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HUMAN:WNT8B

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) WNT8B
Protein Name(s) Protein Wnt-8b
External Links
UniProt Q93098
EMBL Y11094
Y11108
AB073637
AL359759
AL133352
AL133352
AL359759
X91940
CCDS CCDS7494.1
RefSeq NP_003384.2
UniGene Hs.421281
ProteinModelPortal Q93098
SMR Q93098
STRING 9606.ENSP00000340677
PhosphoSite Q93098
DMDM 66774217
PaxDb Q93098
PRIDE Q93098
DNASU 7479
Ensembl ENST00000343737
GeneID 7479
KEGG hsa:7479
UCSC uc001krb.3
CTD 7479
GeneCards GC10P102212
HGNC HGNC:12789
HPA HPA036570
MIM 601396
neXtProt NX_Q93098
PharmGKB PA37390
eggNOG NOG277037
GeneTree ENSGT00690000101857
HOGENOM HOG000039529
HOVERGEN HBG001595
InParanoid Q93098
KO K00714
OMA RCEQCRK
OrthoDB EOG7C8GJ8
PhylomeDB Q93098
TreeFam TF105310
Reactome REACT_163710
REACT_18372
REACT_200610
REACT_200777
GeneWiki WNT8B
GenomeRNAi 7479
NextBio 29296
PRO PR:Q93098
Proteomes UP000005640
Bgee Q93098
CleanEx HS_WNT8B
Genevestigator Q93098
GO GO:0005576
GO:0005615
GO:0005578
GO:0005109
GO:0045165
GO:0071300
GO:0048263
GO:0007369
GO:0010629
GO:0007399
GO:0030182
GO:0010628
GO:0032355
GO:0032526
GO:0007165
GO:0016055
InterPro IPR005817
IPR013301
IPR018161
PANTHER PTHR12027
PTHR12027:SF94
Pfam PF00110
PRINTS PR01892
PR01349
SMART SM00097
PROSITE PS00246

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004871

signal transducer activity

ECO:0000304

F

Source: ProtInc

Missing: reference

GO:0007267

cell-cell signaling

ECO:0000304

P

Source: ProtInc

Missing: reference

GO:0007399

nervous system development

ECO:0000304

P

Source: ProtInc

Missing: reference

GO:0007165

signal transduction

ECO:0000304

P

Source: ProtInc

Missing: reference

enables

GO:0048018

receptor ligand activity

PMID:28733458[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

PMID:28733458[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048263

determination of dorsal identity

PMID:7635061[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P31291-1

P

Seeded From UniProt

complete

involved_in

GO:0032526

response to retinoic acid

PMID:11956596[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032355

response to estradiol

PMID:11956596[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007369

gastrulation

PMID:7635061[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P31291-2

P

Seeded From UniProt

complete

involved_in

GO:0071300

cellular response to retinoic acid

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56706

P

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56706

P

Seeded From UniProt

complete

involved_in

GO:0045165

cell fate commitment

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98957
PANTHER:PTN000246517
UniProtKB:P49339
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000246517
RGD:69250
UniProtKB:P56706
UniProtKB:Q98SN7

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010194
MGI:MGI:108061
MGI:MGI:1197020
MGI:MGI:98953
MGI:MGI:98954
MGI:MGI:98956
MGI:MGI:98958
MGI:MGI:98960
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
UniProtKB:P41221
UniProtKB:Q98SN7
WB:WBGene00000858
WB:WBGene00003029
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
MGI:MGI:98956
MGI:MGI:98957
PANTHER:PTN000246517
RGD:1311441
RGD:69250
UniProtKB:P41221
UniProtKB:P56704
UniProtKB:P56705
UniProtKB:Q2LMP1
UniProtKB:Q9UBV4
UniProtKB:Q9YGX6

C

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
FB:FBgn0004360
FB:FBgn0010453
FB:FBgn0038134
MGI:MGI:98956
MGI:MGI:98957
MGI:MGI:98958
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
RGD:69079
UniProtKB:P09544
UniProtKB:P41221
UniProtKB:P56703
UniProtKB:Q98SN7

F

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048018

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR013301
InterPro:IPR034311

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR013301

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR013301
InterPro:IPR034311

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR013301
InterPro:IPR034311

P

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

PMID:9536085[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:9536085[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1904886

beta-catenin destruction complex disassembly

Reactome:R-HSA-4641262

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

Reactome:R-HSA-195721

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-NUL-1458902
Reactome:R-HSA-3247843
Reactome:R-HSA-201677
Reactome:R-HSA-1504186

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Voloshanenko, O et al. (2017) Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 31 4832-4844 PubMed GONUTS page
  2. ↑ 2.0 2.1 Cui, Y et al. (1995) Xwnt-8b: a maternally expressed Xenopus Wnt gene with a potential role in establishing the dorsoventral axis. Development 121 2177-86 PubMed GONUTS page
  3. ↑ 3.0 3.1 Saitoh, T et al. (2002) Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells. Int. J. Oncol. 20 999-1003 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ 5.0 5.1 Lako, M et al. (1998) A novel mammalian wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain. Hum. Mol. Genet. 7 813-22 PubMed GONUTS page
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