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HUMAN:WNT8A

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) WNT8A (synonyms: WNT8D)
Protein Name(s) Protein Wnt-8a

Protein Wnt-8d

External Links
UniProt Q9H1J5
EMBL AB057725
AY009402
CCDS CCDS43368.1
RefSeq NP_001287867.1
NP_001287868.1
NP_490645.1
UniGene Hs.591274
ProteinModelPortal Q9H1J5
SMR Q9H1J5
BioGrid 113315
STRING 9606.ENSP00000381739
PhosphoSite Q9H1J5
DMDM 288558833
REPRODUCTION-2DPAGE Q9H1J5
PaxDb Q9H1J5
PRIDE Q9H1J5
DNASU 7478
Ensembl ENST00000361560
ENST00000398754
GeneID 7478
KEGG hsa:7478
UCSC uc003lcd.1
CTD 7478
GeneCards GC05P137447
HGNC HGNC:12788
HPA HPA038539
MIM 606360
neXtProt NX_Q9H1J5
PharmGKB PA37389
eggNOG NOG277037
GeneTree ENSGT00690000101857
HOGENOM HOG000039529
HOVERGEN HBG001595
InParanoid Q9H1J5
KO K00714
OrthoDB EOG7C8GJ8
PhylomeDB Q9H1J5
TreeFam TF105310
Reactome REACT_163710
REACT_18372
REACT_200610
REACT_200777
SignaLink Q9H1J5
GenomeRNAi 7478
NextBio 29292
PRO PR:Q9H1J5
Proteomes UP000005640
Bgee Q9H1J5
CleanEx HS_WNT8A
ExpressionAtlas Q9H1J5
Genevestigator Q9H1J5
GO GO:0005576
GO:0005615
GO:0005578
GO:0005109
GO:0048018
GO:0060070
GO:0061317
GO:0044335
GO:0014034
GO:0030182
GO:0060021
GO:0044324
GO:0032526
InterPro IPR005817
IPR013301
IPR018161
PANTHER PTHR12027
PTHR12027:SF92
Pfam PF00110
PRINTS PR01892
PR01349
SMART SM00097
PROSITE PS00246

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0048018

receptor ligand activity

PMID:28733458[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

PMID:28733458[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061317

canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment

PMID:20559569[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

PMID:11408932[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28026

P

Seeded From UniProt

complete

involved_in

GO:0062009

secondary palate development

PMID:18413325[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0048018

receptor ligand activity

PMID:11408932[3]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0044335

canonical Wnt signaling pathway involved in neural crest cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28026

P

Seeded From UniProt

complete

involved_in

GO:0044324

regulation of transcription involved in anterior/posterior axis specification

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28026

P

Seeded From UniProt

complete

involved_in

GO:0032526

response to retinoic acid

PMID:11956596[5]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0014034

neural crest cell fate commitment

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28026

P

Seeded From UniProt

complete

colocalizes_with

GO:0005615

extracellular space

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28026

C

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28026

C

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

PMID:11408932[3]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045165

cell fate commitment

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98957
PANTHER:PTN000246517
UniProtKB:P49339
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000246517
RGD:69250
UniProtKB:P56706
UniProtKB:Q98SN7

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010194
MGI:MGI:108061
MGI:MGI:1197020
MGI:MGI:98953
MGI:MGI:98954
MGI:MGI:98956
MGI:MGI:98958
MGI:MGI:98960
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
UniProtKB:P41221
UniProtKB:Q98SN7
WB:WBGene00000858
WB:WBGene00003029
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
MGI:MGI:98956
MGI:MGI:98957
PANTHER:PTN000246517
RGD:1311441
RGD:69250
UniProtKB:P41221
UniProtKB:P56704
UniProtKB:P56705
UniProtKB:Q2LMP1
UniProtKB:Q9UBV4
UniProtKB:Q9YGX6

C

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
FB:FBgn0004360
FB:FBgn0010453
FB:FBgn0038134
MGI:MGI:98956
MGI:MGI:98957
MGI:MGI:98958
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
RGD:69079
UniProtKB:P09544
UniProtKB:P41221
UniProtKB:P56703
UniProtKB:Q98SN7

F

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048018

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048018

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR013301
InterPro:IPR034312

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR013301

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR013301
InterPro:IPR034312

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR013301
InterPro:IPR034312

P

Seeded From UniProt

complete

involved_in

GO:1904886

beta-catenin destruction complex disassembly

Reactome:R-HSA-4641262

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

Reactome:R-HSA-195721

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-NUL-1458902
Reactome:R-HSA-3247843
Reactome:R-HSA-201677
Reactome:R-HSA-1504186

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Voloshanenko, O et al. (2017) Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 31 4832-4844 PubMed GONUTS page
  2. ↑ Paige, SL et al. (2010) Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells. PLoS ONE 5 e11134 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Saitoh, T & Katoh, M (2001) Molecular cloning and characterization of human WNT8A. Int. J. Oncol. 19 123-7 PubMed GONUTS page
  4. ↑ Chiquet, BT et al. (2008) Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. Hum. Mol. Genet. 17 2212-8 PubMed GONUTS page
  5. ↑ Saitoh, T et al. (2002) Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells. Int. J. Oncol. 20 999-1003 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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