HUMAN:WNT9B

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	WNT9B (synonyms: WNT14B, WNT15)
Protein Name(s)	Protein Wnt-9b Protein Wnt-14b Protein Wnt-15
External Links
UniProt	O14905
EMBL	AB063483 AY358217 AC015855 AF028703
CCDS	CCDS11506.1
RefSeq	NP_003387.1
UniGene	Hs.326420
ProteinModelPortal	O14905
SMR	O14905
BioGrid	113321
STRING	9606.ENSP00000290015
PhosphoSite	O14905
PaxDb	O14905
PRIDE	O14905
Ensembl	ENST00000290015 ENST00000613753
GeneID	7484
KEGG	hsa:7484
UCSC	uc002ikw.1
CTD	7484
GeneCards	GC17P044910
H-InvDB	HIX0027116
HGNC	HGNC:12779
HPA	HPA058361 HPA059572
MIM	602864
neXtProt	NX_O14905
PharmGKB	PA37380
eggNOG	NOG291879
GeneTree	ENSGT00690000101857
HOGENOM	HOG000039529
HOVERGEN	HBG001595
InParanoid	O14905
KO	K01064
OMA	EEEVYTC
PhylomeDB	O14905
TreeFam	TF105310
Reactome	REACT_163710 REACT_18372
ChiTaRS	WNT9B
GenomeRNAi	7484
NextBio	29318
PRO	PR:O14905
Proteomes	UP000005640 UP000005640
Bgee	O14905
CleanEx	HS_WNT9B
ExpressionAtlas	O14905
Genevestigator	O14905
GO	GO:0005576 GO:0005615 GO:0005578 GO:0005109 GO:0001658 GO:0060070 GO:0045165 GO:0007267 GO:0071300 GO:0009267 GO:0072044 GO:0061303 GO:0048701 GO:0072046 GO:0001701 GO:0072003 GO:0030539 GO:0072038 GO:0072181 GO:0072174 GO:0007275 GO:0030182 GO:0060021 GO:0043085 GO:0009786 GO:0003339 GO:0001932 GO:0035150 GO:0032526 GO:0061038 GO:0016055 GO:0060071
InterPro	IPR005817 IPR026535 IPR018161
PANTHER	PTHR12027 PTHR12027:SF84
Pfam	PF00110
PRINTS	PR01349
SMART	SM00097
PROSITE	PS00246

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1902455	negative regulation of stem cell population maintenance	PMID:25640183^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905438	non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	PMID:25640183^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	negatively_regulates:(GO:0019827) positively_regulates:(GO:0030154)	Seeded From UniProt	complete
involved_in	GO:1904948	midbrain dopaminergic neuron differentiation	PMID:25640183^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:28733458^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:28733458^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061303	cornea development in camera-type eye	PMID:16258938^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3L250	P		Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	PMID:11604992^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56706	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56706	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:9441749^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:9441749^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:9441749^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98957 PANTHER:PTN000246517 UniProtKB:P49339 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246517 RGD:69250 UniProtKB:P56706 UniProtKB:Q98SN7	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010194 MGI:MGI:108061 MGI:MGI:1197020 MGI:MGI:98953 MGI:MGI:98954 MGI:MGI:98956 MGI:MGI:98958 MGI:MGI:98960 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 UniProtKB:P41221 UniProtKB:Q98SN7 WB:WBGene00000858 WB:WBGene00003029 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 MGI:MGI:98956 MGI:MGI:98957 PANTHER:PTN000246517 RGD:1311441 RGD:69250 UniProtKB:P41221 UniProtKB:P56704 UniProtKB:P56705 UniProtKB:Q2LMP1 UniProtKB:Q9UBV4 UniProtKB:Q9YGX6	C		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 FB:FBgn0004360 FB:FBgn0010453 FB:FBgn0038134 MGI:MGI:98956 MGI:MGI:98957 MGI:MGI:98958 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 RGD:69079 UniProtKB:P09544 UniProtKB:P41221 UniProtKB:P56703 UniProtKB:Q98SN7	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0072181	mesonephric duct formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0072174	metanephric tubule formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0072170	metanephric tubule development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0072164	mesonephric tubule development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0072078	nephron tubule morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0072046	establishment of planar polarity involved in nephron morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0072044	collecting duct development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0072038	mesenchymal stem cell maintenance involved in nephron morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0072003	kidney rudiment formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0061038	uterus morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0060993	kidney morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0060021	roof of mouth development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0048701	embryonic cranial skeleton morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
enables	GO:0039706	co-receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	F		Seeded From UniProt	complete
involved_in	GO:0035150	regulation of tube size	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0030539	male genitalia development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0009786	regulation of asymmetric cell division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	F		Seeded From UniProt	complete
involved_in	GO:0003339	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35468 ensembl:ENSMUSP00000018630	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	Reactome:R-HSA-195721	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-3247843	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Lee, CT et al. (2015) Functional consequences of 17q21.31/WNT3-WNT9B amplification in hPSCs with respect to neural differentiation. Cell Rep 10 616-32 PubMed GONUTS page
↑ ^2.0 ^2.1 Voloshanenko, O et al. (2017) Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 31 4832-4844 PubMed GONUTS page
↑ Fokina, VM & Frolova, EI (2006) Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Dev. Dyn. 235 496-505 PubMed GONUTS page
↑ Kirikoshi, H et al. (2001) Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family. Int. J. Oncol. 19 947-52 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Bergstein, I et al. (1997) Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. Genomics 46 450-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25640183-1] 1.0 ^1.1 ^1.2 Lee, CT et al. (2015) Functional consequences of 17q21.31/WNT3-WNT9B amplification in hPSCs with respect to neural differentiation. Cell Rep 10 616-32 PubMed GONUTS page

[PMID:28733458-2] 2.0 ^2.1 Voloshanenko, O et al. (2017) Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 31 4832-4844 PubMed GONUTS page

[PMID:16258938-3] Fokina, VM & Frolova, EI (2006) Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Dev. Dyn. 235 496-505 PubMed GONUTS page

[PMID:11604992-4] Kirikoshi, H et al. (2001) Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family. Int. J. Oncol. 19 947-52 PubMed GONUTS page

[PMID:9441749-5] 5.0 ^5.1 ^5.2 Bergstein, I et al. (1997) Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. Genomics 46 450-8 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:WNT9B

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