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HUMAN:SDC1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SDC1 (synonyms: SDC)
Protein Name(s) Syndecan-1

SYND1

External Links
UniProt P18827
EMBL X60306
J05392
AJ551176
AC104792
CH471053
CH471053
CH471053
CH471053
BC008765
Z48199
CCDS CCDS1697.1
PIR A41776
RefSeq NP_001006947.1
NP_002988.3
UniGene Hs.224607
Hs.665958
PDB 4GVC
4GVD
PDBsum 4GVC
4GVD
ProteinModelPortal P18827
SMR P18827
BioGrid 112284
DIP DIP-1123N
IntAct P18827
MINT MINT-5004100
STRING 9606.ENSP00000254351
PhosphoSite P18827
DMDM 229463011
MaxQB P18827
PaxDb P18827
PRIDE P18827
DNASU 6382
Ensembl ENST00000254351
ENST00000381150
GeneID 6382
KEGG hsa:6382
UCSC uc002rdo.1
CTD 6382
GeneCards GC02M020400
H-InvDB HIX0161948
HGNC HGNC:10658
HPA CAB002424
HPA006185
MIM 186355
neXtProt NX_P18827
PharmGKB PA35588
eggNOG NOG86393
GeneTree ENSGT00530000063116
HOGENOM HOG000133092
HOVERGEN HBG017783
InParanoid P18827
KO K06257
OMA PTKQEEF
OrthoDB EOG79KPG2
PhylomeDB P18827
TreeFam TF320463
Reactome REACT_120752
REACT_121248
REACT_121408
REACT_163942
REACT_24968
REACT_267654
REACT_267659
REACT_267674
REACT_267711
REACT_6841
ChiTaRS SDC1
GeneWiki Syndecan_1
GenomeRNAi 6382
NextBio 24782
PMAP-CutDB P18827
PRO PR:P18827
Proteomes UP000005640
Bgee P18827
CleanEx HS_SDC1
ExpressionAtlas P18827
Genevestigator P18827
GO GO:0009986
GO:0005737
GO:0009897
GO:0070062
GO:0005925
GO:0005796
GO:0005887
GO:0043202
GO:0005886
GO:0043234
GO:0008022
GO:0060070
GO:0005975
GO:0030204
GO:0030198
GO:0006024
GO:0006027
GO:0030203
GO:0006954
GO:0042157
GO:0048627
GO:0042476
GO:0007603
GO:1903543
GO:1903553
GO:0051592
GO:0051591
GO:0051384
GO:0042542
GO:0009636
GO:0001523
GO:0060009
GO:0044281
GO:0055002
GO:0001657
GO:0042060
InterPro IPR003585
IPR001050
IPR027789
PANTHER PTHR10915
Pfam PF01034
SMART SM00294
PROSITE PS00964

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0019089

transmission of virus

PMID:21957484[1]

ECO:0000315

P

Fig. 5, Fig. 6, and Fig. 7

complete
CACAO 2399

involved_in

GO:1903553

positive regulation of extracellular exosome assembly

PMID:22660413[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903543

positive regulation of exosomal secretion

PMID:22660413[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:25063885[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:0055002

striated muscle cell development

PMID:9566955[5]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048627

myoblast development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P18828

P

Seeded From UniProt

complete

enables

GO:0008022

protein C-terminus binding

PMID:16982797[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9GZZ8

F

Seeded From UniProt

complete

involved_in

GO:0016477

cell migration

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000099415
ZFIN:ZDB-GENE-061111-1

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1349162
MGI:MGI:1349164
PANTHER:PTN000099415
RGD:3650
UniProtKB:P18827
WB:WBGene00004749

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:18093920[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P18827

F

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18828
ensembl:ENSMUSP00000020911

P

Seeded From UniProt

complete

involved_in

GO:0048627

myoblast development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18828
ensembl:ENSMUSP00000020911

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18828
ensembl:ENSMUSP00000020911

C

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18828
ensembl:ENSMUSP00000020911

C

Seeded From UniProt

complete

involved_in

GO:0060009

Sertoli cell development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26260
ensembl:ENSRNOP00000072283

P

Seeded From UniProt

complete

involved_in

GO:0051592

response to calcium ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26260
ensembl:ENSRNOP00000072283

P

Seeded From UniProt

complete

involved_in

GO:0051591

response to cAMP

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26260
ensembl:ENSRNOP00000072283

P

Seeded From UniProt

complete

involved_in

GO:0051384

response to glucocorticoid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26260
ensembl:ENSRNOP00000072283

P

Seeded From UniProt

complete

involved_in

GO:0042542

response to hydrogen peroxide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26260
ensembl:ENSRNOP00000072283

P

Seeded From UniProt

complete

involved_in

GO:0042476

odontogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26260
ensembl:ENSRNOP00000072283

P

Seeded From UniProt

complete

involved_in

GO:0042060

wound healing

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26260
ensembl:ENSRNOP00000072283

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26260
ensembl:ENSRNOP00000072283

C

Seeded From UniProt

complete

involved_in

GO:0010033

response to organic substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26260
ensembl:ENSRNOP00000072283

P

Seeded From UniProt

complete

involved_in

GO:0009636

response to toxic substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26260
ensembl:ENSRNOP00000072283

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26260
ensembl:ENSRNOP00000072283

P

Seeded From UniProt

complete

involved_in

GO:0001657

ureteric bud development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26260
ensembl:ENSRNOP00000072283

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001050

C

Seeded From UniProt

complete

involved_in

GO:0042060

wound healing

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031190

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:2324102[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050900

leukocyte migration

Reactome:R-HSA-202733

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043202

lysosomal lumen

Reactome:R-HSA-2024084
Reactome:R-HSA-1667005

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

Reactome:R-HSA-449836

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006027

glycosaminoglycan catabolic process

Reactome:R-HSA-2024096

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006024

glycosaminoglycan biosynthetic process

Reactome:R-HSA-2022928

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-NUL-2731130
Reactome:R-HSA-9009558
Reactome:R-HSA-9009554
Reactome:R-HSA-8870732
Reactome:R-HSA-2731141
Reactome:R-HSA-2731122
Reactome:R-HSA-2731074
Reactome:R-HSA-2684507
Reactome:R-HSA-2429643
Reactome:R-HSA-2423785
Reactome:R-HSA-2404131
Reactome:R-HSA-2024108
Reactome:R-HSA-2024084
Reactome:R-HSA-1678694

ECO:0000304

author statement supported by traceable reference used in manual assertion














C

Seeded From UniProt

complete

part_of

GO:0005796

Golgi lumen

Reactome:R-HSA-9036290
Reactome:R-HSA-9036289
Reactome:R-HSA-9036285
Reactome:R-HSA-9036283
Reactome:R-HSA-4420365
Reactome:R-HSA-3656267
Reactome:R-HSA-3656261
Reactome:R-HSA-3656257
Reactome:R-HSA-3656254
Reactome:R-HSA-3560804
Reactome:R-HSA-3560802
Reactome:R-HSA-2076611
Reactome:R-HSA-2076508
Reactome:R-HSA-2076419
Reactome:R-HSA-2076392
Reactome:R-HSA-2076383
Reactome:R-HSA-2024108
Reactome:R-HSA-2022919
Reactome:R-HSA-2022887
Reactome:R-HSA-2022860
Reactome:R-HSA-2022856
Reactome:R-HSA-2022851
Reactome:R-HSA-1889981
Reactome:R-HSA-1889978
Reactome:R-HSA-1889955
Reactome:R-HSA-1878002

ECO:0000304

author statement supported by traceable reference used in manual assertion


























C

Seeded From UniProt

complete

involved_in

GO:0001523

retinoid metabolic process

Reactome:R-HSA-975634

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0466

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Karasneh, GA et al. (2011) An important role for syndecan-1 in herpes simplex virus type-1 induced cell-to-cell fusion and virus spread. PLoS ONE 6 e25252 PubMed GONUTS page
  2. 2.0 2.1 Baietti, MF et al. (2012) Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. Nat. Cell Biol. 14 677-85 PubMed GONUTS page
  3. Garrigues, HJ et al. (2014) KSHV attachment and entry are dependent on αVβ3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfate. Virology 464-465 118-33 PubMed GONUTS page
  4. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  5. Sogos, V et al. (1998) Developmentally regulated expression and localization of fibroblast growth factor receptors in the human muscle. Dev. Dyn. 211 362-73 PubMed GONUTS page
  6. Ma, P et al. (2006) Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin. J. Cell Biol. 174 1097-106 PubMed GONUTS page
  7. 7.0 7.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. Dews, IC & Mackenzie, KR (2007) Transmembrane domains of the syndecan family of growth factor coreceptors display a hierarchy of homotypic and heterotypic interactions. Proc. Natl. Acad. Sci. U.S.A. 104 20782-7 PubMed GONUTS page
  9. Mali, M et al. (1990) Sequence of human syndecan indicates a novel gene family of integral membrane proteoglycans. J. Biol. Chem. 265 6884-9 PubMed GONUTS page