DANRE:F1QN37

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	No Information Provided.
Protein Name(s)	Uncharacterized protein (ECO:0000313 with Ensembl:ENSDARP00000044431)
External Links
UniProt	F1QN37
EMBL	CU861476 CU915637
Ensembl	ENSDART00000044432
ZFIN	ZDB-GENE-031112-7
GeneTree	ENSGT00530000063749
InParanoid	F1QN37
OMA	IEDCPIN
TreeFam	TF106496
Reactome	REACT_105685 REACT_204274 REACT_226884 REACT_233082 REACT_234903 REACT_235318 REACT_246520 REACT_252367 REACT_254900 REACT_259200 REACT_30407
Proteomes	UP000000437
Bgee	F1QN37
GO	GO:0005737 GO:0005634 GO:0060070 GO:0007050 GO:0006974 GO:0055123 GO:0048565 GO:0035050 GO:0035118 GO:0003157 GO:0031018 GO:0061031 GO:0030855 GO:0031017 GO:0001754 GO:0003146 GO:0001947 GO:0003170 GO:0070365 GO:0001889 GO:0030917 GO:0000281 GO:0055001 GO:0090090 GO:0008285 GO:0007026 GO:0071599 GO:0031016 GO:0043065 GO:0048920 GO:0044030 GO:1900052 GO:0060041 GO:0031290 GO:0048384 GO:0001501 GO:0061380 GO:0003306 GO:0090244 GO:0022006
Gene3D	1.25.10.10
InterPro	IPR026836 IPR009240 IPR009234 IPR009223 IPR026831 IPR026818 IPR011989 IPR016024 IPR000225 IPR009232 IPR009224
PANTHER	PTHR12607 PTHR12607:SF11
Pfam	PF05972 PF05956 PF05923 PF00514 PF05937 PF05924 PF11414
SMART	SM00185
SUPFAM	SSF48371
PROSITE	PS50176

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000281	mitotic cytokinesis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR026836	P	Seeded From UniProt	complete
	GO:0001501	skeletal system development	PMID:15358764^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt	complete
	GO:0001754	eye photoreceptor cell differentiation	PMID:16938888^[2]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-050914-1	P	Seeded From UniProt	complete
	GO:0001889	liver development	PMID:18585699^[3]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-050914-1 ZFIN:ZDB-MRPHLNO-051024-1	P	Seeded From UniProt	complete
	GO:0001889	liver development	PMID:18585699^[3]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-090130-4 ZFIN:ZDB-MRPHLNO-051024-1	P	Seeded From UniProt	complete
	GO:0001889	liver development	PMID:18585699^[3]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-050914-1	P	Seeded From UniProt	complete
	GO:0001889	liver development	PMID:18585699^[3]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090130-4	P	Seeded From UniProt	complete
	GO:0001947	heart looping	PMID:19103803^[4]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090916-1	P	Seeded From UniProt	complete
	GO:0003146	heart jogging	PMID:19103803^[4]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090916-1	P	Seeded From UniProt	complete
	GO:0003157	endocardium development	PMID:14534590^[5]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-050914-1	P	Seeded From UniProt	complete
	GO:0003170	heart valve development	PMID:19374549^[6]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090916-1	P	Seeded From UniProt	complete
	GO:0003306	Wnt signaling pathway involved in heart development	PMID:14534590^[5]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-050914-1	P	Seeded From UniProt	complete
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR026836	C	Seeded From UniProt	complete
	GO:0005737	cytoplasm	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR026836	C	Seeded From UniProt	complete
	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR026836	P	Seeded From UniProt	complete
	GO:0007026	negative regulation of microtubule depolymerization	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR026836	P	Seeded From UniProt	complete
	GO:0007050	cell cycle arrest	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR026836	P	Seeded From UniProt	complete
	GO:0008013	beta-catenin binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009224 InterPro:IPR009232 InterPro:IPR009240 InterPro:IPR026818 InterPro:IPR026836	F	Seeded From UniProt	complete
	GO:0008017	microtubule binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009234	F	Seeded From UniProt	complete
	GO:0008285	negative regulation of cell proliferation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR026836	P	Seeded From UniProt	complete
	GO:0016055	Wnt signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009223 InterPro:IPR009224 InterPro:IPR009232 InterPro:IPR009234 InterPro:IPR009240	P	Seeded From UniProt	complete
	GO:0016477	cell migration	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR026836	P	Seeded From UniProt	complete
	GO:0022006	zona limitans intrathalamica formation	PMID:19397905^[7]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090515-1	P	Seeded From UniProt	complete
	GO:0030178	negative regulation of Wnt signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR026818 InterPro:IPR026836	P	Seeded From UniProt	complete
	GO:0030855	epithelial cell differentiation	PMID:15358764^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt	complete
	GO:0030917	midbrain-hindbrain boundary development	PMID:19397905^[7]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090515-1	P	Seeded From UniProt	complete
	GO:0031016	pancreas development	PMID:18585699^[3]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-050914-1	P	Seeded From UniProt	complete
	GO:0031016	pancreas development	PMID:18585699^[3]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090130-4	P	Seeded From UniProt	complete
	GO:0031017	exocrine pancreas development	PMID:15358764^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt	complete
	GO:0031017	exocrine pancreas development	PMID:19374549^[6]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090916-1	P	Seeded From UniProt	complete
	GO:0031018	endocrine pancreas development	PMID:15358764^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt	complete
	GO:0031290	retinal ganglion cell axon guidance	PMID:19292673^[8]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090515-1	P	Seeded From UniProt	complete
	GO:0033334	fin morphogenesis	PMID:25519245^[9]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090515-1	P	Seeded From UniProt	complete
	GO:0035050	embryonic heart tube development	PMID:15358764^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt	complete
	GO:0035118	embryonic pectoral fin morphogenesis	PMID:15358764^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt	complete
	GO:0043065	positive regulation of apoptotic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR026836	P	Seeded From UniProt	complete
	GO:0044030	regulation of DNA methylation	PMID:20850014^[10]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-090916-1 ZFIN:ZDB-MRPHLNO-060928-5	P	Seeded From UniProt	complete
	GO:0044030	regulation of DNA methylation	PMID:20850014^[10]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-090916-1 ZFIN:ZDB-MRPHLNO-081015-1	P	Seeded From UniProt	complete
	GO:0044030	regulation of DNA methylation	PMID:20850014^[10]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090916-1	P	Seeded From UniProt	complete
	GO:0048384	retinoic acid receptor signaling pathway	PMID:20850014^[10]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-090916-1 ZFIN:ZDB-MRPHLNO-070121-2	P	Seeded From UniProt	complete
	GO:0048565	digestive tract development	PMID:15967793^[11]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090916-1	P	Seeded From UniProt	complete
	GO:0048565	digestive tract development	PMID:19374549^[6]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090916-1	P	Seeded From UniProt	complete
	GO:0048565	digestive tract development	PMID:19450512^[12]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090916-1	P	Seeded From UniProt	complete
	GO:0048565	digestive tract development	PMID:20850014^[10]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090916-1	P	Seeded From UniProt	complete
	GO:0048920	posterior lateral line neuromast primordium migration	PMID:19000839^[13]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-050914-1	P	Seeded From UniProt	complete
	GO:0055001	muscle cell development	PMID:19517013^[14]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-100719-1	P	Seeded From UniProt	complete
	GO:0055123	digestive system development	PMID:14534590^[5]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-050914-1	P	Seeded From UniProt	complete
	GO:0060041	retina development in camera-type eye	PMID:16938888^[2]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-050914-1	P	Seeded From UniProt	complete
	GO:0060041	retina development in camera-type eye	PMID:20549742^[15]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090916-1	P	Seeded From UniProt	complete
	GO:0060041	retina development in camera-type eye	PMID:20850014^[10]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090916-1	P	Seeded From UniProt	complete
	GO:0060070	canonical Wnt signaling pathway	PMID:19292673^[8]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090515-1	P	Seeded From UniProt	complete
	GO:0061031	endodermal digestive tract morphogenesis	PMID:19374549^[6]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090916-1	P	Seeded From UniProt	complete
	GO:0061380	superior colliculus development	PMID:19397905^[7]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090515-1	P	Seeded From UniProt	complete
	GO:0070365	hepatocyte differentiation	PMID:19374549^[6]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090916-1	P	Seeded From UniProt	complete
	GO:0071599	otic vesicle development	PMID:14534590^[5]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-050914-1	P	Seeded From UniProt	complete
	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:19397905^[7]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090515-1	P	Seeded From UniProt	complete
	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:19450512^[12]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090916-1	P	Seeded From UniProt	complete
	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:19517013^[14]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-100719-1	P	Seeded From UniProt	complete
	GO:0090244	Wnt signaling pathway involved in somitogenesis	PMID:19517013^[14]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-100719-1	P	Seeded From UniProt	complete
	GO:1900052	regulation of retinoic acid biosynthetic process	PMID:20850014^[10]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-090916-1 ZFIN:ZDB-MRPHLNO-060214-6	P	Seeded From UniProt	complete
	GO:1900052	regulation of retinoic acid biosynthetic process	PMID:20850014^[10]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-090916-1 ZFIN:ZDB-MRPHLNO-101021-7	P	Seeded From UniProt	complete
	GO:1900052	regulation of retinoic acid biosynthetic process	PMID:20850014^[10]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-090916-1 ZFIN:ZDB-MRPHLNO-101021-8	P	Seeded From UniProt	complete
	GO:1900052	regulation of retinoic acid biosynthetic process	PMID:20850014^[10]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-090916-1 ZFIN:ZDB-MRPHLNO-101021-9	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Nadauld, LD et al. (2004) Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation. J. Biol. Chem. 279 51581-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Nadauld, LD et al. (2006) Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development. Proc. Natl. Acad. Sci. U.S.A. 103 13409-14 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Goessling, W et al. (2008) APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev. Biol. 320 161-74 PubMed GONUTS page
↑ ^4.0 ^4.1 Lin, X & Xu, X (2009) Distinct functions of Wnt/beta-catenin signaling in KV development and cardiac asymmetry. Development 136 207-17 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Hurlstone, AF et al. (2003) The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature 425 633-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Faro, A et al. (2009) T-cell factor 4 (tcf7l2) is the main effector of Wnt signaling during zebrafish intestine organogenesis. Zebrafish 6 59-68 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Paridaen, JT et al. (2009) Apc1 is required for maintenance of local brain organizers and dorsal midbrain survival. Dev. Biol. 331 101-12 PubMed GONUTS page
↑ ^8.0 ^8.1 Paridaen, JT et al. (2009) Apc1-mediated antagonism of Wnt/beta-catenin signaling is required for retino-tectal pathfinding in the zebrafish. Zebrafish 6 41-7 PubMed GONUTS page
↑ Nagendran, M et al. (2015) Canonical Wnt signalling regulates epithelial patterning by modulating levels of laminins in zebrafish appendages. Development 142 320-30 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 ^10.9 Rai, K et al. (2010) DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC. Cell 142 930-42 PubMed GONUTS page
↑ Nadauld, LD et al. (2005) The zebrafish retinol dehydrogenase, rdh1l, is essential for intestinal development and is regulated by the tumor suppressor adenomatous polyposis coli. J. Biol. Chem. 280 30490-5 PubMed GONUTS page
↑ ^12.0 ^12.1 Phelps, RA et al. (2009) A two-step model for colon adenoma initiation and progression caused by APC loss. Cell 137 623-34 PubMed GONUTS page
↑ Aman, A & Piotrowski, T (2008) Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression. Dev. Cell 15 749-61 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Tee, JM et al. (2009) Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling. PLoS ONE 4 e5880 PubMed GONUTS page
↑ Stephens, WZ et al. (2010) Loss of adenomatous polyposis coli (apc) results in an expanded ciliary marginal zone in the zebrafish eye. Dev. Dyn. 239 2066-77 PubMed GONUTS page

[PMID:15358764-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Nadauld, LD et al. (2004) Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation. J. Biol. Chem. 279 51581-9 PubMed GONUTS page

[PMID:16938888-2] 2.0 ^2.1 Nadauld, LD et al. (2006) Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development. Proc. Natl. Acad. Sci. U.S.A. 103 13409-14 PubMed GONUTS page

[PMID:18585699-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Goessling, W et al. (2008) APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev. Biol. 320 161-74 PubMed GONUTS page

[PMID:19103803-4] 4.0 ^4.1 Lin, X & Xu, X (2009) Distinct functions of Wnt/beta-catenin signaling in KV development and cardiac asymmetry. Development 136 207-17 PubMed GONUTS page

[PMID:14534590-5] 5.0 ^5.1 ^5.2 ^5.3 Hurlstone, AF et al. (2003) The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature 425 633-7 PubMed GONUTS page

[PMID:19374549-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Faro, A et al. (2009) T-cell factor 4 (tcf7l2) is the main effector of Wnt signaling during zebrafish intestine organogenesis. Zebrafish 6 59-68 PubMed GONUTS page

[PMID:19397905-7] 7.0 ^7.1 ^7.2 ^7.3 Paridaen, JT et al. (2009) Apc1 is required for maintenance of local brain organizers and dorsal midbrain survival. Dev. Biol. 331 101-12 PubMed GONUTS page

[PMID:19292673-8] 8.0 ^8.1 Paridaen, JT et al. (2009) Apc1-mediated antagonism of Wnt/beta-catenin signaling is required for retino-tectal pathfinding in the zebrafish. Zebrafish 6 41-7 PubMed GONUTS page

[PMID:25519245-9] Nagendran, M et al. (2015) Canonical Wnt signalling regulates epithelial patterning by modulating levels of laminins in zebrafish appendages. Development 142 320-30 PubMed GONUTS page

[PMID:20850014-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 ^10.9 Rai, K et al. (2010) DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC. Cell 142 930-42 PubMed GONUTS page

[PMID:15967793-11] Nadauld, LD et al. (2005) The zebrafish retinol dehydrogenase, rdh1l, is essential for intestinal development and is regulated by the tumor suppressor adenomatous polyposis coli. J. Biol. Chem. 280 30490-5 PubMed GONUTS page

[PMID:19450512-12] 12.0 ^12.1 Phelps, RA et al. (2009) A two-step model for colon adenoma initiation and progression caused by APC loss. Cell 137 623-34 PubMed GONUTS page

[PMID:19000839-13] Aman, A & Piotrowski, T (2008) Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression. Dev. Cell 15 749-61 PubMed GONUTS page

[PMID:19517013-14] 14.0 ^14.1 ^14.2 Tee, JM et al. (2009) Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling. PLoS ONE 4 e5880 PubMed GONUTS page

[PMID:20549742-15] Stephens, WZ et al. (2010) Loss of adenomatous polyposis coli (apc) results in an expanded ciliary marginal zone in the zebrafish eye. Dev. Dyn. 239 2066-77 PubMed GONUTS page

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DANRE:F1QN37

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