalling is not known. |
| Links |
PubMed PMC471547 Online version:10.1186/1471-213X-4-9 |
| Keywords |
Animals; Antibodies/metabolism; Cell Differentiation/genetics; Cell Line; Cells, Cultured; Chick Embryo; Fibroblasts/chemistry; Fibroblasts/metabolism; Fibroblasts/transplantation; Gene Expression Regulation/genetics; Hedgehog Proteins; Hybridomas/secretion; Limb Buds/chemistry; Limb Buds/cytology; Limb Buds/metabolism; Mice; Mice, Knockout/genetics; Muscle Development/genetics; Muscle Fibers, Slow-Twitch/metabolism; Myoblasts, Skeletal/physiology; Signal Transduction/genetics; Trans-Activators/deficiency; Trans-Activators/genetics; Trans-Activators/immunology; Trans-Activators/secretion; Zebrafish/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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