HUMAN:WN10B

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	WNT10B (synonyms: WNT12)
Protein Name(s)	Protein Wnt-10b Protein Wnt-12
External Links
UniProt	O00744
EMBL	U81787 AB070724 AK312906 AC073610 CH471111 BC096353 BC096354 BC096355 BC096356 X97057 AF028700
CCDS	CCDS8775.1
RefSeq	NP_003385.2
UniGene	Hs.91985
ProteinModelPortal	O00744
SMR	O00744
BioGrid	113317
STRING	9606.ENSP00000301061
PhosphoSite	O00744
PaxDb	O00744
PRIDE	O00744
DNASU	7480
Ensembl	ENST00000301061 ENST00000407467
GeneID	7480
KEGG	hsa:7480
UCSC	uc001rss.3 uc001rst.3
CTD	7480
GeneCards	GC12M049359
HGNC	HGNC:12775
HPA	HPA055048
MIM	225300 601906
neXtProt	NX_O00744
Orphanet	2440
PharmGKB	PA37377
eggNOG	NOG240772
GeneTree	ENSGT00690000101857
HOGENOM	HOG000039528
HOVERGEN	HBG001595
InParanoid	O00744
KO	K01357
OMA	RGHNVLQ
OrthoDB	EOG7C8GJ8
PhylomeDB	O00744
TreeFam	TF105310
Reactome	REACT_163710 REACT_18372 REACT_27161
SignaLink	O00744
GeneWiki	WNT10B
GenomeRNAi	7480
NextBio	29300
PRO	PR:O00744
Proteomes	UP000005640
Bgee	O00744
CleanEx	HS_WNT10B
ExpressionAtlas	O00744
Genevestigator	O00744
GO	GO:0005576 GO:0005615 GO:0005578 GO:0005109 GO:0048018 GO:0060346 GO:0060070 GO:0007050 GO:0045165 GO:0071320 GO:0071464 GO:0071374 GO:0071300 GO:0002062 GO:0061196 GO:0000086 GO:0071425 GO:0006629 GO:0014835 GO:0050680 GO:0045599 GO:0000122 GO:0030182 GO:0051885 GO:0043065 GO:0030501 GO:0090263 GO:0008284 GO:0030858 GO:0010971 GO:0045669 GO:0045899 GO:0051091 GO:0050821 GO:0032434 GO:0048641 GO:0050909 GO:0048741 GO:0007224 GO:0016055
InterPro	IPR005817 IPR013302 IPR018161
PANTHER	PTHR12027
Pfam	PF00110
PRINTS	PR01893 PR01349
SMART	SM00097
PROSITE	PS00246

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0007165	signal transduction		ECO:0000303			P	Source: ProtInc	Missing: reference
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:15190075^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48614	P	Seeded From UniProt	complete
involved_in	GO:0071425	hematopoietic stem cell proliferation	PMID:9787155^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:17761539^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:10937998^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:17761539^[3]	ECO:0000305	curator inference used in manual assertion	GO:0060070	F	Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	PMID:10937998^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:17761539^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56706	P	Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56706	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15135146^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0002062	chondrocyte differentiation	PMID:15135146^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98957 PANTHER:PTN000246517 UniProtKB:P49339 ZFIN:ZDB-GENE-980526-332	P	Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246517 RGD:69250 UniProtKB:P56706 UniProtKB:Q98SN7	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010194 MGI:MGI:108061 MGI:MGI:1197020 MGI:MGI:98953 MGI:MGI:98954 MGI:MGI:98956 MGI:MGI:98958 MGI:MGI:98960 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 UniProtKB:P41221 UniProtKB:Q98SN7 WB:WBGene00000858 WB:WBGene00003029 ZFIN:ZDB-GENE-980526-332	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 MGI:MGI:98956 MGI:MGI:98957 PANTHER:PTN000246517 RGD:1311441 RGD:69250 UniProtKB:P41221 UniProtKB:P56704 UniProtKB:P56705 UniProtKB:Q2LMP1 UniProtKB:Q9UBV4 UniProtKB:Q9YGX6	C	Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 FB:FBgn0004360 FB:FBgn0010453 FB:FBgn0038134 MGI:MGI:98956 MGI:MGI:98957 MGI:MGI:98958 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 RGD:69079 UniProtKB:P09544 UniProtKB:P41221 UniProtKB:P56703 UniProtKB:Q98SN7	F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P	Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0071425	hematopoietic stem cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0071374	cellular response to parathyroid hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0071320	cellular response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0061196	fungiform papilla development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0060346	bone trabecula formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0051885	positive regulation of timing of anagen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0051246	regulation of protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0050909	sensory perception of taste	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0048741	skeletal muscle fiber development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0048641	regulation of skeletal muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0045778	positive regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0045598	regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0043403	skeletal muscle tissue regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0030858	positive regulation of epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0014835	myoblast differentiation involved in skeletal muscle regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
involved_in	GO:0000086	G2/M transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48614 ensembl:ENSMUSP00000023732	P	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR013302	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR013302	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR013302	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR013302	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	Reactome:R-HSA-195721	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-3247843	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Longo, KA et al. (2004) Wnt10b inhibits development of white and brown adipose tissues. J. Biol. Chem. 279 35503-9 PubMed GONUTS page
↑ Van Den Berg, DJ et al. (1998) Role of members of the Wnt gene family in human hematopoiesis. Blood 92 3189-202 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Yoshikawa, H et al. (2007) WNT10B functional dualism: beta-catenin/Tcf-dependent growth promotion or independent suppression with deregulated expression in cancer. Mol. Biol. Cell 18 4292-303 PubMed GONUTS page
↑ ^4.0 ^4.1 Ross, SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289 950-3 PubMed GONUTS page
↑ ^5.0 ^5.1 Yates, KE (2004) Demineralized bone alters expression of Wnt network components during chondroinduction of post-natal fibroblasts. Osteoarthr. Cartil. 12 497-505 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15190075-1] Longo, KA et al. (2004) Wnt10b inhibits development of white and brown adipose tissues. J. Biol. Chem. 279 35503-9 PubMed GONUTS page

[PMID:9787155-2] Van Den Berg, DJ et al. (1998) Role of members of the Wnt gene family in human hematopoiesis. Blood 92 3189-202 PubMed GONUTS page

[PMID:17761539-3] 3.0 ^3.1 ^3.2 Yoshikawa, H et al. (2007) WNT10B functional dualism: beta-catenin/Tcf-dependent growth promotion or independent suppression with deregulated expression in cancer. Mol. Biol. Cell 18 4292-303 PubMed GONUTS page

[PMID:10937998-4] 4.0 ^4.1 Ross, SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289 950-3 PubMed GONUTS page

[PMID:15135146-5] 5.0 ^5.1 Yates, KE (2004) Demineralized bone alters expression of Wnt network components during chondroinduction of post-natal fibroblasts. Osteoarthr. Cartil. 12 497-505 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:WN10B

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